Circulating phospholipase A2 and C-reactive protein after polytrauma—Effect of superoxide dismutase

1991 ◽  
Vol 23 (1) ◽  
pp. 2-4 ◽  
Author(s):  
R. Tikku ◽  
I. Marzi ◽  
J. Dike ◽  
O. Trentz ◽  
V. Bühren
Keyword(s):  
Superoxide Dismutase ◽  
Phospholipase A2 ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Comparison of Lipoprotein-Associated Phospholipase A2 and High Sensitive C-Reactive Protein as Determinants of Metabolic Syndrome in Subjects without Coronary Heart Disease: In Search of the Best Predictor

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Mónica Acevedo ◽  
Paola Varleta ◽  
Verónica Kramer ◽  
Giovanna Valentino ◽  
Teresa Quiroga ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Phospholipase A2 ◽  
High Sensitivity ◽  
Roc Curves ◽  
Activity Levels ◽  
Pla2 Activity ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Cv Disease

High sensitivity C-reactive protein (hsCRP) is a marker of metabolic syndrome (MS) and cardiovascular (CV) disease. Lipoprotein-associated phospholipase A2 (Lp-PLA2) also predicts CV disease. There are no reports comparing these markers as predictors of MS.Methods. Cross-sectional study comparing Lp-PLA2 and hsCRP as predictors of MS in asymptomatic subjects was carried out; 152 subjects without known atherosclerosis participated. Data were collected on demographics, cardiovascular risk factors, anthropometric and biochemical measurements, and hsCRP and Lp-PLA2 activity levels. A logistic regression analysis was performed with each biomarker and receiver operating characteristic (ROC) curves were constructed for MS.Results. Mean age was 46 ± 11 years, and 38% of the subjects had MS. Mean Lp-PLA2 activity was 185 ± 48 nmol/mL/min, and mean hsCRP was 2.1 ± 2.2 mg/L. Subjects with MS had significantly higher levels of Lp-PLA2 (P=0.03) and hsCRP (P<0.0001) than those without MS. ROC curves showed that both markers predicted MS.Conclusion. Lp-PLA2 and hsCRP are elevated in subjects with MS. Both biomarkers were independent and significant predictors for MS, emphasizing the role of inflammation in MS. Further research is necessary to determine if inflammation predicts a higher risk for CV events in MS subjects.

scholarly journals Kinetics of C-reactive protein, interleukin-6 and -10, and phospholipase A2-II in severely traumatized septic patients

2010 ◽  
Vol 67 (11) ◽  
pp. 893-897 ◽  
Author(s):  
Zeljko Lausevic ◽  
Goran Vukovic ◽  
Biljana Stojimirovic ◽  
Jasna Trbojevic-Stankovic ◽  
Vladimir Resanovic ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Injury Severity ◽  
C Reactive Protein ◽  
Surgical Intensive Care ◽  
Septic Complications ◽  
Mean Values ◽  
Protein Levels ◽  
Reactive Protein ◽  
Significant Difference ◽  
Kinetics Of

Background/Aim. Injury-induced anergy is one of the key factors contributing to trauma victims' high susceptibility to sepsis. This group of patients is mostly of young age and it is therefore essential to be able to predict as accurately as possible the development of septic complications, so appropriate treatment could be provided. The aim of this study was to assess kinetics of interleukin (IL) -6 and -10, phospholipase A2- II and C-reactive protein (CRP) in severely traumatized patients and explore the possibilities for early detection of potentially septic patients. Methods. This prospective study included 65 traumatized patients with injury severity score (ISS) > 18, requiring treatment at surgical intensive care units, divided into two groups: 24 patients without sepsis and 41 patients with sepsis. C-reactive protein, IL-6 and -10 and phospholipase A2 group II, were determined within the first 24 hours, and on the second, third and seventh day of hospitalization. Results. Mean values of IL-6 and phospholipase A2-II in the patients with and without sepsis did not show a statistically significant difference on any assessed time points. In the septic patients with ISS 29-35 and > 35 on the days two and seven a statistically significantly lower level of IL-10 was found, compared with those without sepsis and with the same ISS. C-reactive protein levels were significantly higher in septic patients with ISS 18-28 on the first day. On the second, third and seventh day CRP levels were significantly lower in the groups of septic patients with ISS 29-35 and > 35, than in those with the same ISS but without sepsis. Conclusion. Mean levels of CRP on the first day after the injury may be useful predictor of sepsis development in traumatized patients with ISS score 18-28. Mean levels of CRP on the days two, three and seven after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score more than 28. Mean levels of IL-10 on the second and seventh day after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score > 28.

Serum amyloid A, phospholipase A2-IIA and C-reactive protein as inflammatory biomarkers for prostate diseases

2013 ◽  
Vol 62 (12) ◽  
pp. 1063-1072 ◽  
Author(s):  
Mario Menschikowski ◽  
Albert Hagelgans ◽  
Susanne Fuessel ◽  
Olga A. Mareninova ◽  
Liana Asatryan ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Inflammatory Biomarkers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Amyloid A ◽  
Prostate Diseases

scholarly journals 1028-170 Higher levels of lipoprotein-associated phospholipase A2 are associated with higher incidence of cardiovascular events at follow-up independent of C-reactive protein

2004 ◽  
Vol 43 (5) ◽  
pp. A454
Author(s):  
Emmanouil S Brikalis ◽  
Joseph P McConnell ◽  
Ryan J Lennon ◽  
Ahmad A Elesber ◽  
Jeffrey G Meyers ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Cardiovascular Events ◽  
C Reactive Protein ◽  
Reactive Protein

Inhibition of human group II phospholipase A2 by C-reactive protein in vitro

1995 ◽  
Vol 11 (2) ◽  
pp. 187-200 ◽  
Author(s):  
Peter Vadas ◽  
Eva Stefanski ◽  
Brigitte Grouix ◽  
B.Diana Schouten ◽  
Waldemar Pruzanski
Keyword(s):  
Phospholipase A2 ◽  
Human Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Group Ii

Serum C-reactive protein parallels secretory phospholipase A2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome

Blood ◽  
2005 ◽  
Vol 105 (8) ◽  
pp. 3384-3385 ◽  
Author(s):  
Emilee M. Bargoma ◽  
Joyce K. Mitsuyoshi ◽  
Sandra K. Larkin ◽  
Lori A. Styles ◽  
Frans A. Kuypers ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Phospholipase A2 ◽  
Sickle Cell ◽  
Acute Chest Syndrome ◽  
Secretory Phospholipase A2 ◽  
Cell Disease ◽  
C Reactive Protein ◽  
Secretory Phospholipase ◽  
Reactive Protein
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