Relationship between single nucleotide polymorphism in TNF-α gene promoter region and inibitory effects of triptolide on TNF-α production in peripheral blood mononuclear cells of healthy humans

2006 ◽  
Vol 26 (3) ◽  
pp. 347-349 ◽  
Author(s):  
Tu Shenghao ◽  
Chen Hongbo ◽  
Sheng Dongyun ◽  
Hu Yonghong ◽  
Liu Peilin
Keyword(s):  
Promoter Region ◽  
Mononuclear Cells ◽  
Gene Promoter ◽  
Nucleotide Polymorphism ◽  
Peripheral Blood Mononuclear ◽  
Single Nucleotide ◽  
Healthy Humans ◽  
Tnf Α ◽  
Blood Mononuclear Cells ◽  
Gene Promoter Region

scholarly journals Interaction Between Single Nucleotide Polymorphism in Catalase Gene and Catalase Activity Under the Conditions of Oxidative Stress

2012 ◽  
pp. 655-658 ◽  
Author(s):  
A. V. KOMINA ◽  
K. A. KOROSTILEVA ◽  
S. N. GYRYLOVA ◽  
R. N. BELONOGOV ◽  
T. G. RUKSHA
Keyword(s):  
Oxidative Stress ◽  
Catalase Activity ◽  
Promoter Region ◽  
Mutant Allele ◽  
Mononuclear Cells ◽  
Oxygen Species ◽  
Nucleotide Polymorphism ◽  
Peripheral Blood Mononuclear ◽  
Single Nucleotide ◽  
Catalase Gene

Catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species. The –262C>T polymorphism in the promoter region of catalase gene was found to be associated with altered catalase levels. In this study, peripheral blood mononuclear cells catalase activity was measured after H2O2-induced oxidative stress. C/T and T/T genotypes were associated with the decrease of catalase levels in contrast to C/C donors who had elevated catalase activity in the presence of 0.4 and 0.7 mM H2O2. Genotype-dependent response of catalase activity to oxidative stress might be related to the predisposition of catalase mutant allele carriers to disorders mediated by oxidative stress.

Single Nucleotide Polymorphism T(861-20)C in TGFbeta1 Gene Affects its Expression in Peripheral Blood Mononuclear Cells in Russian Postmenopausal Women

Bone ◽  
2008 ◽  
Vol 43 ◽  
pp. S45
Author(s):  
Elena Tchetina ◽  
Mikhail Krylov ◽  
Oksana Nikitinskaya ◽  
Nikolai Demin ◽  
Tatiana Korotkova ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Postmenopausal Women ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Nucleotide Polymorphism ◽  
Peripheral Blood Mononuclear ◽  
Single Nucleotide ◽  
Blood Mononuclear Cells

scholarly journals SERPINA1 Gene Promoter Is Differentially Methylated in Peripheral Blood Mononuclear Cells of Pregnant Women

2020 ◽  
Vol 8 ◽  
Author(s):  
John Charles Rotondo ◽  
Lucia Oton-Gonzalez ◽  
Rita Selvatici ◽  
Paola Rizzo ◽  
Rita Pavasini ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Gene Promoter ◽  
Peripheral Blood Mononuclear ◽  
Serpina1 Gene ◽  
Blood Mononuclear Cells
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