A New Cyclo-Oxygenase-2 Gene Variant in the Han Chinese Population is Associated with an Increased Risk of Gastric Carcinoma

2010 ◽  
Vol 14 (6) ◽  
pp. 351-355 ◽  
Author(s):  
Yumin Li ◽  
Wenting He ◽  
Tao Liu ◽  
Quanbao Zhang
Keyword(s):  
Gastric Carcinoma ◽  
Chinese Population ◽  
Han Chinese ◽  
Gene Variant ◽  
Han Chinese Population ◽  
Increased Risk

scholarly journals Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yanmei Ruan ◽  
Jinwei Zhang ◽  
Shiqi Mai ◽  
Wenfeng Zeng ◽  
Lili Huang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Chinese Population ◽  
Conditional Logistic Regression ◽  
Han Chinese ◽  
Control Group ◽  
Environment Interaction ◽  
Noise Induced Hearing Loss ◽  
Han Chinese Population ◽  
Hearing Thresholds ◽  
Increased Risk

AbstractGenetic factors and gene-environment interaction may play an important role in the development of noise induced hearing loss (NIHL). 191 cases and 191 controls were selected by case–control study. Among them, case groups were screened from workers exposed to noise in binaural high-frequency hearing thresholds greater than 25 dB (A). Workers with hearing thresholds ≤ 25 dB (A) in any binaural frequency band were selected to the control group, based on matching factors such as age, exposure time to noise, and operating position. The blood samples from two groups of workers were subjected to DNA extraction and SNP sequencing of CASP3 and CASP7 genes using the polymerase chain reaction ligase detection reaction method. Conditional logistic regression correction was used to analyze the genetic variation associated with susceptibility to NIHL. There was an association between rs2227310 and rs4353229 of the CASP7 gene and the risk of NIHL. Compared with the GG genotype, the CC genotype of rs2227310 reduced the risk of NIHL. Compared with CC genotype, the TT genotype of rs4353229 reduced the risk of NIHL. Workers carrying the rs2227310GG and rs4353229CC genotype had an increased risk of NIHL compared to workers without any high-risk genotype. There were additive interaction and multiplication interaction between CASP7rs2227310 and CNE, and the same interaction between CASP7rs4353229 and CNE. The interaction between the CASP7 gene and CNE significantly increased the risk of NIHL. The genetic polymorphisms of CASP7rs2227310GG and CASP7rs4353229CC were associated with an increased risk of NIHL in Han Chinese population and have the potential to act as biomarkers for noise-exposed workers.

scholarly journals The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Guangsen Hou ◽  
Yong Tang ◽  
Luping Ren ◽  
Yunpeng Guan ◽  
Xiaoyu Hou ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chinese Population ◽  
Han Chinese ◽  
Hebei Province ◽  
Control Group ◽  
Chi Square ◽  
Han Chinese Population ◽  
Increased Risk ◽  
Bonferroni Test

Background. Our aim was to investigate the association between the genetics of the angiopoietin protein-like 8 (ANGPTL8) rs2278426 (C/T) polymorphism with prediabetes (pre-DM) and type 2 diabetes (T2DM) in a Han Chinese population in Hebei Province, China. Methods. We enrolled 1,460 participants into this case-control study: healthy controls, n = 524; pre-DM, n = 460; and T2DM: n = 460. Ligase assays on blood samples from all participants were used to identify polymorphisms. Differences in genotype and allele distributions were compared by the chi-square test and one-way analysis of variance, and a post hoc pairwise analysis was performed using the Bonferroni test. The logistic regression technique was adjusted for age, sex, and body mass index. Results. The frequency of the TT (10.9%) genotype was significantly higher in pre-DM patients than in controls (odds ratio [OR] = 1.696, 95% confidence interval [CI] = 1.026–2.802, P = 0.039 ). In the T2DM group, the CT (48%) and TT (15%) genotypes were significantly higher compared with those in the control group (CT : OR = 1.384, 95% CI = 1.013–1.890, P = 0.041 ; TT : OR = 2.530, 95% CI = 1.476–4.334, P = 0.001 ). The frequency of the T allele was significantly higher in the pre-DM (32.8%) and T2DM (39%) groups compared with the control group (26.9%) and was significantly associated with an increased risk of pre-DM (OR = 1.253, 95% CI = 1.017–1.544, P = 0.034 ) and T2DM (OR = 1.518, 95% CI = 1.214–1.897, P = 0.001 ). Furthermore, insulin levels in the pre-DM and T2DM groups were significantly decreased in those with the TT genotype compared with the CC and CT genotypes. Conclusion. ANGPTL8 rs2278426 may be involved in the mechanism of insulin secretion and could lead to an increased risk of pre-DM and T2DM.

A functional variant in CHK1 contributes to increased risk of nasopharyngeal carcinoma in a Han Chinese population

2020 ◽  
Vol 121 (5-6) ◽  
pp. 3248-3255
Author(s):  
Zhen Guo ◽  
Youhong Wang ◽  
Yu Zhao ◽  
Yi Jin ◽  
Liang An ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Increased Risk ◽  
Functional Variant

GLIS1rs797906: An Increased Risk Factor for Late-Onset Parkinson’s Disease in the Han Chinese Population

2012 ◽  
Vol 68 (2) ◽  
pp. 89-92 ◽  
Author(s):  
Wei Song ◽  
Yong Ping Chen ◽  
Rui Huang ◽  
Ke Chen ◽  
Ping Lei Pan ◽  
...  
Keyword(s):  
Risk Factor ◽  
Chinese Population ◽  
Late Onset ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Increased Risk

scholarly journals A Promoter Region Polymorphism inPDCD-1Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
CuiPing Liu ◽  
JueAn Jiang ◽  
Li Gao ◽  
XiaoHan Hu ◽  
FengMing Wang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Chinese Population ◽  
Direct Sequencing ◽  
Han Chinese ◽  
Chinese Patients ◽  
Sequencing Analysis ◽  
Healthy Controls ◽  
Han Chinese Population ◽  
Increased Risk

Objective. Programmed cell death 1 (PD-1) induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the development of autoimmune diseases such as rheumatoid arthritis (RA). Herein, we investigate the association ofPDCD-1polymorphisms with the risk of RA among Chinese patients and healthy controls.Methods. Using the PCR-direct sequencing analysis, 4PDCD-1SNPs (rs36084323, rs11568821, rs2227982, and rs2227981) were genotyped in 320 RA patients and 309 matched healthy controls. Expression of PD-1 was determined in peripheral blood lymphocytes by flow cytometry and quantitative real-time reverse transcriptase polymerase chain reaction.Results. We observed that the GG genotype of rs36084323 was associated with a increased risk for developing RA (OR 1.70, 95% 1.11–2.61,P=0.049). Patients carrying G/G genotype displayed an increased mRNA level of PD-1(P=0.04)compared with A/A genotype and healthy controls. Meanwhile, patients homozygous for rs36084323 had induced basal PD-1 expression on activated CD4+ T cells.Conclusion. ThePDCD-1polymorphism rs36084323 was significantly associated with RA risk in Han Chinese population. This SNP, which effectively influenced the expression of PD-1, may be a biomarker of early diagnosis of RA and a suitable indicator of utilizing PD-1 inhibitor for treatment of RA.

scholarly journals MDM4 contributes to the increased risk of glioma susceptibility in Han Chinese population

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Peng Sun ◽  
Feng Yan ◽  
Wei Fang ◽  
Junjie Zhao ◽  
Hu Chen ◽  
...  
Keyword(s):  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Increased Risk

scholarly journals Haplotypes of theMTHFRgene are associated with an increased risk of breast cancer in a Han Chinese population in Gansu province

IUBMB Life ◽  
2016 ◽  
Vol 68 (7) ◽  
pp. 526-534 ◽  
Author(s):  
Ailing Song ◽  
Lei Zhao ◽  
Yumin Li ◽  
Li Wu ◽  
Yu Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Population ◽  
Han Chinese ◽  
Gansu Province ◽  
Han Chinese Population ◽  
Increased Risk

scholarly journals Vascular endothelial growth factor-A (VEGFA) gene polymorphisms may serve as genetic marker for Coronary Heart Disease (CHD)

2020 ◽  
Author(s):  
Kang Huang ◽  
Shijuan Lu ◽  
Yilei Zhou ◽  
Dehong Lin ◽  
Zibin Chen ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Han Chinese ◽  
Large Sample Size ◽  
Han Chinese Population ◽  
Chd Risk ◽  
Increased Risk ◽  
Reduced Risk

Abstract Purpose: Coronary heart disease (CHD) is a common cardiovascular disease resulting from interaction of multiple environmental and genetic factors. This study aimed to confirm whether single nucleotide polymorphisms (SNPs) in VEGFA gene were associated with CHD in the Han Chinese population. Materials and Methods: Blood samples were collected from 501 CHD patients and 496 healthy individuals. Genotyping of five SNPs within VEGFA was performed using Agena MassARRAY platform. Odd ratios (ORs) and 95% confidence intervals (95%CIs) were calculated to evaluate the association between SNPs and CHD risk.Results: The genotype “C/T” of rs3025021 in VEGFA was found to be associated with CHD susceptibility (OR = 1.35, 95% CI = 1.02- 1.80, p = 0.038) in the overall. Rs833068 was observed to be associated with the reduced risk of CHD at age > 61 years and ≤ 61 years, respectively. And three loci (rs833068, rs3025021 and rs6905288) were related to the CHD risk in males. In addition, rs3025021 was associated with increased risk of CHD in patients with hypertension or diabetes. Conversely, three loci (rs833068, rs3025030 and rs6905288) were related to the CHD risk in patients without hypertension. The rs833068 was associated with reduced risk of CHD in patients without diabetes. Finally, we found a strong LD between rs833068 and rs833070. Conclusion: Gene polymorphisms in VEGFA were notably correlated with altered CHD risk in the Han Chinese population. Large sample size and well - designed studies are needed to further clarify the potential mechanisms underlying the CHD.

scholarly journals Single-nucleotide polymorphism rs17548629 in RIPK1 gene may be associated with lung cancer in a young and middle-aged Han Chinese population

2020 ◽  
Author(s):  
Shimin Yang ◽  
Fanglin Yu ◽  
Mingyan Lin ◽  
Linyi Sun ◽  
Junjie Wei ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Chinese Population ◽  
Han Chinese ◽  
Luciferase Reporter ◽  
Transcriptional Level ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Han Chinese Population ◽  
Increased Risk

Abstract Background Genetic biomarkers of lung cancer (LC) susceptibility may provide a basis for treatment and prevention. This study analyzed an association between SNPs (single nucleotide polymorphisms) in the complementary region of the 3′-UTR (3' untranslated region) of microRNAs of the gene RIPK1 (receptor-interacting serine/threonine-protein kinase 1) and LC among an adult Han Chinese population aged younger than 60 years. Also explored the effect of regulation of the RIPK1 gene via rs17548629 and microRNA-1197 on the occurrence of LC. Methods RIPK1 variants (rs17548629, rs77736895) were determined in a population of 571 adults (younger than 60 years) with LC, and 609 gender- and age-matched healthy individuals. Bioinformatics methods predicted the microRNAs bound to rs17548629. Dual luciferase reporter assay was performed to confirm the presence of both rs17548629 and the predicted microRNA. Results A mutation (T) of rs17548629 was associated with an increased risk for LC in this population under the codominant and recessive genetic models. The risk of lung adenocarcinoma in rs17548629 mutant carriers was 1.769-fold higher than that of the wildtype. In vitro , the luciferase activity of co-transfected mutant psiCHECK2- RIPK1 and microRNA-1197 mimics was less than that of the group transfected with microRNA-1197 mimics only. Factorial analysis indicated interactions between microRNA-1197 mimics and genotypes of rs17548629. Conclusion A mutation (T) of rs17548629 may increase the risk of LC/lung adenocarcinomain adult Han populations younger than 60 years. When carrying the T allele, rs17548629 may be the target of hsa-miR-1197. This mutation may affect transcriptional level of the RIPK1, thereby promoting the occurrence of LC.

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