Factors Associated with the Serum Myostatin Level in Patients Undergoing Peritoneal Dialysis: Potential Effects of Skeletal Muscle Mass and Vitamin D Receptor Activator Use

2016 ◽  
Vol 99 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Shunsuke Yamada ◽  
Kazuhiko Tsuruya ◽  
Hisako Yoshida ◽  
Masanori Tokumoto ◽  
Kenji Ueki ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Peritoneal Dialysis ◽  
Muscle Mass ◽  
Vitamin D Receptor ◽  
Skeletal Muscle Mass ◽  
Factors Associated ◽  
Receptor Activator

Novel insights into the autonomous role played by vitamin D receptor in the regulation of skeletal muscle mass

2021 ◽  
Author(s):  
Tomer Jordi Chaffer ◽  
Jean‐Philippe Leduc‐Gaudet ◽  
Alaa Moamer ◽  
Felipe E. Broering ◽  
Gilles Gouspillou ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Muscle Mass ◽  
Vitamin D Receptor ◽  
Skeletal Muscle Mass

scholarly journals Combining Amino Acid and Vitamin D Supplementation with Exercise Training Increases Skeletal Muscle Mass and Prevent Bone Mineral Density Loss in Participants with Low Muscle Mass

2017 ◽  
Vol 10 (2) ◽  
pp. 28
Author(s):  
Ha Cao Thi Thu ◽  
Satoshi Kurose ◽  
Yaeko Fukushima ◽  
Nana Takao ◽  
Natsuko Nakamura ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Skeletal Muscle ◽  
Vitamin D ◽  
Body Composition ◽  
Amino Acid ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Vitamin D Supplementation ◽  
Mineral Density ◽  
Supplement Group

This study evaluated the impact of exercise training with amino acid and vitamin D supplementation on muscle and bone mass in participants with low muscle volume. Twenty-nine Japanese participants (56-84 years old) were enrolled and assigned into the supplement (n=15) and non-supplement (n=14) groups. All participants underwent a 6-month exercise program. Supplements and nutrition support were provided to the participants in the supplement group for 12 weeks. Body composition and whole bone mineral density (BMD) were measured using dual energy x-ray absorptiometry. The outcomes, including body composition, whole BMD, and skeletal muscle mass index (SMI), were evaluated twice: pre- and post-intervention. The SMI was 6.51(6.28; 7.14) and 5.58 (5.24; 6.05) (kg/m2) in men and women, respectively. The average SMI change was 0.13% (-0.05%; 0.31%) and 2.33% (-0.88%; 5.48%); [mean (lower; upper quartile)]. The average BMD loss in the non-supplement group was -2.78%, and the BMD increased in the supplement group by 4.34%; there was an absolute difference between the two groups (p<0.05). After the intervention, serum myostatin was changed (p=0.001, non-supplement>supplement), serum vitamin D was increased (p=0.03; supplement>non-supplement), and BMD was maintained (p=0.03, supplement>non-supplement). There was a significant difference in the serum myostatin level at baseline and at 6-month in the non-supplement group, with a mean difference of 483.78 ng/ml (p=0.01). There was no significant improvement in the total lean mass, and handgrip strength. Resistance exercise combined with an amino acid supplement affects muscle and bone mass in the short-term intervention.

scholarly journals Factors associated with skeletal muscle mass, sarcopenia, and sarcopenic obesity in older adults: a multi-continent study

2015 ◽  
Vol 7 (3) ◽  
pp. 312-321 ◽  
Author(s):  
Stefanos Tyrovolas ◽  
Ai Koyanagi ◽  
Beatriz Olaya ◽  
Jose Luis Ayuso-Mateos ◽  
Marta Miret ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Sarcopenic Obesity ◽  
Factors Associated

Vitamin D Status in Obesity Is Associated with Skeletal Muscle Mass Independent of Adiposity

2011 ◽  
pp. P1-207-P1-207
Author(s):  
Prapimporn Shantavasinkul ◽  
Pariya Phanachet ◽  
Orawan Puchaiwattananon ◽  
La-or Chailurkit ◽  
Boonsong Ongphiphadhanakul ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Vitamin D Status

scholarly journals The Association between Serum Uric Acid and Appendicular Skeletal Muscle Mass and the Effect of Their Interaction on Mortality in Patients on Peritoneal Dialysis

2020 ◽  
Vol 45 (6) ◽  
pp. 969-981
Author(s):  
Xi Xiao ◽  
Chunyan Yi ◽  
Yuan Peng ◽  
Hongjian Ye ◽  
Haishan Wu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Uric Acid ◽  
Peritoneal Dialysis ◽  
Serum Uric Acid ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
The Body ◽  
All Cause Mortality ◽  
Appendicular Skeletal Muscle ◽  
Appendicular Skeletal Muscle Mass

<b><i>Background:</i></b> Serum uric acid (SUA) has been revealed to be positively associated with the body composition parameters in hemodialysis patients, but few studies have investigated that in patients on peritoneal dialysis (PD). The aim of this study was to identify the relationship between SUA and appendicular skeletal muscle mass (ASM) and the effect of their interaction on mortality in PD patients. <b><i>Methods:</i></b> This was a single-center retrospective cohort study. Patients who underwent multifrequency bioelectrical impedance analysis between January 1, 2013, and December 31, 2016, and had data on SUA values were enrolled. All patients were followed up until December 31, 2019. <b><i>Results:</i></b> In total, 802 prevalent PD patients (57.9% male), with mean age of 46.2 ± 14.2 years were enrolled. The average SUA and ASM were 6.8 ± 1.3 mg/dL and 21.2 ± 4.9 kg. According to multiple linear regression models, SUA was positively associated with relative ASM in middle-aged and older PD patients (standardized coefficients [β] 0.117; 95% confidence interval [CI] 0.027, 0.200; <i>p</i> = 0.010). Further sex-stratified analysis showed that the association existed only in males (β 0.161; 95% CI 0.017, 0.227; <i>p</i> = 0.023). Moreover, the presence of hyperuricemia was found to predict lower risk of all-cause mortality (hazard ratio [HR] 0.514, 95% CI 0.272, 0.970; <i>p</i> = 0.040) only in patients with lower relative ASM. And, the adjusted HR of every 1 mg/dL elevated SUA level was 0.770 (95% CI 0.609, 0.972; <i>p</i> = 0.028) for all-cause mortality in the lower relative ASM subgroup. <b><i>Conclusions:</i></b> There exists a positive association between the SUA and ASM, and the ASM significantly affected the association between SUA and all-cause PD mortality.

scholarly journals Effects of daily 1,000-IU vitamin D-fortified milk intake on skeletal muscle mass, power, physical function and nutrition status in Japanese

2021 ◽  
Vol 68 (3.4) ◽  
pp. 249-255
Author(s):  
Yasushi Matsuura ◽  
Teruhiro Morishita ◽  
Michiko Sato ◽  
Nami Sumida ◽  
Takafumi Katayama ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Physical Function ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Milk Intake ◽  
Nutrition Status ◽  
Fortified Milk

scholarly journals High skeletal muscle mass is associated with increased serum 25(OH)D levels in elderly

2017 ◽  
Vol 36 (3) ◽  
pp. 236
Author(s):  
Verawati Sudarma ◽  
Lukman Halim
Keyword(s):  
Skeletal Muscle ◽  
Body Mass Index ◽  
Vitamin D ◽  
Body Composition ◽  
Waist Circumference ◽  
Linear Regression ◽  
Muscle Mass ◽  
Body Fat ◽  
Skeletal Muscle Mass ◽  
Anthropometric Measurements

Background<br />Low vitamin D has been associated with various health problems. Aging influences body composition, especially body fat and fat-free mass. Anthropometric measurements, such as body weight (BW), body mass index (BMI), body fat (BF), skeletal muscle mass (SMM), waist circumference (WC) and the waist-height ratio (WHtR) represent body composition which many studies proposed will influence serum vitamin D [25(OH)D]. The objective of the present study was to determine which anthropometric measurements were determinants of 25(OH)D levels in elderly.<br /><br />Methods<br />A cross-sectional study was conducted involving 126 elderly (&gt;60 years old) men and women at Pusat Santunan Dalam Keluarga (PUSAKA) Central Jakarta centers. Anthropometric measurements [body mass index (BMI), skeletal muscle mass (SMM), body fat (BF), and waist circumference (WC)] were determined by bioelectrical impedance analysis using the Omron body composition monitor with scales (HBF-375, Omron, Japan). Fasting blood samples were taken to measure 25(OH)D level by electrochemiluminescence immunoassay. Multivariate linear regression was used to analyze the data.<br /><br />Results <br />The data showed that BMI, BF, and WC were higher than recommended, while SMM and serum 25(OH)D were lower. When the analysis was done based on sex, there were significant differences in BF, SMM, WHtR, and serum 25(OH)D. In the linear regression multivariate analysis of log 25(OH)D with age and body anthropometric measurements, only SMM reached significance level (β=0.019; p=0.025).<br /><br />Conclusions<br />This study demonstrated a positive association between skeletal muscle mass and serum levels of vitamin D in elderly.

Factors Associated With Skeletal Muscle Mass Increase by Rehabilitation in Older Adults With Vertebral Compression Fractures

2021 ◽  
pp. 1-6
Author(s):  
Takahiro Ogawa ◽  
Yuki Sueyoshi ◽  
Shintaro Taketomi ◽  
Nobumasa Chijiiwa
Keyword(s):  
Skeletal Muscle ◽  
Hospital Stay ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Length Of Hospital Stay ◽  
Functional Independence ◽  
Vertebral Compression Fractures ◽  
Skeletal Muscle Index ◽  
Compression Fractures ◽  
Factors Associated

Age-related sarcopenia and osteoporosis-related fractures are critical health issues. Therefore, this study aimed to assess skeletal muscle mass changes in older patients with vertebral compression fractures undergoing rehabilitation and to evaluate factors associated with muscle increases. This study included 179 patients aged ≥80 years in rehabilitation wards with vertebral compression fractures. Appendicular skeletal muscle index was significantly higher at discharge (5.22 ± 1.04 kg/m2, p < .001) than on admission (5.03 ± 1.00 kg/m2). Multiple logistic regression analysis showed that length of hospital stay was significantly associated with increased skeletal muscle index (odds ratios, 1.020; 95% confidence intervals [1.000, 1.032]), whereas age, sex, body mass index, functional independence measure, protein intake, and exercise therapy duration were not. Participants with vertebral compression fractures aged ≥80 years achieved significantly increased skeletal muscle mass in rehabilitation wards. In addition, length of hospital stay was the factor independently associated with increased skeletal muscle index.

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