Biosorption of Ce(III) onto modified Pinus brutia leaf powder using central composite design

Baobab (Adansonia digitata) leaves represent a key nutritional resource; although their consumption is apparently restricted to local communities, mainly as a sticky sauce, cosmetics and a variety of purposes. Ready-to-use powder of oven-dried baobab leaves can improve the availability of the product on markets, and hence its utilisation and shelf life. This study was carried out to optimise the oven-drying temperature and duration for the best conservation of baobab leaf powder and its sustainable availability for multipurpose uses. Different combinations of values of temperature and drying duration were generated, using a central composite design, in response surface methodology framework. Findings showed that dry matter, hue, chroma and lightness were significantly influenced by oven-drying temperature and duration; while the least gelation concentration was significantly influenced by the temperature. Based on leaf dry matter, hue and chroma models, the optimal oven drying conditions for baobab leaves for good preservation leading to human consumption and other purposes are set at 45 °C for 23.5 hours.

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Development and optimization of solid lipid nanoparticles of amikacin by central composite design

Journal of Liposome Research ◽

10.1080/08982100903103904 ◽

2009 ◽

Vol 00 (00) ◽

pp. 090721051030036-8

Author(s):

Jaleh Varshosaz ◽

Solmaz Ghaffari ◽

Mohammad Reza Khoshayand ◽

Fatemeh Atyabi ◽

Shirzad Azarmi ◽

...

Keyword(s):

Central Composite Design ◽

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Solid Lipid ◽

Central Composite

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Central Composite Design for Optimization of Chromium (VI) Removal from Aqueous Solution Using Low Cost Adsorbent

i-manager’s Journal on Future Engineering and Technology ◽

10.26634/jfet.11.1.3654 ◽

2015 ◽

Vol 11 (1) ◽

pp. 1-6

Author(s):

D. Krishna ◽

◽

D.V. Padma ◽

Keyword(s):

Aqueous Solution ◽

Central Composite Design ◽

Low Cost ◽

Chromium Vi ◽

Central Composite

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Selected illustrations of response surface method. Central composite design

10.3403/30242021u ◽

2016 ◽

Keyword(s):

Central Composite Design ◽

Response Surface ◽

Response Surface Method ◽

Surface Method ◽

Central Composite

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Formulation Design and Optimization of Repaglinide Solid Dispersions by Central Composite Design

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2018.11.6.7 ◽

2018 ◽

Vol 11 (6) ◽

pp. 4337-4348

Author(s):

Bhikshapathi D. V. R. N. ◽

Srinivas I

Keyword(s):

Central Composite Design ◽

Dissolution Rate ◽

Solid Dispersion ◽

Solid Dispersions ◽

Solvent Evaporation ◽

Release Mechanism ◽

Solvent Evaporation Method ◽

Onset Of Action ◽

Evaporation Method ◽

Central Composite

Repaglinide is a pharmaceutical drug used for the treatment of type II diabetes mellitus, it is characterized with poor solubility which limits its absorption and dissolution rate and delays onset of action. In the present study, immediate release solid dispersion of repaglinide was formulated by solvent evaporation technique. Repaglinide solid dispersions were prepared using PEG 8000, Pluronic F 127 and Gelucire 44/14 by solvent evaporation method. A 3-factor, 3-level central composite design employed to study the effect of each independent variable on dependent variables. FTIR studies revealed that no drug excipient interaction takes place. From powder X-ray diffraction (p-XRD) and by scanning electron microscopy (SEM) studies it was evident that polymorphic form of repaglinide has been converted into an amorphous form from crystalline within the solid dispersion formulation. The correlation coefficient showed that the release profile followed Higuchi model anomalous behavior and hence release mechanism was indicative of diffusion. The obtained results suggested that developed solid dispersion by solvent evaporation method might be an efficacious approach for enhancing the solubility and dissolution rate of repaglinide.

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