Correction to: A new proposal for secondary surveillance following potentially curative therapy of HCC: alternating MRI and CEUS

Four to eight percent of the population are estimated to be food-allergic. Most food allergies in adolescents and adults are acquired on the basis of cross-reaction to pollen allergens. Theses allergens are ubiquitous in the plant kingdom. Therefore pollen-allergic patients might acquire a multitude of different plant food allergies, and even react to novel foods to which they have never previously been exposed. A curative therapy for food allergy does not yet exist. Food-allergic patients have to rely on strict avoidance diets, The widespread use of industrially processed foods poses a general problem for food-allergic patients. Although the most frequent allergens must be declared openly in the list of ingredients, involuntary contamination with allergy-provoking compounds can occur. The precautionary labelling may contain is sometimes applied even if the chance of contamination is very low; on the other hand, foods not declared to contain possible traces of allergenic components may actually contain relevant amounts of allergenic proteins. Switzerland is the only country in Europe with legal regulations on contamination by allergenic food; however, the allowance of 1 g/kg is too high to protect a relevant proportion of food-allergic individuals.

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Depression – Let’s Talk - Role of Aashwasan Chikitsa

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v2i3.8234 ◽

2017 ◽

Vol 2 (3) ◽

Author(s):

Priya Vishal Naik ◽

Prachi Datta Dalvi U.

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Positive Attitude ◽

Medical Intervention ◽

Medical Illness ◽

Suicidal Tendency ◽

Major Depressive ◽

Curative Therapy ◽

Personal Interaction

The WHO theme for the year 2017 is Depression. Depression (major depressive disorder) is a common and serious medical illness that negatively affects how a person feels, thinks and behaves. Psychotherapy if incorporated along with medications can be of substantial help in depression. It is also called ‘talking therapy’ and is based on personal interaction with the patient. Patients suffering from this disorder do not easily accept it and hence do not feel the need to seek medical intervention or counselling. In this process the symptoms might get aggravated and suicidal tendency (which is the worst effect of this disease) may develop. So it is extremely essential for the patient, family and society to accept, talk, discuss and seek treatment for this disease. This ‘talking therapy’ is of utmost importance in today’s life where concept of privacy is taking its toll. This therapy is mentioned in Ayurveda as Aashwasan Chikitsa. Aashwasan Chikitsa consists of good, pleasing and benevolent thoughts, spiritual ideas, positive attitude, ethics and communication with near ones. So in the treatment of psychological disorders, along with medications counselling therapy plays a very important role. Finally counselling can act as a part of preventive, curative therapy and also aids to avoid recurrence in the patients of depression.

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P46-2 A case of cancer-associated dermatomyositis diagnosed after curative therapy for esophageal and oropharyngeal cancers

Annals of Oncology ◽

10.1016/j.annonc.2021.05.766 ◽

2021 ◽

Vol 32 ◽

pp. S354

Author(s):

Chisaki Suzumori ◽

Naoki Fukuda ◽

Xiaofei Wang ◽

Akihiro Ohmoto ◽

Tetsuya Urasaki ◽

...

Keyword(s):

Curative Therapy

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Recurrence and Coniglobus Volumetric Resolution of Subacute and Chronic Subdural Hematoma Post-Middle Meningeal Artery Embolization

Diagnostics ◽

10.3390/diagnostics11020257 ◽

2021 ◽

Vol 11 (2) ◽

pp. 257

Author(s):

Ambooj Tiwari ◽

Adam A. Dmytriw ◽

Ryan Bo ◽

Nathan Farkas ◽

Phillip Ye ◽

...

Keyword(s):

Subdural Hematoma ◽

Chronic Subdural Hematoma ◽

Middle Meningeal Artery ◽

Volumetric Analysis ◽

Primary Therapy ◽

Curative Therapy ◽

Complete Obliteration ◽

Embolization Treatment ◽

Long Term Follow Up ◽

Meningeal Artery

Objective: To study the efficacy of middle meningeal artery (MMA) embolization for the treatment of chronic subdural hematoma (SDH) and characterize its post-embolization volumetric resolution. Methods: Ten patients diagnosed with 13 cSDH underwent MMA embolization. SDH volumes were measured from time of initial discovery on imaging to pre-operative, post-operative, short-term and long-term follow-up. Time between procedure to obliteration was also measured. Volumetric analysis was done using the coniglobus formula, and recurrence rate as well as resolution timeline was defined using best-fit models. Results: Out of 10 patients, five were recurrent lesions, three were bilateral and seven unilateral cSDH. Average and median pre-operative volumes were 105.3 cc and 97.4 cc, respectively. Embolization on average was performed 21 days after discovery. Sixty percent of patients had concurrent antiplatelets or anticoagulation use. Forty percent underwent embolization treatment as the primary therapy. Recurrence was not seen in any patients treated with embolization. There were no peri- or post-operative complications. Five patients experienced complete or near-complete obliteration, while those with partial resolution showed a composite average of 75% volumetric reduction in 45 days. Post-embolization, the volumetric resolution followed an exponential decay curve over time and was independent of initial volume. Conclusion: MMA embolization contributed to a marked reduction in SDH volume post-operatively and can be used as a curative therapy for primary or recurrent chronic SDH.

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Inborn errors of immunity—recent advances in research on the pathogenesis

Inflammation and Regeneration ◽

10.1186/s41232-021-00159-6 ◽

2021 ◽

Vol 41 (1) ◽

Author(s):

Motoi Yamashita ◽

Kento Inoue ◽

Tsubasa Okano ◽

Tomohiro Morio

Keyword(s):

Immune System ◽

Hematopoietic Cell Transplantation ◽

Epigenetic Modification ◽

Genetic Disorder ◽

Loss Of Function ◽

Inborn Errors ◽

Whole Genome Analysis ◽

Curative Therapy ◽

Inborn Errors Of Immunity ◽

Recent Advances

AbstractPrimary immunodeficiency (PID) is a genetic disorder with a defect of one of the important components of our immune system. Classical PID has been recognized as a disorder with loss of function of the immune system. Recent studies have unveiled disorders with immune dysfunction with autoimmunity, autoinflammation, allergy, or predisposition to malignancy. Some of them were caused by an augmented immune function or a defect in immune regulation. With this background, the term inborn errors of immunity (IEI) is now used to refer to PID in the International Union of Immunological Societies (IUIS) classification. More than 400 responsible genes have been identified in patients with IEI so far, and importantly, many of them identified lately were caused by a heterologous mutation. Moreover, the onset is not necessarily in childhood, and we started seeing more and more IEI patients diagnosed in adulthood in the clinical settings. Recent advances in genetic analysis, including whole-exome analysis, whole-genome analysis, and RNA-seq have contributed to the identification of the disease-causing gene mutation. We also started to find heterogeneity of phenotype even in the patients with the same mutation in the same family, leading us to wonder if modifier gene or epigenetic modification is involved in the pathogenesis. In contrast, we accumulated many cases suggesting genetic heterogeneity is associated with phenotypic homogeneity. It has thus become difficult to deduce a responsible gene only from the phenotype in a certain type of IEI. Current curative therapy for IEI includes hematopoietic cell transplantation and gene therapy. Other curative therapeutic modalities have been long waited and are to be introduced in the future. These include a small molecule that inhibits the gain-of-function of the molecule- and genome-editing technology. Research on IEI will surely lead to a better understanding of other immune-related disorders including rheumatic diseases and atopic disorders.

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DIPG-19. TARGETING ATM MUTATION IN METASTATIC DIFFUSE MIDLINE GLIOMA – A CASE OF SUSTAINED RESPONSE USING PARP INHIBITOR

Neuro-Oncology ◽

10.1093/neuonc/noaa222.069 ◽

2020 ◽

Vol 22 (Supplement_3) ◽

pp. iii290-iii291

Author(s):

Karen Tsui ◽

Andrew Law ◽

Michael K Watson

Keyword(s):

Parp Inhibitor ◽

Standard Of Care ◽

High Grade Glioma ◽

Diffuse Intrinsic Pontine Glioma ◽

Radiological Criteria ◽

Metastatic Recurrence ◽

Curative Therapy ◽

First Case ◽

Metastatic Relapse ◽

Diffuse Midline Glioma

Abstract Diffuse midline glioma (DMG) with H3.3K27M mutation is associated with an extremely poor prognosis, with a median survival of 10 to 12 months. Radiation remains the standard of care however there is no established curative therapy available. We describe a patient diagnosed with a diffuse intrinsic pontine glioma at 5 years of age by clinical and radiological criteria. He was treated with focal radiation 59Gy which resulted in reduction in size of the tumour, and partial improvement of T2 changes on MRI. At 18 months post diagnosis, the patient developed metastatic recurrence at the anterior fornix. This was biopsied and histopathology demonstrated a high grade glioma. Next generation sequencing revealed a H3F3A K27M mutation, and an ATM R3008H mutation. He received whole ventricular radiation 36Gy and boost to the lesion to 45Gy, followed by Olaparib 135mg/m2/day twice daily. He remains in radiological remission 20 months post metastatic relapse and has no organ toxicity to Olaparib. CONCLUSION: H3.3K27M and ATM co-segregating mutations are described in DMG. This is the first case report of targeting ATM mutation with a PARP inhibitor which resulted in prolonged remission of metastatic DMG. Olaparib was well tolerated.

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The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma

Journal of Clinical Medicine ◽

10.3390/jcm10132963 ◽

2021 ◽

Vol 10 (13) ◽

pp. 2963

Author(s):

Corina Kim-Fuchs ◽

Daniel Candinas ◽

Anja Lachenmayer

Keyword(s):

Literature Review ◽

Intrahepatic Cholangiocarcinoma ◽

Microwave Ablation ◽

Treatment Options ◽

Tumor Biology ◽

Tumor Ablation ◽

Curative Treatment ◽

Complication Rates ◽

Curative Therapy ◽

Incidence And Mortality

Background: The incidence and mortality of intrahepatic cholangiocarcinoma (ICCA) is increasing worldwide and curative treatment options are limited due to the aggressive tumor biology and often late diagnosis. Resection of the primary tumor remains the only curative therapy available, as the benefit of palliative chemotherapy and radiotherapy is relatively small. In contrast to hepatocellular carcinoma, minimal-invasive thermal tumor ablation, and in particular stereotactic tumor ablation for small primary cancers or metastases, is not established and data are scarce. Methods: We conducted a literature review in the field of ICCA ablation and retrospective analysis of 10 patients treated by stereotactic microwave ablation (SMWA) for either primary ICCA or liver metastases of ICCA. Results: While current guidelines have no consensus for ablation of primary ICCA, some state that it might be an option in inoperable patients or those with recurrent disease. The literature review revealed 11 studies on microwave ablation for ICCA reporting that MWA for ICCA ≤ 5 cm might be safe and could be a treatment option for patients who are not candidates for surgery. No data has been published on stereotactic microwave ablation (SMWA) for ICCA. The analyses of our own data of 10 patients treated by SMWA for primary ICCA (n = 5) or recurrent ICCA (n = 5) show that the treatment is safe and efficient with short hospital stays and low complication rates. Conclusion: Although thermal ablation, and in particular SMWA, might be a minimally invasive and tissue-sparing curative treatment alternative for small ICCA in the diseased liver and ICCA metastases, the oncologic benefit still needs to be shown in larger studies with longer follow-up.

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Systemic Therapy for Head and Neck Skin Cancers

FACE ◽

10.1177/27325016211013880 ◽

2021 ◽

pp. 273250162110138

Author(s):

Rebecca Knackstedt ◽

Peter Taub ◽

Gary Rogers ◽

Brian Gastman

Keyword(s):

Radiation Therapy ◽

High Risk ◽

Head And Neck ◽

Systemic Therapy ◽

Malignant Tumors ◽

Curative Therapy ◽

Recurrent Tumors ◽

Skin Cancers ◽

Systemic Therapies ◽

Melanoma Skin

The mainstay of curative therapy for head and neck skin cancers relies upon surgery and/or radiation therapy. However, for some aggressive, non-resectable or recurrent tumors, systemic therapy is necessary. Recent emerging classes of drugs have shown to improve survival for high-risk, recurrent, and unresectable variants of these tumors. The goal of this paper is to review options for systemic therapies for head and neck skin cancers including melanoma, non-melanoma skin cancers and other rare and non-malignant tumors.

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Advances toward Curing HIV-1 Infection in Tissue Reservoirs

Journal of Virology ◽

10.1128/jvi.00375-19 ◽

2019 ◽

Vol 94 (3) ◽

Cited By ~ 4

Author(s):

Lisa J. Henderson ◽

Lauren B. Reoma ◽

Joseph A. Kovacs ◽

Avindra Nath

Keyword(s):

Checkpoint Inhibitors ◽

Functional Cure ◽

Viral Transcript ◽

Curative Therapy ◽

Gene Therapies ◽

Recent Developments ◽

The Central Nervous System ◽

Effector Response ◽

Hiv 1 ◽

Cell Effector

ABSTRACT A disease of more than 39.6 million people worldwide, HIV-1 infection has no curative therapy. To date, one man has achieved a sterile cure, with millions more hoping to avoid the potential pitfalls of lifelong antiretroviral therapy and other HIV-related disorders, including neurocognitive decline. Recent developments in immunotherapies and gene therapies provide renewed hope in advancing efforts toward a sterilizing or functional cure. On the horizon is research concentrated in multiple separate but potentially complementary domains: vaccine research, viral transcript editing, T-cell effector response targeting including checkpoint inhibitors, and gene editing. Here, we review the concept of targeting the HIV-1 tissue reservoirs, with an emphasis on the central nervous system, and describe relevant new work in functional cure research and strategies for HIV-1 eradication.

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Minimal Residual Disease, Metastasis and Immunity

Biomolecules ◽

10.3390/biom11020130 ◽

2021 ◽

Vol 11 (2) ◽

pp. 130

Author(s):

Jordi Badia-Ramentol ◽

Jenniffer Linares ◽

Andrea Gómez-Llonin ◽

Alexandre Calon

Keyword(s):

Cancer Cells ◽

Tumor Cells ◽

Minimal Residual Disease ◽

Cancer Progression ◽

Residual Disease ◽

Disseminated Tumor Cells ◽

Curative Therapy ◽

Cancer Dormancy ◽

Distant Tissue ◽

Minimal Residual

Progression from localized to metastatic disease requires cancer cells spreading to distant organs through the bloodstream. Only a small proportion of these circulating tumor cells (CTCs) survives dissemination due to anoikis, shear forces and elimination by the immune system. However, all metastases originate from CTCs capable of surviving and extravasating into distant tissue to re-initiate a tumor. Metastasis initiation is not always immediate as disseminated tumor cells (DTCs) may enter a non-dividing state of cell dormancy. Cancer dormancy is a reversible condition that can be maintained for many years without being clinically detectable. Subsequently, late disease relapses are thought to be due to cancer cells ultimately escaping from dormant state. Cancer dormancy is usually associated with minimal residual disease (MRD), where DTCs persist after intended curative therapy. Thus, MRD is commonly regarded as an indicator of poor prognosis in all cancers. In this review, we examine the current understanding of MRD and immunity during cancer progression to metastasis and discuss clinical perspectives for oncology.

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