Applying multilevel model to the relationship of dietary patterns and colorectal cancer: an ongoing case–control study in Córdoba, Argentina

2011 ◽  
Vol 51 (6) ◽  
pp. 755-764 ◽  
Author(s):  
Sonia Alejandra Pou ◽  
María del Pilar Díaz ◽  
Alberto Rubén Osella
Keyword(s):  
Colorectal Cancer ◽  
Dietary Patterns ◽  
Multilevel Model ◽  
Case Control Study ◽  
Case Control ◽  
Relationship Of ◽  
The Relationship ◽  
Control Study

scholarly journals Lack of association between miR-146a rs2910164 C/G locus and colorectal cancer: from a case–control study to a meta-analysis

2021 ◽  
Vol 41 (1) ◽  
Author(s):  
Jiakai Jiang ◽  
Sheng Zhang ◽  
Weifeng Tang ◽  
Zhiyuan Qiu
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Relationship Of ◽  
Risk Of Cancer ◽  
The Relationship ◽  
Control Study

Abstract Previous studies suggested that miR-146a rs2910164 (C/G) locus was predicted to influence the risk of cancer. However, the relationship of miR-146a rs2910164 locus with colorectal cancer (CRC) susceptibility was controversial. We recruited 1003 CRC patients and 1303 controls, and performed a case–control study to clarify the correlation of miR-146a rs2910164 locus with CRC risk. Subsequently, a comprehensive meta-analysis was conducted to verify our findings. In the case–control study, we suggested that miR-146a rs2910164 variants did not alter CRC risk (CG vs. CC: adjusted P=0.465; GG vs. CC: adjusted P=0.436, CG/GG vs. CC: adjusted P=0.387 and GG vs. CC/CG: adjusted P=0.589), even in subgroup analysis. Next, we conducted a pooled-analysis to identify the correlation of miR-146a rs2910164 locus with CRC risk. In this pooled-analysis, 7947 CRC cases and 12,168 controls were included. We found that miR-146a rs2910164 polymorphism did not influence the risk of CRC (G vs. C: P=0.537; GG vs. CC: P=0.517, CG/GG vs. CC: P=0.520 and GG vs. CC/CG: P=0.167). Our findings suggest that miR-146a rs2910164 C/G polymorphism is not correlated with the susceptibility of CRC. In the future, more case–control studies are needed to confirm our results.

scholarly journals The Relationship of Residential Environment with The Risk of Leptospirosis in Sleman Regency

2017 ◽  
Vol 1 (2) ◽  
pp. 85-92
Author(s):  
Maya Sofiyani ◽  
M Imron Mawardi ◽  
P Sigit Purnomo ◽  
Hariza Adnani
Keyword(s):  
Environmental Factors ◽  
Case Control Study ◽  
Case Control ◽  
Survey Method ◽  
Control Programs ◽  
The Government ◽  
Relationship Of ◽  
The Relationship ◽  
Control Study ◽  
Made In

The effort of leptospirosis prevention in Sleman currently only limited to counseling and treatment of the patient, while the patient search, ways of transmission of leptospirosis from rats to humans, have never implemented in an integrated manner. The study aimed to investigated the relationship between the environmental residential condition with the risk of leptospirosis in Sleman Regency. The research used a survey method  with case control study design. The results showed that environmental factors, which are not proved to have a relationship with the risk of leptospirosis were residential condition ({p=0,108} OR=3,818 {95%CI:0,922–15,811}), the trash bin condition ({p=1,000} OR=1,138 {95%CI:0,420–3,081}) and the sewer condition ({p=0,415} OR=0,551 {95%CI:0,187–1,624}). Environmental factors that associated with the risk of leptospirosis was the presence of rats ({p=0,001} OR=13,594 {95%CI:2,754–67,107}). The effort should be made in order to prevent the increasement of Leptospirosis cases by sanitation improvement and avoiding direct contact with rats as well as it litter. The Government should be pay more attention in the vector control programs, especially in leptospirosis prone areas so the prevention effort to be able run effectively and efficiently.

The Relationship of Drug Therapy to Aplastic Anemia in Pakistan: A Hospital-Based Case Control Study

2021 ◽  
Vol Volume 17 ◽  
pp. 903-908
Author(s):  
Muhammad Asif Syed ◽  
Aneela Atta Ur Rahman ◽  
Muhammad Nadeem Shah Syed ◽  
Naveed Masood Memon
Keyword(s):  
Drug Therapy ◽  
Aplastic Anemia ◽  
Case Control Study ◽  
Case Control ◽  
Relationship Of ◽  
The Relationship ◽  
Control Study

scholarly journals Dietary patterns and risk of colorectal cancer in Tehran Province: a case–control study

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Akram Safari ◽  
Zalilah Mohd Shariff ◽  
Mirnalini Kandiah ◽  
Bahram Rashidkhani ◽  
Foroozandeh Fereidooni
Keyword(s):  
Colorectal Cancer ◽  
Dietary Patterns ◽  
Case Control Study ◽  
Case Control ◽  
Tehran Province ◽  
Control Study

scholarly journals Genetic polymorphisms of PGF and TNFAIP2 genes related to cervical cancer risk among Uygur females from China

2020 ◽  
Author(s):  
Zumurelaiti Ainiwaer ◽  
Reyilanmu Maisaidi ◽  
Jing Liu ◽  
Lili Han ◽  
Sulaiya Husaiyin ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Positive Interaction ◽  
Female Population ◽  
Cervical Cancer Risk ◽  
Increased Risk ◽  
Relationship Of ◽  
The Relationship ◽  
Control Study

Abstract Background: PGF and TNFAIP2 are important angiogenic factors, which were abnormal expression in cervical cancer (CC). However, there is currently no report investigating the relationship of PGF and TNFAIP2 gene polymorphisms to CC risk.Methods: We conducted a case-control study of 342 CC patients and 498 cancer-free controls in a Chinese Uygur female population. Three SNPs (PGF rs8019391, PGF rs2268615, and TNFAIP2 rs710100) were selected and genotyped to assess the possible association of PGF and TNFAIP2 polymorphisms with CC susceptibility. Logistic regression analysis adjusted by age was used.Results: PGF rs2268615 (OR = 1.39, 95% CI = 1.04-1.86, p = 0.024) and TNFAIP2 rs710100 (OR = 1.44, 95% CI =1.07-1.95, p = 0.018) polymorphisms were associated with the increased risk of CC. Moreover, T allele of PGF rs8019391 was highly represented in patients with stage III–IV compared with stage I-II (OR = 2.17, p = 4.58´10-4). MDR analysis revealed a positive interaction between the SNPs.Conclusion: Our data indicated that PGF rs2268615, and TNFAIP2 rs710100 polymorphisms might be risk factors for CC susceptibility, which contributed to the increased risk of CC.Trail registration: Not applicable.

The relationship of indoor radon gas concentration with multiple sclerosis: a case-control study

2020 ◽  
Vol 27 (14) ◽  
pp. 16350-16361 ◽  
Author(s):  
Zeynab Abaszadeh Fathabadi ◽  
Mohamad Hassan Ehrampoush ◽  
Masuod Mirzaei ◽  
Mehdi Mokhtari ◽  
Mohamad Nadi Sakhvidi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Case Control Study ◽  
Indoor Radon ◽  
Case Control ◽  
Gas Concentration ◽  
Radon Gas ◽  
Relationship Of ◽  
The Relationship ◽  
Control Study

scholarly journals The Effect of Tibial Slope on Anterior Cruciate Ligament Reconstruction: A Matched Case-Control Study Including 317 Revisions

2019 ◽  
Vol 7 (7_suppl5) ◽  
pp. 2325967119S0029
Author(s):  
Joseph D. Cooper ◽  
Wei Wang ◽  
Heather A. Prentice ◽  
Tadashi Ted Funahashi ◽  
Gregory B. Maletis
Keyword(s):  
Case Control Study ◽  
Tibial Slope ◽  
Case Control ◽  
Small Sample ◽  
Radiographic Measurement ◽  
Surgeon Experience ◽  
Nested Case Control ◽  
Relationship Of ◽  
The Relationship ◽  
Control Study

Objectives: There is evidence the slope of the tibial plateau may play a role in need for revision following ACL reconstruction (ACLR), however, previous studies are limited by small sample sizes, radiographic measurement, single surgeon experience, lateral tibial posterior slope (LTPS) only, or a lack of confounder adjustment. Further, the role of the medial posterior tibial slope (MTPS) on revision risk has yet to be evaluated. We sought to (1) determine the relationship of revision status following ACLR and LTPS, (2) determine the relationship of revision status and MTPS, and (3) determine the relationship of revision status and the difference between MTPS and LTPS. Methods: We conducted a nested case-control study of 317 matched pairs using an integrated U.S. healthcare system’s ACLR registry (2006- 2014). Cases were defined as patients who underwent a revision following primary unilateral ACLR; controls were defined from the same cohort as non-revised patients during the same time frame. Controls were matched to cases according to age, gender, body mass index, race, graft type, femoral fixation device, and follow-up time. Magnetic resonance imaging (MRI) images were used by a single blinded reviewer to measure tibial slopes. Wilcoxon signed rank test was applied to compare the slopes between revised and non-revised groups continuously and McNemar test to compare slopes of ≥12° between groups. Results: No difference was observed between revised and non-revised patients in LTPS (mean: 6.1 vs. 6.1, p=0.972) or MTPS (mean: 4.6 vs. 4.9, p=0.281) measurement. When comparing revised ACLR to non-revised ACLR, a greater proportion of revised ACLR had a LTPS of ≥12° (7.6% vs. 3.8%, P=0.034), while no difference was found in the proportion of ACLR with a MTPS ≥12° (1.6% vs. 2.5%, P=0.405). No difference was found when evaluating the medial-to-lateral slope difference (-1.5 vs. -1.2, p=0.289). Conclusion: In our nested case-control study of over 300 revised ACLR patients matched to non-revised patients, we did not find an association between the slope of the lateral and medial tibial plateaus and revision. [Figure: see text][Table: see text]

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