scholarly journals Intake of fish and long-chain omega-3 polyunsaturated fatty acids and incidence of metabolic syndrome among American young adults: a 25-year follow-up study

2016 ◽  
Vol 55 (4) ◽  
pp. 1707-1716 ◽  
Author(s):  
Yong-Seok Kim ◽  
Pengcheng Xun ◽  
Carlos Iribarren ◽  
Linda Van Horn ◽  
Lyn Steffen ◽  
...  
2019 ◽  
Vol 59 (1) ◽  
pp. 399-407 ◽  
Author(s):  
Inwhee Park ◽  
Pengcheng Xun ◽  
Cari Lewis Tsinovoi ◽  
Philip Klemmer ◽  
Kiang Liu ◽  
...  

PEDIATRICS ◽  
2003 ◽  
Vol 112 (3) ◽  
pp. e177-e183 ◽  
Author(s):  
N. Auestad ◽  
D. T. Scott ◽  
J. S. Janowsky ◽  
C. Jacobsen ◽  
R. E. Carroll ◽  
...  

Author(s):  
Shuangshuang Chen ◽  
Qingqing Wu ◽  
Li Zhu ◽  
Geng Zong ◽  
Huaixing Li ◽  
...  

ABSTRACT Background Animal studies have highlighted critical roles of glycerophospholipid (GP) metabolism in various metabolic syndrome (MetS)-related features such as dyslipidemia, obesity, and insulin resistance. However, human prospective studies of associations between circulating GPs and risks of MetS are scarce. Objectives We aimed to investigate whether GPs are associated with incidence of MetS in a well-established cohort. Methods A total of 1243 community-dwelling Chinese aged 50–70 y without MetS at baseline and followed up for 6 y were included in current analyses. A total of 145 plasma GPs were quantified by high-throughput targeted lipidomics. MetS was defined using the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. Results After 6 y, 429 participants developed MetS. Eleven GPs, especially those with long-chain polyunsaturated fatty acids (LCPUFAs) or very-long-chain polyunsaturated fatty acids (VLCPUFAs) at the sn-2 position, including 1 phosphatidylcholine (PC) [PC(18:0/22:6)], 9 phosphatidylethanolamines (PEs) [PE(16:0/22:6), PE(18:0/14:0), PE(18:0/18:1), PE(18:0/18:2), PE(18:0/20:3), PE(18:0/22:5), PE(18:0/22:6), PE(18:1/22:6), and PE(18:2/22:6)], and 1 phosphatidylserine (PS) [PS(18:0/18:0)], were positively associated with incident MetS (RRs: 1.16–1.30 per SD change; Bonferroni-corrected P < 0.05). In network analysis, the strongest positive association for MetS incidence was evidenced in a module mainly composed of PEs containing C22:6 and PSs [RR: 1.21; 95% CI: 1.12, 1.31 per SD change; Bonferroni-corrected P < 0.05]. This association was more pronounced in participants with lower erythrocyte total n–3 PUFA concentrations [Bonferroni-corrected Pinter(P value for the interaction)< 0.05]. Conclusions Elevated plasma concentrations of GPs, especially PEs with LCPUFAs or VLCPUFAs at the sn-2 position, are associated with higher risk of incident MetS. Future studies are merited to confirm our findings.


Diabetes Care ◽  
2012 ◽  
Vol 35 (7) ◽  
pp. 1532-1537 ◽  
Author(s):  
P. Xun ◽  
K. Liu ◽  
W. Cao ◽  
S. Sidney ◽  
O. D. Williams ◽  
...  

2014 ◽  
Vol 44 (4) ◽  
pp. 169 ◽  
Author(s):  
Gisele Lago Martinez ◽  
Josely Correa Koury ◽  
Marcela Anjos Martins ◽  
Fernanda Nogueira ◽  
Ricardo Guimarães Fischer ◽  
...  

2017 ◽  
Vol 57 (16) ◽  
pp. 3421-3429 ◽  
Author(s):  
Esther Tortosa-Caparrós ◽  
Diana Navas-Carrillo ◽  
Francisco Marín ◽  
Esteban Orenes-Piñero

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