Physiological impact of the environment on the welfare of transgenic goats raised in a tropical climate

Author(s):  
Matheus Soares Alves ◽  
Raul Andrei de Assis Dantas ◽  
Rosane de Oliveira Cruz ◽  
Vinícius Carvalho Pereira ◽  
Marcos Alves de Souza Filho ◽  
...  
Author(s):  
Margaret Kemeny ◽  
Tara Gruenewald ◽  
Sally Dickerson

2015 ◽  
Vol 1 (5) ◽  
pp. 235-242
Author(s):  
Édio Damásio da Silva Júnior ◽  
Rogério de Araújo Almeida ◽  
Elisa Rodrigues Siqueira ◽  
Ábio Roduvalho da Silva

2010 ◽  
Vol 6 (1) ◽  
pp. 83
Author(s):  
Jagmeet P Singh ◽  

Cardiac resynchronisation therapy (CRT) has gained widespread acceptance as a safe and effective therapeutic strategy for congestive heart failure (CHF) refractory to optimal medical therapy. The use of implantable devices has substantially altered the natural history of systolic heart failure. These devices exert their physiological impact through ventricular remodelling, associated with a reduction in left ventricular (LV) volumes and an improvement in ejection fraction (EF). Several prospective randomised studies have shown that this in turn translates into long-term clinical benefits such as improved quality of life, increased functional capacity and reduction in hospitalisation for heart failure and overall mortality. Despite these obvious benefits, there remain more than a few unresolved concerns, the most important being that up to one-third of patients treated with CRT do not derive any detectable benefit. There are several determinants of successful delivery and response to CRT, including selecting the appropriate patient, patient-specific optimal LV pacing lead placement and appropriate post-implant device care and follow-up. This article highlights the importance of collectively working on all of these aspects of CRT to enhance and maximise response.


Author(s):  
Ricardo Ortiz Ortega ◽  
Alonso Vilches Flores ◽  
Marco Aurelio Rodríguez Monroy ◽  
Patricia Bonilla Lemus

Studies accomplished in freshwater demonstrate the importance of identify the presence of<br />protozoa like free living amoebae (FLA). In particular, the genera Acanthamoeba is associated with<br />severe infections in man, as the Granulomatous Amebic Encephalitis (GAE). The most important<br />factor for the development of these organisms is the high temperature of the water body. The<br />region of the Huasteca Potosina in Mexico, with a tropical climate and great aquatic resorts, like<br />rivers, waterfalls and pools of thermal waters, that allows the development of amoebae. In this<br />study we evaluated the presence of amoebas in the most visited places on the Huasteca Potosina.<br />Samples of a liter were taken in nine sites during the rainy and dry season. 54 strains of amoebas<br />were identify, 46 belong to the genera Acanthamoeba, resulting 30 of them pathogenic in the<br />animal tests. The pathogenic isolated amoebas were present in the most attended resorts by the<br />people in the waterfalls or pools of the places sampling. Temperature turned out to be the most<br />important factor for the presence of amoebae.


Biomolecules ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 24
Author(s):  
Eva Pokorná ◽  
Tomáš Hluska ◽  
Petr Galuszka ◽  
H. Tucker Hallmark ◽  
Petre I. Dobrev ◽  
...  

Cytokinins (CKs) are a class of phytohormones affecting many aspects of plant growth and development. In the complex process of CK homeostasis in plants, N-glucosylation represents one of the essential metabolic pathways. Its products, CK N7- and N9-glucosides, have been largely overlooked in the past as irreversible and inactive CK products lacking any relevant physiological impact. In this work, we report a widespread distribution of CK N-glucosides across the plant kingdom proceeding from evolutionary older to younger plants with different proportions between N7- and N9-glucosides in the total CK pool. We show dramatic changes in their profiles as well as in expression levels of the UGT76C1 and UGT76C2 genes during Arabidopsis ontogenesis. We also demonstrate specific physiological effects of CK N-glucosides in CK bioassays including their antisenescent activities, inhibitory effects on root development, and activation of the CK signaling pathway visualized by the CK-responsive YFP reporter line, TCSv2::3XVENUS. Last but not least, we present the considerable impact of CK N7- and N9-glucosides on the expression of CK-related genes in maize and their stimulatory effects on CK oxidase/dehydrogenase activity in oats. Our findings revise the apparent irreversibility and inactivity of CK N7- and N9-glucosides and indicate their involvement in CK evolution while suggesting their unique function(s) in plants.


Author(s):  
Suhono ◽  
A D Athaya ◽  
L H Anwari ◽  
F D H Sinaga ◽  
S F Hadaina ◽  
...  

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