scholarly journals A pilot study of multilevel analysis of BDNF in paternal and maternal perinatal depression

2022 ◽  
Author(s):  
Sarah Kittel-Schneider ◽  
Petra Davidova ◽  
Miriam Kalok ◽  
Corina Essel ◽  
Fadia Ben Ahmed ◽  
...  
Keyword(s):  
Risk Factors ◽  
Depressive Symptoms ◽  
Pilot Study ◽  
Protein Expression ◽  
Perinatal Depression ◽  
Perinatal Period ◽  
Maternal Depressive Symptoms ◽  
Blood Samples ◽  
Time Points ◽  
Factors Associated

AbstractDepression in the perinatal period is common in mothers worldwide. Emerging research indicates that fathers are also at risk of developing perinatal depression. However, knowledge regarding biological risk factors and pathophysiological mechanisms of perinatal depression is still scarce, particularly in fathers. It has been suggested that the neurotrophin BDNF may play a role in maternal perinatal depression; however, there is currently no data regarding paternal perinatal depression. For this pilot study, 81 expecting parents were recruited and assessed at several time points. We screened for depression using EPDS and MADRS, investigated several psychosocial variables, and took blood samples for BDNF val66met genotyping, epigenetic, and protein analysis. Between pregnancy and 12 months postpartum (pp), we found that 3.7 to 15.7% of fathers screened positive for depression, and 9.6 to 24% of mothers, with at least a twofold increased prevalence in both parents using MADRS compared with EPDS. We also identified several psychosocial factors associated with perinatal depression in both parents. The data revealed a trend that lower BDNF levels correlated with maternal depressive symptoms at 3 months pp. In the fathers, no significant correlations between BDNF and perinatal depression were found. Pregnant women demonstrated lower BDNF methylation and BDNF protein expression compared with men; however, these were found to increase postpartum. Lastly, we identified correlations between depressive symptoms and psychosocial/neurobiological factors. The data suggest that BDNF may play a role in maternal perinatal depression, but not paternal.

scholarly journals Attenuation of Antibody Titers from 3 to 6 Months after the Second Dose of the BNT162b2 Vaccine Depends on Sex, with Age and Smoking Risk Factors for Lower Antibody Titers at 6 Months

Vaccines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1500
Author(s):  
Yushi Nomura ◽  
Michiru Sawahata ◽  
Yosikazu Nakamura ◽  
Ryousuke Koike ◽  
Otohiro Katsube ◽  
...  
Keyword(s):  
Risk Factors ◽  
Healthcare Workers ◽  
Percentage Change ◽  
Median Percentage ◽  
Blood Samples ◽  
Time Points ◽  
Factors Associated ◽  
Median Percentage Change ◽  
Antibody Titers ◽  
Participant Characteristics

Objective: We aimed to determine antibody titers at six months and their percentage change from three to six months after the second dose of the BNT162b2 coronavirus disease 2019 (COVID-19) mRNA vaccine (Pfizer/BioNTech) and to explore clinical variables associated with titers in Japan. Methods: We enrolled 365 healthcare workers (250 women, 115 men) whose three-month antibody titers were analyzed in our previous study and whose blood samples were collected 183 ± 15 days after the second dose. Participant characteristics, collected previously, were used. The relationships of these factors with antibody titers at six months and percentage changes in antibody titers from three to six months were analyzed. Results: Median age was 44 years. Median antibody titer at six months was 539 U/mL. Older participants had significantly lower antibody titers (20s, 752 U/mL; 60s–70s, 365 U/mL). In age-adjusted analysis, smoking was the only factor associated with lower antibody titers. Median percentage change in antibody titers from three to six months was −29.4%. The only factor significantly associated with the percentage change in Ab titers was not age or smoking, but sex (women, −31.6%; men, −25.1%). Conclusion: The most important factors associated with lower antibody titers at six months were age and smoking, as at three months, probably reflecting their effect on peak antibody titers. However, the only factor significantly associated with the attenuation in Ab titers from three to six months was sex, which reduced the sex difference seen during the first three months. Antibody titers may be affected by different factors at different time points.

scholarly journals Attenuation of antibody titres during 3-6 months after the second dose of the BNT162b2 vaccine depends on sex, with age and smoking as risk factors for lower antibody titres at 6 months

2021 ◽  
Author(s):  
Yushi Nomura ◽  
Michiru Sawahata ◽  
Yosikazu Nakamura ◽  
Ryousuke Koike ◽  
Otohiro Katsube ◽  
...  
Keyword(s):  
Risk Factors ◽  
Healthcare Workers ◽  
Rate Of Change ◽  
Blood Samples ◽  
Time Points ◽  
Factors Associated ◽  
Rates Of Change ◽  
Antibody Titres ◽  
Participant Characteristics ◽  
Median Rate

ABSTRACTObjectiveWe aimed to determine antibody titres at 6 months and their rate of change during 3-6 months after the second dose of the BNT162b2 coronavirus disease 2019 (COVID-19) mRNA vaccine (Pfizer/BioNTech) and to explore clinical variables associated with titres in Japan.MethodsWe enrolled 365 healthcare workers (250 women, 115 men) whose 3-month antibody titres were analyzed in our previous study and whose blood samples were collected 183 ± 15 days after the second dose. Participant characteristics collected previously were used. The relationships of these factors with antibody titres at 6 months and rates of change in antibody titres during 3-6 months were analyzed.ResultsMedian age was 44 years. Median antibody titre at 6 months was 539 U/mL. Older participants had significantly lower antibody titres (20s, 752 U/mL; 60s–70s, 365 U/mL). In age-adjusted analysis, smoking was the only factor associated with lower antibody titres. Median rate of change in antibody titres during 3-6 months was −29.4%. The only factor significantly associated with the rate of change in Ab titres was not age or smoking, but sex (women, −31.6%; men, −25.1%).ConclusionThe most important factors associated with lower antibody titres at 6 months were age and smoking, as at 3 months, probably reflecting their effect on peak antibody titres. However, antibody titres significantly attenuated during 3-6 months in women alone, which reduced the sex difference in antibody titres seen during the first 3 months. Antibody titres may be affected by different factors at different time points.

scholarly journals Investigating Factors Associated with Depressive Symptoms of Chronic Kidney Diseases in China with Type 2 Diabetes

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Xu Wang ◽  
Biyu Shen ◽  
Xun Zhuang ◽  
Xueqin Wang ◽  
Weiqun Weng
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Regression Analysis ◽  
Depressive Symptoms ◽  
Kidney Diseases ◽  
Chronic Kidney Diseases ◽  
Factors Associated

Aim.To assess the depressive symptoms status of chronic kidney diseases in Nantong, China, with type 2 diabetes and to identify factors associated with depressive symptoms.Methods.In this cross-sectional analytic study, 210 type 2 diabetic patients were recruited from the Second Affiliated Hospital of Nantong University. Depressive symptoms were assessed with the depression subscale of the Hospital Anxiety and Depression Scale (HAD-D). The quality of life was measured with the RAND 36-Item Health Survey (SF-36). And the independent risk factors of depressive symptoms were assessed by using a stepwise forward model of logistic regression analysis.Results.The mean age of the study subjects was 57.66 years (SD: 11.68). Approximately 21.4% of subjects reported depressive symptoms (n=45). Forward stepwise logistic regression analysis showed that female gender (P=0.010), hypertension (P=0.022), Stage IV (P=0.003), and Stage V (P<0.001) were significant risk factors for depressive symptoms. The quality of life of individuals with HAD-D score <11 was significantly better compared with individuals with HAD-D score ≥ 11.Conclusions.These results indicate that clinicians should be aware that female patients with chronic kidney diseases with T2DM in their late stage with hypertension are at a marked increased risk of depressive symptoms. Providing optimal care for the psychological health of this population is vital.

scholarly journals Seroprevalence and risk factors associated with infection by Neospora caninum of dairy cattle in the state of Alagoas, Brazil

2012 ◽  
Vol 32 (10) ◽  
pp. 1009-1013 ◽  
Author(s):  
Maria E. Sousa ◽  
J.N. Porto Wagnner ◽  
Pedro P.F. Albuquerque ◽  
Orestes L. Souza Neto ◽  
Eduardo B. Faria ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dairy Cattle ◽  
Indirect Immunofluorescence ◽  
Neospora Caninum ◽  
Infection Risk ◽  
Control Measures ◽  
Risk Indicators ◽  
Blood Samples ◽  
Factors Associated ◽  
Serological Investigation

The objective of this study was to investigate the prevalence of anti-Neospora caninum antibodies in cattle from milk producing farms of the microregion of Batalha, state of Alagoas, Brazil, as well as to identify the risk factors associated with the infection. Blood samples were collected from 1,004 cattle of 17 farms for the serological investigation regarding the presence of anti-N. caninum antibodies by the Indirect Immunofluorescence Reaction Technique (IMRT). From the total amount of samples analyzed, 77/1,004 (7.67%) were positive and 927/1,004 (92.33%) were negative. The logistical regression identified that cattle from farms without consortium breeding have an infection risk 6.33 (p<0.001; C.I. 2.89-13.10) times higher than cattle from farms with that type of breeding. Cattle from farms where the aborted fetuses are not adequately buried have an infection risk 3.04 (p<0.001; C.I. 1.64-5.63) times higher than cattle from farms with adequate destination of these fetuses. Infection by N. caninum occurs in cattle of the investigated region. The factors identified in our study can be used as risk indicators, so that control measures could be implemented to avoid infection by N. caninum in the herds of this region.

Perinatal Depression

2014 ◽  
Author(s):  
Jennifer N. Felder ◽  
Abigail Lindemann ◽  
Sona Dimidjian
Keyword(s):  
Risk Factors ◽  
Perinatal Depression ◽  
Perinatal Period ◽  
Future Research ◽  
Childbearing Age ◽  
Research Directions ◽  
Wide Range ◽  
Assessment And Treatment ◽  
Future Research Directions ◽  
Assessment Strategies

Depression is a common problem among pregnant andpostpartum women, with rates comparable to or greater than those among women of childbearing age who are not pregnant or postpartum. Perinatal depression is associated with a wide range of unique assessment and treatment complexities, risk factors, and consequences for women and offspring. In this chapter, we review current research on the prevalence of perinatal depression, etiology, risk factors, and consequences, and we discuss assessment strategies and interventions. Limitations to current research and future research directions are noted. We conclude with guidelines for practitioners for assessing and treating depression during the perinatal period.

scholarly journals Modern foreign studies of depressive disorders during the COVID-19 pandemic

2021 ◽  
Vol 10 (1) ◽  
pp. 39-47
Author(s):  
E.V. Khramov ◽  
V.S. Ivanov
Keyword(s):  
Risk Factors ◽  
Depressive Symptoms ◽  
Chronic Diseases ◽  
Sharp Increase ◽  
Depressive Disorders ◽  
Perinatal Period ◽  
Medical Professionals ◽  
Depression And Anxiety ◽  
Age Related ◽  
Common Risk Factors

The article provides an overview of modern foreign studies aimed at investigating the main risk factors for depressive disorders in different categories of the population during the pandemic. First of all, attention was paid to the analysis of the influence of socio-psychological, social, age and occupational factors on the formation of depressive symptoms. Studies show a sharp increase in depression and anxiety during the COVID-19 pandemic. It has been found that patients with COVID-19, medical professionals directly in contact with COVID-19 cases, patients with any chronic diseases before the pandemic, and women in the perinatal period are most prone to developing depressive and anxiety conditions. In addition to describing common risk factors for development and display of depression, the results of foreign studies provide an understanding of the age-related effects of depressive conditions during the COVID-19 pandemic.

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