The success and effectiveness of miniscrew-assisted rapid palatal expansion are age- and sex-dependent

Abstract Objectives This study aimed to assess the success rate and the amount of suture separation after the miniscrew-assisted rapid palatal expansion (MARPE) procedure in relation to the chronological age and sex of the patients. Materials and methods The periapical radiographs of 215 subjects (95 male; 120 female; range, 6–60 years) who had undergone MARPE treatment were retrospectively analyzed. The success of suture separation was determined and, in suture-separated subjects, the amount of suture separation was evaluated by suture separation ratio calculated from the periapical radiograph obtained after active expansion. Association tests were performed using linear-by-linear association, the Jonckheere-Terpstra test, Fisher’s exact test, and the Mann–Whitney U test, and linear regression models were also developed. Results The success rate of suture separation was 61.05% in male, 94.17% in female, and 79.53% in both sexes. There was a statistically significant association between older age and suture nonseparation in male (p < 0.001), but not in female (p = 0.221). In suture-separated subjects, there was a statistically significant trend toward a low amount of suture separation with older age subgroups in both sexes (p < 0.001); however, there was no statistically significant difference in the amount of suture separation between male and female in all age subgroups. Conclusions Older patients treated with MARPE, particularly in male, may have a reduced likelihood of both success in suture separation and sufficient basal bone expansion. Clinical relevance This study demonstrates that clinicians should consider that the success rate of MARPE and the amount of suture separation may depend on chronological age and sex.

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Success Rate of Obturation of Root Canals by Different Techniques in Primary Molars: A Comparative Clinical Study

Current Dentistry ◽

10.2174/2542579x02999200503032916 ◽

2020 ◽

Vol 2 (1) ◽

pp. 36-44

Author(s):

Satyawan G. Damle ◽

Ritika Bansal ◽

Dhanashree D. Sakhare

Keyword(s):

Success Rate ◽

Study Groups ◽

Primary Molars ◽

Control Group ◽

Second Primary ◽

Chi Square ◽

Exact Test ◽

Root Canals ◽

Significant Difference ◽

Comparative Clinical Study

Objective: To compare the success rate of different obturation procedures in primary mandibular second molars clinically and also by digital radiovisiography. Methods: A total of 40 children aged between 4-8 years with deeply carious mandibular second primary molars indicated for single session pulpectomy were selected. Canals were obturated with Metapex. The 3 study groups (Endodontic plugger, Handheld lentulospiral, Navi Tip syringe) were compared with the control group (reamer) both clinically and radiovisiographically. The data collected were statistically analyzed using Pearson’s Chi-square and Fisher’s exact test. Results: The use of Navi tip syringe led to the least number of voids followed by Endodontic plugger and Reamer and the highest number of voids was reported with Lentulospiral. Navitip presented maximum number of optimally filled cases followed by Endodontic plugger and Lentulospiral and least number of optimally filled cases with reamer. However, there was no statistically significant difference (p>0.05) in any of the groups with clinical (pain and tenderness to percussion) and radiographic parameters (presence or absence of voids and length of obturation). Conclusion: Within the limitations of the present study, though the clinical outcome was statistically insignificant, Navitip syringe exhibited encouraging results and is a promising option for obturation in primary teeth.

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Would midpalatal suture characteristics help to predict the success rate of miniscrew-assisted rapid palatal expansion?

American Journal of Orthodontics and Dentofacial Orthopedics ◽

10.1016/j.ajodo.2020.04.035 ◽

2021 ◽

Author(s):

Adriana Souza de Jesus ◽

Cibele Braga de Oliveira ◽

Wilson Humio Murata ◽

Selly Sayuri Suzuki ◽

Ary dos Santos-Pinto

Keyword(s):

Success Rate ◽

Midpalatal Suture ◽

Palatal Expansion ◽

Rapid Palatal Expansion

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Efficacy of Miniscrew-Assisted Rapid Palatal Expansion (MARPE) in late adolescents and adults: a systematic review and meta-analysis

European Journal of Orthodontics ◽

10.1093/ejo/cjab005 ◽

2021 ◽

Author(s):

Aldin Kapetanović ◽

Christina I Theodorou ◽

Stefaan J Bergé ◽

Jan G J H Schols ◽

Tong Xi

Keyword(s):

Systematic Review ◽

Success Rate ◽

Observational Studies ◽

Risk Of Bias ◽

Late Adolescents ◽

Maxillary Expansion ◽

Palatal Expansion ◽

Rapid Palatal Expansion ◽

Adolescents And Adults ◽

Maxillary Deficiency

Summary Background Miniscrew-Assisted Rapid Palatal Expansion (MARPE) is a non-surgical treatment for transverse maxillary deficiency. However, there is limited evidence concerning its efficacy. Objectives This systematic review aims to evaluate the efficacy of MARPE in late adolescents and adults by assessing success rate and skeletal and dental transverse maxillary expansion, as well as treatment duration, dental and periodontal side effects and soft tissue effects. Search methods Seven electronic databases were searched (MEDLINE, Embase, Cochrane Library, Web of Science, Scopus, ProQuest and ClinicalTrials.gov) without limitations in November 2020. Selection criteria Randomized and non-randomized clinical trials and observational studies on patients from the age of 16 onwards with transverse maxillary deficiency who were treated with MARPE and which included any of the predefined outcomes. Data collection and analysis Inclusion eligibility screening, data extraction and risk of bias assessment were performed independently in duplicate. When possible, exploratory meta-analyses of mean differences (MDs) with their 95% confidence intervals (CIs) were conducted, followed by the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis of the evidence quality. Results Eight articles were included: two prospective and six retrospective observational studies. One study had a moderate risk of bias, whereas seven studies had a serious risk of bias. GRADE quality of evidence was very low. MARPE showed a high success rate (mean: 92.5%; 95%CI: 88.7%–96.3%), resulting in a significant skeletal width increase (MD: 2.33 mm; 95%CI: 1.63 mm–3.03 mm) and dental intermolar width increase (MD: 6.55 mm; 95%CI: 5.50 mm–7.59 mm). A significant increase in dental tipping, a decrease in mean buccal bone thickness and buccal alveolar height, as well as nasal soft tissue change was present (P < 0.05). The mean duration of expansion ranged from 20 to 126 days. Limitations One of the main drawbacks was the lack of high-quality prospective studies in the literature. Conclusions and implications MARPE is a treatment modality that is associated with a high success rate in skeletal and dental maxillary expansion. MARPE can induce dental and periodontal side effects and affect peri-oral soft tissues. Given the serious risk of bias of the included studies, careful data interpretation is necessary and future research of higher quality is strongly recommended. Registration PROSPERO (CRD42020176618). Funding No grants or any other support funding were received.

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Correlation between cerebrospinal fluid and plasma neurofilament light protein in treated HIV infection: results from the COBRA study

Journal of NeuroVirology ◽

10.1007/s13365-021-01026-3 ◽

2021 ◽

Author(s):

Jasmini Alagaratnam ◽

Davide De Francesco ◽

Henrik Zetterberg ◽

Amanda Heslegrave ◽

Jamie Toombs ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Sandwich Elisa ◽

Older Age ◽

Strongly Correlated ◽

Linear Regression Models ◽

Neurofilament Light ◽

Hiv Rna ◽

Significant Difference ◽

Multivariable Regression ◽

Hiv Negative

AbstractCerebrospinal fluid (CSF) neurofilament light protein (NfL) is a marker of central nervous system neuro-axonal injury. A novel, ultra-sensitive assay can determine plasma NfL. In untreated people-with-HIV (PWH), CSF and plasma NfL are strongly correlated. We aimed to assess this correlation in PWH on suppressive antiretroviral treatment (ART) and lifestyle-similar HIV-negative individuals enrolled into the COmorBidity in Relation to AIDS (COBRA) study. Differences in paired CSF (sandwich ELISA, UmanDiagnostics) and plasma (Simoa digital immunoassay, Quanterix™) NfL between PWH and HIV-negative participants were tested using Wilcoxon’s test; associations were assessed using Pearson’s correlation. CSF and plasma NfL, standardised to Z-scores, were included as dependent variables in linear regression models to identify factors independently associated with values in PWH and HIV-negative participants. Overall, 132 PWH (all with plasma HIV RNA < 50 copies/mL) and 79 HIV-negative participants were included. Neither CSF (median 570 vs 568 pg/mL, p = 0.37) nor plasma (median 10.7 vs 9.9 pg/mL, p = 0.15) NfL differed significantly between PWH and HIV-negative participants, respectively. CSF and plasma NfL correlated moderately, with no significant difference by HIV status (PWH: rho = 0.52; HIV-negative participants: rho = 0.47, p (interaction) = 0.63). In multivariable regression analysis, higher CSF NfL Z-score was statistically significantly associated with older age and higher CSF protein, and higher plasma NfL Z-score with older age, higher serum creatinine and lower bodyweight. In conclusion, in PWH on ART, the correlation between CSF and plasma NfL is moderate and similar to that observed in lifestyle-similar HIV-negative individuals. Consideration of renal function and bodyweight may be required when utilising plasma NfL.

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Corticopuncture Facilitated Microimplant-Assisted Rapid Palatal Expansion

Case Reports in Dentistry ◽

10.1155/2018/1392895 ◽

2018 ◽

Vol 2018 ◽

pp. 1-12

Author(s):

Selly Sayuri Suzuki ◽

Laila Fernanda Souza Braga ◽

Denise Nami Fujii ◽

Won Moon ◽

Hideo Suzuki

Keyword(s):

Treatment Plan ◽

Caucasian Patient ◽

Midpalatal Suture ◽

Palatal Expansion ◽

Rapid Palatal Expansion ◽

Basal Bone ◽

Bone Width ◽

Novel Approach ◽

Thread Length ◽

Invasive Method

Introduction. Microimplant-assisted rapid palatal expansion (MARPE) has been considered an alternative to avoid extensive surgical procedures. In order to obtain skeletal results of MARPE, force should be enough to overcome areas of resistance and the first one that is required to be disrupted is the midpalatal suture, which becomes increasingly interdigitated after adolescence. Objective. The present study aimed at providing a novel approach using a minimally invasive method called corticopuncture (CP) in association with MARPE illustrated by a case report of a 35-year-old Brazilian female Caucasian patient presenting maxillary transverse deficiency. Method. Treatment plan started with an orthopedic correction of the transverse problem using a MARPE device. After many unsuccessful attempts to activate MARPE, corticopunctures were performed along the midpalatal suture. CP procedure at the midpalatal suture included 8 perforations (2 mm apart), performed after previous predrilling followed by miniscrew insertion (5 mm thread length and 1.8 mm diameter). Results. After CP and new activation protocol, the opening of the midpalatal suture was observed by CBCT images, showing skeletal results, suture split of 3.14 mm (premolar area) and 2.06 (molar area), an increase of 4.3 mm (premolar) and 3.03 mm (molar) in basal bone width, 4.43 mm (premolar) and 3.1 mm (molar) in cortical bone width, and minimal dental effects (mean of 1.2° of tooth tipping). Conclusion. The combination of MARPE and corticopuncture method was proved to be a nonsurgical treatment option to correct maxillary transverse deficiency in an adult patient. CP was able to weaken suture interdigitation thus facilitating the split.

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Simple Auditory Reaction Time in Blind and Sighted Adolescents

Perceptual and Motor Skills ◽

10.2466/pms.1979.48.2.465 ◽

1979 ◽

Vol 48 (2) ◽

pp. 465-466 ◽

Cited By ~ 4

Author(s):

John Bernard

Keyword(s):

Reaction Time ◽

Auditory Stimulus ◽

Reaction Times ◽

Rest Period ◽

Chronological Age ◽

Same Sex ◽

Significant Difference ◽

Auditory Reaction Time ◽

Age And Sex

This study compared simple auditory reaction times of 20 subjects aged between 11 and 15 yr. ( M = 13), 10 born-blind from the Louis Braille Institut (Montréal) and 10 normal sighted subjects of the same age and sex. Their task was to press a telegraph key as fast as possible after presentation of an auditory stimulus. Each subject executed five blocks of 10 trials; the blocks were separated by a rest period of 1 min. The results showed no significant difference ( p > .05) between born-blind and sighted people of the same sex and chronological age in regard to simple auditory reaction time.

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Outcome of Penetrating Keratoplasty (PKP) and Redo PKP among Jordanian Population

Research in Health Science ◽

10.22158/rhs.v4n3p273 ◽

2019 ◽

Vol 4 (3) ◽

pp. p273

Author(s):

Mohammed A. Abu-Ameerh ◽

Muawyah D. Al-Bdour ◽

Baeth Moh’d Al-Rawashdeh ◽

Kawakib Al-Haidar ◽

Sujood Khraisat ◽

...

Keyword(s):

Visual Acuity ◽

Success Rate ◽

Penetrating Keratoplasty ◽

Repeated Measure ◽

Exact Test ◽

Jordanian Population ◽

Significant Difference ◽

One Year ◽

First Time ◽

Pearson Correlations

Background: The success of penetrating keratoplasty (PKP) is determined by the duration of graft survival, which is the time to graft failure. Our study aims to identify various indications of corneal graft among our Jordanian population, their success rate as well as spotting the light on cases of re-grafting. Methods: In this study, we analyzed data for patients who had PKP as well as re-do PKP in the period from January 2014 to June 2017. For each study eye, we identified pre-operative visual acuity as well as visual acuity at six months and one year. We also focused on the specific indication for PKP, the surgical procedure and graft clarity at one year post-op. On SPSS statistical analysis software, we used repeated measure ANOVA, Pearson correlations, and Fischer’s exact test to analyze our study’s variables.Results: We included a total of 230 patients in this study with a mean age of 34.22 (±19.32). They were 112 (48.7%) males and 118 (±51.3%) females. We found a significant difference in mean age and outcome (p< 0.001), as the mean age for patients with successful PKP was 31.55 (±16.55) compared to 44.1 (±25.1) for patients with failed PKP. the success rate for patients with KC as an indication was 96.7% compared to only 58.3% for other indications. We found that failure rate in redo surgeries was significantly higher than first time surgeries.Conclusion: Among the Jordanian population, we found that Keratoconus was the main indication for PKP in our population, where we also found that it was associated with the best prognosis.

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Surgical Outcomes of Trabeculectomy in Uveitic Glaucoma: A Long-Term, Single-Center, Retrospective Case-Control Study

Journal of Ophthalmology ◽

10.1155/2021/5550776 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Rina Kanaya ◽

Riki Kijima ◽

Yasuhiro Shinmei ◽

Akihiro Shinkai ◽

Takeshi Ohguchi ◽

...

Keyword(s):

Success Rate ◽

Surgical Outcomes ◽

Success Rates ◽

Uveitic Glaucoma ◽

Surgical Success ◽

Case Series Study ◽

Significant Difference ◽

The Mean ◽

Age And Sex

Purpose. To evaluate the long-term outcomes of trabeculectomy with mitomycin C (MMC-TLE) in patients with uveitic glaucoma (UG). Patients and Methods. This was a retrospective, nonrandomized case series study. MMC-TLE was performed on 50 eyes with UG between February 2001 and January 2015 at Hokkaido University Hospital. Age- and sex-matched patients with primary open angle glaucoma (POAG) who underwent MMC-TLE were matched by age and sex and enrolled as controls. Surgical success was defined as an intraocular pressure (IOP) less than 18 or 15 mmHg. The Kaplan–Meier survival curves for surgical failure were analyzed. Results. The mean preoperative IOP in UG and POAG was 27.6 ± 10.6 and 18.0 ± 4.5 mmHg, respectively. After the surgery, the mean IOP in UG and POAG was reduced to 11.7 ± 4.2 and 12.2 ± 3.8 mmHg at 12 months, 11.9 ± 7.0 and 12.1 ± 3.1 mmHg at 36 months, and 13.0 ± 5.2 and 10.6 ± 1.2 mmHg at 120 months, respectively. The success rates (IOP <18 mmHg, IOP reduction >20%) in UG and POAG were 91.7% and 88.0% at 12 months, 82.2% and 75.6% at 36 months, and 66.5% and 61.8% at 120 months, respectively. The success rates (IOP <15 mmHg) in UG and POAG were 64.0% and 58.0% at 12 months, 55.1% and 45.5% at 36 months, and 47.9% and 37.8% at 120 months, respectively. There was no significant difference in the success rate between UG and POAG at 120 months after surgery by either definition of surgical success. Conclusions. MMC-TLE effectively reduced IOP in both UG and POAG. There was no significant difference in the success rate between UG and POAG. Following sufficient inflammation suppression, surgical outcomes of UG may be comparable with those of POAG.

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Treatment of Maxillary Retrusion-Face Mask with or without RPE?

Balkan Journal of Dental Medicine ◽

10.2478/bjdm-2018-0016 ◽

2018 ◽

Vol 22 (2) ◽

pp. 93-97 ◽

Cited By ~ 1

Author(s):

Elona Kongo

Keyword(s):

Treatment Protocol ◽

Face Mask ◽

Maxillary Incisor ◽

Class Iii ◽

Skeletal Class ◽

Maxillary Protraction ◽

Palatal Expansion ◽

Rapid Palatal Expansion ◽

Significant Difference ◽

Incisor Inclination

SummaryBackground/Aim: Maxillary transverse deficiency often combines with retruded maxillary skeletal position causing a skeletal class III malocclusion. In these cases combination of rapid palatal expander and a facial mask to protract the maxilla is a very effective treatment protocol. When the maxilla is not deficient is it necessary to use palatal expansion before protracting? Should we use this combination because it has been proved to be effective? The aim of this paper is to show that maxillary protraction is also effective when applied without expanding the maxilla although there are some statistically significant changes.Material and Methods: Two groups of 20 patients each, were created for this study. The first group were treated with rapid palatal expansion and face mask. In the second group, patients were treated only with face mask.Results: Measurements made at T0 (prior to treatment) and those at T1 (after treatment) were statistically analyzed. At the end of the treatment patients of the 1st group showed significant difference for the values of SNA, SNB, ANB angles (p=0.000). Significant changes were observed also for the second group (SNA, SNB, ANB). The only differences between the two groups were observed regarding SNA angle (p=0.040) and maxillary incisor inclination (p=0.028).Conclusions: At the end of treatment, all patients showed skeletal class III correction and improved facial appearance. Significant changes of SNA angle were observed for each group. There were also significant changes in the position of the mandible. These changes contributed in skeletal class III correction but there was no significant difference between them.

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Skeletal and Alveolar Changes in Conventional Rapid Palatal Expansion (RPE) and Miniscrew-assisted RPE(MARPE): a Prospective Randomized Clinical Trial Using Low-dose CBCT

10.21203/rs.3.rs-1151708/v1 ◽

2022 ◽

Author(s):

Joo-Hee Chun ◽

Amanda Cunha Regal Castro ◽

Sunmee Oh ◽

Kyung-Ho Kim ◽

Sung-Hwan Choi ◽

...

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Low Dose ◽

Adolescent And Young Adult ◽

Maxillary Expansion ◽

Prospective Randomized Clinical Trial ◽

Palatal Expansion ◽

Rapid Palatal Expansion ◽

Computed Tomography Images ◽

Basal Bone

Abstract Background: This prospective randomized clinical trial aimed to evaluate the short-term effects of rapid palatal expansion (RPE) and miniscrew-assisted RPE (MARPE) on skeletal, dentoalveolar, and periodontal structures in adolescent and young adult patients. Methods: Thirty-six patients (12 men and 24 women) requiring maxillary expansion were randomly allocated to RPE (n=17) or MARPE (n=19) groups. Upon identical (35 turns) amount of expansion, low-dose cone-beam computed tomography images were taken before treatment (T0), immediately after expansion (T1), and after a 3-month consolidation period (T2). Skeletal, dentoalveolar, and periodontal measurements were performed at each time point. Results: A greater increase in nasal width in the molar region (M-NW) and greater palatine foramen (GPF) was observed immediately after expansion (T1-T0) and consolidation periods (T2-T0) in MARPE group (P<0.05). MARPE and RPE groups showed similar dentoalveolar changes except for the maxillary width (PM-MW, M-MW) (P<0.05). Through the expansion and consolidation periods (T2-T0), lesser buccal displacement of the anchor teeth was observed in the MARPE group (PM-BBPT, PM-PBPT, M-BBPT [mesial and distal roots], and M-PBPT) (P<0.05).Conclusions: Both RPE and MARPE groups exhibited significant triangular basal bone expansion and skeletal relapse during consolidation. Under identical amounts of expansion, the MARPE group showed lower decrease in the skeletal, dentoalveolar and periodontal variables after consolidation. The reinforcement of RPE with miniscrews contributes to the maintenance of the basal bone during consolidation period. This evidence can help clinicians decide the appliance design for maxillary expansion, while preventing periodontal side effects, such as buccal bone dehiscence Trial registration: WHO Institutional Clinical Trials Registry Platform (IRB No. KCT0006871 / Registration Date 27/12/2021)

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