The impact of obesity on seasonal influenza: a single-center, retrospective study conducted in Israel

Abstract Purpose. The purpose of this study was to evaluate the impact of pre-existing diabetes on in-hospital mortality in patients admitted for Coronavirus Disease 2019 (COVID-19).Methods. This is a single center, retrospective study conducted at Policlinico di Monza hospital, located in the Lombardy region, Northern Italy. We reviewed medical records of 373 consecutive adult patients who were hospitalized with COVID-19 between February 22 and May 15, 2020. Data were collected on diabetes status, comorbid conditions and laboratory findings. Multivariable logistic regression was performed to evaluate the effect of diabetes on in-hospital mortality after adjustment for potential confounding variables.Results. Mean age of the patients was 72 ± 14 years (range 17-98), 244 (65.4%) were male and 69 (18.5%) had diabetes. The most common comorbid conditions were hypertension (237 [64.8%]), cardiovascular disease (140 [37.7%]) and malignant neoplasms (50 [13.6%]). In-hospital death occurred in 142 (38.0%) patients. In the multivariable model older age (Odds Ratio [OR] 1.07 [1.04-1.10] per year), diabetes (OR 2.2 [1.10-4.73]), chronic obstructive pulmonary disease (OR 3.30 [1.22-8.90]), higher values of lactic dehydrogenase and C-reactive protein were independently associated with in-hospital mortality.Conclusion. In this retrospective single-center study, diabetes was independently associated with a higher in-hospital mortality. More intensive surveillance of patients with this condition is to be warranted.

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The impact of influenza A(H1N1)pdm09 compared with seasonal influenza on intensive care admissions in New South Wales, Australia, 2007 to 2010: a time series analysis

BMC Public Health ◽

10.1186/1471-2458-12-869 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 5

Author(s):

Andrea Schaffer ◽

David Muscatello ◽

Michelle Cretikos ◽

Robin Gilmour ◽

Sean Tobin ◽

...

Keyword(s):

Time Series ◽

Intensive Care ◽

Time Series Analysis ◽

Influenza A ◽

Seasonal Influenza ◽

New South ◽

New South Wales ◽

South Wales ◽

Influenza A H1n1 ◽

The Impact

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Endoscopic Yield in Anemia of Chronic Disease: A Single-Center Retrospective Study of U.S. Veteran Population

Clinical Research Open Access ◽

10.16966/2469-6714.164 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Dinh BV ◽

Hussain W ◽

Chan CA ◽

Markert RJ ◽

Krishnamurthy P

Keyword(s):

Retrospective Study ◽

Chronic Disease ◽

Single Center ◽

Anemia Of Chronic Disease ◽

Clinical Variables ◽

Gi Symptoms ◽

The Impact

Goals: The aim of the study was to evaluate endoscopic yield in patients with Anemia of Chronic Disease (ACD) who had no Gastrointestinal (GI) symptoms. We analyzed the impact of laboratory and clinical variables on endoscopic yield in this cohort.

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Influenza-associated mortality in hospital care: a retrospective cohort study of risk factors and impact of oseltamivir in an English teaching hospital, 2016 to 2017

Eurosurveillance ◽

10.2807/1560-7917.es.2019.24.44.1900087 ◽

2019 ◽

Vol 24 (44) ◽

Cited By ~ 5

Author(s):

Mark Reacher ◽

Ben Warne ◽

Lucy Reeve ◽

Neville Q. Verlander ◽

Nicholas K. Jones ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Teaching Hospital ◽

Treatment Effect ◽

Influenza A ◽

Seasonal Influenza ◽

World Health ◽

H3n2 Virus ◽

Hospitalised Patients ◽

The Impact

Background Evidence of an oseltamivir treatment effect on influenza A(H3N2) virus infections in hospitalised patients is incomplete. Aims This cohort study aimed to evaluate risk factors for death among PCR-confirmed hospitalised cases of seasonal influenza A(H3N2) of all ages and the impact of oseltamivir. Methods Participants included all 332 PCR-confirmed influenza A(H3N2) cases diagnosed between 30 August 2016 and 17 March 2017 in an English university teaching Hospital. Oseltamivir treatment effect on odds of inpatient death was assessed by backward stepwise multivariable logistic regression analysis. Results The odds of death were reduced by two thirds (odds ratio (OR): 0.32; 95% confidence interval (CI): 0.11–0.93), in inpatients treated with a standard course of oseltamivir 75 mg two times daily for 5 days – compared with those untreated with oseltamivir, after adjustment for age, sex, current excess alcohol intake, receipt of 2016/17 seasonal influenza vaccine, serum haemoglobin and hospital vs community attribution of acquisition of influenza. Conclusions Oseltamivir treatment given according to National Institutes of Clinical Excellence (NICE); United States Centres for Disease Control and Prevention (CDC); Infectious Diseases Society of America (IDSA) and World Health Organization (WHO) guidelines was shown to be effective in reducing the odds of mortality in inpatients with PCR-confirmed seasonal influenza A(H3N2) after adjustment in a busy routine English hospital setting. Our results highlight the importance of hospitals complying with relevant guidelines for prompt seasonal influenza PCR testing and ensuring standard oseltamivir treatment to all PCR-confirmed cases of seasonal influenza.

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Estimating the impact of the 2009 influenza A(H1N1) pandemic on mortality in the elderly in Navarre, Spain

Eurosurveillance ◽

10.2807/ese.15.05.19481-en ◽

2010 ◽

Vol 15 (5) ◽

Author(s):

J Castilla ◽

J Etxeberria ◽

E Ardanaz ◽

Y Floristán ◽

R López Escudero ◽

...

Keyword(s):

Pandemic Influenza ◽

Influenza A ◽

Excess Mortality ◽

Seasonal Influenza ◽

The Elderly ◽

Significant Excess ◽

Influenza A H1n1 ◽

The Mean ◽

The Impact ◽

Second Wave

We analysed mortality among people aged 65 years or older in Navarre, Spain in 2009 and compared it with the mean for the same period of time in the previous three years. In the pandemic weeks 24 to 52 2009 we observed 4.9% more deaths than expected (p=0.0268). Excess mortality occurred during the circulation of seasonal influenza (8.0%, p=0.0367) and the first wave of pandemic influenza (9.9%, p=0.0079). In the second wave of pandemic influenza there was a non-significant excess of deaths (5.2%, p=0.1166). Surveillance of laboratory-confirmed severe influenza cases detected only one death in this age group.

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The impact of the pandemic influenza A(H1N1) 2009 virus on seasonal influenza A viruses in the southern hemisphere, 2009

Eurosurveillance ◽

10.2807/ese.15.31.19631-en ◽

2010 ◽

Vol 15 (31) ◽

Author(s):

C C Blyth ◽

A Kelso ◽

K A McPhie ◽

V M Ratnamohan ◽

M Catton ◽

...

Keyword(s):

Southern Hemisphere ◽

Pandemic Influenza ◽

Influenza A ◽

Seasonal Influenza ◽

World Health ◽

Influenza A Viruses ◽

Complete Replacement ◽

Influenza A H1n1 ◽

The Impact ◽

Pandemic Wave

Data collected over winter 2009 by five World Health Organisation National Influenza Centres in the southern hemisphere were used to examine the circulation of pandemic and seasonal influenza A strains during the first pandemic wave in the southern hemisphere. There is compelling evidence that the pandemic influenza A(H1N1) 2009 virus significantly displaced seasonal influenza A(H1N1) and, to a lesser extent, A(H3N2) viruses circulating in the southern hemisphere. Complete replacement of seasonal influenza A strains, however, was not observed during the first pandemic wave.

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The Impact of Obesity on the Outcomes of Adult Patients with Acute Lymphoblastic Leukemia – A Single Center Retrospective Study

Blood and Lymphatic Cancer Targets and Therapy ◽

10.2147/blctt.s269748 ◽

2021 ◽

Vol Volume 11 ◽

pp. 1-9

Author(s):

Qiuju Liu ◽

Brittny Major ◽

Jennifer Le-Rademacher ◽

Aref A Al-Kali ◽

Hassan Alkhateeb ◽

...

Keyword(s):

Retrospective Study ◽

Acute Lymphoblastic Leukemia ◽

Lymphoblastic Leukemia ◽

Adult Patients ◽

Single Center ◽

The Impact

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Effects of repeated vaccination and vaccine formulation on the induction of broadly neutralizing antibody responses against influenza A virus in children

10.1101/2021.08.03.21261495 ◽

2021 ◽

Author(s):

Sergey Yegorov ◽

Daniel Celeste ◽

Kimberly Braz Gomes ◽

Jann C Ang ◽

Colin Vandenhof ◽

...

Keyword(s):

Influenza Vaccination ◽

Neutralizing Antibodies ◽

Influenza A ◽

Seasonal Influenza ◽

Natural Infection ◽

Neutralizing Antibody ◽

Seasonal Influenza Vaccination ◽

Vaccine Type ◽

Paediatric Cohort ◽

The Impact

The induction of broadly neutralizing antibodies (bNAbs) that target the hemagglutinin stalk domain is a promising strategy for the development of universal influenza virus vaccines. bNAbs can be boosted in adults by sequential exposure to heterosubtypic viruses through natural infection or vaccination. However, little is known about if/how bNAbs are induced by vaccination in more immunologically naive children. Here, we describe the impact of repeated seasonal influenza vaccination and vaccine type on induction of bNAbs in a well-characterized paediatric cohort enrolled in a series of randomized control trials of seasonal influenza vaccination. Repeated seasonal vaccination resulted in significant boosting of a durable bNAb response. Boosting of serological bNAbs titers was comparable within inactivated and live attenuated (LAIV) vaccinees and declined with age. These data provide new insights into vaccine-elicited bNAb induction in children, which has important implications for the design of universal influenza vaccine modalities in this critical population.

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