scholarly journals Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer

2009 ◽  
Vol 21 (3) ◽  
pp. 331-345 ◽  
Author(s):  
Aditi Hazra ◽  
Charles S. Fuchs ◽  
Takako Kawasaki ◽  
Gregory J. Kirkner ◽  
David J. Hunter ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Carbon Metabolism ◽  
Metabolism Pathway ◽  
One Carbon Metabolism ◽  
The One

scholarly journals Nonsynonymous Polymorphisms in Genes in the One-Carbon Metabolism Pathway and Associations with Colorectal Cancer

2006 ◽  
Vol 15 (12) ◽  
pp. 2408-2417 ◽  
Author(s):  
Anita Koushik ◽  
Peter Kraft ◽  
Charles S. Fuchs ◽  
Susan E. Hankinson ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Carbon Metabolism ◽  
Metabolism Pathway ◽  
One Carbon Metabolism ◽  
The One

scholarly journals Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 580
Author(s):  
Camilo G. Sotomayor ◽  
Isidor Minović ◽  
Manfred L. Eggersdorfer ◽  
Ineke J. Riphagen ◽  
Martin H. de Borst ◽  
...  
Keyword(s):  
Vitamin E ◽  
Carbon Metabolism ◽  
Serum Vitamin ◽  
Elderly Subjects ◽  
Vitamin Supplement ◽  
Total Lipids ◽  
Metabolism Pathway ◽  
Age Related ◽  
One Carbon Metabolism ◽  
The One

Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60–75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of α-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of γ-tocopherol were often opposite to those of α-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for α-tocopherol and γ-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied.

Genetic Variants in One-Carbon Metabolism Pathway Predict Survival Outcomes of Early-Stage Non-Small Cell Lung Cancer

Oncology ◽  
2020 ◽  
Vol 98 (12) ◽  
pp. 897-904
Author(s):  
Sook Kyung Do ◽  
Sun Ha Choi ◽  
Shin Yup Lee ◽  
Jin Eun Choi ◽  
Hyo-Gyoung Kang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Carbon Metabolism ◽  
Genetic Variants ◽  
Early Stage ◽  
Small Cell ◽  
Survival Outcomes ◽  
Small Cell Lung ◽  
Metabolism Pathway ◽  
One Carbon Metabolism ◽  
The One

<b><i>Background:</i></b> This study was conducted to investigate the association between genetic variants in one-carbon metabolism and survival outcomes of surgically resected non-small cell lung cancer (NSCLC). <b><i>Methods:</i></b> We genotyped 41 potentially functional variants of 19 key genes in the one-carbon metabolism pathway among 750 NSCLC patients who underwent curative surgery. The association between genetic variants and overall survival (OS)/disease-free survival (DFS) were analyzed. <b><i>Results:</i></b> Among the 41 single-nucleotide polymorphisms (SNPs) analyzed, 4 SNPs (<i>MTHFD1L</i> rs6919680T&#x3e;G and rs3849794T&#x3e;C, <i>MTR</i> rs2853523C&#x3e;A, and <i>MTHFR</i> rs4846049G&#x3e;T) were significantly associated with survival outcomes. <i>MTHFD1L</i> rs6919680T&#x3e;G and <i>MTR</i> rs2853523C&#x3e;A were significantly associated with better OS (adjusted hazard ratio [aHR] = 0.73, 95% confidence interval [CI] = 0.54–0.99, <i>p</i> = 0.04) and worse OS (aHR = 2.14, 95% CI = 1.13–4.07, <i>p</i> = 0.02), respectively. <i>MTHFD1L</i> rs3849794T&#x3e;C and <i>MTHFR</i> rs4846049G&#x3e;T were significantly associated with worse DFS (aHR = 1.41, 95% CI = 1.08–1.83, <i>p</i> = 0.01; and aHR = 1.97, 95% CI = 1.10–3.53, <i>p</i> = 0.02, respectively). When the patients were divided according to histology, the associations were significant only in squamous cell carcinoma (SCC), but not in adenocarcinoma (AC). In SCC, <i>MTHFD1L</i> rs6919680T&#x3e;G and <i>MTR</i> rs2853523C&#x3e;A were significantly associated with better OS (aHR = 0.64, 95% CI = 0.41–1.00, <i>p</i> = 0.05) and worse OS (aHR = 2.77, 95% CI = 1.11–6.91, <i>p</i> = 0.03), respectively, and <i>MTHFD1L</i> rs3849794T&#x3e;C and <i>MTHFR</i> rs4846049G&#x3e;T were significantly associated with worse DFS (aHR = 1.73, 95% CI = 1.17–2.56, <i>p</i> = 0.01; and aHR = 2.78, 95% CI = 1.12–6.88, <i>p</i> = 0.03, respectively). <b><i>Conclusions:</i></b> Our results suggest that the genetic variants in the one-carbon metabolism pathway could be used as biomarkers for predicting the clinical outcomes of patients with early-stage NSCLC.

scholarly journals Gene expression profiles of the one-carbon metabolism pathway

2009 ◽  
Vol 36 (5) ◽  
pp. 277-282 ◽  
Author(s):  
Yin Leng Lee ◽  
Xinran Xu ◽  
Sylvan Wallenstein ◽  
Jia Chen
Keyword(s):  
Gene Expression ◽  
Carbon Metabolism ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Metabolism Pathway ◽  
One Carbon Metabolism ◽  
The One

scholarly journals Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway

2009 ◽  
Vol 18 (23) ◽  
pp. 4677-4687 ◽  
Author(s):  
Aditi Hazra ◽  
Peter Kraft ◽  
Ross Lazarus ◽  
Constance Chen ◽  
Stephen J. Chanock ◽  
...  
Keyword(s):  
Carbon Metabolism ◽  
Metabolism Pathway ◽  
Genome Wide ◽  
One Carbon Metabolism ◽  
The One

scholarly journals Gene-Metabolite Interaction in the One Carbon Metabolism Pathway: Predictors of Colorectal Cancer in Multi-Ethnic Families

2018 ◽  
Vol 8 (3) ◽  
pp. 26 ◽  
Author(s):  
S. Shiao ◽  
James Grayson ◽  
Chong Yu
Keyword(s):  
Colorectal Cancer ◽  
Carbon Metabolism ◽  
Vegetable Intake ◽  
Characteristic Curve ◽  
Gene Mutations ◽  
Supervised Machine Learning ◽  
Misclassification Rate ◽  
Blood Metabolites ◽  
One Carbon Metabolism ◽  
The One

For personalized healthcare, the purpose of this study was to examine the key genes and metabolites in the one-carbon metabolism (OCM) pathway and their interactions as predictors of colorectal cancer (CRC) in multi-ethnic families. In this proof-of-concept study, we included a total of 30 participants, 15 CRC cases and 15 matched family/friends representing major ethnic groups in southern California. Analytics based on supervised machine learning were applied, with the target variable being specified as cancer, including the ensemble method and generalized regression (GR) prediction. Elastic Net with Akaike’s Information Criterion with correction (AICc) and Leave-One-Out cross validation GR methods were used to validate the results for enhanced optimality, prediction, and reproducibility. The results revealed that despite some family members sharing genetic heritage, the CRC group had greater combined gene polymorphism-mutations than the family controls (p < 0.1) for five genes including MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRR A66G, and DHFR 19bp. Blood metabolites including homocysteine (7 µmol/L), methyl-folate (40 nmol/L) with total gene mutations (≥4); age (51 years) and vegetable intake (2 cups), and interactions of gene mutations and methylmalonic acid (MMA) (400 nmol/L) were significant predictors (all p < 0.0001) using the AICc. The results were validated by a 3% misclassification rate, AICc of 26, and >99% area under the receiver operating characteristic curve. These results point to the important roles of blood metabolites as potential markers in the prevention of CRC. Future intervention studies can be designed to target the ways to mitigate the enzyme-metabolite deficiencies in the OCM pathway to prevent cancer.

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