Patterns of vascular response immediately after passive mobilization in patients with sepsis: an observational transversal study

2021 ◽  
Author(s):  
Débora Mayumi de Oliveira Kawakami ◽  
José Carlos Bonjorno-Junior ◽  
Tamara Rodrigues da Silva Destro ◽  
Thaís Marina Pires de Campos Biazon ◽  
Naiara Molina Garcia ◽  
...  
Keyword(s):  
Vascular Response ◽  
Passive Mobilization ◽  
Transversal Study

The Triad Nocturia, Smoking and Obstructive Sleep APnea

2019 ◽  
Vol 70 (5) ◽  
pp. 1839-1842 ◽  
Author(s):  
Mihaela Trenchea ◽  
Ioan Anton Arghir ◽  
Gilda Georgeta Popescu ◽  
Stefan Rascu ◽  
Edwin Sever Bechir ◽  
...  
Keyword(s):  
Multidisciplinary Approach ◽  
Sleep Apnoea ◽  
Obstructive Pulmonary Disease ◽  
Sleep Breathing Disorders ◽  
Smoking Exposure ◽  
Obstructive Sleep ◽  
Spss Software ◽  
The Relationship ◽  
Transversal Study

In patients with obstructive sleep apnoea (OSA), a consequence of the intermittent hypoxia is nocturia. The frequency of nocturia related OSA is increased because many pathological pathways are present simultaneously. The aim was to assess the prevalence of nocturia among OSA patients and to identify the relationship with OSA and its comorbidities. A transversal study determining the prevalence of OSA�s comorbidities and nocturia related OSA and smoking was assessed, from 2011 to 2015, in 2 Romanian centres of Somnology, in Constanta county. All patients suspected of sleep breathing disorders were investigated by polygraphy and all patients diagnosed with OSA were recruited. Demographic and clinical characteristics were assessed, including the onset of nocturia. The comparison between groups with and without nocturia was performed using SPSS software, using Anova for numerical outcomes and c2 test for the categorical ones. Nocturia was highly prevalent (62.75 %) among 204 OSA patients, especially in elderly (p [ 0.00001). High blood pressure (hypertension), obstructive pulmonary disease (COPD), smoking exposure were more frequently reported in the OSA patients presenting nocturia (p[0.05). Type 2 diabetes and cardiac failure were also frequent, but did not reach a significant threshold of 95%. In conclusion, the nocturia is a frequent symptom and it is influenced by the OSA severity and comorbidities as hypertension and COPD. A further multidisciplinary approach in these patients is justified, especially in smokers.

scholarly journals Patients with multiple sclerosis do not necessarily consume more alcohol or tobacco than the general population

2015 ◽  
Vol 73 (10) ◽  
pp. 828-833 ◽  
Author(s):  
Yara Dadalti Fragoso ◽  
Sidney Gomes ◽  
Marcus Vinicius M. Goncalves ◽  
Suzana C. Nunes Machado ◽  
Rogerio de Rizo Morales ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Alcohol Consumption ◽  
General Population ◽  
Alcohol Misuse ◽  
Case Control ◽  
Control Population ◽  
Higher Alcohol ◽  
Control Subjects ◽  
Culturally Different ◽  
Transversal Study

Purpose Recent papers suggest that patients with multiple sclerosis (MS) are prone to alcohol misuse. This may be due to the combination of a lifelong and disabling disease with a psychiatric profile typical of MS. The objective of the present study was to assess these findings in a culturally different population of patients with MS.Method The present case-control transversal study assessed 168 patients with MS and 168 control subjects from Brazil.Results There were no evidence that patients with MS drank more alcohol or, smoked more than did controls. In fact, control subjects had a significantly higher alcohol consumption. The only trait associated to higher alcohol consumption was anxiety, both for patients and controls.Conclusion Unlike previous reports in the literature, patients with MS in our study did not drink or smoked more than a control population.

scholarly journals Influence of group B streptococci on piglet pulmonary artery response to bradykinin

1999 ◽  
Vol 86 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Richard M. Whitehurst ◽  
Rachel Laskey ◽  
Ronald N. Goldberg ◽  
Donald Herbert ◽  
Cornelius Van Breemen
Keyword(s):  
Pulmonary Artery ◽  
Contractile Response ◽  
Isometric Force ◽  
Control Group ◽  
Relaxed Controls ◽  
Vascular Response ◽  
Group B Streptococci ◽  
Resting Tension ◽  
Neonatal Group ◽  
Group B

To study whether a sepsis-induced increase in des-Arg9-bradykinin (des-Arg9-BK) and bradykinin (BK) B1-receptor activity participates in the observed increase in pulmonary vascular resistance in neonatal group B streptococcal sepsis (GBS), isometric force bioassays of pulmonary artery (PA) rings were studied, after 4-h exposure to either Krebs or GBS, by using the following protocols: 1) BK dose-response curve, 2) vascular response to BK with N G-nitro-l-arginine methyl ester (l-NAME), and 3) response to des-Arg9-BK (BK metabolite and B1 agonist). PA rings exposed to BK resulted in contraction in the GBS group and a decrease in resting tension in the Control group ( P = 0.034) at a concentration of 10−5 M. GBS-treated PA rings contracted more to des-Arg9-BK than did Controls ( P < 0.001). BK (10−6 M) relaxed preconstricted PA rings incubated in GBS less than BK relaxed Controls ( P < 0.001), and preincubation withl-NAME decreased relaxation in both. These results suggest that GBS decreased endothelium-dependent BK relaxation and increased contractile response to des-Arg9-BK. We speculate that this occurs secondary to upregulation of B1 receptors reflected by B1-agonist-mediated PA contraction.

Mechanical Design of a Bioinspired Compliant Robotic Wrist Rehabilitation Equipment

2021 ◽  
Vol 11 (3) ◽  
pp. 1246
Author(s):  
Ovidiu Filip ◽  
Andrea Deaconescu ◽  
Tudor Deaconescu
Keyword(s):  
Mechanical Design ◽  
Pneumatic Muscle ◽  
Social Reintegration ◽  
Constructive Solution ◽  
Fin Ray ◽  
Patient Pain ◽  
Passive Mobilization ◽  
Robotic Wrist ◽  
Compliant Actuator

Early social reintegration of patients with disabilities of the wrist is possible with the help of dedicated rehabilitation equipment. Using such equipment reduces the duration of recovery and reduces significantly rehabilitation costs. Based on these considerations the paper puts forward a novel constructive solution of rehabilitation equipment that ensures the simultaneous passive mobilization of the radiocarpal, metacarpophalangeal, and interphalangeal joints. The novelty of this equipment consists in the bioinspired concept of the hand support based on the Fin-Ray effect and in driving it by means of a pneumatic muscle, an inherently compliant actuator. The paper places an emphasis on the compliant character of the rehabilitation equipment that is responsible for its adaptability to the concrete conditions of patient pain tolerability.

scholarly journals The Importance of Platelet Glycoside Residues in the Haemostasis of Patients with Immune Thrombocytopaenia

2021 ◽  
Vol 10 (8) ◽  
pp. 1661
Author(s):  
Andrés Ramírez-López ◽  
María Teresa Álvarez Román ◽  
Elena Monzón Manzano ◽  
Paula Acuña ◽  
Elena G. Arias-Salgado ◽  
...  
Keyword(s):  
Platelet Count ◽  
Sialic Acid ◽  
Healthy Controls ◽  
Caspase Activity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Activation Markers ◽  
Platelet Surface ◽  
Mannose Binding ◽  
Transversal Study ◽  
Binding Lectin

Loss of sialic acid from the carbohydrate side chains of platelet glycoproteins can affect platelet clearance, a proposed mechanism involved in the etiopathogenesis of immune thrombocytopaenia (ITP). We aimed to assess whether changes in platelet glycosylation in patients with ITP affected platelet counts, function, and apoptosis. This observational, prospective, and transversal study included 82 patients with chronic primary ITP and 115 healthy controls. We measured platelet activation markers and assayed platelet glycosylation and caspase activity, analysing samples using flow cytometry. Platelets from patients with ITP with a platelet count <30 × 103/µL presented less sialic acid. Levels of α1,6-fucose (a glycan residue that can directly regulate antibody-dependent cellular cytotoxicity) and α-mannose (which can be recognised by mannose-binding-lectin and activate the complement pathway) were increased in the platelets from these patients. Platelet surface exposure of other glycoside residues due to sialic acid loss inversely correlated with platelet count and the ability to be activated. Moreover, loss of sialic acid induced the ingestion of platelets by human hepatome HepG2 cells. Changes in glycoside composition of glycoproteins on the platelets’ surface impaired their functional capacity and increased their apoptosis. These changes in platelet glycoside residues appeared to be related to ITP severity.

Involvement of proteinase activated receptor-2in the vascular response to sphingosine 1-phosphate

2013 ◽  
Vol 126 (8) ◽  
pp. 545-556 ◽  
Author(s):  
Fiorentina Roviezzo ◽  
Antonella De Angelis ◽  
Luana De Gruttola ◽  
Antonio Bertolino ◽  
Nikol Sullo ◽  
...  
Keyword(s):  
Vascular Inflammation ◽  
Vascular Response ◽  
Vascular Effect ◽  
Vascular Responses ◽  
Sphingosine 1 Phosphate

S1P exerts a diverse set of vascular responses, and PAR-2 has been shown to be involved in vascular inflammation as well as in other inflammatory-based diseases. In the present study, we demonstrate that S1P-mediated vascular effect involves PAR-2 activation.

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