Evaluation of 28 balm and lemon balm (Melissa officinalis) accessions for content and composition of essential oil and content of rosmarinic acid

2017 ◽  
Vol 65 (3) ◽  
pp. 745-757 ◽  
Author(s):  
J. Kittler ◽  
H. Krüger ◽  
U. Lohwasser ◽  
D. Ulrich ◽  
B. Zeiger ◽  
...  
Keyword(s):  
Essential Oil ◽  
Rosmarinic Acid ◽  
Melissa Officinalis ◽  
Lemon Balm

scholarly journals Content and composition of essential oil and content of rosmarinic acid in lemon balm and balm genotypes (Melissa officinalis)

2018 ◽  
Vol 65 (5) ◽  
pp. 1517-1527
Author(s):  
J. Kittler ◽  
H. Krüger ◽  
D. Ulrich ◽  
B. Zeiger ◽  
W. Schütze ◽  
...  
Keyword(s):  
Essential Oil ◽  
Rosmarinic Acid ◽  
Melissa Officinalis ◽  
Lemon Balm

scholarly journals The Comparative Effect of Hydro Alcoholic and Hydro Distillation Extracts of Melissa officinalis on Acne and Pimple

2019 ◽  
Vol 12 ◽  
pp. 35-43 ◽  
Author(s):  
Giti Sabet Teymouri ◽  
Mozhgan Sabet Teimouri
Keyword(s):  
Essential Oil ◽  
Rosmarinic Acid ◽  
Dry Matter ◽  
Water Extract ◽  
Distilled Water ◽  
Alcoholic Extract ◽  
Melissa Officinalis ◽  
Sebaceous Glands ◽  
Comparative Effect ◽  
The People

One of the famous plants in family Lamiaceae isMelissa officinaliswhich is one of the important herbs for health and Medicine. Melisa contains Rosmarinic acid, flavonoids and phenolic. These components have tightening and rejuvenation effect on skin. Also, it has monoterpenes and di-terpenes which are antibacterial. Essential oil of Melisa forms a good complex with sebum, so it can decrease inflammation and acne pain 30 gr of dry leaves and stems of Melisa in 500 ml of distilled water were used for hydro-distillation. For hydro alcoholic extract, we used 150 gr of dry matter (leaves and stems) in 500 ml of ethyl alcohol at 25 °C for 10 days. Then, the alcoholic extract was diluted 5 times with water 20 persons were under experiment for 3 months. Extracts were sprayed on skin 3-5 times a day. The results showed that all the people treated got the best result of this treatment. After the application of the water extract of Melissa, we observed 75% of clients improved the skin pore, 65% of clients improved neurological problems and Acne infections and 92% recovery of hyper secretion of Sebaceous glands. We observed the same results with Hydro Alcoholic extracts. 75% recovery of clients with improved skin pore, 95% of clients with improved neurological problems and Acne infections and 90% recovery of hyper secretion of Sebaceous glands. The results showed that Melisa extract has value of applying on some skin problems.

Essential oil content and its composition in herb of lemon balm (Melissa officinalis L.) breeding strains

2017 ◽  
Vol 29 (4) ◽  
pp. 351-356 ◽  
Author(s):  
Katarzyna Seidler-Łożykowska ◽  
Renata Zawirska-Wojtasiak ◽  
Elżbieta Wojtowicz ◽  
Jan Bocianowski
Keyword(s):  
Essential Oil ◽  
Oil Content ◽  
Melissa Officinalis ◽  
Lemon Balm

scholarly journals Rosmarinic Acid andMelissa officinalisExtracts Differently Affect Glioblastoma Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Kristina Ramanauskiene ◽  
Raimondas Raudonis ◽  
Daiva Majiene
Keyword(s):  
Cell Death ◽  
Cytotoxic Activity ◽  
Rosmarinic Acid ◽  
Biological Effects ◽  
Biological Properties ◽  
Neuroprotective Activity ◽  
Glioblastoma Cells ◽  
Melissa Officinalis ◽  
Prooxidant Effect ◽  
Lemon Balm

Lemon balm (Melissa officinalisL.) has many biological effects but especially important is its neuroprotective activity. The aim of the study is to produce different extracts ofMelissa officinalisand analyse their chemical composition and biological properties on rat glioblastoma C6 cells. Results revealed that rosmarinic acid (RA) is the predominant compound of lemon balm extracts. RA has cytotoxic effect on glioblastoma cells (LC50290.5 μM after the incubation of 24 h and LC50171.3 μM after 48 h). RA at concentration 80–130 μM suppresses the cell proliferation and has an antioxidant effect. 200 μM and higher concentrations of RA have a prooxidant effect and initiate cell death through necrosis. The aqueous extract of lemon balm is also enriched in phenolic compounds: protocatechuic, caftaric, caffeic, ferulic, and cichoric acids and flavonoid luteolin-7-glucoside. This extract at concentrations 50 μM–200 μM RA has cytotoxic activity and initiates cell death through apoptosis. Extracts prepared with 70% ethanol contain the biggest amount of active compounds. These extracts have the highest cytotoxic activity on glioblastoma cells. They initiate generation of intracellular ROS and cell death through apoptosis and necrosis. Our data suggest that differently prepared lemon balm extracts differently affect glioblastoma cells and can be used as neuroprotective agents in several therapeutic strategies.

scholarly journals Organic and mineral fertilization and chemical composition of lemon balm (Melissa officinalis) essential oil

2012 ◽  
Vol 22 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Ana Carolina B. Sodré ◽  
José Magno Q. Luz ◽  
Lenita L. Haber ◽  
Marcia O. M. Marques ◽  
Carlos R. Rodrigues ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Melissa Officinalis ◽  
Mineral Fertilization ◽  
Lemon Balm

scholarly journals Quantitative Analysis of Phenolic Acids and Antiplatelet Activity of Melissa officinalis Leaf Extracts

2017 ◽  
Vol 12 (1) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Željan Maleš ◽  
Andrea Antolić ◽  
Ivana Babić ◽  
Sandra Jurić ◽  
Mirza Bojić
Keyword(s):  
Statistical Analysis ◽  
Quantitative Analysis ◽  
Phenolic Acids ◽  
Rosmarinic Acid ◽  
Final Concentration ◽  
Total Phenolic ◽  
Antiplatelet Activity ◽  
Melissa Officinalis ◽  
Leaf Extracts ◽  
Lemon Balm

The contents of total phenolic acids and rosmarinic acid were determined and the antiplatelet potential assessed of extracts of lemon balm ( Melissa officinalis L., Lamiaceae) leaf samples collected during 2014 and 2015. The quantity of total phenolic acids ranged from 4.8 to 8.5%, while the rosmarinic acid content ranged from 1.78 to 4.35%. Results of statistical analysis showed that the undiluted extracts have antiplatelet activity in the ADP test (final concentration 31.25 mg/L). While there are reports on antiplatelet activity of lemon balm essential oil, to the best of our knowledge, this is the first report on antiplatelet activity of lemon balm leaf extracts.

scholarly journals Solid-Phase Extraction for Photometric Determination of Rosmarinic Acid in Lemon Balm (Melissa Officinalis) Extracts

2012 ◽  
Vol 11 (1) ◽  
pp. 62-72 ◽  
Author(s):  
Miroslav Ondrejovič ◽  
Tibor Maliar ◽  
Hana Benkovičová ◽  
Jana Kubincová
Keyword(s):  
Solid Phase Extraction ◽  
Flow Rate ◽  
Rosmarinic Acid ◽  
Mobile Phase ◽  
Solid Phase ◽  
Photometric Determination ◽  
Phase Extraction ◽  
Melissa Officinalis ◽  
Lemon Balm

Solid-Phase Extraction for Photometric Determination of Rosmarinic Acid in Lemon Balm (Melissa Officinalis) Extracts The aim of this study was evaluation of the solid-phase extraction for elimination of interference compounds from lemon balm extracts aimed for photometric determination of rosmarinic acid. In experiments, evaluated conditions were as follows: composition and volume of mobile phase, ratio between volume of sample and mass of stationary phase and flow rate of mobile phase during separation. The results indicated that interfered compounds were eliminated. The lemon balm extracts should be pretreated by adsorption on normal stationary phase (silica gel) in ratio sample volume to silica gel weight 1:1 (v/w) elution by mobile phase - diethyl ether: acetic acid (9:1; v/v) - volume - 40 times of crude extract volume - with flow rate 5 ml/min. After selection of SPE conditions, the method was validated with comparison to HPLC analysis. The results suggest that this method may be useable for determination of rosmarinic acid by photometric measurement based on the complexation of Fe2+ ions with rosmarinic acid.

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