In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life

Background. The study of features of comorbid pathology in patients with epilepsy is of particular interest due to the high prevalence of this pathology and a significant impact on the quality of life of patients and their social adaptation. Aim. The aim of the research was to detect versatile cognitive impairments and affective disorders in epilepsy, and to study the results of cognitive training and psychoeducation. Materials and methods. The theoretical analysis of modern scientific researches in the field of cognitive and affective impairments during epilepsy was carried out. We studied the features of clinical and psychopathological manifestations in patients, suffering from epilepsy. The study covered 146patients (85 men and 61 women) who were in inpatient care. The following psychodiagnostic techniques were used: the MOCA test, the Toronto Cognitive Assessment (TorCA), the MiniMult test, the Münsterberg test, the quality of life scale, the Hamilton scale of depression and anxiety. Results. This publication offers the results of a study of cognitive and affective disorders the quality of life in patients who suffer from epilepsy and the results of online cognitive training and psychoeducation. We found cognitive decline in 88% of patients with epilepsy and improvement of cognitive functions by methods of non-pharmacological correction. Conclusions. Affective and cognitive disorders significantly affects the quality of life of patients, their ability to work and socialization. The conducted research showed that compared to the control group of healthy persons, patients with epilepsy showed improvement in their cognitive decline, anxiety and depressive disorders. Cognitive online training appeared to be effective for the patients with epilepsy.

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Inflammatory cytokines and oxidative stress biomarkers in irritable bowel syndrome: Association with digestive symptoms and quality of life

Cytokine ◽

10.1016/j.cyto.2017.05.005 ◽

2017 ◽

Vol 93 ◽

pp. 34-43 ◽

Cited By ~ 43

Author(s):

Razieh Choghakhori ◽

Amir Abbasnezhad ◽

Amin Hasanvand ◽

Reza Amani

Keyword(s):

Quality Of Life ◽

Oxidative Stress ◽

Irritable Bowel Syndrome ◽

Inflammatory Cytokines ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Irritable Bowel ◽

And Oxidative Stress ◽

Syndrome Association

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Study assessing the efficacy of herbal teas on bone health and quality of life in a population with osteopenia: rooibos actions on melatonin and tulsi actions on quality of life.

Melatonin Research ◽

10.32794/mr11250095 ◽

2021 ◽

Vol 4 (2) ◽

pp. 270-298

Author(s):

Fahima Munmun ◽

Alyssa Linden ◽

Hunter Hanlon ◽

Hannah Enderby ◽

Paula Witt-Enderby

Keyword(s):

Quality Of Life ◽

Oxidative Stress ◽

Bone Health ◽

Human Mesenchymal Stem Cell ◽

Melatonin Receptors ◽

Cooperative Effort ◽

Translational Study ◽

Before And After

The purpose of the OsTea translational study was to assess the efficacy of teas (tulsi, rooibos, oolong) compared to placebo (coriander) on markers of bone health and quality of life (QOL) in those with osteopenia and on human mesenchymal stem cell (hMSC) differentiation into osteoblasts to identify potential mechanisms of action. Following consumption of tea (3 times/day; 90 days), participants collected a urine sample during the night (10pm-6am) and filled in questionnaires before and after the study. Rooibos consumption demonstrated a significant decrease in urinary CTX levels vs placebo; trended towards increases in nocturnal melatonin levels (p=0.06); significantly decreased serotonin-producing microbes in the gut; and demonstrated trends towards improvements (p=0.09) in QUALIOST emotional parameters. Tulsi consumption primarily affected subjective measures, such as significantly improved scores for PSS, STAI-trait anxiety, and osteoporosis/osteopenia-related parameters in the QUALIOST. To further identify potential mechanisms underlying these actions of rooibos on CTX and melatonin (urinary and gut), rooibos and melatonin effects on human osteoblastogenesis were carried out for 21 days under oxidative stress conditions to mimic osteopenia. Although both rooibos and melatonin protected against oxidative stress-induced loss of osteoblasts in vitro, their underlying mechanisms were different. Melatonin, like tulsi and oolong, demonstrated the greatest protection against oxidative stress at days 10-11 of exposure, which was due to effects on hMSC viability and through melatonin receptors. Rooibos, on the other hand, demonstrated protection at days 10-11 and 20-21, which was through signaling mechanisms involved in differentiation processes and not on cell viability. These findings suggest that the clinical actions of rooibos on decreasing CTX levels in a population with osteopenia may be through a cooperative effort between melatonin and rooibos by protecting hMSC viability against oxidative stress-induced loss and by promoting osteoblast differentiation, respectively. This study also supports the use of tulsi for improving quality of life in a population susceptible to osteoporosis.

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Role of Polyherbal Formulations of Medicinal Plants From Himalayan Regions in the Management of Diabetes

10.4018/978-1-7998-8251-0.ch007 ◽

2022 ◽

pp. 212-229

Author(s):

Ashfaq Ahmad Shah ◽

Sumaira Qayoom ◽

Amit Gupta ◽

Aqueel Ur Rehman

Keyword(s):

Quality Of Life ◽

Oxidative Stress ◽

Metabolic Diseases ◽

Polyphenolic Compounds ◽

Health Concern ◽

Glucose Measurement ◽

Diabetes Research ◽

Cardiovascular Disorders

Current research on phytochemicals is mainly focused on novel phenolic and polyphenolic compounds expressing their potential as therapeutic agents in various diseases like cancer, autoimmune diseases, cardiovascular disorders, diabetes, oxidative stress-related diseases, as well as their properties to inhibit the growth and proliferation of infectious agents. Among the human physiological disorders, one of the most severe endocrine metabolic diseases is Diabetes mellitus which is a clinical disease distinguished by a deficit in the production of insulin or resistance to the action of insulin. Globally, diabetes is an increasing health concern which is now emerging as an epidemic. About 700-800 plants are exhibiting anti-diabetic activity that has been studied. As far as nanotechnology in diabetes research is concerned, it has made possible the buildout of novel glucose measurement as well as insulin delivery modalities that possess the potential to excellently enhance the quality of life of the diabetic patient.

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Strawberry Intake Ameliorates Oxidative Stress and Decreases GABA Levels Induced by High-Fat Diet in Frontal Cortex of Rats

Antioxidants ◽

10.3390/antiox8030070 ◽

2019 ◽

Vol 8 (3) ◽

pp. 70 ◽

Cited By ~ 1

Author(s):

Cuauhtémoc Sandoval-Salazar ◽

Cecilia Oviedo-Solís ◽

Edmundo Lozoya-Gloria ◽

Herlinda Aguilar-Zavala ◽

Martha Solís-Ortiz ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Oxidative Damage ◽

Frontal Cortex ◽

Protein Oxidation ◽

High Fat Diet ◽

High Fat ◽

Gaba Concentration ◽

Obese Rats ◽

Lipid And Protein Oxidation

It has been proposed that there is a correlation between high-fat diet (HFD), oxidative stress and decreased γ-aminobutyric acid (GABA) levels, but this has not been thoroughly demonstrated. In the present study, we determined the effects of strawberry extract intake on the oxidative stress and GABA levels in the frontal cortex (FC) of obese rats. We observed that an HFD increased lipid and protein oxidation, and decreased GABA levels. Moreover, UV-irradiated strawberry extract (UViSE) decreased lipid peroxidation but not protein oxidation, whereas non-irradiated strawberry extract (NSE) reduced protein oxidation but not lipid peroxidation. Interestingly, NSE increased GABA concentration, whereas UViSE was not as effective. In conclusion, our results suggest that an HFD increases oxidative damage in the FC, whereas strawberry extract intake may ameliorate the disturbances associated with HFD-induced oxidative damage.

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Oxidative Stress Induction by Lead in Leaves of Radish (Raphanus sativus) Seedlings

Notulae Scientia Biologicae ◽

10.15835/nsb346360 ◽

2011 ◽

Vol 3 (4) ◽

pp. 93-99 ◽

Cited By ~ 3

Author(s):

Nadjet BITEUR ◽

Abdelkader AOUES ◽

Omar KHAROUBI ◽

Miloud SLIMANI

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Protein Oxidation ◽

Raphanus Sativus ◽

Lead Concentration ◽

Control Treatment ◽

Enzymatic Antioxidants ◽

Carotenoid Concentration ◽

Hydroponic System ◽

Physiological Processes

Oxidative stress was induced by lead acetate (Pb) in Raphanus sativus seedlings grown in a hydroponic system using sand as substrate. Thirty day old acclimated seeds were treated for 7 days with five Pb levels (0 as control, 100, 200, 500 and 1000 mg l-1). Parameters such as growth, oxidative damage markers (lipid peroxidation, protein oxidation and hydrogen peroxide contents) and enzymatic activities of catalase (CAT) and peroxidase (POD) were investigated. Lead concentration in plant tissues increased with increasing of Pb levels. Shoot fresh weight, chlorophyll and carotenoid concentration were significantly decreased at 100 mg l-1 Pb. Lipid peroxidation, protein oxidation and H2O2 levels were increased at 500 and 1000 mg l-1 Pb compared to control treatment, in shoots. Peroxidase activity showed a straight correlation with H2O2 concentration, whereas CAT activity decreased only in shoots. These changes in enzymatic and non-enzymatic antioxidants showed that the Pb exposition had a significant disturbance on Raphanus sativus plantlets and affect the biochemical and physiological processes.

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