XRCC1 Arg399Gln polymorphism contributes to increased risk of colorectal cancer in Chinese population

2013 ◽  
Vol 40 (7) ◽  
pp. 4147-4151 ◽  
Author(s):  
Zhong Tian ◽  
Yi-Ling Li ◽  
Jin-Gang Liu
Keyword(s):  
Colorectal Cancer ◽  
Chinese Population ◽  
Xrcc1 Arg399gln ◽  
Increased Risk ◽  
Arg399gln Polymorphism

scholarly journals Meta-Analysis of the Relationship between XRCC1-Arg399Gln and Arg280His Polymorphisms and the Risk of Prostate Cancer

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jie Yan ◽  
Xiantao Wang ◽  
Hui Tao ◽  
Zengfu Deng ◽  
Wang Yang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Prostate Cancer Risk ◽  
Recessive Model ◽  
Dominant Model ◽  
Xrcc1 Arg399gln ◽  
Increased Risk ◽  
Arg399gln Polymorphism ◽  
The Relationship

Abstract Prostate cancer is one of the most common noncutaneous malignancies in Western countries. Because there has been a debate regarding the relationship between the XRCC1-Arg399Gln and Arg280His polymorphisms and prostate cancer risk, we therefore performed this meta-analysis. The electronic databases PubMed, EMBASE and Medline were searched prior to October 1, 2014. An odds ratio and 95% confidence interval were used to calculate association. Heterogeneity was tested by both a chi-square test and I2statistic. Funnel plots and Egger’s test were used to assess publication bias. All statistical analyses were performed using STATA 12.0 software. A significant association between the XRCC1-Arg399Gln polymorphism and prostate cancer risk was found under a homozygote model and a recessive model. A significant association between XRCC1-Arg280His and prostate cancer risk was found under a heterozygote model and a dominant model. Overall, the results of this meta-analysis show that the XRCC1-Arg399Gln polymorphism may be associated with an increased risk for prostate cancer under the homozygote model and the recessive model. And XRCC1-Arg280His polymorphism is likely to be related with prostate cancer risk under the heterozygote model and the dominant model. Additional larger well-designed studies are needed to validate our results.

scholarly journals An Insertion/Deletion Polymorphism within the Promoter of EGLN2 is Associated with Susceptibility to Colorectal Cancer

2017 ◽  
Vol 32 (3) ◽  
pp. 274-277 ◽  
Author(s):  
Chaoyang Li ◽  
Lanjun Feng ◽  
Luwei Niu ◽  
Teng Teng Li ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gel Electrophoresis ◽  
Chinese Population ◽  
Functional Role ◽  
Polyacrylamide Gel Electrophoresis ◽  
Proximal Promoter ◽  
Deletion Polymorphism ◽  
Increased Risk ◽  
Codominant Model ◽  
Pcr Products

Objective To investigate the association between susceptibility to colorectal cancer (CRC) and a 4-bp insertion/deletion polymorphism (rs10680577) in the proximal promoter of the EGLN2 gene. Method The first step in genotyping EGLN2 was PCR, then the PCR products were separated using 7% nondenaturing polyacrylamide gel electrophoresis and visualized by silver staining according to the final product band location and quantity to determine the genotype of the sample. The final count was done by two different pathologists. Result In the codominant model, compared with the ins/ins genotype, subjects with the heterozygous ins/del or homozygous del/del genotype had a significantly increased risk of CRC (adjusted OR = 1.45, p<0.0001 and OR = 2.44, p = 0.0001, respectively). Each additional copy of the 4-bp deletion allele conferred a significantly increased risk of CRC (OR = 1.47, 95% CI 1.28-1.66, p<0.0001). In the stratification analysis, we further proved that the association was more prominent in TNM stage III and IV cancer compared with stage I and II (adjusted OR = 1.43, 95% CI 1.07-1.93, p for heterogeneity = 0.02). Conclusions Our study provided initial evidence that the insertion/deletion polymorphism rs10680577 may play a functional role in the development of CRC in the Chinese population.

scholarly journals Association of XRCC1 Arg399Gln Polymorphism with Colorectal Cancer Risk: A HuGE Meta Analysis of 35 Studies

2015 ◽  
Vol 16 (8) ◽  
pp. 3285-3291 ◽  
Author(s):  
Mohammad Forat-Yazdi ◽  
Mohsen Gholi-Nataj ◽  
Hossein Neamatzadeh ◽  
Parisa Nourbakhsh ◽  
Hossein Shaker-Ardakani
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Colorectal Cancer Risk ◽  
Xrcc1 Arg399gln ◽  
Arg399gln Polymorphism

scholarly journals Association between Long noncoding RNA rs944289 and rs7990916 polymorphisms and the risk of colorectal cancer in a Chinese population

2021 ◽  
Author(s):  
Yan Wang ◽  
Zhiyuan Qiu ◽  
Guangyu Tian ◽  
Qianqian Zhu ◽  
Zhao Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Logistic Regression ◽  
Chinese Population ◽  
Noncoding Rna ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Increased Risk ◽  
Union Hospital ◽  
Medical University ◽  
The Relationship

Abstract Long non-coding RNAs (LncRNAs) play vital roles in the tumorigenesis of many cancers. Single nucleotide polymorphisms (SNPs) of the lncRNA also play vital roles in tumorigenesis. We explored lncRNA rs944289 and rs7990916 polymorphisms and analyzed the relationship between these lncRNA polymorphisms with the colorectal cancer (CRC) risk in a Chinese population. We recruited 1,003 CRC patients from the Affiliated People’s Hospital of Jiangsu University and the Fujian Medical University Union Hospital from October 2014 to August 2017. Genomic DNA was extracted using a DNA Kit from lymphocytes of peripheral blood and the genotyping was performed with a SNPscan method. We found that the rs944289 TT homozygote was associated with the decreased CRC risk. However, there was no statistically significant association between lncRNA rs7990916 polymorphism and the CRC risk. LncRNA rs944289 TT decreased the CRC risk in the subgroup of female by logistic regression, male, age≥61, without alcohol intake, smoking and BMI≥24. The subgroup analysis revealed that lncRNA rs7990916 was not associated with the CRC risk except for age<61. Logistic regression analysis revealed that the lncRNA rs944289 TT homozygote was associated with the increased risk of rectum cancer (TT vs. CC+CT: adjusted OR=1.29, 95% CI: 1.10-1.66, P=0.041) or colon cancer. In summary, we proved that the lncRNA rs944289 might be significantly related to the decreased CRC risk in the Chinese Han populations and lncRNA rs7990916 was not associated with the CRC risk except for patients of age<61. In the future, studies with larger samples should be conducted to validate our results.

scholarly journals The association between IL-17 gene variants and risk of colorectal cancer in a Chinese population: A case–control study

2019 ◽  
Vol 39 (11) ◽  
Author(s):  
Haiyang Feng ◽  
Rongbiao Ying ◽  
Tengjiao Chai ◽  
Hailang Chen ◽  
Haixing Ju
Keyword(s):  
Colorectal Cancer ◽  
Chinese Population ◽  
Case Control Study ◽  
Fragment Length Polymorphism ◽  
Case Control ◽  
Chain Reaction ◽  
Node Metastasis ◽  
Increased Risk ◽  
Polymerase Chain ◽  
Control Study

Abstract Interleukin (IL)-17 have been reported to be associated with the pathogenesis of colorectal cancer (CRC). Few studies investigated the association between IL-17 gene polymorphisms and risk of CRC with inconsistent findings. Thus, we recruited 352 CRC cases and 433 controls in a Chinese population and their genotyping was done using polymerase chain reaction-restriction fragment length polymorphism method. Our data showed that IL-17A rs2275913 polymorphism was associated with the increased risk of CRC, while no association was observed for IL-17F rs763780 polymorphism. Stratified analyses revealed that the significant association was also obtained in the females, smokers, drinkers and age ≥ 60 years groups for rs2275913 polymorphism. Moreover, the CC and/or GC genotype of rs2275913 polymorphism were correlated with TNM stage and lymph node metastasis. No association was shown between IL-17F rs763780 polymorphism and clinical characteristics of CRC. In conclusion, our data indicate that IL-17A rs2275913 polymorphism but not IL-17F rs763780 polymorphism contributes to increased risk for CRC patients in this Chinese population.

scholarly journals Association between phytosterol intake and colorectal cancer risk: a case–control study

2017 ◽  
Vol 117 (6) ◽  
pp. 839-850 ◽  
Author(s):  
Jing Huang ◽  
Ming Xu ◽  
Yu-Jing Fang ◽  
Min-Shan Lu ◽  
Zhi-Zhong Pan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Case Control Study ◽  
Positive Association ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Inverse Association ◽  
Increased Risk ◽  
Control Study

AbstractA study in rodent models showed that phytosterols protected against colon carcinogenesis, probably by inhibiting dysregulated cell cycle progression and inducing cellular apoptosis. However, epidemiological studies on the relationship between phytosterols and colorectal cancer risk are quite limited. The aim of this study was to investigate dietary phytosterol intake in relation to colorectal cancer risk in the Chinese population. A case–control study was conducted from July 2010 to June 2016, recruiting 1802 eligible colorectal cancer cases plus 1813 age (5-year interval) and sex frequency-matched controls. Dietary information was collected by using a validated FFQ. The OR and 95 % CI of colorectal cancer risk were assessed by multivariable logistic regression models. A higher total intake of phytosterols was found to be associated with a 50 % reduction in colorectal cancer risk. After adjusting for various confounders, the OR of the highest quartile intake compared with the lowest quartile intake was 0·50 (95 % CI 0·41, 0·61, Ptrend<0·01) for total phytosterols. An inverse association was also found between the consumption of β-sitosterol, campesterol, campestanol and colorectal cancer risk. However, stigmasterol intake was related to an increased risk of colorectal cancer. No statistically significant association was found between β-sitostanol and colorectal cancer risk. Stratified analysis by sex showed that the positive association of stigmasterol intake with colorectal cancer risk was found only in women. These data indicated that the consumption of total phytosterols, β-sitosterol, campesterol and campestanol is inversely associated with colorectal cancer risk in a Chinese population.

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