scholarly journals The regenerating protein 3A: a crucial molecular with dual roles in cancer

2021 ◽  
Author(s):  
Liying Wang ◽  
Yanchun Quan ◽  
Yanxi Zhu ◽  
Xiaoli Xie ◽  
Zhiqiang Wang ◽  
...  
Keyword(s):  
Immune Cells ◽  
Tissue Repair ◽  
Potential Role ◽  
Data Organization ◽  
Dual Roles ◽  
The Third ◽  
The Past ◽  
Inflammatory Stimuli ◽  
Regulation Function

Abstract Introduction REG3A, a member of the third subclass of the Reg family, has been found in a variety of tissues but is not detected in immune cells. In the past decade, it has been determined that REG3A expression is regulated by injury, infection, inflammatory stimuli, and pro-cytokines via different signaling pathways, and it acts as a tissue-repair, bactericidal, and anti-inflammatory molecule in human diseases. Recently, the role of REG3A in cancer has received increasing attention. The present article aims to investigate the structure, expression, regulation, function of REG3A, and to highlight the potential role of REG3A in tumors. Methods A detailed literature search and data organization were conducted to find information about the role of REG3A in variety of physiological functions and tumors. Results Contradictory roles of REG3A have been reported in different tumor models. Some studies have demonstrated that high expression of REG3A in cancers can be oncogenic. Other studies have shown decreased REG3A expression in cancer cells as well as suppressed tumor growth. Conclusions Taken together, better understanding of REG3A may lead to new insights that make it a potentially useful target for cancer therapy.

Acid ceramidase, a double-edged sword in cancer aggression: A minireview

2020 ◽  
Vol 20 ◽  
Author(s):  
Helen Shiphrah Vethakanraj ◽  
Niveditha Chandrasekaran ◽  
Ashok Kumar Sekar
Keyword(s):  
Cell Fate ◽  
Cancer Progression ◽  
Potential Role ◽  
Tumour Progression ◽  
Acid Ceramidase ◽  
The Core ◽  
The Past ◽  
Sphingosine 1 Phosphate ◽  
Key Enzyme

: Acid ceramidase (AC), the key enzyme of the ceramide metabolic pathway hydrolyzes pro-apoptotic ceramide to sphingosine, which by the action of sphingosine-1-kinase is metabolized to mitogenic sphingosine-1-phosphate. The intracellular level of AC determines ceramide/sphingosine-1-phosphate rheostat which in turn decides the cell fate. The upregulated AC expression during cancerous condition acts as a “double-edged sword” by converting pro-apoptotic ceramide to anti-apoptotic sphingosine-1-phosphate, wherein on one end, the level of ceramide is decreased and on the other end, the level of sphingosine-1-phosphate is increased, thus altogether aggravating the cancer progression. In addition, cancer cells with upregulated AC expression exhibited increased cell proliferation, metastasis, chemoresistance, radioresistance and numerous strategies were developed in the past to effectively target the enzyme. Gene silencing and pharmacological inhibition of AC sensitized the resistant cells to chemo/radiotherapy thereby promoting cell death. The core objective of this review is to explore AC mediated tumour progression and the potential role of AC inhibitors in various cancer cell lines/models.

scholarly journals Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Moon Ley Tung ◽  
Bryce Tan ◽  
Robin Cherian ◽  
Bharatendu Chandra
Keyword(s):  
Endothelial Dysfunction ◽  
Severe Acute Respiratory Syndrome ◽  
Potential Role ◽  
Molecular Mimicry ◽  
Thromboembolic Events ◽  
The Past ◽  
High Prevalence ◽  
Connecting The Dots ◽  
Anti Phospholipid Syndrome

Abstract As the coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide, it has emerged as a leading cause of mortality, resulting in >1 million deaths over the past 10 months. The pathophysiology of COVID-19 remains unclear, posing a great challenge to the medical management of patients. Recent studies have reported an unusually high prevalence of thromboembolic events in COVID-19 patients, although the mechanism remains elusive. Several studies have reported the presence of aPLs in COVID-19 patients. We have noticed similarities between COVID-19 and APS, which is an autoimmune prothrombotic disease that is often associated with an infective aetiology. Molecular mimicry and endothelial dysfunction could plausibly explain the mechanism of thrombogenesis in acquired APS. In this review, we discuss the clinicopathological similarities between COVID-19 and APS, and the potential role of therapeutic targets based on the anti-phospholipid model for COVID-19 disease.

Unresolved Questions of German Medicine and Medical History in the Past and Present

1992 ◽  
Vol 25 (4) ◽  
pp. 407-423 ◽  
Author(s):  
Michael H. Kater
Keyword(s):  
Significant Influence ◽  
Weimar Republic ◽  
Third Reich ◽  
Second Empire ◽  
Sociology Of Medicine ◽  
The Third ◽  
The Past ◽  
Victim Status ◽  
The Third Reich

While in recent years a great deal has been written to clarify Germany's medical past, the picture is not yet complete in several important respects. In the realm of the sociology of medicine, for example, we still do not know enough about physicianpatient relationships from, say, the founding of the Second Empire to the present. On the assumption, based on the meager evidence available, that this relationship had an authoritarian structure from the physician on downward, did it have anything to do with the shape of German medicine in the Weimar Republic and, later, the Third Reich? Another relative unknown is the role of Jews in the development of medicine as a profession in Germany. Surely volumes could be written on the significant influence Jews have exerted on medicine in its post-Wilhelmian stages, as well as the irreversible victim status Jewish doctors were forced to assume after Hitler's ascension to power

Nitric oxide: a new role in intensive care

2020 ◽  
Vol 22 (1) ◽  
pp. 72-79
Author(s):  
Alexandra Lee ◽  
◽  
Warwick Butt ◽  
◽  
◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Potential Role ◽  
Nitric Oxide Donors ◽  
Ischaemia Reperfusion Injury ◽  
Surface Receptors ◽  
The Past ◽  
Ischaemia Reperfusion ◽  
Human Experiments ◽  
Endogenous Nitric Oxide

Inhaled nitric oxide has been used for 30 years to improve oxygenation and decrease pulmonary vascular resistance. In the past 15 years, there has been increased understanding of the role of endogenous nitric oxide on cell surface receptors, mitochondria, and intracellular processes involving calcium and superoxide radicals. This has led to several animal and human experiments revealing a potential role for administered nitric oxide or nitric oxide donors in patients with systemic inflammatory response syndrome or ischaemia–reperfusion injury, and in patients for whom exposure of blood to artificial surfaces has occurred.

Conclusion

2018 ◽  
pp. 189-206
Author(s):  
Michael P. Roller
Keyword(s):  
Twentieth Century ◽  
Social Control ◽  
Everyday Life ◽  
Symbolic Violence ◽  
The Third ◽  
The Past ◽  
The Social ◽  
Semiotic Systems ◽  
Oppressed Group

The conclusion revisits the three major inquiries addressed in the text, drawing together the evidence and contexts provided in the previous seven chapters. The first investigates the role of objective settings, such as the systemic and symbolic violence of landscapes and semiotic systems of racialization in justifying or triggering moments of explicit subjective violence such as the Lattimer Massacre. The second inquiry, traces the trajectory of immigrant groups into contemporary patriotic neoliberal subjects. In other terms, it asks how an oppressed group can become complicit with oppression later in history. The third inquiry traces the development of soft forms of social control and coercion across the longue durée of the twentieth century. Specifically, it asks how vertically integrated economic and governmental structures such as neoliberalism and governmentality which serve to stabilize the social antagonisms of the past are enunciated in everyday life.

Fifty years ago: ‘The scope of occupational medicine in a university health service’

2020 ◽  
pp. 202-203
Author(s):  
Anthony Ryle
Keyword(s):  
Health Service ◽  
Physical Health ◽  
Occupational Medicine ◽  
Potential Role ◽  
Health And Safety ◽  
Academic Achievements ◽  
The Past ◽  
Selection Of

This series provides a selection of articles from the past. In Fifty years ago: The scope of occupational medicine in a university health service Anthony Ryle briefly explores the potential role of a University Health Service in relation to students’ academic achievements and failures, rather than their physical health and safety.

scholarly journals Endocrine Significance of SARS-CoV-2’s Reliance on ACE2

Endocrinology ◽  
2020 ◽  
Vol 161 (9) ◽  
Author(s):  
Eric Lazartigues ◽  
Mirza Muhammad Fahd Qadir ◽  
Franck Mauvais-Jarvis
Keyword(s):  
Potential Role ◽  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Angiotensin System ◽  
Angiotensin Converting Enzyme 2 ◽  
Global Impact ◽  
The Past ◽  
And Function ◽  
Endocrine Tissues

Abstract The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases.

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