The Differential Absorption of a Series of P-Glycoprotein Substrates in Isolated Perfused Lungs from Mdr1a/1b Genetic Knockout Mice can be Attributed to Distinct Physico-Chemical Properties: an Insight into Predicting Transporter-Mediated, Pulmonary Specific Disposition

The content, purpose and findings of a research program undertaken between 1996 and 1999 into the behavior of crude oil during transport is reviewed. Crude oil, being the most complex liquid carried by sea, required investigation due to its behavioral characteristics that impact the efficiency of its transportation, handling and general tanker operations. The research program broke the subject matter down to the three phases of crude oil each of which, either on its own or in conjunction with other phases, creates problems onboard tankers. Clearly the three physical phases are those of the vapor, liquid and sludge phases. The program collected both data of diverse type/description from the numerous vessels participating in the program together with cargo samples of the various types of crude oil carried for each voyage. The samples were obtained at discrete points throughout the voyage and discharge of the diverse cargoes and were subsequently analyzed for their physico-chemical properties. With the analytical information of the various cargoes and the cargo and environmental reports from the vessels, researchers can gain an overview as to the diverse types of behavior occurring to the cargoes during their transportation. Subsequent empirical modeling of a proportion of the data has allowed equations to be created that would assist a vessel's command to gain an insight into cargo behavior that would assist in decision making for operational matters. This paper provides the initial information and models developed as a result of this extensive piece of data collection and work

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PCDD/F removal at low temperatures over Vanadium-based catalyst: insight into the superiority of mechanochemical method

10.21203/rs.3.rs-463575/v1 ◽

2021 ◽

Author(s):

Minghui Tang ◽

Qiulin Ye ◽

Cuicui Du ◽

Yaqi Peng ◽

Chengetai Portia Makwarimba ◽

...

Keyword(s):

Removal Efficiency ◽

Low Temperatures ◽

Chemical Properties ◽

Catalytic Degradation ◽

Impregnation Method ◽

Key Factors ◽

Mechanochemical Method ◽

Physico Chemical ◽

Stable Source ◽

Insight Into

Abstract The high toxicity and low volatility of PCDD/Fs prevent detailed study of their catalytic degradation removal characteristics. In this study, firstly, 1,2-dichlorobenzene (1,2-DCBz) was initially used as a model to investigate the catalytic characteristics of various vanadium-based catalysts prepared by different methods. Then, the optimized catalyst was used for catalytic degradation of real PCDD/Fs at low-temperatures based on a self-made stable source. The VOx/TiO2 catalysts synthesized by the mechanochemical method (VTi-MC2) had a higher 1,2-DCBz removal efficiency (> 85%) and stability (> 420 min) at low temperatures (< 200 oC) compared to VTi-SG (sol-gol method) and VTi-WI (wetness impregnation method). The physico-chemical properties of catalysts were studied using comprehensive characterization. It was found that the VTi-MC2 has better VOx species distribution and possesses the highest V5+ species and surface adsorbed oxygen content, which are the key factors contributed to the higher removal efficiency. Accordingly, the mechanochemical method can be used to control the physico-chemical properties of catalyst by adjusting the milling parameters. The optimum ball-milling time is 2 h and the suitable precursor is NH4VO3 for VOx/TiO2. Moreover, the removal efficiency of gas phase PCDD/Fs catalyzed by VTi-MC2 is 97% within a temperature range below 200 ℃, and the catalytic degradation of PCDD/Fs surges to 50%, which is higher than those reported research. In general, the mechanochemical strategy reported provides a means for seeking more efficient catalysts used for low-temperature degradation of various trace organic pollutants.

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Insight into the Self-Assembling Properties of a Peptergent: A Molecular Dynamics Study

10.20944/preprints201804.0284.v1 ◽

2018 ◽

Author(s):

Jean-Marc Crowet ◽

Mehmet Nail Nasir ◽

Antoine Deschamps ◽

Vincent Stroobant ◽

Pierre Morsomme ◽

...

Keyword(s):

Molecular Dynamics ◽

Membrane Proteins ◽

Chemical Properties ◽

Beta Sheets ◽

The Self ◽

Self Assembling ◽

Beta Barrel ◽

Physico Chemical ◽

Ordered Nanostructures ◽

Insight Into

By manipulating the various physico-chemical properties of amino acids, design of peptides with specific self-assembling properties has been emerging since more than a decade. In this context, short peptides possessing detergent properties (so-called “peptergents”) have been developed to self-assemble into well-ordered nanostructures that can stabilize membrane proteins for crystallization. In this study, the peptide with “peptergency” properties, called ADA8 extensively described by Zhang et al., is studied by molecular dynamics for its self-assembling properties in different conditions. In water, it spontaneously forms beta sheets with a β barrel-like structure. We next simulated the interaction of this peptide with a membrane protein, the bacteriorhodopsin, in the presence or absence of a micelle of dodecylphosphocholine. According to the literature, the peptergent ADA8 is thought to generate a belt of β structures around the hydrophobic helical domain that could help stabilize purified membrane proteins. Molecular dynamics is here used to challenge this view and to provide further molecular details for the replacement of detergent molecules around the protein. To our best knowledge, this is the first molecular mechanism proposed for ''peptergency''. In addition, our calculation approach should serve as a predicting tool for the design of beta peptergent with diverse amphipathic properties.

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Insight into the formation mechanism of azo dye-based hybrid colorant: Physico-chemical properties and potential applications

Dyes and Pigments ◽

10.1016/j.dyepig.2019.04.022 ◽

2019 ◽

Vol 167 ◽

pp. 236-244 ◽

Cited By ~ 4

Author(s):

Bolesław Szadkowski ◽

Anna Marzec ◽

Jacek Rogowski ◽

Waldemar Maniukiewicz ◽

Marian Zaborski

Keyword(s):

Formation Mechanism ◽

Azo Dye ◽

Chemical Properties ◽

Physico Chemical ◽

Potential Applications ◽

Insight Into

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Hydroxymethyluracil modifications enhance the flexibility and hydrophilicity of double-stranded DNA

Nucleic Acids Research ◽

10.1093/nar/gkv1199 ◽

2015 ◽

Vol 44 (5) ◽

pp. 2085-2092 ◽

Cited By ~ 14

Author(s):

Spencer Carson ◽

James Wilson ◽

Aleksei Aksimentiev ◽

Peter R. Weigele ◽

Meni Wanunu

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulations ◽

Chemical Properties ◽

Double Stranded Dna ◽

Physico Chemical ◽

Translocation Experiments ◽

Dynamics Simulations ◽

Regulatory Dna ◽

The Impact ◽

Insight Into

Abstract Oxidation of a DNA thymine to 5-hydroxymethyluracil is one of several recently discovered epigenetic modifications. Here, we report the results of nanopore translocation experiments and molecular dynamics simulations that provide insight into the impact of this modification on the structure and dynamics of DNA. When transported through ultrathin solid-state nanopores, short DNA fragments containing thymine modifications were found to exhibit distinct, reproducible features in their transport characteristics that differentiate them from unmodified molecules. Molecular dynamics simulations suggest that 5-hydroxymethyluracil alters the flexibility and hydrophilicity of the DNA molecules, which may account for the differences observed in our nanopore translocation experiments. The altered physico-chemical properties of DNA produced by the thymine modifications may have implications for recognition and processing of such modifications by regulatory DNA-binding proteins.

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Insight into the effect of hydrogenation on efficiency of hydrothermal liquefaction and physico-chemical properties of biocrude oil

Bioresource Technology ◽

10.1016/j.biortech.2014.04.015 ◽

2014 ◽

Vol 163 ◽

pp. 143-151 ◽

Cited By ~ 23

Author(s):

HongYi Li ◽

Jiao Hu ◽

ZhiJian Zhang ◽

Hang Wang ◽

Fan Ping ◽

...

Keyword(s):

Chemical Properties ◽

Hydrothermal Liquefaction ◽

Physico Chemical ◽

Biocrude Oil ◽

Insight Into

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Green synthesized Silver Nanoparticles as Silver Lining in Antimicrobial Resistance: A Review

Current Drug Delivery ◽

10.2174/1567201818666210331123022 ◽

2021 ◽

Vol 18 ◽

Author(s):

Sonia Parashar ◽

Manish Kumar Sharma ◽

Chanchal Garg ◽

Munish Garg

Keyword(s):

Silver Nanoparticles ◽

Antimicrobial Resistance ◽

Green Synthesis ◽

Chemical Properties ◽

Positive Role ◽

Physico Chemical ◽

Green Synthesized Silver Nanoparticles ◽

Insight Into ◽

Silver Lining

: Unprincipled use of antibiotics has led to the antimicrobial resistance (AMR) against mostly available compounds and now become a major cause of concern for the scientific community. However, in the past decade, green synthesized silver nanoparticles (AgNPs) have received greater attention for the development of newer therapies as antimicrobials by virtue of their unique physico-chemical properties. Unlike traditional antibiotics, AgNPs exert their action by acting on multiple mechanisms which make them potential candidates against AMR. Green synthesis of AgNPs using various medicinal plants has demonstrated broader spectrum of action against several microbes in a number of attempts. The present paper provides an insight into the scientific studies that have elucidated the positive role of plant extracts/phytochemicals during green synthesis of AgNPs and their future perspectives. The studies conducted so far seem promising still, a few factors like, the precise mechanism of action of AgNPs, their synergistic interaction with biomolecules, and industrial scalability need to be explored further till effective drug development using green synthesized AgNPs in healthcare systems against AMR is established.

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Insight into the Effect of Inhibitor Resistant S130G Mutant on Physico-Chemical Properties of SHV Type Beta-Lactamase: A Molecular Dynamics Study

PLoS ONE ◽

10.1371/journal.pone.0112456 ◽

2014 ◽

Vol 9 (12) ◽

pp. e112456 ◽

Cited By ~ 13

Author(s):

Mohd Hassan Baig ◽

D. Raja Sudhakar ◽

Ponnusamy Kalaiarasan ◽

Naidu Subbarao ◽

Gulshan Wadhawa ◽

...

Keyword(s):

Molecular Dynamics ◽

Chemical Properties ◽

Beta Lactamase ◽

Physico Chemical ◽

Insight Into

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Decoration of specific sites on freeze-fractured membranes

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100081565 ◽

1978 ◽

Vol 36 (2) ◽

pp. 140-141

Author(s):

H. Gross ◽

H. Moor

Keyword(s):

Pure Water ◽

Freeze Fracture ◽

Chemical Properties ◽

Surface Forces ◽

Sulfate Pentahydrate ◽

Copper Sulfate Pentahydrate ◽

Physico Chemical ◽

Water Of Hydration ◽

Small Container ◽

Binding Forces

Fracturing under ultrahigh vacuum (UHV, p ≤ 10-9 Torr) produces membrane fracture faces devoid of contamination. Such clean surfaces are a prerequisite foe studies of interactions between condensing molecules is possible and surface forces are unequally distributed, the condensate will accumulate at places with high binding forces; crystallites will arise which may be useful a probes for surface sites with specific physico-chemical properties. Specific “decoration” with crystallites can be achieved nby exposing membrane fracture faces to water vopour. A device was developed which enables the production of pure water vapour and the controlled variation of its partial pressure in an UHV freeze-fracture apparatus (Fig.1a). Under vaccum (≤ 10-3 Torr), small container filled with copper-sulfate-pentahydrate is heated with a heating coil, with the temperature controlled by means of a thermocouple. The water of hydration thereby released enters a storage vessel.

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