scholarly journals Psycholinguistic features, design attributes, and respondent-reported cognition predict response time to patient-reported outcome measure items

2021 ◽  
Author(s):  
Matthew L. Cohen ◽  
Aaron J. Boulton ◽  
Alyssa M. Lanzi ◽  
Elyse Sutherland ◽  
Rebecca Hunting Pompon
Keyword(s):  
Response Time ◽  
Cognitive Processing ◽  
Cognitive Abilities ◽  
Neurological Disorders ◽  
Task Difficulty ◽  
Patient Reported Outcome ◽  
Future Research ◽  
Design Attributes ◽  
Patient Reported ◽  
Symptom Frequency

Abstract Purpose Patient-reported outcome measures (PROMs) vary in their psycholinguistic complexity. This study examined whether response time to PROM items is related to psycholinguistic attributes of the item and/or the self-reported cognitive ability of the respondent. Methods Baseline data from Wave 2 of the Quality of Life in Neurological Disorders (Neuro-QoL) development study were reanalyzed. That sample contained 581 adults with neurological disorders and whose self-reported cognitive abilities were quantified by the Neuro-QoL v2.0 Cognitive Function Item Bank. 185 Neuro-QoL items were coded for several psycholinguistic variables and design attributes: number of words and syllables, mean imageability of words, mean word frequency, mean age of word acquisition, and response format (e.g., about symptom frequency or task difficulty). Data were analyzed with linear and generalized linear mixed models. Results Main effects models revealed that slower response times were associated with respondents with lower self-reported cognitive abilities and with PROM items that contained more syllables, less imageable (e.g., more abstract) words, and that asked about task difficulty rather than symptom frequency. Interaction effects were found between self-reported cognition and those same PROM attributes such that people with worse self-reported cognitive abilities were disproportionately slow when responding to items that were longer (more syllables), contained less imageable words, and asked about task difficulty. Conclusion Completing a PROM requires multiple cognitive skills (e.g., memory, executive functioning) and appraisal processes. Response time is a means of operationalizing the amount or difficulty of cognitive processing, and this report indicates several aspects of PROM design that relate to a measure’s cognitive burden. However, future research with better experimental control is needed.

scholarly journals Patient-reported outcomes in obsessive-compulsive disorder

2014 ◽  
Vol 16 (2) ◽  
pp. 239-254 ◽  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Patient Reported Outcomes ◽  
Functional Disability ◽  
Psychometric Evaluation ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Future Research ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Patient Reported

The purpose of the article was to provide an overview of patient-reported outcomes (PROs) and related measures that have been examined in the context of obsessive-compulsive disorder (OCD). The current review focused on patient-reported outcome measures (PROMs) that evaluated three broad outcome domains: functioning, health-related quality of life (HRQoL), and OCD-related symptoms. The present review ultimately included a total of 155 unique articles and 22 PROMs. An examination of the PROs revealed that OCD patients tend to suffer from significant functional disability, and report lower HRQoL than controls. OCD patients report greater symptom severity than patients with other mental disorders and evidence indicates that PROMs are sensitive to change and may be even better than clinician-rated measures at predicting treatment outcomes. Nonetheless, it should be noted that the measures reviewed lacked patient input in their development. Future research on PROMs must involve patient perspectives and include rigorous psychometric evaluation of these measures.

scholarly journals Promising New Approaches to Assess Cognitive Functioning in People with Multiple Sclerosis

2012 ◽  
Vol 14 (2) ◽  
pp. 71-76 ◽  
Author(s):  
Heather Becker ◽  
Alexa Stuifbergen ◽  
Janet Morrison
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Functioning ◽  
Performance Measures ◽  
Cognitive Abilities ◽  
Exploratory Study ◽  
White Women ◽  
Future Research ◽  
Measurement Information ◽  
Neurocognitive Performance ◽  
Patient Reported

Cognitive impairment has a major impact on the lives of people with multiple sclerosis (MS). Yet it is often underdiagnosed, and more-effective assessment methods are needed. In particular, brief measures that focus on cognitive functioning in daily life situations, are sensitive to modest change over time, and do not require a highly skilled assessor merit exploration. The purpose of this exploratory study was to investigate the performance of individuals with MS on three relatively new measures—the Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive Concerns and Abilities Scales and the Everyday Problems Test (EPT)—and to compare scores on these measures with scores on neurocognitive performance measures typically used to assess cognitive functioning in people with MS. Twenty-nine individuals with MS who reported cognitive concerns participated in the study. Most were non-Hispanic white women with relapsing-remitting MS that was diagnosed approximately 18 years previously. All three measures yielded reliability coefficients of 0.80 or above and also demonstrated sensitivity to change following an educational intervention. Scores on the Revised EPT (EPT-R) were moderately correlated with scores on five standard neuropsychological measures. Compared with scores on the PROMIS Cognitive Concerns Scale, those on the self-reported PROMIS Cognitive Abilities Scale tended to correlate more highly with the neurocognitive performance measures, although the correlations were generally small. While results of this exploratory study are promising, future research should be conducted with larger and more diverse samples of people with MS to determine the broader utility of these measures.

Current Applications of Single Shoulder-Specific or Upper Extremity Region-Specific Patient-Reported Outcome Measures in Swimmers: A Critically Appraised Topic

2020 ◽  
Vol 25 (5) ◽  
pp. 227-232
Author(s):  
Mark A. Sutherlin
Keyword(s):  
Upper Extremity ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Future Research ◽  
Bottom Line ◽  
Specific Patient ◽  
Perceived Disability ◽  
Patient Reported ◽  
Research Findings ◽  
Competitive Swimmers

Clinical Question: What single shoulder-specific or upper extremity region-specific patient-reported outcome (PRO) measures (I) are used to assess self-perceived disability (O) in competitive swimmers (P)? Clinical Bottom Line: There is limited research on the use of single shoulder-specific or upper extremity region-specific PRO measures for self-perceived disability in competitive swimmers. Current use of single shoulder-specific or upper extremity region-specific PRO measures are inconsistent and select applications vary across studies. Future research on competitive swimmers should include single shoulder-specific or upper extremity region-specific PRO measures that address sport-related self-perceived disability. This would allow for additional evidence to support the recommendation and use of appropriate single shoulder-specific or upper extremity region-specific PRO measures for competitive swimmers, increased clinical applicability, and comparison of research findings across studies to assist with evidence-based practices.

scholarly journals Psychosocial Impact of Dysarthria: The Patient-Reported Outcome as Part of the Clinical Management

2019 ◽  
Vol 19 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Cyril Atkinson-Clement ◽  
Alban Letanneux ◽  
Guillaume Baille ◽  
Marie-Charlotte Cuartero ◽  
Lauriane Véron-Delor ◽  
...  
Keyword(s):  
Neurological Disorders ◽  
Speech Intelligibility ◽  
Discriminant Validity ◽  
Short Form ◽  
Neurological Diseases ◽  
Patient Reported Outcome ◽  
Psychosocial Impact ◽  
Assessment Tools ◽  
Psychosocial Consequences ◽  
Patient Reported

Background: Dysarthria in neurological disorders can have psychosocial consequences. The dysarthric speaker’s perspective towards the disorder’s psychosocial impact is essential in its global assessment and management. For such purposes, assessment tools such as the Dysarthria Impact Profile (DIP) are indispensable. Objective: We aimed to confirm the relevance of using the DIP to quantify the psychosocial consequences of dysarthria in neurological diseases. Methods: We studied 120 participants, 15 healthy controls and 105 patients with different kinds of dysarthria induced by several neurological disorders (Parkinson’s disease [PD], Huntington’s disease, dystonia, cerebellar ataxia, progressive supranuclear palsy [PSP], multiple system atrophy, lateral amyotrophic sclerosis). All participants underwent a cognitive evaluation and a speech intelligibility assessment and completed three self-reported questionnaires: the 36-Item Short Form Health Survey, the Voice Handicap Index (VHI), and the DIP. Results: The psychometric properties of the DIP were confirmed, including internal consistency (α = 0.93), concurrent validity (correlation with the VHI: r = –0.77), and discriminant validity (accuracy = 0.93). Psychosocial impact of dysarthria was revealed by the DIP for all patients. Intelligibility loss was found strongly correlated with the psychosocial impact of dysarthria: for a similar level of intelligibility impairment, the DIP total score was similar regardless of the pathological group. However, our findings suggest that the psychosocial impact measured by the DIP could be partially independent from the severity of dysarthria (indirectly addressed here via speech intelligibility): the DIP was able to detect patients without any intelligibility impairment, but with a psychosocial impact. Conclusions: All patients reported a communication complaint, attested by the DIP scores, despite the fact that not all patients, notably PD, ataxic, and PSP patients, had an intelligibility deficit. The DIP should be used in clinical practice to contribute to a holistic evaluation and management of functional communication in patients with dysarthria.

Performance of the Achilles Tendon Total Rupture Score Over Time in a Large National Database: Development of an Instruction Manual for Accurate Use

2020 ◽  
Vol 48 (6) ◽  
pp. 1423-1429 ◽  
Author(s):  
Maria Swennergren Hansen ◽  
Katarina Nilsson Helander ◽  
Jón Karlsson ◽  
Kristoffer Weisskirchner Barfod
Keyword(s):  
Achilles Tendon ◽  
Achilles Tendon Rupture ◽  
Patient Reported Outcome ◽  
National Database ◽  
Future Research ◽  
Item Score ◽  
Level Of Evidence ◽  
Instruction Manual ◽  
Patient Reported ◽  
The Difference

Background: The Achilles tendon Total Rupture Score (ATRS) is a commonly used patient-reported outcome measure for patients with an acute Achilles tendon rupture. The score consists of 10 questions, the last 3 of which include activities that some patients cannot or do not do. No instruction manual has been developed for the ATRS. Hypothesis/Purpose: The purpose was to evaluate the ATRS at 4, 12, and 24 months after a rupture. The hypothesis was that the results at 4 months would be inconsistent when compared with the results at 1 year and 2 years. We also aimed to develop a manual that explains how to use the ATRS. Study Design: Cohort study (Diagnosis); Level of evidence, 3. Methods: This was a mixed-methods study. The first section was a registry study, where prospectively collected data were analyzed. Data were collected 4, 12, and 24 months after rupture. The original score based on 10 items was compared with a score based on the first 7 items adjusted to the same scale as the original score. Density plots and scatterplots were made and differences between the scores were tested using the Mann-Whitney U test. The second section of the study consisted of discussions among the authors, which resulted in a manual for the ATRS. Results: In total, 2790 complete ATRSs were included. The 7-item score significantly overestimated the value of the 10-item score at all time points ( P < .001), but only at 4 months was the difference clinically relevant (9.7 points). Conclusion: When the ATRS is used for short-term evaluation, there is a risk of results being inconsistent because of the last 3 questions. A manual explaining how to use the ATRS was therefore developed. We recommend that the full ATRS together with the manual should be used in future research rather than eliminating the 3 last questions.

scholarly journals Patient-reported outcome measures in Huntington disease: Quality of life in neurological disorders (Neuro-QoL) social functioning measures.

2018 ◽  
Vol 30 (4) ◽  
pp. 450-458 ◽  
Author(s):  
Noelle E. Carlozzi ◽  
Elizabeth A. Hahn ◽  
Siera M. Goodnight ◽  
Anna L. Kratz ◽  
Jane S. Paulsen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Functioning ◽  
Outcome Measures ◽  
Huntington Disease ◽  
Neurological Disorders ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Patient Reported

Patient-reported outcome instruments in clinical trials of systemic sclerosis

2019 ◽  
Vol 5 (2) ◽  
pp. 90-102 ◽  
Author(s):  
John D Pauling ◽  
Joana Caetano ◽  
Corrado Campochiaro ◽  
Giacomo De Luca ◽  
Ana Maria Gheorghiu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Systemic Sclerosis ◽  
Patient Reported Outcome ◽  
Future Research ◽  
Valuable Insight ◽  
Surrogate Outcome ◽  
American College Of Rheumatology ◽  
Patient Reported ◽  
And Performance

Patient-reported outcome instruments provide valuable insight into disease-related morbidity known only to the patient and complement more objective outcome tools in the clinical trial setting. They are of particular importance in systemic sclerosis owing to the challenges around defining disease activity, the episodic nature of many disease-specific manifestations and the paucity of validated objective surrogate outcome measures for use in clinical trials. Early clinical trials of systemic sclerosis often incorporated legacy patient-reported outcome instruments, but the last 20 years has witnessed the emergence of several scleroderma-specific instruments that are now being routinely used alongside other outcomes in systemic sclerosis clinical trials. More recently, the value of patient-reported outcomes has been highlighted by their prominence in the American College of Rheumatology Combined Response Index for Systemic Sclerosis that has been utilized as the primary endpoint of recent clinical trials of early diffuse systemic sclerosis. This review considers the role and performance of the various patient-reported outcome instruments utilized in systemic sclerosis clinical trials, the current positioning of patient-reported outcome instruments within clinical trial endpoint models across the range of systemic sclerosis disease manifestations and, where applicable, we shall highlight areas for future research.

scholarly journals Aroused and Impulsive Effects of Colour Stimuli on Lateral and Logical Abilities

2021 ◽  
Vol 11 (2) ◽  
pp. 24
Author(s):  
Guobin Xia ◽  
Muzi Li ◽  
Philip Henry ◽  
Stephen Westland ◽  
Francisco Queiroz ◽  
...  
Keyword(s):  
Response Time ◽  
Error Rate ◽  
Cognitive Abilities ◽  
Environmental Design ◽  
Impulsive Effects ◽  
Future Research ◽  
Psychometric Tests ◽  
Psychometric Test ◽  
Indirect Impacts ◽  
Study Participants

The purpose of this study was to explore the influence of environmental colour on people’s lateral and logical abilities. This was done by evaluating study participants’ response time and error rate when completing six types of psychometric tests that were performed in various hue backgrounds on a computer. To maximise the colour stimulation provided by the monitor, the experiment was carried out in a dark laboratory. Analysis of participants’ response time and error rate showed that different colours could significantly influence arousal and impulsiveness, which suggests that colour has indirect impacts on cognitive abilities. Further analysis revealed that different colours had various effects depending on the type of psychometric test given. These findings suggest that future research on environmental design should consider how to effectively use colour to impact people’s performance and behaviour.

scholarly journals Patient interactive digital support for women with adjuvant endocrine therapy in order to increase compliance and quality of life

2020 ◽  
Vol 29 (1) ◽  
pp. 491-497
Author(s):  
Jenny Bergqvist ◽  
Staffan Lundström ◽  
Yvonne Wengström
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Physical Exercise ◽  
Breast Cancer Survivors ◽  
Self Care ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Future Research ◽  
Patient Reported

Abstract Purpose The primary aim of the study was to develop and investigate a patient interactive digital support (an app) for patients on adjuvant endocrine breast cancer treatment. Patient’s interactive digital applications are a fast-growing area for research and development. In general, patients want more information and support with regard to their diagnosis, treatment and self-care. At the same time, the health care system has limited resources for follow-up. Our primary endpoints were usability of the app and if it added any value to the patients. Methods We designed and constructed a prototype, in dialogue with patients, containing four main modules for registration of drug compliance, performed physical exercise, self-care activities, and questions on health and quality of life. The app was then tested by patients and improved further before we completed a pilot study in which 15 patients used the app for 3 months. Results Patients perceived the app easy to use with a very high median system usability score of 88.8, range 30–100. The 15 women registered in total 4251 times, range 118 to 372. The majority of registrations concerned compliance (adherence to treatment) and physical exercise. Conclusion The app was perceived easy to use and of support in every-day life of breast cancer survivors. How to best integrate electronically collected patient reported outcome measures in clinical routine needs to be further studied, and future research will show if it will be cost-effective in terms of better health outcome and less resource use.

Sign in / Sign up

Export Citation Format

Share Document