Effective Bioremediation of Endocrine-Disrupting Phthalate Esters, Mediated by Bacillus Strains

2017 ◽  
Vol 228 (10) ◽  
Author(s):  
Muhammad Ali Surhio ◽  
Farah N. Talpur ◽  
Shafi M. Nizamani ◽  
Marvi Kanwal Talpur ◽  
Farah Amin ◽  
...  
Keyword(s):  
Phthalate Esters ◽  
Endocrine Disrupting ◽  
Bacillus Strains

Environmental exposures to endocrine disrupting chemicals (EDCs) and their role in endometriosis: a systematic literature review

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Diksha Sirohi ◽  
Ruqaiya Al Ramadhani ◽  
Luke D. Knibbs
Keyword(s):  
Bisphenol A ◽  
Phthalate Esters ◽  
Endocrine Disrupting Chemicals ◽  
Environmental Pollutants ◽  
Positive Association ◽  
Environmental Chemicals ◽  
Reproductive Age ◽  
Organochlorinated Pesticides ◽  
Endocrine Disrupting ◽  
The Relationship

AbstractPurposeEndocrine-related diseases and disorders are on the rise globally. Synthetically produced environmental chemicals (endocrine-disrupting chemicals (EDCs)) mimic hormones like oestrogen and alter signalling pathways. Endometriosis is an oestrogen-dependent condition, affecting 10–15% of women of the reproductive age, and has substantial impacts on the quality of life. The aetiology of endometriosis is believed to be multifactorial, ranging from genetic causes to immunologic dysfunction due to environmental exposure to EDCs. Hence, we undertook a systematic review and investigated the epidemiological evidence for an association between EDCs and the development of endometriosis. We also aimed to assess studies on the relationship between body concentration of EDCs and the severity of endometriosis.MethodFollowing PRISMA guidelines, a structured search of PubMed, Embase and Scopus was conducted (to July 2018). The included studies analysed the association between one or more EDCs and the prevalence of endometriosis. The types of EDCs, association and outcome, participant characteristics and confounding variables were extracted and analysed. Quality assessment was performed using standard criteria.ResultsIn total, 29 studies were included. Phthalate esters were positively associated with the prevalence of endometriosis. The majority (71%) of studies revealed a significant association between bisphenol A, organochlorinated environmental pollutants (dioxins, dioxin-like compounds, organochlorinated pesticides, polychlorinated biphenyls) and the prevalence of endometriosis. A positive association between copper, chromium and prevalence of endometriosis was demonstrated in one study only. Cadmium, lead and mercury were not associated with the prevalence of endometriosis. There were conflicting results for the association between nickel and endometriosis. The relationship of EDCs and severity of endometriosis was not established in the studies.ConclusionWe found some evidence to suggest an association between phthalate esters, bisphenol A, organochlorinated environmental pollutants and the prevalence of endometriosis. Disentangling these exposures from various other factors that affect endometriosis is complex, but an important topic for further research.

scholarly journals Phthalate Esters and Their Potential Risk in PET Bottled Water Stored under Common Conditions

2019 ◽  
Vol 17 (1) ◽  
pp. 141 ◽  
Author(s):  
Xiangqin Xu ◽  
Gang Zhou ◽  
Kun Lei ◽  
Gerald A. LeBlanc ◽  
Lihui An
Keyword(s):  
Storage Time ◽  
Storage Temperature ◽  
Pure Water ◽  
Phthalate Esters ◽  
Storage Condition ◽  
Bottled Water ◽  
Pet Bottles ◽  
Short Period ◽  
Endocrine Disrupting ◽  
Ethylhexyl Phthalate

A great deal of attention has been paid lately to release of phthalate esters (PAEs) from polyethylene terephthalate (PET) bottles into PET bottled drinking water due to their potential endocrine-disrupting effects. Three kinds of PAEs, including diethyl phthalate (DEP), dimethyl phthalate (DMP) and dibutyl phthalate (DBP), were detected in 10 popular brands of PET bottles in Beijing, ranging from 101.97 μg/kg to 709.87 μg/kg. Meanwhile, six kinds of PAEs, including DEP, DMP, DBP, n-butyl benzyl phthalate (BBP), di-n-octyl phthalate (DOP) and di(2-ethylhexyl) phthalate (DEHP), were detected in PET bottled water, ranging from 0.19 μg/L to 0.98 μg/L, under an outdoor storage condition, while their concentrations ranged from 0.18 μg/L to 0.71 μg/L under an indoor storage condition. Furthermore, the concentrations of PAEs in brand D and E bottles were slightly increased when the storage time was prolonged. In addition, the concentrations of PAEs in commercial water contained in brand B and H bottles and pure water contained in brand E and G bottles were also slightly increased with the increase of storage temperature. Interestingly, DBP mainly contributed to the increased PAEs levels in simulation water. These results suggest that a part of the PAEs in PET bottled water originated from plastic bottles, which was related to the storage time and temperature. However, the PAEs in PET bottled water only pose a negligible risk to consumers if they follow the recommendations, such as storage at a common place (24 °C), away from sun and in a short period of time.

Methods for the Determination of Endocrine-Disrupting Phthalate Esters

2015 ◽  
Vol 46 (2) ◽  
pp. 146-159 ◽  
Author(s):  
Munawar Saeed Qureshi ◽  
Abdull Rahim bin Mohd Yusoff ◽  
Mohd Dzul Hakim Wirzal ◽  
Jiri Barek ◽  
Hassan Imran Afridi ◽  
...  
Keyword(s):  
Phthalate Esters ◽  
Endocrine Disrupting

scholarly journals Prenatal Exposure to Endocrine-Disrupting Chemicals and Subsequent Brain Structure Changes Revealed by Voxel-Based Morphometry and Generalized Q-Sampling MRI

2021 ◽  
Vol 18 (9) ◽  
pp. 4798
Author(s):  
Chao-Yu Shen ◽  
Jun-Cheng Weng ◽  
Jeng-Dau Tsai ◽  
Pen-Hua Su ◽  
Ming-Chih Chou ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Brain Structure ◽  
Phthalate Esters ◽  
Endocrine Disrupting Chemicals ◽  
Positive Association ◽  
Orientation Distribution ◽  
Voxel Based Morphometry ◽  
Third Trimester ◽  
Structure Changes ◽  
Endocrine Disrupting

Previous studies have indicated that prenatal exposure to endocrine-disrupting chemicals (EDCs) can cause adverse neuropsychiatric disorders in children and adolescents. This study aimed to determine the association between the concentrations of prenatal EDCs and brain structure changes in teenagers by using MRI. We recruited 49 mother–child pairs during the third trimester of pregnancy, and collected and examined the concentration of EDCs—including phthalate esters, perfluorochemicals (PFCs), and heavy metals (lead, arsenic, cadmium, and mercury)—in maternal urine and/or serum. MRI voxel-based morphometry (VBM) and generalized q-sampling imaging (GQI) mapping—including generalized fractional anisotropy (GFA), normalized quantitative anisotropy (NQA), and the isotropic value of the orientation distribution function (ISO)—were obtained in teenagers 13–16 years of age in order to find the association between maternal EDC concentrations and possible brain structure alterations in the teenagers’ brains. We found that there are several specific vulnerable brain areas/structures associated with prenatal exposure to EDCs, including decreased focal brain volume, primarily in the frontal lobe; high frontoparietal lobe, temporooccipital lobe and cerebellum; and white matter structural alterations, which showed a negative association with GFA/NQA and a positive association with ISO, primarily in the corpus callosum, external and internal capsules, corona radiata, superior fronto-occipital fasciculus, and superior longitudinal fasciculus. Prenatal exposure to EDCs may be associated with specific brain structure alterations in teenagers.

Role of dissolved humic substances surrogates on phthalate esters migration from sewage sludge

2008 ◽  
Vol 57 (4) ◽  
pp. 607-612 ◽  
Author(s):  
Z. Zheng ◽  
P. J. He ◽  
H. Zhang ◽  
L. M. Shao
Keyword(s):  
Humic Substances ◽  
Phthalate Esters ◽  
Average Molecular Weight ◽  
Endocrine Disrupting Chemicals ◽  
Fulvic Acids ◽  
Facilitated Transport ◽  
Hydrophobic Property ◽  
Endocrine Disrupting ◽  
Dissolved Humic Substances ◽  
Ethylhexyl Phthalate

The facilitated transport of dibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP), the priority endocrine disrupting chemicals in sludge, by dissolved humic substances (HS) was evaluated by batch extraction. The DBP, much less hydrophobic than DEHP, was inclined to migrate from sludge matrix into humic substances solutions, while the DEHP could not migrate facilitated by most humic and fulvic acids solutions, except the humic acid surrogate of high humification. This result revealed that the affinity of DEHP in sludge matrix exceeded DBP and was not susceptible by weak HS. The hydrophobic property controlled the association of phthalic acid esters on sludge residual phases. Migration rate of DBP was positively correlated to the weight-average molecular weight of HS surrogates and the aromatic extents of HA. Some functional groups in HS molecules benefited to the facilitated transport of DBP.

Degradation of dimethyl phthalate esters by a filamentous fungus Aspergillus versicolor isolated from deep-sea sediments

2017 ◽  
Vol 60 (3) ◽  
Author(s):  
Jing-Wen Wang ◽  
Wei Xu ◽  
Tian-Hua Zhong ◽  
Gao-Yang He ◽  
Zhu-Hua Luo
Keyword(s):  
Filamentous Fungus ◽  
Deep Sea ◽  
Enrichment Culture ◽  
Phthalate Esters ◽  
Environmental Pollutants ◽  
Culture Technique ◽  
Dimethyl Phthalate ◽  
Endocrine Disrupting ◽  
Deep Sea Sediments ◽  
The Indian Ocean

AbstractDimethyl phthalate esters (DMPEs), which belong to phthalate esters (PAEs), are widely distributed environmental pollutants with endocrine-disrupting toxicity. The present study focused on a filamentous fungus capable of degrading DMPEs isolated from deep-sea sediments of the Indian Ocean at a water depth of 3300 m using an enrichment culture technique. The filamentous fungus was identified as

scholarly journals Degradability and Biochemical Pathways of the Endocrine-disrupting Plasticizers Phthalate Esters in Plastics by Microorganisms

2021 ◽  
Vol 6 (1) ◽  
pp. 16-30
Author(s):  
Ji-Dong Gu ◽  
◽  
Tsz Ching Mak ◽  
Keyword(s):  
Public Awareness ◽  
Phthalate Esters ◽  
Practical Importance ◽  
Significant Risk ◽  
Phthalate Ester ◽  
Potential Health ◽  
Degrading Bacteria ◽  
Wide Range ◽  
Significant Difference ◽  
Endocrine Disrupting

Phthalate esters (PAEs) are a group of endocrine-disrupting organic chemicals commonly used as additives in the manufacturing of a wide range of plastics. Large quantities of different phthalate esters have been used in specific products for quality and performance by the manufacturing industries, and they pose a significant risk to human health and the ecological quality of the environments due to leaching out of phthalates from plastic products and their high mobility. Since phthalate esters are most removed efficiently through biodegradation by microorganisms in the environments, it is important to understand the efficiency, microorganisms involved, biochemical transformation processes and mechanisms of phthalate metabolism by the specific microorganisms. This article addresses the degradation of endocrine-disrupting phthalates and their fates by an integrative comparison and analysis on efficient PAEs-degrading microorganisms, the microbial metabolism, and the biochemical processes and limitation. The comparison reveals that no significant difference is evident on efficiencies between single strains of bacteria or the mixed bacterial consortia when degradation can be carried out. However, there are a few important characteristics among the efficiencies of the PAEs-degrading bacteria. The microorganisms shall utilize the specific phthalate ester as the sole source of carbon and energy. They shall mineralize the substrates, including the original compound and its degradation intermediates to achieve a complete removal. In addition, it is of practical importance for the bacteria to adapt and survive in a range of temperatures, salinity and pH as well as in the presence of indigenous microorganisms in bioremediation of contaminated sites or wastewater treatment. This review also reveals that caution should be given to both the presentation and interpretation of the degradation results for a comprehensive knowledge, particularly data on bacterial growth, extraction and analysis of residual PAEs, and the confounding use of surfactants or co-substrate in the research. The public awareness of plasticizers as an environmental pollutant is mostly due to its increasing quantities being used, constant contacts with human population on a daily basis and potential health hazards. Its toxicity shall be address more focused on reproductive biology meaningfully than the traditional mortality test in toxicology for the significant effects on animals including human.

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