Early Identification of Infectious Complications in Bariatric Surgery by the Determination of Peritoneal and Systemic Cytokines

Abstract We describe a liquid-chromatographic assay for AZT in human plasma and urine. This assay involves the use of two internal standards, allowing reference of AZT peaks to the appropriate internal standard, the choice depending on the range of concentrations encountered. This method is isocratic, specific, sensitive enough to allow quantification of AZT in concentrations observed clinically, and requires only 13 min of chromatographic time. We saw no interference from various over-the-counter and prescription drugs often used in treating the infectious complications of AIDS.

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Determination of a Focused Mini Kinase Panel for Early Identification of Selective Kinase Inhibitors

Journal of Chemical Information and Modeling ◽

10.1021/acs.jcim.8b00222 ◽

2018 ◽

Vol 58 (7) ◽

pp. 1434-1440 ◽

Cited By ~ 5

Author(s):

Scott D. Bembenek ◽

Gavin Hirst ◽

Taraneh Mirzadegan

Keyword(s):

Early Identification ◽

Kinase Inhibitors

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Intraoperative determination of respiratory mechanics and oxygenation in morbid obese patients undergoing bariatric surgery

European Journal of Anaesthesiology ◽

10.1097/00003643-201206001-00279 ◽

2012 ◽

Vol 29 ◽

pp. 86

Author(s):

L. Rovira Soriano ◽

J. Hernández Laforet ◽

J. Moreno Pachón ◽

M. Ballester Luján ◽

F. J. Belda Nácher ◽

...

Keyword(s):

Bariatric Surgery ◽

Respiratory Mechanics ◽

Obese Patients ◽

Morbid Obese

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The under-reporting of energy intake influences the dietary pattern reported by obese women in the waiting list for bariatric surgery

Revista de Nutrição ◽

10.1590/1678-98652018000200009 ◽

2018 ◽

Vol 31 (2) ◽

pp. 235-249 ◽

Cited By ~ 1

Author(s):

Michele Novaes RAVELLI ◽

Maria Márcia Pereira SARTORI ◽

José Eduardo CORRENTE ◽

Irineu RASERA JUNIOR ◽

Noa Pereira Prada de SOUZA ◽

...

Keyword(s):

Physical Activity ◽

Bariatric Surgery ◽

Energy Intake ◽

Dietary Patterns ◽

Activity Level ◽

Waiting List ◽

Obese Women ◽

Nutrient Intakes ◽

Study Results

ABSTRACT Objective To verify the interference of the energy intake under-reporting in the determination of the dietary patterns and nutrient intakes reported by obese women in the waiting list for bariatric surgery. Methods The study included 412 women aged 20 to 45 years with a body mass index ranging from 35 to 60kg/m2 who were on waiting list for bariatric surgery. Data from three reported food intake and physical activity, body weight, and height were used for estimating the reported energy intake, physical activity level, and resting energy expenditure. Subsequently, it was checked the biological plausibility of the reported energy intakes, classifying all participants as plausible reporters or under-reporters. Exploratory factor analysis was used to determine the participants’ dietary patterns. The Mann-Whitney test assessed the reported energy and nutrient intakes between plausible reporters and under-reporters groups. The Z-test assessed the variables of plausible reporters or under-reporters in relation to all participants of the study. Results Six dietary patterns were determined for all participants of study. After excluding information from under-reporting women, only two dietary patterns remained similar to those of all participants, while three other dietary patterns presented different conformations from food subgroups to plausible reporters. The reported energy intake did not present difference for the subgroups of fruits, leaf vegetables and vegetables. However, the energetic value reported for the other food subgroups was higher for the plausible reporters. Conclusion The under-reporting of energy intake influenced the determination of dietary patterns of obese women waiting for bariatric surgery.

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Phagocytosis by Hairy Cells as Demonstrated by Serial Sectioning Techniques

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s1431927600003251 ◽

1980 ◽

Vol 38 ◽

pp. 746-747

Author(s):

M. C. Rosner ◽

H. M. Golomb

Keyword(s):

B Lymphocytes ◽

Early Identification ◽

Infectious Complications ◽

Polystyrene Latex ◽

Exact Nature ◽

Hairy Cell ◽

Cell Leukemia ◽

Serial Sectioning ◽

Hairy Cells ◽

And Staphylococcus Aureus

Leukemic reticuloendotheliosis or Hairy Cell Leukemia was first described in 1958. The hairy cells have been described as being modified monocytes, B-lymphocytes, B-lymphocytes with phagocytic capacities, or T-lymphocytes. Hairy cells have also been shown to have the ability to ingest foreign particles, a function usually associated with monocytes1. In addition to providing clues to the origin of the disease, phagocytosis has been cited as being useful in providing early identification of potential infectious complications in patients afflicted with the disease. A recent study by Jansen et al2 suggested that the particles observed within the cytoplasm of the cell were not ingested but merely entrapped between the cytoplasmic projections of the hairy cell. Our present study was designed to use serial sectioning techniques and electron microscopy evaluations to determine the exact nature of phagocytosis by hairy cells of polystyrene latex and Staphylococcus aureus particles after three hours of incubation.

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Utility Of D-Dimer As a Marker For Differentiation Syndrome and Infections In Acute Promyelocytic Leukemia (APL)

Blood ◽

10.1182/blood.v122.21.4986.4986 ◽

2013 ◽

Vol 122 (21) ◽

pp. 4986-4986

Author(s):

Joshua Mansour ◽

Abhishek Mangaonkar ◽

Yousef Zakharia ◽

Arati Rani Chand ◽

Anand Jillella ◽

...

Keyword(s):

Acute Promyelocytic Leukemia ◽

Early Identification ◽

Conflicts Of Interest ◽

Retrospective Chart Review ◽

Infectious Complications ◽

Promyelocytic Leukemia ◽

The Other ◽

Induction Treatment ◽

Radiology Reports ◽

D Dimer

Abstract Background Acute Promyelocytic Leukemia is a highly curable malignancy with cure rates of greater than 90% in most co-operative group trials. However, population based studies indicate that the survival is much lower with up to 30% early deaths. The most common causes of early deaths are bleeding, differentiation syndrome and infection. Early identification and management of these three complications is essential if the outcomes are to be improved further. Bleeding in APL is secondary to disseminated intravascular coagulation (DIC) a peculiar complication of the disease and coagulation panel including d-dimer, fibrinogen levels, prothrombin time, activated partial thromboplastin time are commonly used as markers of DIC. There are presently no available tests to identify DS or infection early and are entirely clinical diagnoses. Here we report the importance of d-dimer levels as probable markers of DS or infection during induction treatment for APL. Methods We performed a retrospective chart review on forty one patients diagnosed with Acute Promyelocytic Leukemia and treated with ATRA from September 2005 – June 2013 from Georgia Regents University and those referred here from surrounding treatment centers. Data obtained included D-Dimer levels at diagnosis, daily d-dimer levels when available, dates of differentiation syndrome from start of treatment and dates of infectious complications when available which was obtained from progress notes and microbiology lab and radiology reports. Results 41 consecutive APL patients were evaluated for this study. One patient refused treatment and 15 patients did not have coagulation labs (specifically d-dimer) done throughout the course of induction treatment and had to be excluded. Age range of all the patients treated was 21-75 years. There were seven deaths overall and 21 patients had some evidence of DS. The diagnosis of DS was made clinically as per standard guidelines. We included 25 patients in whom there were d-dimer levels done throughout the hospitalization in this study. In these 25 patients, all had an increase in d-dimer levels after an initial drop as the DIC is corrected. 6 patients did not have any complications. In 4 patients the rise in d-dimer was followed by infectious complications. In the other 15 patients, their hospitalization was complicated by DS. In these 15 patients, 6 had elevation in d-dimer prior (0-5 days) to development of DS. In 3 patients the DS developed followed shortly by an elevation in d-dimer. The correlation between d-dimer elevation and DS could not be clearly ascertained from the available documentation in the other 6 patients. Conclusions APL is a curable malignancy but early deaths leads to poor outcomes outside of clinical trials. Early identification of the complications of the disease and treatment will allow us to further improve the outcomes in the community. D-dimer is an acute phase reactant and is elevated in any inflammatory state. From our data, the elevation in d-dimers following an initial decrease after correction of coagulopathy secondary to DIC might be marker of differentiation syndrome and or infection. These two conditions are pro-inflammatory states and might explain the increase in d-dimers observed. A larger scale validation is essential to confirm this observation which then might lead to more prompt identification of the complications and ultimately improved outcomes. Disclosures: No relevant conflicts of interest to declare.

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Processo de enfermagem fundamentado na teoria do autocuidado de Orem a um paciente submetido à cirurgia bariátrica

Revista de Enfermagem UFPE on line ◽

10.5205/reuol.581-3802-1-rv.0304200904 ◽

2009 ◽

Vol 3 (4) ◽

pp. 814 ◽

Cited By ~ 1

Author(s):

Lidiany Galdino Felix ◽

Maria Miriam Lima da Nóbrega ◽

Maria Júlia Guimarães de Oliveira Soares

Keyword(s):

Bariatric Surgery ◽

Nursing Care ◽

Clinical Case ◽

Self Care ◽

Nursing Interventions ◽

Nursing Process ◽

Qualified Individual ◽

Case Type ◽

Nursing Diagnoses

Objective: to apply the nursing process fundament on the Theory of Orem’ Self-care, through the conduct of a report of clinical case, with a patient submitted to bariatric surgery. Methods: this is about a descriptive study, from qualitative approach, report of clinical case type, performed in a patient with morbid obesity, included in Bariatric Surgery Group of a teaching hospital in João Pessoa-PB city. For data collection was used a script adapted to Theory of Orem’ Self-care, which led to the identification of deficits of self-care and therefore to nursing diagnoses. It was then developed the plan of nursing care, with the determination of goals, objectives, method of assistance, type of system and nursing interventions. This study has been approved by the Research Ethics Committee of the Hospital of the Federal University of Paraiba (054/07). Results: from the identification of nursing diagnoses was established and implemented the plan of nursing care with the aim of restoring the patient to prevent postoperative complications, promote recovery and prepare you for the self-care. Conclusion: it is considered that the application of the nursing process, based on Theory of Orem’ Self-care, enabled the provision of assistance and qualified individual, encouraging the patient to participate actively in their treatment, but also to increase their responsibility in the outcome of care. Descriptors: nursing; nursing process; self care; bariatric surgery.

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