Is There a Role of Coronary CTA in Primary Prevention? Current State and Future Directions

2021 ◽  
Vol 23 (8) ◽  
Author(s):  
Martin Bødtker Mortensen ◽  
Michael J. Blaha
Keyword(s):  
Primary Prevention ◽  
Coronary Cta ◽  
Future Directions ◽  
Current State

scholarly journals Diet and Chronic Non-Cancer Pain: The State of the Art and Future Directions

2021 ◽  
Vol 10 (21) ◽  
pp. 5203
Author(s):  
Katherine Brain ◽  
Tracy L. Burrows ◽  
Laura Bruggink ◽  
Anneleen Malfliet ◽  
Chris Hayes ◽  
...  
Keyword(s):  
Pain Management ◽  
Cancer Pain ◽  
State Of The Art ◽  
Future Research ◽  
Cancer Pain Management ◽  
Future Directions ◽  
Current State ◽  
Monounsaturated Fats ◽  
Management Recommendations

Nutrition plays an important role in pain management. Healthy eating patterns are associated with reduced systemic inflammation, as well as lower risk and severity of chronic non-cancer pain and associated comorbidities. The role of nutrition in chronic non-cancer pain management is an emerging field with increasing interest from clinicians and patients. Evidence from a number of recent systematic reviews shows that optimising diet quality and incorporating foods containing anti-inflammatory nutrients such as fruits, vegetables, long chain and monounsaturated fats, antioxidants, and fibre leads to reduction in pain severity and interference. This review describes the current state of the art and highlights why nutrition is critical within a person-centred approach to pain management. Recommendations are made to guide clinicians and highlight areas for future research.

scholarly journals Current basis and future directions of zebrafish nutrigenomics

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Michael B. Williams ◽  
Stephen A. Watts
Keyword(s):  
Animal Model ◽  
Cell Function ◽  
Disease Onset ◽  
Zebrafish Model ◽  
Future Directions ◽  
Genomic Changes ◽  
Current State ◽  
Β Cell Function ◽  
Genomic Response

AbstractThis review investigates the current state of nutrigenomics in the zebrafish animal models. The zebrafish animal model has been used extensively in the study of disease onset and progression and associated molecular changes. In this review, we provide a synopsis of nutrigenomics using the zebrafish animal model. Obesity and dyslipidemia studies describe the genomics of dietary-induced obesity in relation to high-fat/high-calorie diets. Inflammation and cardiovascular studies describe dietary effects on the expression of acute inflammatory markers and resulting chronic inflammatory issues including atherosclerosis. We also evaluated the genomic response to bioactive dietary compounds associated with metabolic disorders. Carbohydrate metabolism and β-cell function studies describe the impacts of high-carbohydrate dietary challenges on nutritional programming. We also report tumorigenesis in relation to dietary carcinogen exposure studies that can result in permanent genomic changes. Vitamin and mineral deficiency studies demonstrate transgenerational genomic impacts of micronutrients in the diet and temporal expression changes. Circadian rhythm studies describe the relation between metabolism and natural temporal cycles of gene expression that impacts health. Bone formation studies describe the role of dietary composition that influences bone reabsorption regulation. Finally, this review provides future directions in the use of the zebrafish model for nutrigenomic and nutrigenetic research.

scholarly journals The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 437
Author(s):  
Alexander Ou ◽  
Martina Ott ◽  
Dexing Fang ◽  
Amy B. Heimberger
Keyword(s):  
Immune Escape ◽  
Janus Kinase ◽  
Molecular Heterogeneity ◽  
Signal Transducer ◽  
Therapeutic Targeting ◽  
Future Directions ◽  
Stem Cell Maintenance ◽  
Current State ◽  
Stat Signaling

Glioblastoma remains one of the deadliest and treatment-refractory human malignancies in large part due to its diffusely infiltrative nature, molecular heterogeneity, and capacity for immune escape. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway contributes substantively to a wide variety of protumorigenic functions, including proliferation, anti-apoptosis, angiogenesis, stem cell maintenance, and immune suppression. We review the current state of knowledge regarding the biological role of JAK/STAT signaling in glioblastoma, therapeutic strategies, and future directions for the field.

Ambulatory Monitoring of Daily Voice Use

2011 ◽  
Vol 21 (2) ◽  
pp. 56-61 ◽  
Author(s):  
Robert E. Hillman ◽  
Daryush D. Mehta
Keyword(s):  
State Of The Art ◽  
Ambulatory Monitoring ◽  
Vocal Behavior ◽  
Future Directions ◽  
Vocal Function ◽  
Current State ◽  
Voice Use ◽  
Insight Into

Many common voice disorders are chronic or recurring conditions likely to result from faulty and/or abusive patterns of vocal behavior. Such behaviorally based disorders can be difficult to assess accurately in the clinical setting and potentially could be much better characterized by long-term ambulatory monitoring of vocal function as individuals engage in their typical daily activities. Ambulatory monitoring also could provide new insight into the actual role of voice use in common disorders and missing quantitative data on what constitutes normal levels of daily voice use for different groups of individuals, activities, and occupations. This report describes the motivation, previous development efforts, current state-of-the-art technology, and future directions in ambulatory monitoring of voice use.

scholarly journals The role of neuroimaging in diagnosis and personalized medicine--current position and likely future directions

2009 ◽  
Vol 11 (4) ◽  
pp. 389-396 ◽  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Future Directions ◽  
New Methods ◽  
Current State ◽  
General Relevance ◽  
And Personalized Medicine

The main aim of this article is to discuss the current state of in vivo brain imaging methods in the context of the diagnosis and treatment of mental illness. The background to current practice is discussed, and the new methods introduced which may have the capacity to increase the relevance of magnetic resonance imaging, particularly functional magnetic resonance imaging, for clinical application. The main focus will be on magnetic resonance imaging, but many of the comments have a general relevance across imaging modalities.

Current Advances and Future Directions in Behavior Assessment

2016 ◽  
Vol 42 (2) ◽  
pp. 77-80 ◽  
Author(s):  
T. Chris Riley-Tillman ◽  
Austin H. Johnson
Keyword(s):  
Educational Research ◽  
Student Behavior ◽  
Progress Monitoring ◽  
Assessment Methods ◽  
Behavior Assessment ◽  
Positive Outcomes ◽  
Special Issue ◽  
Future Directions ◽  
Current State

Multi-tiered problem-solving models that focus on promoting positive outcomes for student behavior continue to be emphasized within educational research. Although substantial work has been conducted to support systems-level implementation and intervention for behavior, concomitant advances in behavior assessment have been limited. This is despite the central role that data derived from behavior assessment methods must play in making defensible multi-tiered decisions such as those for screening and progress monitoring. In this commentary, the role of assessment in the evidence-based practice movement is described, alongside necessary features of behavior assessment methods utilized in multi-tiered systems. The relevance of these features to articles in this special issue is described. Finally, observations and suggestions for future directions regarding the current state of behavior assessment in educational research are offered.

On Future Directions in Pathology

1982 ◽  
Vol 40 ◽  
pp. 274-277
Author(s):  
Benjamin F. Trump ◽  
Irene K. Berezesky ◽  
Raymond T. Jones
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Clinical Pathology ◽  
Future Directions ◽  
Diagnostic Pathology ◽  
The Past ◽  
Transmission Electron ◽  
Organ Systems ◽  
The Many

The role of electron microscopy and associated techniques is assured in diagnostic pathology. At the present time, most of the progress has been made on tissues examined by transmission electron microscopy (TEM) and correlated with light microscopy (LM) and by cytochemistry using both plastic and paraffin-embedded materials. As mentioned elsewhere in this symposium, this has revolutionized many fields of pathology including diagnostic, anatomic and clinical pathology. It began with the kidney; however, it has now been extended to most other organ systems and to tumor diagnosis in general. The results of the past few years tend to indicate the future directions and needs of this expanding field. Now, in addition to routine EM, pathologists have access to the many newly developed methods and instruments mentioned below which should aid considerably not only in diagnostic pathology but in investigative pathology as well.

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