scholarly journals Bi-layered disulfiram-loaded fiber membranes with antibacterial properties for wound dressing

2021 ◽  
Author(s):  
Chenchen Xie ◽  
Jin Yan ◽  
Siyuan Cao ◽  
Ri Liu ◽  
Baishun Sun ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Antibacterial Properties ◽  
Fiber Membranes ◽  
Loaded Fiber

Bi-Layered Disulfiram-Loaded Fiber Membranes With Antibacterial Properties for Wound Dressing

2021 ◽  
Author(s):  
Chenchen Xie ◽  
Jin Yan ◽  
Siyuan Cao ◽  
Ri Liu ◽  
Baishun Sun ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Wound Dressing ◽  
Polyvinylidene Fluoride ◽  
Antibacterial Properties ◽  
Wound Dressings ◽  
Plasma Modification ◽  
Bottom Surface ◽  
Chemical Compositions ◽  
Fiber Membranes ◽  
Loaded Fiber

Abstract In this study, the bi-layered disulfiram-loaded fiber membranes with antibacterial activity and different surface wettabilities are prepared using electrospinning technology. In the application of wound dressing, the hydrophilic surface of fiber membranes is beneficial for the cell adhesion and drug release to heal the wound, meanwhile the hydrophobic outside surface is able to block water penetration to reduce the probability of wound infection. The obtained bi-layered drug-loaded fiber membranes are composed of polyvinylidene fluoride (PVDF) bottom surface and disulfiram (DSF)/polylactic acid (PLA) top surface. To modify the top surface wettability, the oxygen plasma modification of bi-layered membranes was carried out. We analyzed the morphology, wettability and chemical compositions of bi-layered drug-loaded fiber membranes by various techniques. And the bi-layered disulfiram-loaded membranes showed potent antibacterial activity in vitro against both Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). Thus, the obtained bi-layered disulfiram-loaded fiber membranes are very suitable for wound dressings application.

Investigations and Concerns about the Fate of Transgenic DNA and Protein in Livestock

2021 ◽  
Author(s):  
Ahmet Aykaç ◽  
İzel Ok
Keyword(s):  
Zinc Oxide Nanoparticles ◽  
Wound Dressing ◽  
Mesoporous Silica Nanoparticles ◽  
Healing Process ◽  
Antibacterial Properties ◽  
Release Time ◽  
Wound Healing Process ◽  
Zno Nps ◽  
And Control ◽  
Scanning Electron

Hydrogels are biocompatible and swollen materials that have been used as a wound dressing for years. Among them, chitosan-based hydrogels have become popular in the wound healing process owing to their low toxic, biocompatible, biodegradable, antibacterial properties. Chitosan (CS) has been used either as a pure form or incorporated with polymers or nanoparticles to increase antimicrobial activity and stability. In this context, zinc oxide nanoparticles (ZnO NPs) have been used to enhance antibacterial activity and mesoporous silica nanoparticles (MSN) have been employed to develop mechanical strength and control of drug release time. In this study, we report the synthesis and fully characterizations of ZnO NPs, MSN and the hydrogel by using dynamic light scattering (DLS), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR). We have also prepared and characterized chitosan-based hydrogels functionalized by MSNs and ZnO NPs.

Evaluating the antibacterial properties of chitosan fibres embedded with copper ions for wound dressing applications

2013 ◽  
Vol 44 (2) ◽  
pp. 232-244 ◽  
Author(s):  
John Barnabas ◽  
Mohsen Miraftab ◽  
Yimin Qinand ◽  
Zhu Changjun
Keyword(s):  
Wound Dressing ◽  
Copper Ions ◽  
Antibacterial Properties

scholarly journals Antibacterial-Integrated Collagen Wound Dressing for Diabetes-Related Foot Ulcers: An Evidence-Based Review of Clinical Studies

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2168
Author(s):  
Ibrahim N. Amirrah ◽  
Mohd Farhanulhakim Mohd Razip Wee ◽  
Yasuhiko Tabata ◽  
Ruszymah Bt Hj Idrus ◽  
Abid Nordin ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Trials ◽  
Clinical Studies ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Gentian Violet ◽  
Antibacterial Properties ◽  
Small Sample ◽  
Wound Dressings ◽  
Sample Sizes

Diabetic foot ulcer (DFU) is a chronic wound frequently delayed from severe infection. Wound dressing provides an essential barrier between the ulcer and the external environment. This review aimed to analyse the effectiveness of antibacterial collagen-based dressing for DFU treatment in a clinical setting. An electronic search in four databases, namely, Scopus, PubMed, Ovid MEDLINE(R), and ISI Web of Science, was performed to obtain relevant articles published within the last ten years. The published studies were included if they reported evidence of (1) collagen-based antibacterial dressing or (2) wound healing for diabetic ulcers, and (3) were written in English. Both randomised and non-randomised clinical trials were included. The search for relevant clinical studies (n) identified eight related references discussing the effectiveness of collagen-based antibacterial wound dressings for DFU comprising collagen impregnated with polyhexamethylene biguanide (n = 2), gentamicin (n = 3), combined-cellulose and silver (n = 1), gentian violet/methylene blue mixed (n = 1), and silver (n = 1). The clinical data were limited by small sample sizes and multiple aetiologies of chronic wounds. The evidence was not robust enough for a conclusive statement, although most of the studies reported positive outcomes for the use of collagen dressings loaded with antibacterial properties for DFU wound healing. This study emphasises the importance of having standardised clinical trials, larger sample sizes, and accurate reporting for reliable statistical evidence confirming DFU treatment efficiency.

Studies of mechanical properties of electrospun zein/poly(ɛ-caprolactone) composites and antibacterial properties against Listeria monocytogenes strains of zein/poly(ɛ-caprolactone)/ poly(ɛ-lysine) films

2017 ◽  
Vol 88 (24) ◽  
pp. 2800-2809 ◽  
Author(s):  
Xiyu Hu ◽  
Liang liang Yang ◽  
Kaijun Wang ◽  
Yanli Zixuan Wei ◽  
Hongwu Deng ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Listeria Monocytogenes ◽  
Wound Dressing ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
Mechanical Analysis ◽  
Hydrophilic Surface ◽  
Packing Materials ◽  
Antimicrobial Films ◽  
Scanning Electron

Ultra-fine fibers of zein/poly(ɛ-caprolactone) (PCL) composites were prepared by oriented electrospun technology to enhance the toughness and ductility of zein. The mechanical, morphological and thermal properties of fibrous films of zein/PCL were studied by texture analysis and nanoindentation tests, scanning electron microscopy and dynamic mechanical analysis. Wettability of fibrous films was also measured and discussed. The mechanical properties of these fibrous films were significantly improved with the addition of PCL. Research on the antibacterial activities of poly(ɛ-lysine) (EPL) loaded films of zein/PCL/poly(ɛ-lysine) shows that the films could inhibit the growth of Listeria monocytogenes. Films of zein/PCL blend systems with a hydrophilic surface do not dissolve in water and have excellent toughness and ductility. This is very favorable for applications in biodegradable materials, food packing materials, facial masks and as antimicrobial films for wound dressing.

Bacterial cellulose-MMTs nanoreinforced composite films: novel wound dressing material with antibacterial properties

Cellulose ◽  
2012 ◽  
Vol 20 (2) ◽  
pp. 589-596 ◽  
Author(s):  
Mazhar Ul-Islam ◽  
Taous Khan ◽  
Waleed Ahmad Khattak ◽  
Joong Kon Park
Keyword(s):  
Bacterial Cellulose ◽  
Wound Dressing ◽  
Composite Films ◽  
Antibacterial Properties

Feasibility study of an active wound dressing based on hollow fiber membranes in a porcine wound model

Burns ◽  
2015 ◽  
Vol 41 (4) ◽  
pp. 778-788 ◽  
Author(s):  
Jörn Plettig ◽  
Christa M. Johnen ◽  
Kirsten Bräutigam ◽  
Fanny Knöspel ◽  
Eva C. Wönne ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Hollow Fiber ◽  
Wound Dressing ◽  
Hollow Fiber Membranes ◽  
Wound Model ◽  
Fiber Membranes

Fabrication and optimization of PCL/PVP nanofibers with Lawsonia inermis for antibacterial wound dressings

2021 ◽  
Vol 29 (9_suppl) ◽  
pp. S1403-S1413
Author(s):  
Mehdi Varsei ◽  
Nadia Rahimi Tanha ◽  
Mohsen Gorji ◽  
Saeedeh Mazinani
Keyword(s):  
Wound Dressing ◽  
Mechanical Performance ◽  
Polymer Concentration ◽  
Antibacterial Properties ◽  
Wound Dressings ◽  
Gram Negative Bacteria ◽  
Lawsonia Inermis ◽  
Accelerate Wound Healing ◽  
Hydrophobic Polymer ◽  
Surface Method

Anti-infection ability and desirable air permeability (AP) are the important aspects of wound dressings that should be regulated with regard to primary polymers and antibacterial agents. This study aims to fabricate and optimize a wound dressing with antibacterial properties. For this purpose, polycaprolactone (PCL) as a hydrophobic polymer and polyvinylpyrrolidone (PVP) as a hydrophilic polymer were electrospun with Lawsonia inermis (Henna) extract as an antibacterial component based on the experiments proposed by Design-Expert software. The morphology and properties of the wound dressing were studied by scanning electron microscopy, Fourier transform infrared, and AP. The response surface method (RSM) was used to determine the optimal fiber diameter and AP of the samples as a function of the polymer concentration and feed rate. The optimal PCL/PVL/Henna wound dressing has antibacterial properties against Gram-positive and Gram-negative bacteria while being biocompatible according to the MTT assay. These fibrous structures can be used as a wound dressing to prevent infection and accelerate wound healing; thanks to proper Henna release, breathability, swelling ratio, and mechanical performance.

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