Hepatotoxicity Induced by Subchronic Exposure of Fluoride and Chlorpyrifos in Wistar Rats: Mitigating Effect of Ascorbic Acid

2015 ◽  
Vol 166 (2) ◽  
pp. 157-162 ◽  
Author(s):  
Rajinder Raina ◽  
Naseer Ahmad Baba ◽  
Pawan K Verma ◽  
Mudasir Sultana ◽  
Maninder Singh
Keyword(s):  
Ascorbic Acid ◽  
Wistar Rats ◽  
Subchronic Exposure

Ascorbic acid improves extrapyramidal syndromes and corpus striatal degeneration induced by dopamine-2 receptor inhibition in Wistar rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Sirajo U. Mujittapha ◽  
Murtala Kauthar ◽  
Ishola O. Azeez ◽  
John C. Oyem
Keyword(s):  
Ascorbic Acid ◽  
Normal Saline ◽  
Wistar Rats ◽  
Corpus Striatum ◽  
Extrapyramidal Symptoms ◽  
Motor Deficit ◽  
Cylinder Test ◽  
Extrapyramidal Syndromes ◽  
Dopamine 2 Receptor ◽  
Inhibition Group

AbstractObjectivesThe prolonged uses of fourth-generation antipsychotics have been implicated in inducing extrapyramidal syndromes characterized by the motor deficit. This was attributed to the loss of dopamine-2 receptor (D2R) signaling. However, ascorbic acid (SVCT2R stimulation) in the brain is proposed to modulate D2R activity. We, therefore, investigated the beneficial roles of ascorbic acid in improving the extrapyramidal symptoms seen in D2R loss.MethodsTwenty adult male Wistar rats of average weight 200 g were distributed randomly into four groups. The control (NS) received normal saline for 28 days, Untreated D2R inhibition group (−D2R) received normal saline for seven days and then subsequently received chlorpromazine for 21 days, D2R inhibition group treated with ascorbic acid (−D2R+SVCT2R) received chlorpromazine for 21 days and was subsequently treated with ascorbate for seven days while the withdrawal group (WG) received chlorpromazine for 21 days and subsequently received normal saline for seven days. Motor deficits were assessed using a rotarod and cylinder test. The corpus striatum was harvested, processed, and stained using H&E and Nissl stains. Cellular density was analyzed using Image J software 1.8.0.ResultsMotor deficit was observed in −D2R animals administered chlorpromazine with less improvement in WG compared to control (p<0.05) in both rotarod and cylinder test. Ascorbic acid (SVCT2R stimulation) significantly (p<0.001) improved the latency of fall and climbing attempts observed in −D2R animals. The density of basophilic trigoid bodies was significantly (p<0.001) restored in −D2R+SVCT2R group, suggesting recovery of neural activity in the corpus striatum. Moreover, the hallmarks of neuronal degeneration were less expressed in the ascorbic acid treatment groups.ConclusionsAscorbic acid putatively ameliorates extrapyramidal symptoms observed in D2R blockage by chlorpromazine in Wistar rats.

Determination of the L-ascorbic acid requirements in Wistar osteogenic disorder Shionogi rats for prolonged carcinogenesis experiments

1996 ◽  
Vol 30 (4) ◽  
pp. 337-346 ◽  
Author(s):  
S. W. Y. Chan ◽  
P. C. Reade
Keyword(s):  
Animal Model ◽  
Ascorbic Acid ◽  
Drinking Water ◽  
Normal Level ◽  
Physical Condition ◽  
Wistar Rats ◽  
Clinical Signs ◽  
Supplement Group ◽  
Palatal Mucosa

Wistar Shionogi rats of the ( od/od) substrain with the osteogenic disorder are unable to synthesize L-ascorbic acid ( L-AA) and appear to be an appropriate animal model for studying the effect of L-AA in carcinogenesis. To determine the minimal L-AA requirements of these animals for prolonged survival in a satisfactory physical condition during experimentation, four concentrations of L-AA (0.33 g/l, 0.67 g/l, 1.67 g/l and 3.33 g/l) were administered via drinking water to four groups of animals ( n=2). Their water intake per cage was recorded three times weekly and the plasma L-AA levels were determined at the start, after 2, 4, 8 and 12 weeks and at the termination of the experiment. To simulate the procedures to be undertaken in oral mucosal carcinogenesis experiments, the animals were gently restrained and a designated amount of sterile NaCl was applied to the palatal mucosa three times a week for 26 weeks. The L-AA supplement group with the lowest concentration (0.33 g/l L-AA) achieved mean plasma levels of 7 ± 1.38 μM, approximately one-eighth that of the normal level (mean plasma L-AA level in outbred Wistar rats was found to be 58 ± 3 μM) whilst those in the higher supplement group (3.33 g/l L-AA) achieved a mean of 18 ± 1.25 μM. All of the animals employed in the present study survived for 26 weeks and showed no clinical signs of L-AA deficiency during this period.

scholarly journals Histomorphological effect of ascorbic acid on mercury chloride-induced changes on the cerebellum of adult wistar rats

2014 ◽  
Vol 31 (04) ◽  
pp. 219-224 ◽  
Author(s):  
A. Ibegbu ◽  
A. Animoku Abdulrazaq ◽  
Ayuba Micheal ◽  
Brosu Daniel ◽  
A. Adamu Sadeeq ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Cerebellar Cortex ◽  
Wistar Rats ◽  
Oral Route ◽  
Mercury Chloride ◽  
Average Weight ◽  
The Central Nervous System ◽  
Living Organisms ◽  
Induced Changes ◽  
Acid Administration

Abstract Introduction. Mercury is one of the most hazardous environmental contaminants to living organisms and the central nervous system has been shown to be the main target. Objective. The present work was aimed at evaluating the effect of ascorbic acid on mercury chloride-induced changes on the cerebellar cortex of adult Wistar rats. Material and method. Thirty Wistar rats of average weight of 200g and were randomly divided into 6 groups of 5 rats each. The animals in Group 1 (control) were administered with distilled water, Groups 2 and 3 were administered with 52mg/kg and 26.25mg/kg body weight of HgCl respectively while Groups 4 and 5 were administered with 52mg/kg of HgCl and 5mg/kg of ascorbic acid and 26.25gm/kg of HgCl and 5mg/kg of ascorbic acid respectively, while Group 6 was administered with 5mg/kg of ascorbic acid. The administration was through oral route, daily for 3 weeks. Results. The result of the biochemical parameters showed a significant increase (P < 0.05) on the mean SOD and LPO values after the administration of mercury chloride and Ascorbic acid. Histological observation of the cerebellar cortex, showed normal histo-morphology in Groups 1 and 6 while, the cerebellum in Groups 2, 3, 4 and 5 showed some degenerative, necrotic and cellular changes. Conclusion. However, ascorbic acid administration has shown to ameliorate the induced degenerative changes in the cerebellum caused by mercury chloride toxicity in Wistar rats.

scholarly journals Deltamethrin and Permethrin in the liver and heart of Wistar rats submitted to oral subchronic exposure

2011 ◽  
Vol 22 (5) ◽  
pp. 891-896 ◽  
Author(s):  
Mônica A. T Santos ◽  
Marili V. N Rodrigues ◽  
Miguel A Áreas ◽  
Felix G. R Reyes
Keyword(s):  
Wistar Rats ◽  
Subchronic Exposure

Evaluation of oxidative stress and its modulation by L-Arginine and L-Ascorbic acid in repetitive restraint stress model in Wistar rats

2020 ◽  
Vol 17 ◽  
pp. 100172
Author(s):  
Giridhari Pal ◽  
Tapan Behl ◽  
Vishwajeet Rohil ◽  
Mimansa Khandelwal ◽  
Garima Gupta ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Restraint Stress ◽  
Wistar Rats ◽  
Stress Model

scholarly journals Local treatment with ascorbic acid accelerates recovery of post-sutured Achilles tendon in male Wistar rats

2019 ◽  
Vol 52 (9) ◽  
Author(s):  
M. Souza ◽  
S.A.S. Moraes ◽  
D.R. de Paula ◽  
A.A. Maciel ◽  
E.J.O. Batista ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Achilles Tendon ◽  
Wistar Rats ◽  
Local Treatment ◽  
Male Wistar Rats

Preventive activity of ascorbic acid on lead acetate induced cerebellar damaged in adult Wistar rats

2012 ◽  
Vol 13 (4) ◽  
pp. 99-104 ◽  
Author(s):  
Sunday Abraham Musa ◽  
Iliyasu, Musa Omoniye ◽  
Wilson Oliver Hamman ◽  
Augustine Oseloka Ibegbu ◽  
Uduak Emmanuel Umana
Keyword(s):  
Ascorbic Acid ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Preventive Activity

Effects of the subchronic exposure to an organomodified clay mineral for food packaging applications on Wistar rats

2014 ◽  
Vol 95 ◽  
pp. 37-40 ◽  
Author(s):  
Sara Maisanaba ◽  
Daniel Gutiérrez-Praena ◽  
María Puerto ◽  
Rosario Moyano ◽  
Alfonso Blanco ◽  
...  
Keyword(s):  
Clay Mineral ◽  
Food Packaging ◽  
Wistar Rats ◽  
Subchronic Exposure

scholarly journals Comparative studies on the hypercholesterolaemia induced by excess dietary tyrosine or polychlorinated biphenyls in rats

1986 ◽  
Vol 56 (2) ◽  
pp. 509-517 ◽  
Author(s):  
Sahoshi Nagaoka ◽  
Mitsuhiro Kato ◽  
Yoritaka Aoyama ◽  
Akira Yoshida†
Keyword(s):  
Ascorbic Acid ◽  
Polychlorinated Biphenyls ◽  
Comparative Studies ◽  
Wistar Rats ◽  
Serum Levels ◽  
Liver Lipids ◽  
Male Wistar Rats

1. The effects of dietary polychlorinated biphenyls (PCB) and excess tyrosine on serum and liver lipids, urinary ascorbic acid and catecholamines were compared in male Wistar rats.2. Serum levels of cholesterol, urinary ascorbic acid, norepinephrine, epinephrine, dopamine and histamine were significantly increased in rats given either PCB or excess tyrosine.3. The hypercholesterolaemia induced by PCB or excess tyrosine was blocked by the adrenergic α-blocker, phenoxybenzamine.4. The present results suggest causal interrelations between the hypercholesterolaemia induced by dietary PCB or excess tyrosine and the secretion of catecholamines.

scholarly journals The effect of ascorbic acid on mercury-induced changes on the histomorphology of the cerebellum of adult wistar rats

2014 ◽  
Vol 3 (9) ◽  
pp. 9-15
Author(s):  
AO Ibegbu ◽  
AA Animoku ◽  
M, Ayuba ◽  
D Brosu ◽  
SA Adamu ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Wistar Rats ◽  
Induced Changes
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