Assessment of Titanium Dioxide Nanoparticles (TiO2-NPs) Induced Hepatotoxicity and Ameliorative Effects of Cinnamomum cassia in Sprague-Dawley Rats

High salt levels are one of the significant and major limiting factors on crop yield and productivity. Out of the available attempts made against high salt levels, engineered nanoparticles (NPs) have been widely employed and considered as effective strategies in this regard. Of these NPs, titanium dioxide nanoparticles (TiO2 NPs) and selenium functionalized using chitosan nanoparticles (Cs–Se NPs) were applied for a quite number of plants, but their potential roles for alleviating the adverse effects of salinity on stevia remains unclear. Stevia (Stevia rebaudiana Bertoni) is one of the reputed medicinal plants due to their diterpenoid steviol glycosides (stevioside and rebaudioside A). For this reason, the current study was designed to investigate the potential of TiO2 NPs (0, 100 and 200 mg L−1) and Cs–Se NPs (0, 10 and 20 mg L−1) to alleviate salt stress (0, 50 and 100 mM NaCl) in stevia. The findings of the study revealed that salinity decreased the growth and photosynthetic traits but resulted in substantial cell damage through increasing H2O2 and MDA content, as well as electrolyte leakage (EL). However, the application of TiO2 NPs (100 mg L−1) and Cs–Se NPs (20 mg L−1) increased the growth, photosynthetic performance and activity of antioxidant enzymes, and decreased the contents of H2O2, MDA and EL under the saline conditions. In addition to the enhanced growth and physiological performance of the plant, the essential oil content was also increased with the treatments of TiO2 (100 mg L−1) and Cs–Se NPs (20 mg L−1). In addition, the tested NPs treatments increased the concentration of stevioside (in the non-saline condition and under salinity stress) and rebaudioside A (under the salinity conditions) in stevia plants. Overall, the current findings suggest that especially 100 mg L−1 TiO2 NPs and 20 mg L−1 Cs–Se could be considered as promising agents in combating high levels of salinity in the case of stevia.

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Impact of titanium dioxide nanoparticles on intestinal community in the 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced acute colitis mice and the intervention effect of vitamin E

Nanoscale ◽

10.1039/d0nr08106j ◽

2020 ◽

Author(s):

Yanjun Gao ◽

Tingyu Li ◽

Shuming Duan ◽

Lizhi Lv ◽

Yuan Li ◽

...

Keyword(s):

Antibacterial Activity ◽

Titanium Dioxide ◽

Vitamin E ◽

Titanium Dioxide Nanoparticles ◽

Trinitrobenzenesulfonic Acid ◽

Acute Colitis ◽

Intervention Effect ◽

Tio2 Nps

Titanium dioxide nanoparticles (TiO2-NPs) is widely applicated as additives in foods for its excellent whitening and brightening capability. Although the toxicity and antibacterial activity of TiO2-NPs has been extensively studied,...

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A Coronopus didymus based eco-benign synthesis of Titanium dioxide nanoparticles (TiO2 NPs) with enhanced photocatalytic and biomedical applications

Inorganic Chemistry Communications ◽

10.1016/j.inoche.2021.109179 ◽

2021 ◽

pp. 109179

Author(s):

Khalil ur Rehman ◽

Umber Zaman ◽

Kamran Tahir ◽

Dilfaraz Khan ◽

Noor Saeed Khattak ◽

...

Keyword(s):

Titanium Dioxide ◽

Biomedical Applications ◽

Titanium Dioxide Nanoparticles ◽

Tio2 Nps ◽

Benign Synthesis

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Cinnamomum cassia ameliorates Ni-NPs-induced liver and kidney damage in male Sprague Dawley rats

Human & Experimental Toxicology ◽

10.1177/0960327120930125 ◽

2020 ◽

Vol 39 (11) ◽

pp. 1565-1581

Author(s):

S Iqbal ◽

F Jabeen ◽

C Peng ◽

MU Ijaz ◽

AS Chaudhry

Keyword(s):

Dependent Manner ◽

Sprague Dawley ◽

Cinnamomum Cassia ◽

Preliminary Information ◽

Sprague Dawley Rats ◽

Liver And Kidney ◽

Altered Blood ◽

Biochemical Analyses ◽

Dose Dependent ◽

Different Doses

Nickel nanoparticles (Ni-NPs) have been widely used in various industries related to electronics, ceramics, textiles, and nanomedicine. Ambient and occupational exposure to Ni-NPs may bring about potential detrimental effects on animals and humans. Thus, there is a growing effort to identify compounds that can ameliorate NPs-associated pathophysiologies. The present study examined Cinnamomum cassia ( C. cassia) bark extracts (CMBE) for its ameliorative activity against Ni-NPs-induced pathophysiological and histopathological alterations in male Sprague Dawley rats. The biochemical analyses revealed that dosing rats with Ni-NPs at 10 mg/kg/body weight (b.w.) significantly altered the normal structural and biochemical adaptations in the liver and kidney. Conversely, supplementations with CMBE at different doses (225, 200, and 175 mg/kg/b.w. of rat) ameliorated the altered blood biochemistry and reduced the biomarkers of liver and kidney function considerably ( p < 0.05) in a dose-dependent manner. However, the best results were at 225 mg/kg/b.w. of rat. The study provided preliminary information about the protective effect of C. cassia against Ni-NPs indicated liver and kidney damages. Future investigations are needed to explore C. cassia mechanism of action and isolation of single constituents of C. cassia to assess their pharmaceutical importance accordingly.

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Impact of Titanium Dioxide Nanoparticles on Cd Phytotoxicity and Bioaccumulation in Rice (Oryza sativa L.)

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17092979 ◽

2020 ◽

Vol 17 (9) ◽

pp. 2979 ◽

Cited By ~ 2

Author(s):

Wei Zhang ◽

Jinghua Long ◽

Jianmin Geng ◽

Jie Li ◽

Zhongyi Wei

Keyword(s):

Titanium Dioxide ◽

Oryza Sativa ◽

Plant Height ◽

Oryza Sativa L ◽

Titanium Dioxide Nanoparticles ◽

Engineered Nanoparticles ◽

Control Treatment ◽

Booting Stage ◽

Tio2 Nps ◽

The Impact

The impact of engineered nanoparticles (ENPs) on the migration and toxicity of coexisting pollutants is still unclear, especially in soil media. This study aims to evaluate the impact of titanium dioxide nanoparticles (TiO2 NPs) on the phytotoxicity of cadmium (Cd) to Oryza sativa L., and the migration of cadmium (Cd) in the soil-rice system. Three different Cd stress groups (C1 group: 1.0 mg kg−1, C2 group: 2.5 mg kg−1 and C3 group: 5.0 mg kg−1) were set in the pot experiment, and the target concentration of TiO2 NPs in each group were 0 mg kg−1 (T0), 50 mg kg−1 (T1), 100 mg kg−1 (T2) and 500 mg kg−1 (T3). Plant height and biomass decreased with the increasing of Cd content in paddy soil. TiO2 NPs could lower the phytotoxicity of Cd in terms of the changes in the morphological and biochemical characteristics, especially in the tillering and booting stage. In the tillering stage, TiO2 NPs addition caused a significant increase in plant height, biomass and the total chlorophyll content in the leaves of Oryza saliva L. In the booting stage, TiO2 NPs addition caused a 15% to 32% and 24% to 48% reduction of malondialdehyde (MDA) content for the C2 and C3 group, respectively, compared to that of the respective control treatment (T0). TiO2-NPs addition reduced the activity of peroxidase (POD) in the leaves in the booting and heading stage, and the activity of catalase (CAT) in the tillering stage. In the C1 and C2 group, the grain Cd content in the 100 and 500 mg kg−1 TiO2 NPs treatments reached 0.47–0.84 mg kg−1, obviously higher than that of the treatment without TiO2 NPs (0.27–0.32 mg kg−1), suggesting that TiO2-NPs could promote Cd migration in the soil-rice system.

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