Single-nucleotide polymorphisms in peroxisome proliferator-activated receptor γ and their association with plasma levels of resistin and the metabolic syndrome in a South Indian population

2009 ◽  
Vol 34 (3) ◽  
pp. 405-414 ◽  
Author(s):  
Abdul Haseeb ◽  
Mohammad Iliyas ◽  
Subhabrata Chakrabarti ◽  
Arif A. Farooqui ◽  
Sudhir R. Naik ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Plasma Levels ◽  
Indian Population ◽  
Peroxisome Proliferator ◽  
South Indian Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Peroxisome Proliferator Activated Receptor ◽  
The Metabolic Syndrome ◽  
South Indian

scholarly journals Screening of Peroxisome Proliferator-activated Receptors (PPARs) α, γ and δ Gene Polymorphisms for Obesity and Metabolic Syndrome Association in the Multi-ethnic Malaysian Population

2015 ◽  
Vol 25 (4) ◽  
pp. 383 ◽  
Author(s):  
Phee-Phee Chia ◽  
Sook-Ha Fan ◽  
Yee-How Say
Keyword(s):  
Metabolic Syndrome ◽  
Demographic Data ◽  
Plasma Lipid ◽  
Peroxisome Proliferator ◽  
Nucleotide Polymorphisms ◽  
Ethnic Population ◽  
Single Nucleotide ◽  
Peroxisome Proliferator Activated Receptor ◽  
Ethnic Chinese ◽  
Peroxisome Proliferator Activated Receptors

<p class="Pa7"><strong>Objective: </strong>This study aimed to investigate the association of peroxisome proliferator-activated receptor (PPAR) genes <em>PPAR</em>α L162V, <em>PPAR</em><em>γ</em><em>2 </em>C161T and <em>PPAR</em><em>δ </em>T294C single nucleotide polymorphisms (SNPs) with obesity and metabolic syndrome (Met- S) in a multi-ethnic population in Kampar, Malaysia.</p><p class="Pa7"><strong>Methods: </strong>Socio-demographic data, anthropometric and biochemical measure­ments (plasma lipid profile, adiponectin and interleukin-6 [IL-6] levels) were taken from 307 participants (124 males; 180 obese; 249 Met-S; 97 Malays, 85 ethnic Chinese, 55 ethnic Indians).</p><p class="Pa7"><strong>Results: </strong>The overall minor allele frequen­cies were .08, .22 and .30 for <em>PPAR </em>α L162V, γ C161T, δ T294C, respectively. All SNPs were not associated with obesity, Met-S and obesity with/without Met-S by χ2 analysis, ethnicity-stratified and logistic re­gression analyses. Nevertheless, participants with V162 allele of <em>PPAR</em><em>α </em>had significantly higher IL-6, while those with T161 allele of <em>PPAR</em><em>γ</em><em>2 </em>had significantly lower HOMA-IR.</p><p><strong>Conclusions: </strong>All <em>PPAR </em>SNPs were not associated with obesity and Met-S in the suburban population of Kampar, Malay­sia, where only <em>PPAR</em><em>α </em>V162 and <em>PPAR</em><em>γ</em><em>2 </em>T161 alleles were associated with plasma IL-6 and HOMA-IR, respectively. <em>Ethn Dis. </em>2015;25(4):383-390; doi:10.18865/ ed.25.4.383</p>

scholarly journals Effects of the PPARG Gene Polymorphisms on Markers of Obesity and the Metabolic Syndrome in Bosnian Subjects

2014 ◽  
Vol 33 (4) ◽  
pp. 323-332 ◽  
Author(s):  
Tanja Dujić ◽  
Tamer Bego ◽  
Barbara Mlinar ◽  
Sabina Semiz ◽  
Maja Malenica ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Metabolic Phenotype ◽  
Polymorphism Analysis ◽  
Peroxisome Proliferator ◽  
Nucleotide Polymorphisms ◽  
Peroxisome Proliferator Activated Receptor ◽  
The Metabolic Syndrome ◽  
Obesity And Diabetes ◽  
Pparg Gene ◽  
Relationship Of

Summary Background: Peroxisome proliferator-activated receptor gamma (PPARg) is a key transcription factor in adipogene-sis, and also regulates a number of genes associated with lipid storage and insulin sensitivity. Single nucleotide polymorphisms (SNPs) in the PPARG gene have been associated with obesity and diabetes. In this study, we explored the relationship of three PPARG gene variants with the metabolic syndrome (MetS) and related traits in a population from Bosnia and Herzegovina. Methods: Anthropometric and biochemical parameters were measured in 43 patients with MetS and 43 healthy controls. Subjects were genotyped for Pro12Ala (rs1801282) and 1431C>T (rs3856806) SNPs by classic PCR–restriction fragment length polymorphism analysis, and for-681C>G (rs10865710) variant by real-time PCR. Results: The genotype distributions for the three polymorphisms were not significantly different between MetS patients and controls. The Pro12Ala and 1431C>T variants were associated with lower body mass index in the control subjects (p=0.012 and p=0.049, respectively). In this group, the carriers of Pro12Ala had also lower waist circumference compared to the wild-type homozygotes (p=0.045). Conclusions: Results of our preliminary study indicate a beneficial effect of a common Pro12Ala variant on the metabolic phenotype in healthy non-obese subjects.

scholarly journals Association of A1538G and C2437T single nucleotide polymorphisms in heat shock protein-70 genes with diabetic nephropathy among South Indian population

2017 ◽  
Vol 37 (2) ◽  
Author(s):  
Umapathy Dhamodharan ◽  
Krishnamoorthy Ezhilarasi ◽  
Balashanmugam Ponjayanthi ◽  
Dornadula Sireesh ◽  
Kunka Mohanram Ramkumar ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Heat Shock ◽  
Indian Population ◽  
Clinical Symptoms ◽  
Control Group ◽  
South Indian Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
South Indian ◽  
Stage Renal Disease

Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease, characterized by progressive albuminuria and conferring additional risk of cardiovascular disease (CVD) and mortality. The crucial role of heat-shock proteins (HSPs) on renal function in patients with DN has been well documented. The present study was aimed to understand the association of HSP-70 gene variants on the susceptibility of Type 2 Diabetes Mellitus (T2DM) and DN. A total of 946 subjects (549 Males; 397 Females) were recruited and divided into four groups according to the levels of urinary albumin excretion (UAE): those with normoalbuminuria (UAE <30 mg/24 h; n=230), those with microalbuminuria (30≤ UAE ≤300 mg/24 h; n=230), and those with macroalbuminuria (UAE> 300 mg/24 h; n=230). The control group randomly enrolled a consecutive population of 256 healthy subjects who had a routine medical check-up in our hospital. Those subjects had no history or clinical symptoms of diabetes. Subjects were genotyped for HSP70-2 (+1538 A/G; rs2763979) and HSP70-hom (+2437 C/T; rs2227956) by PCR-restriction fragment length polymorphism (RFLP). The ‘G’ allele of HSP70-2 (+1538 A/G) single nucleotide polymorphism (SNP) showed relative risk for normoalbuminuria, microalbuminuria and macroalbuminuria subjects whereas the ‘T’ allele of HSP70-hom (+2437 C/T) SNP showed significant protection against macroalbuminuria subjects. In conclusion, our results indicate that the HSP70-2 (+1538 A/G) and HSP70-hom (+2437 C/T) SNPs are highly associated with renal complications in T2DM among the South Indian population.

Sign in / Sign up

Export Citation Format

Share Document