scholarly journals Non-Target Detection of Diversity of Volatile Chlorine Compounds in Frying Oil and Study on the Influencing Factors of Their Formation

2021 ◽  
Author(s):  
Yaxiong Liu ◽  
Jiaxin Wen ◽  
Zhuoya Luo
Keyword(s):  
Ion Mobility ◽  
Capillary Column ◽  
Heating Temperature ◽  
Frying Oil ◽  
Negative Ion ◽  
Deep Frying ◽  
Study Results ◽  
Headspace Gas ◽  
Negative Ion Mode ◽  
Work First

AbstractHeadspace-gas-chromatography ion-mobility spectrometry (HS-GC-IMS) proved the diversity of volatile chlorinated compounds (VCCs) in frying oil in this work. First, the VCCs were obtained by headspace by heating the frying oil at 80 °C for 30 min. Then, those compounds were separated by GC capillary column in the first dimension and by IMS in the second dimension, respectively. And at last, those compounds were detected in negative ion mode for non-targeting. The study results indicated that VCCs' formation depends on the contents of NaCl and water, heating temperature and time, and the types of oil. The refining process does not affect the detection of VCCs, indicating the durability of such targets as indicators for assessing deep-frying oil. Using HS-GC-IMS, the VCCs were detected to evaluate 16 authentic refined deep-frying oils from the market with an accuracy of 100%.

scholarly journals Fast Sensing of Hydrogen Cyanide (HCN) Vapors Using a Hand-Held Ion Mobility Spectrometer with Nonradioactive Ionization Source

Sensors ◽  
2021 ◽  
Vol 21 (15) ◽  
pp. 5045
Author(s):  
Victor Bocos-Bintintan ◽  
Ileana Andreea Ratiu
Keyword(s):  
Ion Mobility ◽  
Hydrogen Cyanide ◽  
Limit Of Detection ◽  
Chemical Warfare Agent ◽  
Source Model ◽  
Negative Ion ◽  
Industrial Chemicals ◽  
Ionization Source ◽  
Toxic Industrial Chemicals ◽  
Negative Ion Mode

Sensitive real-time detection of vapors produced by toxic industrial chemicals (TICs) always represents a stringent priority. Hydrogen cyanide (HCN) is definitely a TIC, being widely used in various industries and as an insecticide; it is a reactive, very flammable, and highly toxic compound that affects the central nervous system, cardiovascular system, eyes, nose, throat, and also has systemic effects. Moreover, HCN is considered a blood chemical warfare agent. This study was focused toward quick detection and quantification of HCN in air using time-of-flight ion mobility spectrometry (ToF IMS). Results obtained clearly indicate that IMS can rapidly detect HCN at sub-ppmv levels in air. Ion mobility spectrometric response was obtained in the negative ion mode and presented one single distinct product ion, at reduced ion mobility K0 of 2.38 cm2 V−1 s−1. Our study demonstrated that by using a miniaturized commercial IMS system with nonradioactive ionization source model LCD-3.2E (Smiths Detection Ltd., London, UK), one can easily measure HCN at concentrations of 0.1 ppmv (0.11 mg m−3) in negative ion mode, which is far below the OSHA PEL-TWA value of 10 ppmv. Measurement range was from 0.1 to 10 ppmv and the estimated limit of detection LoD was ca. 20 ppbv (0.02 mg m−3).

scholarly journals Sensing Precursors of Illegal Drugs—Rapid Detection of Acetic Anhydride Vapors at Trace Levels Using Photoionization Detection and Ion Mobility Spectrometry

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1852
Author(s):  
Victor Bocos-Bintintan ◽  
George-Bogdan Ghira ◽  
Mircea Anton ◽  
Aurel-Vasile Martiniuc ◽  
Ileana-Andreea Ratiu
Keyword(s):  
Acetic Anhydride ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Operation Mode ◽  
Analytical Techniques ◽  
Negative Ion ◽  
Illegal Drugs ◽  
Product Ions ◽  
Ultra Trace ◽  
Negative Ion Mode

Sensitive real-time detection of vapors produced by the precursors, reagents and solvents used in the illegal drugs manufacture represents a priority nowadays. Acetic anhydride (AA) is the key chemical used as acetylation agent in producing the illegal drugs heroin and methaqualone. This study was directed towards quick detection and quantification of AA in air, using two fast and very sensitive analytical techniques: photoionization detection (PID) and ion mobility spectrometry (IMS). Results obtained indicated that both PID and IMS can sense AA at ultra-trace levels in air, but while PID produces a non-selective response, IMS offers richer information. Ion mobility spectrometric response in the positive ion mode presented one product ion, at reduced ion mobility K0 of 1.89 cm2 V−1 s−1 (almost overlapped with positive reactant ion peak), while in the negative ion mode two well separated product ions, with K0 of 1.90 and 1.71 cm2 V−1 s−1, were noticed. Our study showed that by using a portable, commercial IMS system (model Mini IMS, I.U.T. GmbH Berlin) AA can be easily measured at concentrations of 0.05 ppmv (0.2 mg m−3) in negative ion mode. Best selectivity and sensitivity of the IMS response were therefore achieved in the negative operation mode.

scholarly journals Hunting for Toxic Industrial Chemicals: Real-Time Detection of Carbon Disulfide Traces by Means of Ion Mobility Spectrometry

Toxics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 121
Author(s):  
Victor Bocos-Bintintan ◽  
Ileana Andreea Ratiu
Keyword(s):  
Real Time ◽  
Carbon Disulfide ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Limit Of Detection ◽  
Negative Ion ◽  
Industrial Chemicals ◽  
Toxic Industrial Chemicals ◽  
Real Time Detection ◽  
Negative Ion Mode

Sensitive real-time detection of vapors produced by toxic industrial chemicals (TICs) represents a stringent priority nowadays. Carbon disulfide (CS2) is such a chemical, being widely used in manufacturing synthetic textile fibers and as a solvent. CS2 is simultaneously a very reactive, highly flammable, irritant, corrosive, and highly toxic compound, affecting the central nervous system, cardiovascular system, eyes, kidneys, liver, skin, and reproductive system. This study was directed towards quick detection and quantification of CS2 in air, using time-of-flight ion mobility spectrometry (IMS); photoionization detection (PID) was also used as confirmatory technique. Results obtained indicated that IMS can detect CS2 at trace levels in air. The ion mobility spectrometric response was in the negative ion mode and presented one product ion, at a reduced ion mobility (K0) of 2.25 cm2 V−1 s−1. Our study demonstrated that by using a portable, commercial IMS system (model Mini IMS, I.U.T. GmbH Berlin Germany) one can easily measure CS2 at concentrations of 0.1 ppmv (0.3 mg m−3) in the negative ion mode, which is below the lowest threshold value of 1 ppmv given for industrial hygiene. A limit of detection (LOD) of ca. 30 ppbv (0.1 mg m−3) was also estimated.

scholarly journals MALDI-ion mobility mass spectrometry of lipids in negative ion mode

2014 ◽  
Vol 6 (14) ◽  
pp. 5001-5007 ◽  
Author(s):  
Shelley N. Jackson ◽  
Damon Barbacci ◽  
Thomas Egan ◽  
Ernest K. Lewis ◽  
J. Albert Schultz ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Negative Ion ◽  
Ion Mobility Mass Spectrometry ◽  
Maldi Imaging ◽  
Mobility Separation ◽  
Ion Mobility Separation ◽  
Negative Ion Mode

Ion mobility separation of two lipids prior to MALDI imaging.

Characterization of Tear Gas Residues by Ion Mobility Spectrometry

1997 ◽  
Vol 51 (12) ◽  
pp. 1880-1889 ◽  
Author(s):  
Graeme Allinson ◽  
Cameron W. McLeod
Keyword(s):  
Ambient Temperature ◽  
Ion Mobility ◽  
Degradation Products ◽  
Negative Ion ◽  
Ion Mobility Spectrometer ◽  
Relative Standard ◽  
Acquisition Mode ◽  
Tear Gas ◽  
Negative Ion Mode

In this study a hand-held ion mobility spectrometer was used to characterize the vapors produced by α-chloroacetophenone (CN) and 2-chlorobenzylidenemalononitrile (CS), their isomers, and then-degradation products at ambient temperature and 50 °C, and in both the positive- and negative-ion acquisition modes. Minimum determinable residues were as follows: in the negative-ion acquisition mode at ambient temperature, CN 0.5 μg, CS 10 mg; at 50 °C, CN 0.5 μg, CS 16 μg; and in the positive-ion acquisition mode at ambient temperature, CN 0.5 μg, CS not detected; at 50 °C, CN 0.1 μg, CS not detected. The steady-state reproducibility was found to be independent of ion acquisition mode but dependent on signal intensity and background noise [relative standard deviation (RSD) 3–17%]—the smaller the signal, the greater the variation. The day-to-day variation in positive- and negative-mode signal intensities showed the same trends (RSD 3–33%). By comparing positive- and negative-ion mode spectra, it was possible to differentiate not only between CN and CS but also between their isomers and breakdown products.

scholarly journals Headspace analyses using multi-capillary column-ion mobility spectrometry allow rapid pathogen differentiation in hospital-acquired pneumonia relevant bacteria

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nils Kunze-Szikszay ◽  
Maximilian Euler ◽  
Martin Kuhns ◽  
Melanie Thieß ◽  
Uwe Groß ◽  
...  
Keyword(s):  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Capillary Column ◽  
Bacterial Species ◽  
Klebsiella Oxytoca ◽  
Negative Ion ◽  
Species Differentiation ◽  
Microbiological Methods ◽  
Hospital Acquired Pneumonia ◽  
Hospital Acquired

Abstract Background Hospital-acquired pneumonia (HAP) is a common problem in intensive care medicine and the patient outcome depends on the fast beginning of adequate antibiotic therapy. Until today pathogen identification is performed using conventional microbiological methods with turnaround times of at least 24 h for the first results. It was the aim of this study to investigate the potential of headspace analyses detecting bacterial species-specific patterns of volatile organic compounds (VOCs) for the rapid differentiation of HAP-relevant bacteria. Methods Eleven HAP-relevant bacteria (Acinetobacter baumanii, Acinetobacter pittii, Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Staphylococcus aureus, Serratia marcescens) were each grown for 6 hours in Lysogeny Broth and the headspace over the grown cultures was investigated using multi-capillary column-ion mobility spectrometry (MCC-IMS) to detect differences in the VOC composition between the bacteria in the panel. Peak areas with changing signal intensities were statistically analysed, including significance testing using one-way ANOVA or Kruskal-Wallis test (p < 0.05). Results 30 VOC signals (23 in the positive ion mode and 7 in the negative ion mode of the MCC-IMS) showed statistically significant differences in at least one of the investigated bacteria. The VOC patterns of the bacteria within the HAP panel differed substantially and allowed species differentiation. Conclusions MCC-IMS headspace analyses allow differentiation of bacteria within HAP-relevant panel after 6 h of incubation in a complex fluid growth medium. The method has the potential to be developed towards a feasible point-of-care diagnostic tool for pathogen differentiation on HAP.

Collision cross section calibrants for negative ion mode traveling wave ion mobility-mass spectrometry

The Analyst ◽  
2015 ◽  
Vol 140 (20) ◽  
pp. 6853-6861 ◽  
Author(s):  
Jay G. Forsythe ◽  
Anton S. Petrov ◽  
Chelsea A. Walker ◽  
Samuel J. Allen ◽  
Jarrod S. Pellissier ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cross Section ◽  
Ion Mobility ◽  
Traveling Wave ◽  
Collision Cross Section ◽  
Negative Ion ◽  
Ion Mobility Mass Spectrometry ◽  
Negative Mode ◽  
Negative Ion Mode ◽  
Traveling Wave Ion Mobility

Introduction of a novel negative mode calibrant and evaluation of calibration strategies for TWIM CCS determination.

Confounding contaminants in mass spectrometric reaction monitoring

2018 ◽  
Author(s):  
Gilian T. Thomas ◽  
Landon MacGillivray ◽  
Natalie L. Dean ◽  
Rhonda L. Stoddard ◽  
Lars Yunker ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometric ◽  
Negative Ion ◽  
Reaction Monitoring ◽  
Schlenk Flask ◽  
Dynamic Analyses ◽  
Rubber Septa ◽  
Negative Ion Mode ◽  
Mode A

<p>Reactions carried out in the presence of rubber septa run the risk of additives being leached out by the solvent. Normally, such species are present at low enough levels that they do not interfere with the reaction significantly. However, when studying reactions using sensitive methods such as mass spectrometry, the appearance of even trace amounts of material can confuse dynamic analyses of reactions. A wide variety of additives are present in rubber along with the polymer: antioxidants, dyes, detergent, and vulcanization agents, and these are all especially problematic in negative ion mode. A redesigned Schlenk flask for pressurized sample infusion (PSI) is presented as a means of practically eliminating the presence of contaminants during reaction analyses.</p>

scholarly journals Dopant-Enriched Nitrogen Gas for Enhanced Electrospray Ionization of Released Glycans in Negative Ion Mode

2021 ◽  
Author(s):  
Katarina Madunić ◽  
Sander Wagt ◽  
Tao Zhang ◽  
Manfred Wuhrer ◽  
Guinevere S.M. Lageveen-Kammeijer
Keyword(s):  
Electrospray Ionization ◽  
Negative Ion ◽  
Nitrogen Gas ◽  
Negative Ion Mode

scholarly journals Identification of N-glycans with GalNAc-containing antennae from recombinant HIV trimers by ion mobility and negative ion fragmentation

2021 ◽  
Author(s):  
David J. Harvey ◽  
Anna-Janina Behrens ◽  
Max Crispin ◽  
Weston B. Struwe
Keyword(s):  
Cross Sections ◽  
Ion Mobility ◽  
Travelling Wave ◽  
Negative Ion ◽  
Ion Fragmentation ◽  
Structural Identity ◽  
Immunodeficiency Virus ◽  
Different Types ◽  
Complex Glycans ◽  
Ion Collision

AbstractNegative ion collision-induced dissociation (CID) of underivatized N-glycans has proved to be a simple, yet powerful method for their structural determination. Recently, we have identified a series of such structures with GalNAc rather than the more common galactose capping the antennae of hybrid and complex glycans. As part of a series of publications describing the negative ion fragmentation of different types of N-glycan, this paper describes their CID spectra and estimated nitrogen cross sections recorded by travelling wave ion mobility mass spectrometry (TWIMS). Most of the glycans were derived from the recombinant glycoproteins gp120 and gp41 from the human immunodeficiency virus (HIV), recombinantly derived from human embryonic kidney (HEK 293T) cells. Twenty-six GalNAc-capped hybrid and complex N-glycans were identified by a combination of TWIMS, negative ion CID, and exoglycosidase digestions. They were present as the neutral glycans and their sulfated and α2→3-linked sialylated analogues. Overall, negative ion fragmentation of glycans generates fingerprints that reveal their structural identity.

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