Cervical cancer prognosis using genetic algorithm and adaptive boosting approach

2019 ◽  
Vol 9 (5) ◽  
pp. 877-886 ◽  
Author(s):  
Manoj Sharma
Keyword(s):  
Genetic Algorithm ◽  
Cervical Cancer ◽  
Cancer Prognosis ◽  
Adaptive Boosting

scholarly journals Immunogenomic Identification for Predicting the Prognosis of Cervical Cancer Patients

2021 ◽  
Vol 22 (5) ◽  
pp. 2442
Author(s):  
Qun Wang ◽  
Aurelia Vattai ◽  
Theresa Vilsmaier ◽  
Till Kaltofen ◽  
Alexander Steger ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Clinical Data ◽  
Regulatory Network ◽  
Univariate Analysis ◽  
Predictive Biomarkers ◽  
Enrichment Analysis ◽  
The Cancer Genome Atlas ◽  
Cancer Prognosis ◽  
Functional Enrichment ◽  
Wilcoxon Test

Cervical cancer is primarily caused by the infection of high-risk human papillomavirus (hrHPV). Moreover, tumor immune microenvironment plays a significant role in the tumorigenesis of cervical cancer. Therefore, it is necessary to comprehensively identify predictive biomarkers from immunogenomics associated with cervical cancer prognosis. The Cancer Genome Atlas (TCGA) public database has stored abundant sequencing or microarray data, and clinical data, offering a feasible and reliable approach for this study. In the present study, gene profile and clinical data were downloaded from TCGA, and the Immunology Database and Analysis Portal (ImmPort) database. Wilcoxon-test was used to compare the difference in gene expression. Univariate analysis was adopted to identify immune-related genes (IRGs) and transcription factors (TFs) correlated with survival. A prognostic prediction model was established by multivariate cox analysis. The regulatory network was constructed and visualized by correlation analysis and Cytoscape, respectively. Gene functional enrichment analysis was performed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). A total of 204 differentially expressed IRGs were identified, and 22 of them were significantly associated with the survival of cervical cancer. These 22 IRGs were actively involved in the JAK-STAT pathway. A prognostic model based on 10 IRGs (APOD, TFRC, GRN, CSK, HDAC1, NFATC4, BMP6, IL17RD, IL3RA, and LEPR) performed moderately and steadily in squamous cell carcinoma (SCC) patients with FIGO stage I, regardless of the age and grade. Taken together, a risk score model consisting of 10 novel genes capable of predicting survival in SCC patients was identified. Moreover, the regulatory network of IRGs associated with survival (SIRGs) and their TFs provided potential molecular targets.

Cervical cancer prognosis in women aged 35 and younger

2013 ◽  
Vol 130 (1) ◽  
pp. e44-e45
Author(s):  
E. Pelkofski ◽  
J. Stine ◽  
N. Wages ◽  
P. Gehrig ◽  
K. Kim ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Prognosis

Pruning Adaptive Boosting Ensembles by Means of a Genetic Algorithm

2006 ◽  
pp. 322-329 ◽  
Author(s):  
Daniel Hernández-Lobato ◽  
José Miguel Hernández-Lobato ◽  
Rubén Ruiz-Torrubiano ◽  
Ángel Valle
Keyword(s):  
Genetic Algorithm ◽  
Adaptive Boosting

scholarly journals The Prognostic Significance of MAFK and its Methylation in Cervical Cancer

2021 ◽  
Author(s):  
Mengjun Zhang ◽  
Hao Li ◽  
Yuan Liu ◽  
Siyu Hou ◽  
Ping Cui ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Significance ◽  
Enrichment Analysis ◽  
The Cancer Genome Atlas ◽  
Cancer Prognosis ◽  
Aberrant Methylation ◽  
Cancer Data ◽  
Drug Candidates ◽  
Cancer Genome Atlas ◽  
Cancer Tissues

Abstract Background: The purpose of this study was to determine the value of MAFK as a biomarker of cervical cancer prognosis and to explore its methylation and possible cellular signaling pathways. Methods: We analyzed the cervical cancer data of The Cancer Genome Atlas (TCGA) through bioinformatics, including MAFK expression, methylation, prognosis and genome enrichment analysis. Results: MAFK expression was higher in cervical cancer tissues and was negatively correlated with the methylation levels of five CpG sites. MAFK is an independent prognostic factor of cervical cancer and is involved in the Nod-like receptor signaling pathway. CMap analysis screened four drug candidates for cervical cancer treatment. Conclusions: We confirmed that MAFK is a novel prognostic biomarker for cervical cancer and aberrant methylation may also affect MAFK expression and carcinogenesis. This study provides a new molecular target for the prognostic evaluation and treatment of cervical cancer.

scholarly journals Development and validation of an immune-related prognostic signature in cervical cancer

2021 ◽  
Author(s):  
Rongjia Su ◽  
Chengwen Jin ◽  
Hualei Bu ◽  
Xiaoyun Wang ◽  
Menghua Kuang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cox Regression ◽  
Clinical Information ◽  
Risk Groups ◽  
Gene Signature ◽  
Cancer Prognosis ◽  
Prognostic Signature ◽  
Cox Regression Analysis ◽  
Gynecological Malignancy ◽  
Immune Infiltration

Abstract Background Cervical cancer is the fourth most frequently gynecological malignancy across the world. Immunotherapies have proved to improve prognosis of cervical cancer. However, few studies on immune-related prognostic signature had been reported in cervical cancer. Methods Raw data and clinical information of cervical cancer samples were download from TCGA and UCSC Xena website. Immunophenoscore of immune infiltration cells in cervical cancer samples was calculated through ssGSEA method using GSVA package. WGCNA, Cox regression analysis, LASSO analysis and GSEA analysis were performed to classify cervical cancer prognosis and explore the biological signaling pathway. Results There were 8 immune infiltration cells associated with prognosis of cervical cancer. Through WGCNA, 153 genes from 402 immune-related genes were significantly correlated with prognosis of cervical cancer. A 15-gene signature demonstrated powerful predictive ability in prognosis of cervical cancer. GSEA analysis showed multiple signaling pathways containing PD-L1 expression and PD-1 checkpoint pathway differences between high risk and low risk groups. Furthermore, the 15-gene signature was associated with multiple immune cells and immune infiltration in tumor microenvironment. Conclusion The 15-gene signature is an effective potential prognostic classifier in the immunotherapies and surveillance of cervical cancer.

scholarly journals Diagnosis of breast cancer using machine learning algorithms based on features selected by Genetic Algorithm: Assessed on five datasets

2021 ◽  
Vol 23 (11) ◽  
pp. 749-758
Author(s):  
Saranya N ◽  
◽  
Kavi Priya S ◽  
Keyword(s):  
Breast Cancer ◽  
Machine Learning ◽  
Genetic Algorithm ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Cancer Prognosis ◽  
Support Vector ◽  
Breast Cancer Dataset ◽  
Human Beings ◽  
Original Dataset

Breast Cancer is one of the chronic diseases occurred to human beings throughout the world. Early detection of this disease is the most promising way to improve patients’ chances of survival. The strategy employed in this paper is to select the best features from various breast cancer datasets using a genetic algorithm and machine learning algorithm is applied to predict the outcomes. Two machine learning algorithms such as Support Vector Machines and Decision Tree are used along with Genetic Algorithm. The proposed work is experimented on five datasets such as Wisconsin Breast Cancer-Diagnosis Dataset, Wisconsin Breast Cancer-Original Dataset, Wisconsin Breast Cancer-Prognosis Dataset, ISPY1 Clinical trial Dataset, and Breast Cancer Dataset. The results exploit that SVM-GA achieves higher accuracy of 98.16% than DT-GA of 97.44%.

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