Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit α-amylase, α-glucosidase and DPP-IV activity in high fat and low dose streptozotocin-induced diabetic rat

Author(s):  
Arpita Das ◽  
J. Naveen ◽  
Y. N. Sreerama ◽  
B. S. Gnanesh Kumar ◽  
V. Baskaran
2020 ◽  
Vol 10 (4) ◽  
pp. 488-494 ◽  
Author(s):  
Venugopal Singamaneni ◽  
Sudheer Kumar Dokuparthi ◽  
Nilanjana Banerjee ◽  
Ashish Kumar ◽  
Tulika Chakrabarti

Background: Emblica officinalis Gaertn. which belongs to the family Euphorbiaceae, Terminalia chebula Retz. and Terminalia bellerica Roxb. belong to the family Combretaceae. These are well known medicinal plants with phytochemical reservoir of great medicinal values and possess a vast ethnomedical history. Objective: The aim of the present study is to isolation of major compounds and to evaluate antimutagenic potential of the ethanol extracts of these plants. Methods: The dried fruits of E. officinalis, T. bellirica and T. chebula were powdered and extracted with 95% ethanol. The ethyl acetate portions were chromatographed over silica gel to isolate major compounds. Antimutagenic activity was determined by Ames test using TA98 and TA100 strains of Salmonella typhimurium. Results: Two major known compounds, gallic acid and ellagic acid were isolated from the dried fruits of Emblica officinalis, Terminalia chebula and T. bellirica. All the three extracts counteracted the mutagenicity induced by different genotoxic compounds in a dose dependent manner. Conclusion: This study showed that ethyl acetate portion of three extracts contain two major compounds, gallic acid and ellagic acid which might be responsible for potent antimutagenic activity of these extracts.


Bone ◽  
2008 ◽  
Vol 42 ◽  
pp. S66
Author(s):  
Liping Zhang ◽  
Haiqin Rong ◽  
Hong Ji ◽  
Yaping Liu ◽  
Dong Wang

2019 ◽  
Vol 8 (1) ◽  
pp. 428-444 ◽  
Author(s):  
Nuntawat Khat‐udomkiri ◽  
Parichart Toejing ◽  
Sasithorn Sirilun ◽  
Chaiyavat Chaiyasut ◽  
Narissara Lailerd

2016 ◽  
Vol 7 (2) ◽  
Author(s):  
Griva Bhatt ◽  
Harmeet Kaur ◽  
Harisha C R ◽  
Galib Ruknuddin ◽  
Prajapati P K

Triphala is a traditional Ayurvedic herbal formulation consisting of dried pericarp of three medicinal plants Terminalia chebula Retz., Terminalia bellerica Roxb. and Emblica officinalis Gaertn. Masi (Black ash) prepared from this combination is of great use. No pharmacognostical profiles are available on Triphala Masi till date. So the same is attempted in current study. Aim: To evaluate pharmacognostical profiles of Triphala Masi prepared at three different levels of temperature. Materials and Methods: Tripahla Masi was prepared at three different levels of temperature and samples were coded as TM 1, TM 2 and TM 3 and further subjected for pharmacognostical profiles. Results: Loosened walls of epicarp cells were observed in TM 1 sample prepared at 3000C; showed that these cells sustained up to this temp. At 3500C, epicarp cells in the sample TM 2 were seen disturbed. But when heat was increased up to 4000C, only black mass was observed in TM 3 sample. Conclusion: Based on pharmacognostical observations, 4000C temperature is required for preparation of Triphala Masi.  


Author(s):  
Pundareekaksha Rao P.

Triphala is a popular polyherbal drug, which has been used to treat long list of diseases in the traditional systems from the ancient times. Acharya Charaka mentioned in his text as daily consumption of the Triphala for a period of one year, is act like Rasayana, makes a person live for hundred years. Triphala is a composite mixture of three herbs Amalaki (Emblica officinalis), Haritaki (Terminalia chebula) and Vibhitali (Terminalia belerica) also known as the ‘three myrobalans’. Emblica officinalis Gaertn. belongs to Euphorbiaceae, and Terminalia chebula Retz. Terminalia bellerica belongs to Combretaceae family. The generic name ‘Terminalia’ comes from Latin word ‘terminus’ or ‘terminalis’ (ending), and refers to the habit of the leaves being crowded or borne on the tips of the shoots. Throughout the world, there are lot of studies carried out on this, well established the knowledge and documented. Triphala is rich in Vitamin-C, gallic acid, ellagic acid, chebulic acid, bellericanin, β-sitosterol and Flavonoids etc and a potent laxative, immumo modulator, antioxidant, antimicrobial, traditionally been used in eye diseases, stress, arthritis, colon diseases, etc. Present paper deals with antioxidant effect of individual plants and its combination (Triphala).


2014 ◽  
Vol 92 (4) ◽  
pp. 338-349 ◽  
Author(s):  
Kiranj K. Chaudagar ◽  
Anita A. Mehta

Atorvastatin, a lipid lowering agent, possesses various pleiotropic vasculoprotective effects, but its role in coronary angiogenesis is still controversial. Our objective was to study the effects of atorvastatin on the angiogenic responsiveness of coronary endothelial cells (cEC) from normal and diabetic rats. Male Wistar rats were distributed among 9 groups; (i) normal rats, (ii) 30 day diabetic rats, (iii) 60 day diabetic rats, (iv) normal rats administered a low dose of atorvastatin (1 mg/kg body mass, per oral (p.o.), for 15 days); (v) 30 day diabetic rats administered a low dose of atorvastatin; (vi) 60 day diabetic rats administered a low dose of atorvastatin; (vii) normal rats administered a high dose of atorvastatin (5 mg/kg, p.o., for 15 days); (viii) 30 day diabetic rats administered a high dose of atorvastatin; (ix) 60 day diabetic rats administered a high dose of atorvastatin. Each group was further divided into 2 subgroups, (i) sham ischemia–reperfusion and (ii) rats hearts that underwent ischemia–reperfusion. Angiogenic responsiveness the and nitric oxide (NO) releasing properties of the subgroups of cECs were studied using a chorioallantoic membrane assay and the Griess method, respectively. Atorvastatin treatment significantly increased VEGF-induced angiogenic responsiveness and the NO-releasing properties of cECs from all of the subgroups, compared with their respective non-treated subgroups except for the late-phase diabetic rat hearts that underwent ischemia–reperfusion, and the high dose of atorvastatin treatment groups. These effects of atorvastatin were significantly inhibited by pretreatment of cECs with l-NAME, wortmannin, and chelerythrine. Thus, treatment with a low dose of atorvastatin improves the angiogenic responsiveness of the cECs from normal and diabetic rats, in the presence of VEGF, via activation of eNOS–NO release.


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