Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma: An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype

Oral squamous cell carcinoma (OSCC) is one of the leading presentations of head and neck cancer (HNC). The first part of this review will describe the highlights of the oral microbiome in health and normal development while demonstrating how both the oral and gut microbiome can map OSCC development, progression, treatment and the potential side effects associated with its management. We then scope the dynamics of the various microorganisms of the oral cavity, including bacteria, mycoplasma, fungi, archaea and viruses, and describe the characteristic roles they may play in OSCC development. We also highlight how the human immunodeficiency viruses (HIV) may impinge on the host microbiome and increase the burden of oral premalignant lesions and OSCC in patients with HIV. Finally, we summarise current insights into the microbiome–treatment axis pertaining to OSCC, and show how the microbiome is affected by radiotherapy, chemotherapy, immunotherapy and also how these therapies are affected by the state of the microbiome, potentially determining the success or failure of some of these treatments.

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miR-146a Overexpression in Oral Squamous Cell Carcinoma Potentiates Cancer Cell Migration and Invasion Possibly via Targeting HTT

Frontiers in Oncology ◽

10.3389/fonc.2020.585976 ◽

2020 ◽

Vol 10 ◽

Author(s):

Liping Wang ◽

Yunxin Chen ◽

Yongyong Yan ◽

Xueqi Guo ◽

Ying Fang ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Migration ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Cancer Cell ◽

Squamous Cell ◽

Migration And Invasion ◽

Cancer Cell Migration ◽

Cell Migration And Invasion

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Serum and salivary levels of lactate dehydrogenase in oral squamous cell carcinoma, oral lichen planus and oral lichenoid reaction

BMC Oral Health ◽

10.1186/s12903-020-01306-0 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Narges Gholizadeh ◽

Maryam Alipanahi Ramandi ◽

Maziar Motiee-Langroudi ◽

Mehrdad Jafari ◽

Hadi Sharouny ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lactate Dehydrogenase ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Lichen Planus ◽

Squamous Cell ◽

Oral Lichen Planus ◽

Roc Analysis ◽

Prospective Longitudinal ◽

Oral Lichen

Abstract Background Increased levels of lactate dehydrogenase (LDH) as a tumor marker have been reported in malignant and some premalignant oral lesions such as oral lichen planus (OLP) and oral lichenoid reactions (OLRs). This study aimed to assess the level of total LDH in the saliva and serum of patients with oral squamous cell carcinoma (OSCC), OLP and OLRs. Methods In this case–control study, the participants were divided into four groups (n = 25) of healthy controls, OLP, OLRs, and OSCC. The serum and stimulated/unstimulated salivary levels of LDH were spectrophotometrically measured using standard LDH kits (Pars Azmoun). One-way ANOVA, Chi-square test, Pearson’s correlation test, and receiver operating characteristic (ROC) analysis were applied to analyze the data. Results The serum and salivary levels of LDH in OSCC patients were significantly higher than that the corresponding values in other groups (P = 0.0001). The serum level of LDH in OLR group was significantly higher than that in the control and OLP groups (P = 0.0001), but the difference in salivary level of LDH was not significant. The ROC analysis showed that both the serum and salivary levels of LDH had significant diagnostic ability for detection of OSCC and OLRs. Significant associations were noted between the serum and salivary levels of LDH. Conclusions Patients with OSCC and OLRs had higher serum levels of LDH than OLP and control groups. Further prospective longitudinal studies are required to assess the tissue level of LDH and monitor the transformation of OLRs because they have low rate of malignant transformation compared with other oral premalignant lesions.

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Erianin Induces Apoptosis and Autophagy in Oral Squamous Cell Carcinoma Cells

The American Journal of Chinese Medicine ◽

10.1142/s0192415x2050010x ◽

2020 ◽

Vol 48 (01) ◽

pp. 183-200 ◽

Cited By ~ 1

Author(s):

Yi-Tzu Chen ◽

Ming-Ju Hsieh ◽

Pei-Ni Chen ◽

Chia-Jui Weng ◽

Shun-Fa Yang ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cancer ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Cancer Cell ◽

Squamous Cell ◽

Mapk Signaling ◽

Therapeutic Interventions ◽

Oral Cancer Cell ◽

Close Relationship

Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide. It has a very poor prognosis with over a 5-year survival rate of only 50%. Thus, it is important to identify effective therapeutic interventions against oral cancer. Apoptosis and autophagy have reported genetically regulated in physiology and diseases, which close relationship. Many natural compound study objects anticancer effect have been studied between apoptosis and autophagy relationship. The present study was designed to evaluate the effect of erianin on human oral cancer cell proliferation. Results of the study revealed that treatment with erianin significantly reduced the viability of different OSCC cell lines. Erianin exerted its cytotoxic effect by inducing cell cycle arrest and caspase-dependent apoptotic pathways. Both intrinsic and extrinsic pathways were found to be involved in erianin-mediated cell death. In addition, treatment with erianin also increased autophagy in OSCC cells. With further analysis, it was found that erianin induced both apoptosis and autophagy by regulating MAPK signaling pathways. Taken together, our study indicates that erianin plays an important role in reducing oral cancer cell viability, and thus, can be considered as a potential anticancer agent.

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