Cardiometabolic index: a new tool for screening the metabolically obese normal weight phenotype

2020 ◽  
Author(s):  
X. Liu ◽  
Q. Wu ◽  
G. Yan ◽  
J. Duan ◽  
Z. Chen ◽  
...  
Keyword(s):  
Normal Weight ◽  
Cardiometabolic Index ◽  
Metabolically Obese Normal Weight

Metabolically healthy obesity and metabolically obese normal weight: a review

2021 ◽  
Vol 77 (1) ◽  
pp. 175-189 ◽  
Author(s):  
Saioa Gómez-Zorita ◽  
Maite Queralt ◽  
Maria Angeles Vicente ◽  
Marcela González ◽  
María P. Portillo
Keyword(s):  
Normal Weight ◽  
Metabolically Healthy Obesity ◽  
Metabolically Obese Normal Weight ◽  
Metabolically Healthy

The triglycerides and glucose index is associated with cardiovascular risk factors in metabolically obese normal-weight subjects

2020 ◽  
Vol 43 (7) ◽  
pp. 995-1000 ◽  
Author(s):  
G. Morales-Gurrola ◽  
L. E. Simental-Mendía ◽  
F. X. Castellanos-Juárez ◽  
J. M. Salas-Pacheco ◽  
F. Guerrero-Romero
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Normal Weight ◽  
Metabolically Obese Normal Weight

scholarly journals Prevalence of Metabolically Obese, Normal-Weight Individuals and Its Dietary Patterns Characteristics: A Cross-Sectional Study in Thai Adults

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1464-1464
Author(s):  
Hung Nguyen Ngoc ◽  
Wantanee Kriengsinyos ◽  
Nipa Rojroongwasinkul ◽  
Wichai Aekplakorn
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Dietary Patterns ◽  
Lower Risk ◽  
Normal Weight ◽  
Normal Body Mass Index ◽  
Health Examination ◽  
Cross Sectional ◽  
Metabolically Obese Normal Weight

Abstract Objectives Metabolically obese normal weight (MONW) individuals are subjects who have a normal body mass index (BMI), but manifest obesity-related metabolic syndrome (MetS). Nevertheless, the prevalence and correlation between MONW and dietary patterns have not been fully explored in Thais. This study aimed to investigate the national prevalence of MONW, determine which dietary patterns are consumed in Thai normal-weight adults and to identify whether those patterns were associated with the risk of MetS and its features. Methods Total 6899 Thais ≥18 years with normal BMI (18.5–22.9 kg/m2) were obtained from the Thai National Health Examination Survey IV. Sociodemographic, eating-habits, anthropometric, blood pressure and biochemical parameters were measured. MONW was diagnosed by the National Cholesterol Education Program/Adult Treatment Panel III within normal BMI. Dietary patterns were determined by means of factor analysis, and were evaluated by multiple logistic regressions for its association with MONW. Results Overall, the weighted prevalence of MONW was 9.9% (95% CI: 9.1–10.6%), particularly, the MONW prevalence was 7.2% (95% CI: 6.5–8.0%) and 13.1% (95% CI: 11.6–14.7%) in male and female respectively. Three major dietary patterns were distinguished: “westernized”, “healthy” and “carbohydrate” patterns. After controlling for potential confounders, compared with the lowest quartile, individuals in the highest quartile of the westernized and carbohydrate pattern were connected with the greater risk of MONW (adjusted odds ratio [OR]: 1.64, 95% CI: 1.25–2.17, P < 0.001) and (OR: 1.57, 95% CI: 1.19–2.08, P < 0.05) respectively, whereas subjects in the fourth quartile of healthy pattern reduce the risk of MONW and its components, except for elevated blood pressure and hyperglycemia (OR: 0.68, 95% CI: 0.50–0.92 for MONW, P < 0.05; OR: 0.43, 95% CI: 0.28–0.68 for abdominal obesity, P < 0.001; OR: 0.63, 95% CI: 0.49–0.81 for hypertriglyceridemia, P < 0.001; OR: 0.67, 95% CI: 0.54–0.82 for low high-density lipoprotein cholesterol [HDL-C], P < 0.01). Conclusions In Thai normal-weight adults, high consumption of whole grains, fruits, beans, juices, and dairy products is connected with a lower risk of metabolic syndrome and its features, i.e., lower risk of abdominal obesity, hypertriglyceridemia, and low HDL-C. Funding Sources This research received no funding.

scholarly journals Evidence of genetic predisposition for metabolically healthy obesity and metabolically obese normal weight

2018 ◽  
Vol 50 (3) ◽  
pp. 169-178 ◽  
Author(s):  
Lam O. Huang ◽  
Ruth J. F. Loos ◽  
Tuomas O. Kilpeläinen
Keyword(s):  
Public Health ◽  
Insulin Resistance ◽  
Adipose Tissue ◽  
Pancreatic Beta Cells ◽  
Large Scale ◽  
Normal Weight ◽  
Tissue Storage ◽  
Public Health Action ◽  
Metabolically Obese Normal Weight ◽  
Metabolically Healthy

Obesity has evolved into a global pandemic that constitutes a major threat to public health. The majority of obesity-related health care costs are due to cardiometabolic complications, such as insulin resistance, dyslipidemia, and hypertension, which are risk factors for Type 2 diabetes and cardiovascular disease. However, many obese individuals, often called metabolically healthy obese (MHO), seem to be protected from these cardiometabolic complications. Conversely, there is a group of individuals who suffer from cardiometabolic complications despite being of normal weight; a condition termed metabolically obese normal weight (MONW). Recent large-scale genomic studies have provided evidence that a number of genetic variants show an association with increased adiposity but a favorable cardiometabolic profile, an indicator for the genetic basis of the MHO and MONW phenotypes. Many of these loci are located in or near genes that implicate pathways involved in adipogenesis, fat distribution, insulin signaling, and insulin resistance. It has been suggested that a threshold for subcutaneous adipose tissue expandability may be at play in the manifestation of MHO and MONW, where expiry of adipose tissue storage capacity could lead to ectopic lipid accumulation in non-adipose tissues such as liver, muscle, heart, and pancreatic beta cells. Understanding the genetic aspects of the mechanisms that underpin MHO and MONW is crucial to define appropriate public health action points and to develop effective intervention measures.

Characteristics of metabolically obese normal-weight (MONW) subjects

2007 ◽  
Vol 32 (1) ◽  
pp. 4-12 ◽  
Author(s):  
Florence Conus ◽  
Rémi Rabasa-Lhoret ◽  
François Péronnet
Keyword(s):  
Blood Pressure ◽  
Normal Weight ◽  
Scientific Data ◽  
Phenotypic Characteristics ◽  
Atherogenic Lipid Profile ◽  
Metabolically Obese Normal Weight ◽  
Lower Physical Activity ◽  
Altered Insulin Sensitivity ◽  
Atherogenic Lipid

The existence of a subgroup of normal-weight individuals displaying obesity-related phenotypic characteristics was first proposed in 1981. These individuals were identified as metabolically obese but normal weight (MONW). It was hypothesized that these individuals might be characterized by hyperinsulinemia and (or) insulin resistance, as well as by hypertriglyceridemia and high blood pressure despite having a body mass index (BMI) < 25 kg/m2. Such characteristics could confer upon MONW subjects a higher cardiovascular risk; however, scientific data on MONW subjects are scarce since only 9 publications are directly related to this topic. Despite differences in the criteria for identifying MONW subjects and the small number of subjects involved in most of these studies, their consistent results indicate that: (i) the prevalence of the MONW syndrome ranges between 5% and 45%, depending on the criteria used, age, BMI, and ethnicity; (ii) when compared with control subjects, MONW subjects display an altered insulin sensitivity, a higher abdominal and visceral adiposity, a more atherogenic lipid profile, a higher blood pressure, and a lower physical activity energy expenditure; and (iii) MONW subjects are at higher risks for type 2 diabetes and cardiovascular diseases.

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