scholarly journals Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Nan Yang ◽  
Wanyue Xiao ◽  
Xuejiao Song ◽  
Wenjun Wang ◽  
Xiaochen Dong
Keyword(s):  
Hydrogen Peroxide ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Anticancer Agents ◽  
Inorganic Materials ◽  
High Concentration ◽  
Responsive Materials ◽  
Challenges And Opportunities

AbstractPhotodynamic therapy (PDT), as one of the noninvasive clinical cancer phototherapies, suffers from the key drawback associated with hypoxia at the tumor microenvironment (TME), which plays an important role in protecting tumor cells from damage caused by common treatments. High concentration of hydrogen peroxide (H2O2), one of the hallmarks of TME, has been recognized as a double-edged sword, posing both challenges, and opportunities for cancer therapy. The promising perspectives, strategies, and approaches for enhanced tumor therapies, including PDT, have been developed based on the fast advances in H2O2-enabled theranostic nanomedicine. In this review, we outline the latest advances in H2O2-responsive materials, including organic and inorganic materials for enhanced PDT. Finally, the challenges and opportunities for further research on H2O2-responsive anticancer agents are envisioned.

Double pH-sensitive Nanotheranostics of Polypeptide Nanoparticle-Encapsulated BODIPY with Both NIR Activated Fluorescence and Enhanced Photodynamic Therapy

2021 ◽  
Author(s):  
Huiping Dang ◽  
Quan Cheng ◽  
Youliang Tian ◽  
Changchang Teng ◽  
Kai Xie ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Intelligent Systems ◽  
Ph Sensitive ◽  
Nir Fluorescence

To achieve accurate fluorescence imaging-guided cancer therapy, intelligent systems with specific responsiveness to the tumor microenvironment need to be designed. Here, we have achieved both enhanced NIR fluorescence and photodynamic...

scholarly journals Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(iv)-based anticancer agents

Metallomics ◽  
2015 ◽  
Vol 7 (8) ◽  
pp. 1256-1264 ◽  
Author(s):  
Sarah Theiner ◽  
Christoph Kornauth ◽  
Hristo P. Varbanov ◽  
Markus Galanski ◽  
Sushilla Van Schoonhoven ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Anticancer Agents ◽  
Tumor Tissue ◽  
Tumor Model ◽  
High Concentration ◽  
Concentration Gradients ◽  
Icp Ms

Bioimaging of Pt in tumor tissue exhibited unexpected high concentration gradients, correlating with histologic features.

Tumor microenvironment acid-sensitive liposomes enhanced colorectal cancer therapy by acting on both tumor cells and cancer-associated fibroblasts

Nanoscale ◽  
2021 ◽  
Author(s):  
chenglei li ◽  
Zhaohuan Li ◽  
Xue Gong ◽  
Jianhao Liu ◽  
Tingyue Zheng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Crucial Role ◽  
Tumor Invasion ◽  
Cancer Associated Fibroblasts ◽  
Invasion And Metastasis ◽  
Promising Strategy

Cancer-associated fibroblasts (CAFs) play a crucial role in facilitating tumor invasion and metastasis, which act as the “soils” in tumor microenvironment (TME). Accordingly, it would be a promising strategy to...

A photo and tumor microenvironment activated nano-enzyme with enhanced ROS generation and hypoxia relief for efficient cancer therapy

2021 ◽  
Vol 9 (39) ◽  
pp. 8253-8262
Author(s):  
Yali Chen ◽  
Yujun Cai ◽  
Xingsu Yu ◽  
Hong Xiao ◽  
Haozhe He ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Therapy Strategies

Reactive oxygen species (ROS) mediated tumor therapy strategies have exhibited great prospects and attracted increasing attention, among which photodynamic therapy (PDT) has been well-established.

scholarly journals Anti-Tumor Effects of Chinese Medicine Compounds by Regulating Immune Cells in Microenvironment

2021 ◽  
Vol 11 ◽  
Author(s):  
Fengqian Chen ◽  
Jingquan Li ◽  
Hui Wang ◽  
Qian Ba
Keyword(s):  
Dendritic Cells ◽  
Chinese Medicine ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Traditional Chinese Medicine ◽  
Tumor Cells ◽  
Immune Cells ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Adaptive Immune Cells

As the main cause of death in the world, cancer is one of the major health threats for humans. In recent years, traditional Chinese medicine has gained great attention in oncology due to the features of multi-targets, multi-pathways, and slight side effects. Moreover, lots of traditional Chinese medicine can exert immunomodulatory effects in vivo. In the tumor microenvironment, tumor cells, immune cells as well as other stromal cells often coexist. With the development of cancer, tumor cells proliferate uncontrollably, metastasize aggressively, and modulate the proportion and status of immune cells to debilitate the antitumor immunity. Reversal of immunosuppressive tumor microenvironment plays an essential role in cancer prevention and therapy. Immunotherapy has become the most promising strategy for cancer therapy. Chinese medicine compounds can stimulate the activation and function of immune cells, such as promoting the maturation of dendritic cells and inducing the differentiation of myeloid-derived suppressor cells to dendritic cells and macrophages. In the present review, we summarize and discuss the effects of Chinese medicine compounds on immune cells in the tumor microenvironment, including innate immune cells (dendritic cells, natural killer cells, macrophages, and myeloid-derived suppressor cells) and adaptive immune cells (CD4+/CD8+ T lymphocytes and regulatory T cells), and the various immunomodulatory roles of Chinese medicine compounds in cancer therapy such as improving tumor-derived inflammation, enhancing the immunity after surgery or chemotherapy, blocking the immune checkpoints, et al., aiming to provide more thoughts for the anti-tumor mechanisms and applications of Chinese medicine compounds in terms of tumor immunity.

scholarly journals Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy

2016 ◽  
Vol 12 (1) ◽  
pp. 120-132 ◽  
Author(s):  
Yuanhong Zheng ◽  
Guifang Yin ◽  
Vanminh Le ◽  
Anle Zhang ◽  
Siyu Chen ◽  
...  
Keyword(s):  
Immune Response ◽  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Tumor Cells

scholarly journals Mesenchymal stem cells and cancer therapy: insights into targeting the tumour vasculature

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Surendar Aravindhan ◽  
Sura Salman Ejam ◽  
Methaq Hadi Lafta ◽  
Alexander Markov ◽  
Alexei Valerievich Yumashev ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Progression ◽  
Tumor Cells ◽  
Tumor Tissue ◽  
Angiogenic Therapy ◽  
Final Destination ◽  
Tumour Vasculature

AbstractA crosstalk established between tumor microenvironment and tumor cells leads to contribution or inhibition of tumor progression. Mesenchymal stem cells (MSCs) are critical cells that fundamentally participate in modulation of the tumor microenvironment, and have been reported to be able to regulate and determine the final destination of tumor cell. Conflicting functions have been attributed to the activity of MSCs in the tumor microenvironment; they can confer a tumorigenic or anti-tumor potential to the tumor cells. Nonetheless, MSCs have been associated with a potential to modulate the tumor microenvironment in favouring the suppression of cancer cells, and promising results have been reported from the preclinical as well as clinical studies. Among the favourable behaviours of MSCs, are releasing mediators (like exosomes) and their natural migrative potential to tumor sites, allowing efficient drug delivering and, thereby, efficient targeting of migrating tumor cells. Additionally, angiogenesis of tumor tissue has been characterized as a key feature of tumors for growth and metastasis. Upon introduction of first anti-angiogenic therapy by a monoclonal antibody, attentions have been drawn toward manipulation of angiogenesis as an attractive strategy for cancer therapy. After that, a wide effort has been put on improving the approaches for cancer therapy through interfering with tumor angiogenesis. In this article, we attempted to have an overview on recent findings with respect to promising potential of MSCs in cancer therapy and had emphasis on the implementing MSCs to improve them against the suppression of angiogenesis in tumor tissue, hence, impeding the tumor progression.

Integration of a porous coordination network and black phosphorus nanosheets for improved photodynamic therapy of tumor

Nanoscale ◽  
2020 ◽  
Vol 12 (16) ◽  
pp. 8890-8897
Author(s):  
Miao-Deng Liu ◽  
Yun Yu ◽  
Deng-Ke Guo ◽  
Shi-Bo Wang ◽  
Chu-Xin Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Black Phosphorus ◽  
Coordination Network ◽  
Photodynamic Cancer Therapy

A biodegradable nanoplatform was constructed by integrating a porous coordination network, black phosphorus sheets, and folate to weaken the cytoprotection of tumor cells for improved photodynamic cancer therapy.

scholarly journals A self-illuminating nanoparticle for inflammation imaging and cancer therapy

2019 ◽  
Vol 5 (1) ◽  
pp. eaat2953 ◽  
Author(s):  
Xiaoqiu Xu ◽  
Huijie An ◽  
Dinglin Zhang ◽  
Hui Tao ◽  
Yin Dou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
In Vivo Imaging ◽  
Resonance Energy ◽  
External Irradiation ◽  
Tissue Penetration ◽  
Photodynamic Therapy Of Cancer ◽  
Inflammation Imaging

Nanoparticles have been extensively used for inflammation imaging and photodynamic therapy of cancer. However, the major translational barriers to most nanoparticle-based imaging and therapy applications are the limited depth of tissue penetration, inevitable requirement of external irradiation, and poor biocompatibility of the nanoparticles. To overcome these critical limitations, we synthesized a sensitive, specific, biodegradable luminescent nanoparticle that is self-assembled from an amphiphilic polymeric conjugate with a luminescent donor (luminol) and a fluorescent acceptor [chlorin e6 (Ce6)] for in vivo luminescence imaging and photodynamic therapy in deep tissues. Mechanistically, reactive oxygen species (ROS) and myeloperoxidase generated in inflammatory sites or the tumor microenvironment trigger bioluminescence resonance energy transfer and the production of singlet oxygen (1O2) from the nanoparticle, enabling in vivo imaging and cancer therapy, respectively. This self-illuminating nanoparticle shows an excellent in vivo imaging capability with suitable tissue penetration and resolution in diverse animal models of inflammation. It is also proven to be a selective, potent, and safe antitumor nanomedicine that specifically kills cancer cells via in situ1O2produced in the tumor microenvironment, which contains a high level of ROS.

Enhanced Cancer Starvation Therapy via Autophagy Inhibition With a Functional Dendritic Mesoporous Organosilicon Nanoagent

2021 ◽  
Author(s):  
fan Wu ◽  
yang Liu ◽  
hui Cheng ◽  
yun Meng ◽  
yan Yi ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cancer Therapy ◽  
Tumor Growth ◽  
Tumor Cells ◽  
Synergetic Effect ◽  
Therapy Effect ◽  
Autophagy Inhibition ◽  
Tumor Growth Suppression

Abstract Glucose oxidase (GOx) can effectively catalyze glucose intogluconic acid and hydrogen peroxide (H2O2) in the presence of O2, which is considered as an attractive starvation strategy for cancer therapy. However, the autophagy phenomenon protects tumor cells from starvation therapy, limiting the therapy effect, thus autophagy inhibition could be used as a troubleshooting method to enhance tumor starvation therapy. Herein, biodegradable dendritic mesoporous organosilicon nanoagent (DMON) was used as the nanocarrier to deliver GOx and 3-MA (an autophagyinhibition agent), designed as DMON@GOx/3-MA. T his formulation could have a synergetic effect on autophagy inhibition and starvation therapy. All in vitro and in vivo results demonstrated that autophagy inhibition obviously enhanced the efficacy of starvation therapy, leading to tumor growth suppression. Our strategy will provide a new way to enhance the efficacy of starvation cancer therapy.

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