scholarly journals Effect of nano-hydroxyapatite on protein adsorption and cell adhesion of poly(lactic acid)/nano-hydroxyapatite composite microspheres

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
H. M. C. Suboda Wijerathne ◽  
Dong Yan ◽  
Bin Zeng ◽  
Yanping Xie ◽  
Hongchao Hu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Cell Adhesion ◽  
Protein Adsorption ◽  
Poly Lactic Acid ◽  
Composite Microspheres ◽  
Hydroxyapatite Composite

Electrospinning of chitosan/poly(lactic acid-co-glycolic acid)/hydroxyapatite composite nanofibrous mats for tissue engineering applications

2014 ◽  
Vol 71 (11) ◽  
pp. 2999-3016 ◽  
Author(s):  
Tugba Endogan Tanir ◽  
Vasif Hasirci ◽  
Nesrin Hasirci
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Glycolic Acid ◽  
Poly Lactic Acid ◽  
Engineering Applications ◽  
Hydroxyapatite Composite

scholarly journals Grafting collagen on poly (lactic acid) by a simple route to produce electrospun scaffolds, and their cell adhesion evaluation

2016 ◽  
Vol 13 (4) ◽  
pp. 375-387 ◽  
Author(s):  
Alida Ospina-Orejarena ◽  
Ricardo Vera-Graziano ◽  
Maria Monica Castillo-Ortega ◽  
Juan Paulo Hinestroza ◽  
Mabel Rodriguez-Gonzalez ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Cell Adhesion ◽  
Poly Lactic Acid ◽  
Simple Route ◽  
Electrospun Scaffolds

scholarly journals Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures

2019 ◽  
Author(s):  
Asako Otomo ◽  
Mahoko Takahashi Ueda ◽  
Toshinori Fujie ◽  
Arihiro Hasebe ◽  
Yosuke Okamura ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Cell Adhesion ◽  
Cortical Neurons ◽  
Molecular Mechanisms ◽  
Cultured Cells ◽  
Structural Features ◽  
Poly Lactic Acid ◽  
Adhesion Properties ◽  
Expression Of Genes ◽  
Cultured Cortical Neurons

AbstractSynthetic biodegradable polymers including poly(lactic acid) (PLA) are attractive cell culture substrates because their surfaces can be micropatterned to support cell adhesion. The cell adhesion properties of a scaffold mainly depend on its surface chemical and structural features; however, it remains unclear how these characteristics affect the growth and differentiation of cultured cells or their gene expression. In this study, we fabricated two differently structured PLA nanosheets: flat and microgrooved. We assessed the growth and differentiation of mouse primary cultured cortical neurons on these two types of nanosheets after pre-coating with poly-D-lysine and vitronectin. Interestingly, prominent neurite bundles were formed along the grooves on the microgrooved nanosheets, whereas thin and randomly extended neurites were only observed on the flat nanosheets. Comparative RNA sequencing analyses revealed that the expression of genes related to postsynaptic density, dendritic shafts, and asymmetric synapses was significantly and consistently up-regulated in cells cultured on the microgrooved nanosheets when compared with those cultured on the flat nanosheets. These results indicate that microgrooved PLA nanosheets can provide a powerful means of establishing a culture system for the efficient and reproducible differentiation of neurons, which will facilitate future investigations of the molecular mechanisms underlying the pathogenesis of neurological disorders.

scholarly journals The Study of Chemical, Mechanical, Thermal, and Morphological Properties of Poly Lactic Acid-nano Hydroxyapatite Composite Scaffold

2018 ◽  
Vol 23 (1) ◽  
pp. 1-11
Author(s):  
Md Foisal ◽  
Ajoy Kumer ◽  
Umma Nasrin ◽  
Mohammad Ismail ◽  
Mohammad Alam
Keyword(s):  
Lactic Acid ◽  
Composite Scaffold ◽  
Morphological Properties ◽  
Poly Lactic Acid ◽  
Hydroxyapatite Composite

Preparation of poly(lactic acid)/sintered hydroxyapatite composite biomaterial by supercritical CO2

2017 ◽  
Vol 29 (1) ◽  
pp. 67-79
Author(s):  
Yumin Zhang ◽  
Jianru Wang ◽  
Yanmiao Ma ◽  
Bo Han ◽  
Xiaojun Niu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Supercritical Co2 ◽  
Poly Lactic Acid ◽  
Hydroxyapatite Composite

scholarly journals Preparation and In Vitro Behavior of a Poly(lactic acid)-Fiber/Hydroxyapatite Composite Sheet

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Yasuhiro Tanimoto ◽  
Norihiro Nishiyama
Keyword(s):  
Lactic Acid ◽  
Type I Collagen ◽  
Poly Lactic Acid ◽  
Apatite Formation ◽  
Type I ◽  
Composite Sheet ◽  
Precipitate Formation ◽  
Hydroxyapatite Composite ◽  
Fiber Sheet

This paper describes the processing and in vitro behavior of a poly(lactic acid) (PLA)-fiber/hydroxyapatite (HA) composite sheet consisting of a knitted PLA-fiber sheet and HA powder for bone tissue engineering. Type I collagen was used as a binding agent to combine the PLA fibers and the HA powder. Precipitate formation in Hanks' balanced salt (HBS) solution was monitored to evaluate the in vitro apatite formation ability of the PLA-fiber/HA composite sheet. Precipitate formation was observed on the surface of the PLA-fiber/HA composite sheet after immersion in HBS solution for only 1 day, while no precipitate formation was observed on the PLA-fiber sheet without HA as a control. In conclusion, a PLA-fiber/HA composite sheet for use as a scaffold was successfully prepared. Within the limitations of this investigation, we confirmed that the PLA-fiber/HA composite sheet has a high apatite formation activity compared with the PLA-fiber sheet and represents a promising material for use as a scaffold.

scholarly journals Wettability Effect of PECVD-SiOxFilms on Poly(lactic acid) Induced by Oxygen Plasma on Protein Adsorption and Cell Attachment

2013 ◽  
Vol 423 ◽  
pp. 012042 ◽  
Author(s):  
S Sarapirom ◽  
J S Lee ◽  
S B Jin ◽  
D H Song ◽  
L D Yu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Protein Adsorption ◽  
Oxygen Plasma ◽  
Cell Attachment ◽  
Poly Lactic Acid

Diamond nanoparticles into poly (lactic acid) electrospun fibers: Cytocompatible and bioactive scaffolds with enhanced wettability and cell adhesion

2016 ◽  
Vol 183 ◽  
pp. 420-424 ◽  
Author(s):  
F.A.S. Pereira ◽  
G.N. Salles ◽  
B.V.M. Rodrigues ◽  
F.R. Marciano ◽  
C. Pacheco-Soares ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Cell Adhesion ◽  
Poly Lactic Acid ◽  
Electrospun Fibers ◽  
Diamond Nanoparticles ◽  
Bioactive Scaffolds

Cell Adhesion and Morphology in Porous Scaffold Based on Enantiomeric Poly(lactic acid) Graft-type Phospholipid Polymers

2002 ◽  
Vol 3 (6) ◽  
pp. 1375-1383 ◽  
Author(s):  
Junji Watanabe ◽  
Takahisa Eriguchi ◽  
Kazuhiko Ishihara
Keyword(s):  
Lactic Acid ◽  
Cell Adhesion ◽  
Porous Scaffold ◽  
Poly Lactic Acid
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