Cell Adhesion and Morphology in Porous Scaffold Based on Enantiomeric Poly(lactic acid) Graft-type Phospholipid Polymers

2002 ◽  
Vol 3 (6) ◽  
pp. 1375-1383 ◽  
Author(s):  
Junji Watanabe ◽  
Takahisa Eriguchi ◽  
Kazuhiko Ishihara
Keyword(s):  
Lactic Acid ◽  
Cell Adhesion ◽  
Porous Scaffold ◽  
Poly Lactic Acid

scholarly journals Effect of nano-hydroxyapatite on protein adsorption and cell adhesion of poly(lactic acid)/nano-hydroxyapatite composite microspheres

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
H. M. C. Suboda Wijerathne ◽  
Dong Yan ◽  
Bin Zeng ◽  
Yanping Xie ◽  
Hongchao Hu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Cell Adhesion ◽  
Protein Adsorption ◽  
Poly Lactic Acid ◽  
Composite Microspheres ◽  
Hydroxyapatite Composite

Mechanical behavior of hydroxyapatite-poly(lactic acid) hybrid porous scaffold

2020 ◽  
Vol 29 (6) ◽  
pp. 587-602
Author(s):  
Yu Zusho ◽  
Satoshi Kobayashi ◽  
Toshiko Osada
Keyword(s):  
Lactic Acid ◽  
Mechanical Behavior ◽  
Porous Scaffold ◽  
Poly Lactic Acid

Effect of Size on Degradation of Porous Poly(Lactic Acid) Scaffold

2011 ◽  
Vol 311-313 ◽  
pp. 1741-1745
Author(s):  
Chao Guo ◽  
Xiao Bo Sheng ◽  
Cheng Lin Chu ◽  
Yin Sheng Dong
Keyword(s):  
Molecular Weight ◽  
Lactic Acid ◽  
Mass Loss ◽  
Porous Scaffold ◽  
Repeat Unit ◽  
Poly Lactic Acid ◽  
Porous Scaffolds ◽  
Degradation Behaviors ◽  
The Difference ◽  
Autocatalytic Effect

Poly (lactic acid) (PLA) scaffolds with different sizes are often fabricated for various requirements. A cellular automaton simulation was used to investigate the effect of the size on the degradation behaviors of porous PLA scaffolds. Four porous PLA scaffolds with 90% initial porosity and different sizes were established by a novel repeat unit method. Mass loss and the change in molecular weight during the degradation were simulated. The results indicate that mass loss is related to the size of the porous scaffold while molecular weight change is independent on the size. With the size of the porous scaffold increasing, the mass loss increases while the difference in mass loss between the scaffolds with different sizes decreases. All these changes can be attributed to the difference in the autocatalytic effect and corresponding oligomer diffusion ability of the porous scaffolds with different sizes.

scholarly journals Grafting collagen on poly (lactic acid) by a simple route to produce electrospun scaffolds, and their cell adhesion evaluation

2016 ◽  
Vol 13 (4) ◽  
pp. 375-387 ◽  
Author(s):  
Alida Ospina-Orejarena ◽  
Ricardo Vera-Graziano ◽  
Maria Monica Castillo-Ortega ◽  
Juan Paulo Hinestroza ◽  
Mabel Rodriguez-Gonzalez ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Cell Adhesion ◽  
Poly Lactic Acid ◽  
Simple Route ◽  
Electrospun Scaffolds

scholarly journals Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures

2019 ◽  
Author(s):  
Asako Otomo ◽  
Mahoko Takahashi Ueda ◽  
Toshinori Fujie ◽  
Arihiro Hasebe ◽  
Yosuke Okamura ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Cell Adhesion ◽  
Cortical Neurons ◽  
Molecular Mechanisms ◽  
Cultured Cells ◽  
Structural Features ◽  
Poly Lactic Acid ◽  
Adhesion Properties ◽  
Expression Of Genes ◽  
Cultured Cortical Neurons

AbstractSynthetic biodegradable polymers including poly(lactic acid) (PLA) are attractive cell culture substrates because their surfaces can be micropatterned to support cell adhesion. The cell adhesion properties of a scaffold mainly depend on its surface chemical and structural features; however, it remains unclear how these characteristics affect the growth and differentiation of cultured cells or their gene expression. In this study, we fabricated two differently structured PLA nanosheets: flat and microgrooved. We assessed the growth and differentiation of mouse primary cultured cortical neurons on these two types of nanosheets after pre-coating with poly-D-lysine and vitronectin. Interestingly, prominent neurite bundles were formed along the grooves on the microgrooved nanosheets, whereas thin and randomly extended neurites were only observed on the flat nanosheets. Comparative RNA sequencing analyses revealed that the expression of genes related to postsynaptic density, dendritic shafts, and asymmetric synapses was significantly and consistently up-regulated in cells cultured on the microgrooved nanosheets when compared with those cultured on the flat nanosheets. These results indicate that microgrooved PLA nanosheets can provide a powerful means of establishing a culture system for the efficient and reproducible differentiation of neurons, which will facilitate future investigations of the molecular mechanisms underlying the pathogenesis of neurological disorders.

Diamond nanoparticles into poly (lactic acid) electrospun fibers: Cytocompatible and bioactive scaffolds with enhanced wettability and cell adhesion

2016 ◽  
Vol 183 ◽  
pp. 420-424 ◽  
Author(s):  
F.A.S. Pereira ◽  
G.N. Salles ◽  
B.V.M. Rodrigues ◽  
F.R. Marciano ◽  
C. Pacheco-Soares ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Cell Adhesion ◽  
Poly Lactic Acid ◽  
Electrospun Fibers ◽  
Diamond Nanoparticles ◽  
Bioactive Scaffolds

Poly(lactic acid) porous scaffold with calcium phosphate mineralized surface and bone marrow mesenchymal stem cell growth and differentiation

2011 ◽  
Vol 31 (3) ◽  
pp. 612-619 ◽  
Author(s):  
So-Hee Kim ◽  
Sun-Ae Oh ◽  
Woo-Kul Lee ◽  
Ueon Sang Shin ◽  
Hae-Won Kim
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Lactic Acid ◽  
Calcium Phosphate ◽  
Cell Growth ◽  
Mesenchymal Stem Cell ◽  
Porous Scaffold ◽  
Poly Lactic Acid ◽  
Cell Growth And Differentiation

Preparation and Characterization of Porous Scaffold Based on Poly(Lactic Acid) and Poly(Ethylene Glycol) by Phase Separation Method

2012 ◽  
Vol 11 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Min Fan ◽  
Gang Guo ◽  
Shuai Shi ◽  
XiuHong Wang ◽  
ShaoZhi Fu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Phase Separation ◽  
Ethylene Glycol ◽  
Porous Scaffold ◽  
Separation Method ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

The in-vitro biological properties of 3D printed poly lactic acid/akermanite composite porous scaffold for bone tissue engineering

2021 ◽  
Vol 27 ◽  
pp. 102176
Author(s):  
Masoud Arastouei ◽  
Mohammad Khodaei ◽  
Seyed Mohammad Atyabi ◽  
Milad Jafari Nodoushan
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Porous Scaffold ◽  
Biological Properties ◽  
Poly Lactic Acid ◽  
3D Printed
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