Long-term sublethal and short-term high dose effects of physically and chemically dispersed oil on accumulation and clearance from various tissues of juvenile coho salmon, Oncorhynchus kisutch

1981 ◽  
Vol 5 (4) ◽  
pp. 295-300 ◽  
Author(s):  
B.A. McKeown
Keyword(s):  
Coho Salmon ◽  
Oncorhynchus Kisutch ◽  
High Dose ◽  
Short Term ◽  
Dispersed Oil ◽  
Dose Effects ◽  
Chemically Dispersed Oil

scholarly journals Association between inhaled corticosteroids and upper respiratory tract infection in patients with chronic obstructive pulmonary disease: a meta-analysis of randomized controlled trials

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hong Chen ◽  
Yulin Feng ◽  
Ke Wang ◽  
Jing Yang ◽  
Yuejun Du
Keyword(s):  
Inhaled Corticosteroids ◽  
Chronic Obstructive ◽  
Controlled Trials ◽  
High Dose ◽  
Upper Respiratory Tract ◽  
Short Term ◽  
Obstructive Pulmonary Disease ◽  
Randomized Controlled ◽  
Upper Respiratory

Abstract Background We aimed to assess the association between inhaled corticosteroids (ICSs) and the risk of upper respiratory tract infection (URTI) in patients with chronic obstructive pulmonary disease (COPD). Methods PubMed, Embase, Cochrane Library and Clinical Trials.gov were searched from inception to October 2019. Randomized controlled trials (RCTs) of any ICSs vs control for COPD with reporting of URTI as an adverse event were included. The study was registered with PROSPERO prospectively (#CRD42020153134). Results Seventeen RCTs (20,478 patients) were included. ICSs significantly increased the risk of URTI in COPD patients (RR, 1.13; 95% CI 1.03–1.24; P = 0.01; heterogeneity: I2 = 7%). Futher subgroup analyses suggested that short-term use of ICSs increased the risk of URTI (RR, 1.29; 95% CI 1.06–1.56; P = 0.01; heterogeneity: I2 = 14%) but not for long-term use (RR, 1.08; 95% CI 0.97–1.2; P = 0.14; heterogeneity: I2 = 0%). Short-term use of high-dose fluticasone increased the risk of URTI (RR, 1.33; 95% CI 1.03–1.71; P = 0.03; heterogeneity: I2 = 0%) but not for long-term use (RR, 1.12; 95% CI 0.97–1.29; P = 0.13; heterogeneity: I2 = 50%). Medium-dose (RR, 0.97; 95% CI 0.71–1.32; P = 0.84; heterogeneity: I2 = 0%) and low-dose (RR, 1.39; 95% CI 0.92–2.1; P = 0.12; heterogeneity: I2 = 30%) fluticasone did not increase the risk of URTI regardless of duration. Neither mometasone (RR, 1.05; 95% CI 0.87–1.26; P = 0.61; heterogeneity: I2 = 0%) nor budesonide (RR, 1.08; 95% CI 0.77–1.5; P = 0.67; heterogeneity: I2 = 46%) increased the risk of URTI, regardless of dosage or duration. Conclusions Long-term use of ICSs does not increase the risk of URTI in patients with COPD. Short-term use of high-dose fluticasone increases the risk of URTI in patients with COPD, but not mometasone or budesonide.

THE EFFECTS OF CHEMICALLY AND PHYSICALLY DISPERSED OIL ON THE BRAIN CORAL DIPLOMA STRIGOSA (DANA)—A SUMMARY REVIEW

1985 ◽  
Vol 1985 (1) ◽  
pp. 547-551 ◽  
Author(s):  
Anthony H. Knap ◽  
Sheila C. Wyers ◽  
Richard E. Dodge ◽  
Thomas D. Sleeter ◽  
Harold R. Frith ◽  
...  
Keyword(s):  
Petroleum Hydrocarbons ◽  
Lipid Synthesis ◽  
Staining Technique ◽  
Skeletal Growth ◽  
Long Term Effects ◽  
Alizarin Red ◽  
Total Recovery ◽  
Dispersed Oil ◽  
Chemically Dispersed Oil

ABSTRACT The Coroil project in Bermuda has been an intensive, multidisciplinary study of the effects of physically and chemically dispersed Arabian light crude oil on the main reef-building coral in Bermuda, Diploria strigosa. This paper reviews the results of this three year study. Corals were exposed to dispersed oil in a flow system, using spectrofluorimetry and gas chromatography to characterize and quantify the dose. Appropriate controls were included in all experiments. The studies included effects of dispersed oil on survival and behavior, the uptake and depuration of petroleum hydrocarbons, photosynthesis by symbiotic zoo-xanthellae, and skeletal growth. In behavioral and growth studies, corals were dosed in the laboratory or in the field. Laboratory-dosed colonies were returned to the field to determine long-term effects. Exposure to 20 ppm of chemically dispersed oil for 24 hours induced various behavioral reactions, including tentacle retraction, tissue contraction and mesenterial filament extrusion. However, effects were typically sublethal, and recovery was usually evident within four days. These symptoms were not significant in long-term transplants. Using the alizarin red staining technique, no long-term effects on skeletal growth could be detected following any of our treatments. Depuration studies using (9-I4C) -phenanthrene and gas chromatographic analysis showed that the uptake of petroleum hydrocarbons by the tissue of Diploria was rapid, but 75 percent of the hydrocarbon dose was eliminated within 14 days. Photosynthesis studies showed a short-term inhibition of photosynthesis only by chemically dispersed oil, with lipid synthesis being most severely affected. Total recovery occurred within 24 hours of exposure.

EFFECTS OF UNTREATED AND CHEMICALLY DISPERSED OIL ON TROPICAL MARINE COMMUNITIES: A LONG-TERM FIELD EXPERIMENT

1989 ◽  
Vol 1989 (1) ◽  
pp. 447-454 ◽  
Author(s):  
Thomas G. Ballou ◽  
Stephen C. Hess ◽  
Richard E. Dodge ◽  
Anthony H. Knap ◽  
Thomas D. Sleeter
Keyword(s):  
Field Experiment ◽  
Sea Urchins ◽  
Exposure Level ◽  
Long Term Effects ◽  
Worst Case ◽  
Dispersed Oil ◽  
Trade Offs ◽  
Chemically Dispersed Oil ◽  
Term Field

ABSTRACT A multidisciplinary long-term field experiment was conducted to evaluate the use of chemical dispersants to reduce the adverse environmental effects of oil spills in nearshore, tropical waters. Three study sites, whose intertidal and subtidal components consisted of mangroves, seagrass beds, and coral reefs, were studied in detail before, during, and after exposure to untreated crude oil or chemically dispersed oil. This study simulated an unusually high (“worst case”) exposure level of dispersed oil and a moderate exposure level of untreated oil. The third site served as an untreated reference site. Assessments were made of the distribution and extent of contamination by hydrocarbons over time, and the short- and long-term effects on survival, abundance, and growth of the dominant flora and fauna of each habitat. The whole, untreated oil had severe, long-term effects on survival of mangroves and associated fauna, and relatively minor effects on seagrasses, corals, and associated organisms. Chemically dispersed oil caused declines in the abundance of corals, sea urchins, and other reef organisms, reduced coral growth rate in one species, and had minor or no effects on seagrasses and mangroves. Conclusions were drawn from these results on decision making for actual spills based on trade-offs between dispersing or not dispersing the oil. This report deals only with the major results of the study. A large number of parameters were monitored, but in the interest of brevity only the most important aspects of the study are reported here. A detailed description of the methods used and a complete presentation and discussion of results is given in Ballou et al.2

Long-term versus short-term androgen deprivation combined with high-dose radiotherapy for localized prostate cancer: A Spanish multicenter phase III trial.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e15036-e15036 ◽  
Author(s):  
A. Zapatero ◽  
A. Guerrero ◽  
X. Maldonado ◽  
A. Alvarez ◽  
C. González San Segundo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation ◽  
Phase Iii ◽  
Localized Prostate Cancer ◽  
High Dose ◽  
Short Term ◽  
Phase Iii Trial ◽  
Multicenter Phase

Acute and long-term biological effects of mechanically and chemically dispersed oil on lumpsucker (Cyclopterus lumpus)

2015 ◽  
Vol 105 ◽  
pp. 8-19 ◽  
Author(s):  
Marianne Frantzen ◽  
Bjørn Henrik Hansen ◽  
Perrine Geraudie ◽  
Jocelyn Palerud ◽  
Inger-Britt Falk-Petersen ◽  
...  
Keyword(s):  
Biological Effects ◽  
Cyclopterus Lumpus ◽  
Dispersed Oil ◽  
Chemically Dispersed Oil

Changes in Territorial, Gill-flaring, and Feeding Behavior in Juvenile Coho Salmon (Oncorhynchus kisutch) following Short-term Pulses of Suspended Sediment

1985 ◽  
Vol 42 (8) ◽  
pp. 1410-1417 ◽  
Author(s):  
L. Berg ◽  
T. G. Northcote
Keyword(s):  
Feeding Behavior ◽  
Suspended Sediment ◽  
Brine Shrimp ◽  
Coho Salmon ◽  
Oncorhynchus Kisutch ◽  
Turbid Water ◽  
Short Term ◽  
Dominance Hierarchies ◽  
Short Term Exposure ◽  
Laboratory Stream

The territorial, gill-flaring, and feeding behavior of juvenile coho salmon (Oncorhynchus kisutch) in a laboratory stream was disrupted by short-term exposure to suspended sediment pulses. At the higher turbidities tested (30 and 60 nephelometric turbidity units (NTU)), dominance hierarchies broke down, territories were not defended, and gill flaring occurred more frequently. Only after return to lower turbidities (0–20 NTU) was social organization reestablished. The reaction distance of the fish to adult brine shrimp decreased significantly in turbid water (30 and 60 NTU) as did capture success per strike and the percentage of prey ingested. Implications of these behavioral modifications suggest that the fitness of salmonid populations exposed to short-term pulses of suspended sediment may be impaired.

High-dose radiotherapy with short-term or long-term androgen deprivation in localised prostate cancer (DART01/05 GICOR): a randomised, controlled, phase 3 trial

2015 ◽  
Vol 16 (3) ◽  
pp. 320-327 ◽  
Author(s):  
Almudena Zapatero ◽  
Araceli Guerrero ◽  
Xavier Maldonado ◽  
Ana Alvarez ◽  
Carmen Gonzalez San Segundo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation ◽  
High Dose ◽  
Short Term ◽  
Phase 3 ◽  
Randomised Controlled

scholarly journals The Effects of Short-Term and Long-Term Testosterone Supplementation on Blood Viscosity and Erythrocyte Deformability in Healthy Adult Mice

Endocrinology ◽  
2015 ◽  
Vol 156 (5) ◽  
pp. 1623-1629 ◽  
Author(s):  
Wen Guo ◽  
Eric Bachman ◽  
Johannes Vogel ◽  
Michelle Li ◽  
Liming Peng ◽  
...  
Keyword(s):  
Blood Viscosity ◽  
Term Treatment ◽  
Erythrocyte Deformability ◽  
Normal Male ◽  
High Dose ◽  
Short Term ◽  
Vascular Events ◽  
Long Term Treatment ◽  
Normal Males

Testosterone treatment induces erythrocytosis that could potentially affect blood viscosity and cardiovascular risk. We thus investigated the effects of testosterone administration on blood viscosity and erythrocyte deformability using mouse models. Blood viscosity, erythrocyte deformability, and hematocrits were measured in normal male and female mice, as well as in females and castrated males after short-term (2 wk) and long-term (5–7 mo) testosterone intervention (50 mg/kg, weekly). Castrated males for long-term intervention were studied in parallel with the normal males to assess the effect of long-term testosterone deprivation. An additional short-term intervention study was conducted in females with a lower testosterone dose (5 mg/kg). Our results indicate no rheological difference among normal males, females, and castrated males at steady-state. Short-term high-dose testosterone increased hematocrit and whole-blood viscosity in both females and castrated males. This effect diminished after long-term treatment, in association with increased erythrocyte deformability in the testosterone-treated mice, suggesting the presence of adaptive mechanism. Considering that cardiovascular events in human trials are seen early after intervention, rheological changes as potential mediator of vascular events warrant further investigation.

scholarly journals DDEL-09. HIGH DOSE MTX110 (SOLUBLE PANOBINOSTAT) SAFELY ADMINISTERED INTO THE FOURTH VENTRICLE IN A NON-HUMAN PRIMATE MODEL

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii285-iii285
Author(s):  
Rachael W Sirianni ◽  
Natasha Kharas ◽  
Bangning Yu ◽  
Christopher F Janssen ◽  
Amanda Trimble ◽  
...  
Keyword(s):  
Fourth Ventricle ◽  
High Dose ◽  
Short Term ◽  
Primate Model ◽  
Lumbar Drain ◽  
Group I ◽  
Term Administration ◽  
Mri Scans ◽  
Group Ii

Abstract OBJECTIVE This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma, UK) into the fourth ventricle of non-human primates. METHODS Four rhesus macaque monkeys underwent posterior fossa craniectomy and catheter insertion into the fourth ventricle. In Group I (n=2), catheters were externalized and lumbar drain catheters were placed simultaneously to assess cerebrospinal fluid (CSF) distribution after short-term infusions. MTX110 (0.5 ml of 300 μM panobinostat solution) was infused into the fourth ventricle daily for five consecutive days. Serial CSF and serum panobinostat levels were measured. In Group II (n=2), fourth ventricle catheters were connected to a subcutaneously-placed port for subsequent long-term infusions. Four cycles of MTX110, each consisting of 5 daily infusions (0.5 ml of 300 μM panobinostat solution), were administered over 8 weeks. Animals underwent detailed neurological evaluations, MRI scans, and post-mortem histological analysis. RESULTS Neurological assessments, MRI, and histology confirmed catheter placement and an absence of neurotoxicity. Panobinostat was undetectable in serum collected two and four hours after infusions in all samples in both groups. In Group I, mean peak panobinostat level in fourth ventricle CSF (6242 ng/ml) was significantly higher than in lumbar CSF (9 ng/ml; p < 0.0001). In Group II, mean peak CSF panobinostat level (11,042 ng/ml) was significantly higher than mean trough CSF level (33 ng/ml; p<0.0001). CONCLUSION MTX110 can be safely delivered via 4th ventricle at supra-therapeutic doses. These results provide data for a pilot clinical trial in patients with recurrent medulloblastoma.

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