The significance of diagnostic procedures before and after palliative endobronchial ND: YAG laser therapie to access the effectiveness and necessity for repeatedly debulking

Lung Cancer ◽  
1993 ◽  
Vol 8 (5-6) ◽  
pp. 356
Author(s):  
R.J. Elfeldt ◽  
D. Schröder ◽  
F. Fändrich
Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1038
Author(s):  
Simone Agnes Schenke ◽  
Jan Wuestemann ◽  
Michael Zimny ◽  
Michael Christoph Kreissl

The Thyroid Imaging and Reporting System (TIRADS) allows a sonographic assessment of the malignancy risk of thyroid nodules (TNs). To date, there is a lack of systematic data about the change in ultrasound (US) features after therapeutic interventions. The aim of this study was to characterize the changes in autonomously functioning thyroid nodules (AFTNs) after radioiodine therapy (RIT) by using TIRADS. We retrospectively assessed data from 68 patients with AFTNs treated with RIT between 2016 and 2018 who had available first and second follow-up US imaging. Before RIT, 69.1% of the AFTNs were classified as low-risk TNs when applying Kwak TIRADS (EU-TIRADS 52.9%), 22.1% were intermediate-risk TNs (EU-TIRADS 19.1%), and 8.8% were high-risk TNs (EU-TIRADS 27.9%). Twelve months after RIT, 22.1% of the AFTNs showed features of high-risk TNs according to Kwak TIRADS (EU-TIRADS 45.6%). The proportion of intermediate TNs also increased to 36.8% (EU-TIRADS 29.4%), and 41.2% were low-risk TNs (EU-TIRADS 25%). A significant percentage of AFTNs presented with features suspicious for malignancy according to TIRADS before RIT, and this number increased significantly after therapy. Therefore, before thyroid US, thorough anamnesis regarding prior radioiodine treatment is necessary to prevent unneeded diagnostic procedures.


Author(s):  
Y.Y. Khzardzhan ◽  
◽  
V.P. Fokin ◽  
S.V. Balalin ◽  
A.S. Balalin ◽  
...  

2018 ◽  
Vol 25 (2) ◽  
pp. 139
Author(s):  
S. Harricharan ◽  
K. Biederman ◽  
A.M. Bombassaro ◽  
A. Lazo-Langner ◽  
S. Elsayed ◽  
...  

Background A twice-weekly galactomannan (gm) screening protocol was implemented in high-risk hematology inpatients. Study objectives were to determine adherence to the protocol, use of selected resources, and patient outcomes.Methods This retrospective cohort study compared outcomes of interest before and after implementation of gm screening. Adults undergoing matched related allogeneic hematopoietic stem-cell transplantation or induction chemotherapy for acute leukemia were eligible. Patients could be enrolled more than once and were evaluated as episodes. Adherence to the gm protocol was assessed in post-implementation episodes. Use of broad-spectrum antifungals (bsafs), consultations (infectious diseases, respirology), and diagnostic procedures (computed tomography imaging, bronchoalveolar lavage) were compared between phases, as were the patient outcomes of all-cause mortality and clinical success (alive and not taking a bsaf).Results Of 182 episodes consecutively screened, 70 per phase were enrolled. Clinical characteristics and duration of assessment were similar for the phases. Full or partial adherence to the protocol was observed in 61 post implementation episodes (87%), with full adherence in 40 episodes (57%). More episodes in the pre-implementation phase than in the post-implementation phase involved receipt of bsafs, consultations, and diagnostics (27% vs. 7%, p = 0.02; 46% vs. 26%, p = 0.014; and 46% vs. 31%, p = 0.083 respectively). Although mortality was similar in the two phases, clinical success at the final assessment was observed in fewer pre-implementation than post-implementation episodes (79% vs. 98%, p < 0.001).Conclusions Implementation of a gm screening protocol was feasible and associated with significantly fewer episodes involving receipt of bsafs and consultations, and with significantly more episodes showing clinical success.


2021 ◽  
Author(s):  
Ayse Betul Kolemen ◽  
Enes Akyuz ◽  
Ali Toprak ◽  
Erdem Deveci ◽  
Gozde Yesil

Abstract Background The diagnosis of the rare genetic disease has great importance in treating multi-systemic conditions, preventing potential complications, and estimating disease risk for family members. The duration of getting genetic test results is variable. The demand of learning the diagnosis of a possible untreatable illness is a double-edged sword between obscurity and a lifetime chronic disease. The current uncertainty of their child's condition and the long duration time of diagnosis may increase the parents' anxiety level and causes difficulties to a continuation of diagnostic procedures in some families. This study aimed to investigate the pre-diagnosis and the post-diagnosis anxiety levels of parents who have a child with a rare genetic disorder. Results The state anxiety levels of parents decreased significantly after learning the diagnosis. However, there was no statistically significant decrease observed in trait anxiety levels. Conclusion Data from this study revealed that informing parents about their child's disease and properly explaining to them expected difficulties might help to reduce their anxiety levels. Psychological support from the hospital should be provided to help them cope with the stress before and after the diagnosis. Increasing the number of samples, interviews, and psychological inventory are recommended for future studies.


2004 ◽  
Vol 471-472 ◽  
pp. 644-648
Author(s):  
Dun Wen Zuo ◽  
Wen Zhuang Lu ◽  
Xiang Feng Li ◽  
X.Q. Chu ◽  
Min Wang

Few research works have been reported on hole making in EACVD thick diamond film, though many papers have been published on the preparation and smoothing of the film. In this paper, YAG laser and EDM were used to make holes in un-doped and Boron-doped diamond film respectively. Fundamental investigation was carried out on the effects of processing parameters on the holing efficiency and processed surface quality. The film surface was analyzed by means of Raman spectrum before and after holing. It is shown that YAG laser has a higher processing efficiency than EDM, but the latter can get a rounder hole.


2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Lene Seibaek ◽  
Lise Hounsgaard ◽  
Niels Christian Hvidt

Introduction. This paper deals with secular, spiritual, and religious existential concerns during severe illness.Materials and Methods. Qualitative research interviews were made before and after surgery with women who underwent final diagnostics, surgery, and chemotherapy for ovarian cancer. By applying a phenomenological-hermeneutic text interpretation methodology the findings were systematically identified, placed into meaning structures, interpreted, and critically discussed.Results. The analysis offered insight into the complexity of challenges and personal development over time in being a woman with ovarian cancer during her first treatment period. Although the women experienced their health to be seriously threatened, they also felt hope, will, and courage. The diagnostic procedures and treatment had comprehensive impact on their lives. However, hope and spirituality were important resources of comfort and meaning.Conclusion. Hope and courage to face life represent significant personal resources that are created not only in the interplay between body and mind but also between patients and their healthcare professionals. The women dealt with this in a dialectical manner, so that hope and despair could be present simultaneously. In this process secular, spiritual, and religious existential meaning orientations assisted the women in creating new narratives and obtain new orientations in life.


2018 ◽  
Vol 13 ◽  
Author(s):  
Mama Moussa Diaw ◽  
Mamoudou Ndiaye ◽  
Niccolò Riccardi ◽  
Riccardo Ungaro ◽  
Riccardo Alagna ◽  
...  

Background: Since 2013 StopTB Italia Onlus supports the Senegalese National Tuberculosis Programme by improving diagnostic capability with technological interventions, ameliorating educational programs for health care personnel, rising awareness among civil society and providing economical support for patients during treatment. The purpose of our study was to assess the preliminary results of an interventional cooperation project in a peripheral health care facility in Senegal. Methods: An observational, retrospective, pre-post study was conducted to compare Tuberculosis (TB) retention in care and outcome between a one-year period before and a four-year period after. Results: Overall, 239 patients with active TB were included, 196 (82%) of whom after the starting of the collaboration project. At diagnosis 35/43(81.4%) vs 151/196 (77%) patients were smear sputum positive before and after the beginning of the project, respectively. At 2 months follow up 23/35 (65.7%) patients in 2012 vs. 139/151 (92%) patients in 2013–2016 had negative control AFB stain (p = 0.249), 4/35 (11.4%) vs 12/151 (8%) patients remained AFB stain positive (p = 0.17), 7/35 (20%) vs 0/151 died before the 2 months follow up (p < 0.0001). TB treatment outcome was more frequently favourable after the beginning of cooperation 29/43 (67.4%) vs. 176/196 (89.8%) patients, (p < 0.0001). Patients’ mortality during treatment decreased from 8/43 (18.6%) in 2012 to 11/196 (5.6%) patients in the following years (p = 0.009). Conclusion: The implementation of diagnostic procedures, if integrated in a socio-economical intervention, impacts favourably on TB retention in care and treatment outcomes.


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