Silybum marianum, antioxidant activity, and cancer patients

Cancer ◽  
2021 ◽  
pp. 483-493
Author(s):  
Sepideh Elyasi
Keyword(s):  
Antioxidant Activity ◽  
Cancer Patients ◽  
Silybum Marianum

scholarly journals TOTAL POLYPHENOLIC CONTENT AND ANTIOXIDANT ACTIVITY OF SILYBUM MARIANUM CULTURES GROWN ON DIFFERENT GROWTH REGULATORS

2017 ◽  
Vol 9 (4) ◽  
pp. 44 ◽  
Author(s):  
Hattem Mekky ◽  
Samah El Sohafy ◽  
Rasha Abu El-khair ◽  
Amr El Hawiet
Keyword(s):  
Antioxidant Activity ◽  
Gallic Acid ◽  
Growth Regulators ◽  
Phenolic Content ◽  
Wild Plant ◽  
Total Phenolic ◽  
Silybum Marianum ◽  
Polyphenolic Content ◽  
Trolox Equivalent ◽  
Total Polyphenolic Content

Objective: The present study was designed to study the effect of supplementing Silybum marianum cultures with different combinations and concentrations of growth regulators on the total phenolic content and the antioxidant activity of the produced cultures.Methods: The total polyphenolic content of 23 extracts of calli was calculated as µg of gallic acid/mg of dry weight extract (DWE) using Folin–Ciocalteu reagent. The antioxidant activity was calculated as trolox equivalent antioxidant capacity using 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) assay for extracts containing more than 10 µg gallic acid/mg DWE.Results: Most of the combinations showed an increase in the total polyphenolic concentration compared to the wild plant. However, cultures grown on media supplemented with combinations of benzyl aminopurine (BAP) and gebberellic acid (Gb), adenine (Ad) and kinetin (Kin), BAP and indole acetic acid (IAA) possessed the highest total polyphenolic contents 20.5, 13.09 and 12.15 µg gallic acid/mg DWE, respectively. However, only (BAP+Gb), (BAP+1-Naphthaleneacetic acid (NAA), IAA, kin and (BAP+Ad) showed a significant increase in the antioxidant activity calculated as trolox equivalent with 2.65, 1.56, 1.56, 1.35 and 1.22 folds increase over the wild plant, respectively.Conclusion: The results obtained clearly indicated that changing the growth regulator system of Silybum marianum cultures serves as an easy and reliable method for increasing the total phenolic content and the antioxidant activity of cultures.

scholarly journals A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 108 ◽  
Author(s):  
Valeria Romanucci ◽  
Giovanni Di Fabio ◽  
Armando Zarrelli
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Chemistry ◽  
Biological Response ◽  
Milk Thistle ◽  
Silybum Marianum ◽  
New Class ◽  
Therapeutic Value ◽  
Recent Developments

In recent years, there has been increasing interest in dimeric molecules due to reports of their promising therapeutic value in the treatment of numerous diseases (such as cancer, HIV, Alzheimer’s and, malaria). Many reports in the literature have highlighted the ability of these molecules to interact not only with specific biologic receptors but also to induce a biological response that more than doubles the results of the corresponding monomeric counterpart. In this regard, flavonolignan dimers or simply bi-flavonolignans are an emerging class of dimeric compounds that unlike bi-flavonoids, which are very widespread in nature, consist of synthetic dimers of some flavonolignans isolated from the milk thistle Silybum marianum [L. Gaertn. (Asteraceae)]. This mini-review will discuss recent developments in the synthesis, characterization and antioxidant activity of new families of flavonolignan dimers, in light of emerging medicinal chemistry strategies.

scholarly journals Comparative study of the antioxidant properties of silymarin and milk thistle extracts

2021 ◽  
Vol 19 (1) ◽  
pp. 1-6
Author(s):  
V. Ivanov ◽  
M. Pavlova
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Water Extract ◽  
Total Phenolic ◽  
Milk Thistle ◽  
Flavonoid Content ◽  
Silybum Marianum ◽  
Dpph Method ◽  
Phenolic And Flavonoid

Purpose: Milk thistle (Silybum marianum (L.) Gaertn) has been used for centuries as a natural remedy for liver and gall bladder / biliary tract diseases. Silymarin is the purified and standardized extract from milk thistle seeds. The purpose of the present study is to present a comparative analysis of the total phenolic substances content and the antioxidant effect of silymarin and three different types of Silybum marianum extracts (i.e. ethanol extract, water extract and lyophilized extract). Methods: Total phenolic and flavonoid content of extracts was analysed and the antioxidant activity was assessed by determining their free radical scavenging ability by DPPH method. Results: Total phenolic content is the highest in silymarin– 134.12±3.22 mg GAE/g, followed by lyophilized water extract – 51.74±2.10 mg GAE/g. Silymarin has also been found to have the highest antioxidant activity among all extract samples (338.03 VCEAC µmol /g), followed by S.marianum lyophilised extract (123.05 VCEAC µmol/g). Conclusions: A strong correlation between total phenolic and flavonoid content in the extracts and their antioxidant activity has been found.

scholarly journals Effects of Different Extraction Methods and Solvents on the Phenolic Composition and Antioxidant Activity of Silybum Marianum Leaves Extracts

2018 ◽  
Vol 5 (3) ◽  
pp. 3641-3647 ◽  
Author(s):  
Abbassia Benchaachoua ◽  
Hassiba Mahdjoub Bessam ◽  
Imene Saidi
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Condensed Tannin ◽  
Ethanolic Extract ◽  
Extraction Methods ◽  
Aqueous Methanol ◽  
Silybum Marianum ◽  
Antioxidant Power ◽  
Extraction Solvent ◽  
Percentage Yield

Objective: The objectives of this study were essentially to evaluate the best technique for extracting phenolic compounds from Silybum marianum leaves. Subjects and Methods: Two extraction methods (maceration and decoction), using four extraction solvents. The efficiency of the extraction methods was estimated by quantifying the total polyphenol contents by the Folin -Ciocalteu method and by determining the antioxidant power of the various extracts by the ability to trap the free radical DPPH °, and the influence of these parameters on the antioxidant activity. Results: The results showed that the extracts of the leaves by maceration have contained the highest percentage yield (24.68%); the highest content in the aqueous -methanol polyphenols extract (18.75 ± 0.55 mg GAE / g DW ) against the decoction is more effective for the extraction of flavonoids and condensed tannins. The highest content of flavonoids had been recorded for the aqueous- ethanolic extract (5.08 ± 0.57 CE mg / g DW). The water had the highest content of condensed tannin (03.86 ± 0.22 TAE / g DW). On the other hand, the aqueous -ethanolic and aqueous -methanol extract of the leaves obtained by maceration have the best antioxidant capacity (73.84 ± 5.90 EAG / g DW and 73.64 ± 5.93 mg EAG / g DW respectively) and the aqueous extract of the leaves by decoction had a better antiradical power (48.64 μg / ml). Conclusion: The extraction of phenolic compounds from Silybum marianum leaves was strongly influenced by the type of solvent and the extraction method. In addition, it is very difficult to choose an appropriate extraction solvent for all plant samples.

scholarly journals Assessment of the Antioxidant Activity and Quality Attributes of Yogurt Enhanced with Wild Herbs Extracts

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Adriana Dabija ◽  
Georgiana Gabriela Codină ◽  
Sorina Ropciuc ◽  
Anca-Mihaela Gâtlan ◽  
Lăcrămioara Rusu
Keyword(s):  
Antioxidant Activity ◽  
Rheological Properties ◽  
Antioxidant Properties ◽  
Control Sample ◽  
Rheological Parameters ◽  
Aqueous Extracts ◽  
Silybum Marianum ◽  
Origanum Vulgare ◽  
Qualitative Characteristics ◽  
Herb Extracts

The milk and yogurt products assortment has expanded by their enhancement with herb extracts, fibres extracted from by-products of the fruit processing industry and also fresh spices. The aim of the present study was to test to what extent the addition of different herb extracts in yogurt will improve its qualitative characteristics and antioxidant activity. The aqueous extracts obtained from the four plants are considered in this study, respectively, thistle (Silybum marianum L.), hawthorn (Crataegus monogyna), sage (Salvia officinalis L.), and marjoram (Origanum vulgare L.). It was examined the effect of aqueous extracts prepared from four herbs (0.25/1%) (w/w) on yogurt’s qualitative characteristics (pH, titratable acidity, syneresis, water holding capacity, antioxidant activity, colour parameters, and rheological parameters) on both one day and 28 days after preparation. The final results show that the physicochemical and rheological properties of the yoghurt with herb extracts addition were improved compared to the control sample after 28 days of storage. The best results in terms of antioxidant properties were obtained when marjoram extract (Origanum vulgare L.) was incorporated. According to the data obtained, the best quality in terms of the physicochemical and rheological properties were in the case of the sample with 0.5% thistle extract (Silybum marianum L.) addition, while from point of view of the nutritional value, the best quality was in the case of the sample with 1% marjoram extract (Origanum vulgare L.) addition. The present study leads to the conclusion that yogurts enhanced with natural extracts may serve as functional food products, with significant health benefits.

scholarly journals Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: a pilot study

2017 ◽  
Vol Volume 9 ◽  
pp. 11-18 ◽  
Author(s):  
Kwanjit Danwilai ◽  
Jitprapa Konmun ◽  
Bungorn Sripanidkulchai ◽  
Suphat Subongkot
Keyword(s):  
Antioxidant Activity ◽  
Pilot Study ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Ginger Extract
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