Effects of fluid flow on the in vitro degradation kinetics of biodegradable scaffolds for tissue engineering

Biomaterials ◽  
2000 ◽  
Vol 21 (23) ◽  
pp. 2443-2452 ◽  
Author(s):  
C.M Agrawal ◽  
J.S McKinney ◽  
D Lanctot ◽  
K.A Athanasiou
Keyword(s):  
Tissue Engineering ◽  
Fluid Flow ◽  
Degradation Kinetics ◽  
In Vitro Degradation ◽  
Biodegradable Scaffolds ◽  
Kinetics Of

In vitro degradation kinetics of pure PLA and Mg/PLA composite: Effects of immersion temperature and compression stress

2017 ◽  
Vol 48 ◽  
pp. 468-478 ◽  
Author(s):  
Xuan Li ◽  
Chenglin Chu ◽  
Yalin Wei ◽  
Chenxi Qi ◽  
Jing Bai ◽  
...  
Keyword(s):  
Degradation Kinetics ◽  
Compression Stress ◽  
In Vitro Degradation ◽  
Kinetics Of

The In Vitro Degradation Kinetics of Polyurethane Prodrug Materials

2011 ◽  
Vol 399-401 ◽  
pp. 1067-1070
Author(s):  
Chun Yan Li ◽  
Cong Cong Hu ◽  
Zhi Guo Wen ◽  
Sheng Xiong Dong
Keyword(s):  
Drug Release ◽  
High Performance ◽  
Degradation Kinetics ◽  
Hplc Method ◽  
In Vitro Degradation ◽  
Erosion Mechanism ◽  
First Order ◽  
First Order Kinetics ◽  
Kinetics Of

The method of high performance liquid chromatography (HPLC) is established to determine the content of antibacterial agent — ciprofloxacin (CF) in the degradation solution of ciprofloxacin-polyurethane (CFPU) and investigate the in vitro degradation kinetics by plotting and fitting the cumulative release curves to inspect the effects of different medium and different concentrations on drug release. The results showed that the HPLC method is accurate, reliable and simple. The drug-release of CFPU was bioresponsive and could be accorded with first order kinetics. It was observed that CF was released from CFPU by a combination of diffusion and erosion mechanism, mainly in the manner of diffusion in the absence of infection while erosion mechanism in the presence of infection.

Cytotoxicity and in Vitro Degradation Kinetics of Foundry-Compatible Semiconductor Nanomembranes and Electronic Microcomponents

ACS Nano ◽  
2018 ◽  
Vol 12 (10) ◽  
pp. 9721-9732 ◽  
Author(s):  
Jan-Kai Chang ◽  
M. A. Bashar Emon ◽  
Chia-Shuo Li ◽  
Quansan Yang ◽  
Hui-Ping Chang ◽  
...  
Keyword(s):  
Degradation Kinetics ◽  
In Vitro Degradation ◽  
Kinetics Of

Bioengineered Teeth from Cultured Rat Tooth Bud Cells

2004 ◽  
Vol 83 (7) ◽  
pp. 523-528 ◽  
Author(s):  
M.T. Duailibi ◽  
S.E. Duailibi ◽  
C.S. Young ◽  
J.D. Bartlett ◽  
J.P. Vacanti ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Engineering Applications ◽  
Adult Rat ◽  
Dental Tissues ◽  
Biodegradable Scaffolds ◽  
Bioengineered Tooth ◽  
Tooth Tissue

The recent bioengineering of complex tooth structures from pig tooth bud tissues suggests the potential for the regeneration of mammalian dental tissues. We have improved tooth bioengineering methods by comparing the utility of cultured rat tooth bud cells obtained from three- to seven-day post-natal (dpn) rats for tooth-tissue-engineering applications. Cell-seeded biodegradable scaffolds were grown in the omenta of adult rat hosts for 12 wks, then harvested. Analyses of 12-week implant tissues demonstrated that dissociated 4-dpn rat tooth bud cells seeded for 1 hr onto PGA or PLGA scaffolds generated bioengineered tooth tissues most reliably. We conclude that tooth-tissue-engineering methods can be used to generate both pig and rat tooth tissues. Furthermore, our ability to bioengineer tooth structures from cultured tooth bud cells suggests that dental epithelial and mesenchymal stem cells can be maintained in vitro for at least 6 days.

Scaffolds in tissue engineering of blood vessels

2010 ◽  
Vol 88 (9) ◽  
pp. 855-873 ◽  
Author(s):  
Divya Pankajakshan ◽  
Devendra K. Agrawal
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Blood Vessels ◽  
Vascular Tissue ◽  
Small Diameter ◽  
Biological Scaffolds ◽  
Hemodynamic Forces ◽  
Biodegradable Scaffolds

Tissue engineering of small diameter (<5 mm) blood vessels is a promising approach for developing viable alternatives to autologous vascular grafts. It involves in vitro seeding of cells onto a scaffold on which the cells attach, proliferate, and differentiate while secreting the components of extracellular matrix that are required for creating the tissue. The scaffold should provide the initial requisite mechanical strength to withstand in vivo hemodynamic forces until vascular smooth muscle cells and fibroblasts reinforce the extracellular matrix of the vessel wall. Hence, the choice of scaffold is crucial for providing guidance cues to the cells to behave in the required manner to produce tissues and organs of the desired shape and size. Several types of scaffolds have been used for the reconstruction of blood vessels. They can be broadly classified as biological scaffolds, decellularized matrices, and polymeric biodegradable scaffolds. This review focuses on the different types of scaffolds that have been designed, developed, and tested for tissue engineering of blood vessels, including use of stem cells in vascular tissue engineering.

scholarly journals Chemical-bromatological composition and in vitro ruminal kinetics of sugar cane silage with maniçoba

2018 ◽  
Vol 40 (1) ◽  
pp. 42569
Author(s):  
Francisco Allan Leandro de Carvalho ◽  
Percivaldo Xavier Resende ◽  
Clístenes Amorim Benicio ◽  
Jackson De Oliveira Siqueira ◽  
Daniel Ribeiro Menezes ◽  
...  
Keyword(s):  
Sugar Cane ◽  
Nutritive Value ◽  
Degradation Kinetics ◽  
Gas Production ◽  
Metabolizable Energy ◽  
Randomized Design ◽  
In Vitro Gas Production ◽  
Inclusion Level ◽  
Kinetics Of

The objective this study was to evaluate the effect of maniçoba supplementation in sugar cane silage with respect to chemical-bromatological composition and the in vitro degradation kinetics of the silage. This experiment was conducted in a completely randomized design with four treatments (maniçoba levels: 0, 20, 30, and 40%) and six repetitions. Silage samples were analyzed for their chemical-bromatological composition, digestible energy, metabolizable energy, total digestible nutrients, in vitro gas production and degradability parameters. The silage with higher inclusion level had better bromatological composition (p < 0.05) than the silage without maniçoba for CP, NDF, ADF and MM (6.49, 56.64, 38.66 and 4.52% versus 2.21, 70.96, 49.95 and 2.78%). Higher ME content (2.35 MJ kg-1 MS versus 1.85 MJ kg-1 MS), DE (2.87 Mcal kg-1 MS versus 2.25 Mcal kg-1 MS) and TDN (65.16% versus 51.11%), respectively. The highest values for gas production were also observed in silage with added maniçoba due to higher NFC content (34.87%). With an increase in the proportion of maniçoba, there was an increase in the soluble a fraction, b fraction, and thus a higher effective degradability of dry matter (46.56%). The addition of maniçoba improves the nutritive value of sugarcane silage.  

Synthesis of Biodegradable Polyester by Polycondensation with Tunable Properties

2015 ◽  
Vol 1119 ◽  
pp. 418-422
Author(s):  
Lee Xiau Yeen ◽  
Mat Uzir Wahit
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Material Properties ◽  
Drug Delivery Systems ◽  
Molar Ratio ◽  
Cross Link ◽  
In Vitro Degradation ◽  
Broad Application ◽  
Dodecanedioic Acid

A biodegradable cross-linked polyester, poly (1, 8-octanediol-glycerol-dodecanedioate) (POGDA) was prepared from 1, 8-octanediol (Oct), glycerol (Gly) and dodecanedioic acid (DA) without any catalyst. One of the factors, molar ratio of monomers greatly affects the material properties of POGDA and the effect was evaluated. Result showed that the glycerol acts as cross-link agent. When the molar ratio of glycerol increased, the gel content of POGDA became higher. POGDA has a range of glass transition temperature (Tg) with different monomers’ molar ratio. Exist of melting point (Tm) indicated the crystallline region in the polymer. POGDA with low molar ratio of glycerol has high Tm due to the bigger region of crystal. In vitro degradation was performed to investigate the biodegradation behaviour of POGDA. The polymer with tunable material properties by tailoring monomers’ molar ratio is expected to have broad application in medical fields such as drug delivery systems and tissue engineering.

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