Effects of pomegranate (Punica granatum L.) peel extract supplementation on serum lipid profile and oxidative stress in obese women with knee osteoarthritis: A double blind, randomized, placebo controlled study

2020 ◽  
Author(s):  
Mahdiyeh Khadem Haghighian ◽  
Maryam Rafraf ◽  
Salar Hemmati ◽  
Simin Haghravan ◽  
Mohammad Asghari-Jafarabadi
Keyword(s):  
Oxidative Stress ◽  
Knee Osteoarthritis ◽  
Serum Lipid ◽  
Punica Granatum ◽  
Controlled Study ◽  
Obese Women ◽  
Double Blind ◽  
Punica Granatum L ◽  
And Oxidative Stress ◽  
Peel Extract

scholarly journals Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2021 ◽  
Vol Volume 14 ◽  
pp. 525-534
Author(s):  
Laine de Carvalho Guerra Pessoa Mamede ◽  
Rafaela Lira Formiga Cavalcanti de Lima ◽  
Alexandre Sérgio Silva ◽  
João Carlos Lima Rodrigues Pita ◽  
Nadjeanny Ingrid Galdino Gomes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Vitamin D3 ◽  
Controlled Clinical Trial ◽  
Oxidative Stress Markers ◽  
Obese Women ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Stress Markers ◽  
And Oxidative Stress

scholarly journals The Multispecies Probiotic Effectively Reduces Homocysteine Concentration in Obese Women: A Randomized Double-Blind Placebo-Controlled Study

2020 ◽  
Vol 9 (4) ◽  
pp. 998 ◽  
Author(s):  
Karolina Majewska ◽  
Matylda Kręgielska-Narożna ◽  
Hieronim Jakubowski ◽  
Monika Szulińska ◽  
Paweł Bogdański
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Controlled Trial ◽  
Density Lipoprotein ◽  
Controlled Study ◽  
Obese Women ◽  
Bacterial Strains ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Homocysteine Concentration

Dysregulated metabolism of homocysteine (Hcy) is associated with obesity. Supplementation with probiotics can potentially be a natural therapeutic method for metabolic disorders. The precise mechanism in which microbiota affect Hcy metabolism in obese individuals is still unknown. The aim of this study was to evaluate the effects of a 12-week supplementation with a multispecies probiotic on Hcy levels, oxidative stress, inflammation and lipid profile in obese patients. This randomized double-blind placebo-controlled trial was performed on 50 obese women (aged 45–70 years). Subjects were randomly assigned to take either a multispecies probiotic supplement (n = 25) or placebo (n = 25) for 12 weeks. The probiotic contained nine bacterial strains containing 2.5 × 109 CFU/g. Biochemical and anthropometric measurements were carried out at baseline and after 12 weeks of intervention. At the end of the study, a significant decrease in Hcy, tumor necrosis factor α (TNF-α), total cholesterol (TC), low-density lipoprotein cholesterol (LDL) and triglyceride (TG) levels were observed in the probiotic group. The amelioration of total antioxidant status (TAS) was also observed. The 12-week supplementation of the multispecies probiotic (Ecologic® BARIER) effectively reduced Hcy concentration, oxidative stress and inflammation, and improved the lipid profile. These multidirectional effects can potentially reduce cardiometabolic risks.

An antioxidant probiotic reduces postprandial lipemia and oxidative stress

2011 ◽  
Vol 6 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Tiiu Kullisaar ◽  
Jelena Shepetova ◽  
Kersti Zilmer ◽  
Epp Songisepp ◽  
Aune Rehema ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Healthy Subjects ◽  
Oxidized Ldl ◽  
Postprandial Lipemia ◽  
Blood Parameters ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Positive Effect ◽  
And Oxidative Stress

AbstractReducing postprandial oxidative stress (OxS), decreasing postprandial blood triglyceride level (TG) and improving lipoprotein status is likely to have a preventive impact on the development of cardiovascular disease (CVD). Previously we have shown that the antioxidant probiotic Lactobacillus fermentum ME-3 (DSM14241) is characterized by antiatherogenic effects. This randomized double-blind placebo-controlled study evaluated the influence of kefir enriched with an antioxidative probiotic L. fermentum ME-3 (LfKef) on postprandial OxS, blood TG response and lipoprotein status. 100 clinically healthy subjects were recruited into the study. Blood parameters of postprandial OxS, TG and lipoprotein status were determined by oxidized LDL, baseline diene conjugation in LDL (BDC-LDL), oxidized LDL complex with beta-2 glycoprotein (Beta2-GPI-oxLDL), paraoxonase (PON) activity, LDL-Chol, HDL-Chol and TG. To evaluate general body postprandial OxS-load we measured 8-isoprostanes (8-EPI) in the urine. Consumption of LfKef significantly reduced the postprandial level of oxidized LDL, BDC-LDL, Beta2-GPI-oxLDL, urinary 8-isoprostanes and postprandial TG and caused a significant increase in HDL-Chol and PON activity. This is the first evidence that kefir enriched with an antioxidant probiotic may have a positive effect on both postprandial OxS and TG response as well as on lipoprotein status.

Sign in / Sign up

Export Citation Format

Share Document