Prehypertension and Elevated Risk of Cardiovascular Disease: Physiopathologic Mechanisms

2007 ◽  
Vol 120 (4) ◽  
pp. e11 ◽  
Author(s):  
Flora Affuso ◽  
Antonio Ruvolo ◽  
Serafino Fazio
Author(s):  
Jessica Sherman ◽  
Christina Dyar ◽  
Jodi McDaniel ◽  
Nicholas T. Funderburg ◽  
Karen M. Rose ◽  
...  

1999 ◽  
Vol 17 (5) ◽  
pp. 369-377 ◽  
Author(s):  
MARIT SORENSEN ◽  
SIGMUND ANDERSSEN ◽  
INGVAR HJERMAN ◽  
INGAR HOLME ◽  
HOLGER URSIN

Author(s):  
Alexander Meyer ◽  
Sanjay Dandamudi ◽  
Chad Achenbach ◽  
Donald Lloyd-Jones ◽  
Matthew Feinstein

Background: Persons with HIV have elevated risk for cardiovascular disease, but little is known about the risk of ventricular ectopy and ventricular tachycardia (VE/VT) for HIV-infected (HIV+) persons. Methods: We evaluated the presence and anatomic origin of VE/VT for HIV+ persons and controls by screening a cohort using International Classification of Diseases codes and adjudicating positive screens by chart review. We sought to evaluate (1) presence of VE/VT and (2) likely anatomic origin of the VE/VT based on electrocardiogram. Results: There was no significant difference in the prevalence of VE/VT for HIV+ or uninfected persons. Among HIV+ persons, worse HIV control was associated with significantly greater odds of VE/VT. Exploratory analyses suggested that HIV+ persons may have a greater likelihood of VE/VT originating from the left ventricle. Conclusion: Although worse HIV control was associated with higher odds of VE/VT among persons with HIV, odds of VE/VT were not higher for persons with HIV than uninfected persons.


2018 ◽  
Vol 25 (18) ◽  
pp. 1990-1999 ◽  
Author(s):  
Bahira Shahim ◽  
Sofia Hasselberg ◽  
Oscar Boldt-Christmas ◽  
Viveca Gyberg ◽  
Linda Mellbin ◽  
...  

Background Identifying type 2 diabetes mellitus (T2DM) is a prerequisite for the institution of preventive measures to reduce future micro and macrovascular complications. Approximately 50% of people with T2DM are undiagnosed, challenging the assumption that a traditional primary healthcare setting is the most efficient way to reach people at risk of T2DM. A setting of this kind may be even more suboptimal when it comes to reaching immigrants, who often appear to have inferior access to healthcare and/or are less likely to attend routine health checks at primary healthcare centres. Objectives The objective of this study was to identify the best strategy to reach individuals at high risk of T2DM and thereby cardiovascular disease in a heterogeneous population. Methods All 18–65-year-old inhabitants in the Swedish municipality of Södertälje ( n∼51,000) without known T2DM and cardiovascular disease were encouraged to complete the Finnish Diabetes Risk Score (FINDRISC: score > 15 indicating a high and > 20 a very high risk of future T2DM and cardiovascular disease) through the following communication channels: primary care centres, workplaces, Syrian orthodox churches, pharmacies, crowded public places, mass media, social media and mail. Data collection lasted for six weeks. Results The highest response rate was obtained through workplaces (27%) and the largest proportion of respondents at high/very high risk through the Syrian orthodox churches (18%). The proportion reached through primary care centres was 4%, of whom 5% were at elevated risk. The cost of identifying a person at elevated risk through the Syrian orthodox church was €104 compared with €8 through workplaces and €112 through primary care centres. Conclusions The choice of communication channels was important to reach high/very high-risk individuals for T2DM and for screening costs. In this immigrant-dense community, primary care centres were inferior to strategies using workplaces and churches in terms of both the proportion of identified at-risk individuals and costs.


CNS Spectrums ◽  
2008 ◽  
Vol 13 (S10) ◽  
pp. 7-8 ◽  
Author(s):  
Roger S. McIntyre

The 12-month and lifetime prevalences of bipolar I and II disorder in the United States are 2.0% and 3.3%, respectively. Similar to schizophrenia, bipolar disorder is also associated with premature and excess mortality, with an estimated loss of ∼15 years of life expectancy. Most of the excess mortality in individuals with mood disorders results from natural causes, not suicide. Again, similar to schizophrenia, the most common cause of death in patients with bipolar disorder is cardiovascular disease (CVD), which occurs approximately twice as often in this group as in the general population. Although the data are more limited than in schizophrenia, people with bipolar disorder are differentially affected by medical comorbidity. Bipolar disorder is associated with elevated risk of a wide variety of comorbid medical illnesses, including migraine, asthma, chronic bronchitis, hypertension, and gastric ulcer, which compound disability and increase the burden of the disease.


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