scholarly journals Increased serum levels of cadmium are associated with an elevated risk of cardiovascular disease in adults

2021 ◽  
Author(s):  
Siyu Ma ◽  
Jie Zhang ◽  
Cheng Xu ◽  
Min Da ◽  
Yang Xu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Serum Levels ◽  
Elevated Risk

Serum Retinol and β-carotene Levels and Risk Factors for Cardiovascular Disease in Morbid Obesity

2010 ◽  
Vol 80 (3) ◽  
pp. 159-167 ◽  
Author(s):  
Gabriela Villaça Chaves ◽  
Gisele Gonçalves de Souza ◽  
Andréa Cardoso de Matos ◽  
Dra. Wilza Abrantes Peres ◽  
Silvia Elaine Pereira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Morbid Obesity ◽  
Serum Levels ◽  
World Health ◽  
Morbidly Obese ◽  
Serum Retinol ◽  
Significant Difference ◽  
Β Carotene

Objective: To evaluate retinol and β-carotene serum levels and their relationship with risk factors for cardiovascular disease in individuals with morbid obesity, resident in Rio de Janeiro. Methodology: Blood serum concentrations of retinol and β-carotene of 189 morbidly obese individuals were assessed. The metabolic syndrome was identified according to the criteria of the National Cholesterol Education Program (NCEP) and World Health Organization (WHO). Lipid profile, insulin resistance, basal insulin, glycemia, blood pressure, and anthropometry and their correlation with retinol and β-carotene serum levels were evaluated. Results: Metabolic syndrome diagnosis was observed in 49.0% of the sample. Within this percentage the levels of β-carotene were significantly lower when body mass index increased. Serum retinol didn't show this behavior. Serum retinol inadequacy in patients with metabolic syndrome (61.3%), according to WHO criterion, was higher (15.8%) than when the whole sample was considered (12.7%). When metabolic syndrome was diagnosed by NCEP criterion, β-carotene inadequacy was higher (42.8%) when compared to the total sample (37.5%). There was a significant difference between average β-carotene values of patients with and without metabolic syndrome (p=0.048) according to the classification of the NCEP. Lower values were found in patients with metabolic syndrome. Conclusion: Considering the vitamin A contribution in antioxidant protection, especially when risk factors for cardiovascular disease are present, it is suggested that great attention be given to morbidly obese. This could aid in prevention and treatment of cardiovascular disease, which affects a significant part of the population.

Risk factors for cardiovascular diseases and development of prehypertension

2018 ◽  
pp. 37-43
Author(s):  
В.В. Шерстнев ◽  
М.А. Грудень ◽  
В.П. Карлина ◽  
В.М. Рыжов ◽  
А.В. Кузнецова ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
Left Ventricular ◽  
Optimal Blood Pressure

Цель - исследование взаимосвязи факторов риска сердечно-сосудистых заболеваний и развития предгипертонии. Методика. Проведен сравнительный и корреляционный анализы показателей модифицируемых и немодифицируемых факторов риска сердечно-сосудистых заболеваний у обследованных лиц в возрасте 30-60 лет с «оптимальным» артериальным давлением, (n = 63, АД <120/80 мм рт.ст.) и лиц с предгипертонией (n = 52, АД = 120-139/80-89 мм рт.ст.). Результаты. Показано, что лица с предгипертонией по сравнению с группой лиц, имеющих «оптимальное» артериальное давление характеризуются статистически значимо повышенным содержанием холестерина и холестерина липопротеидов низкой плотности, интеллектуальным характером трудовой деятельности, а также значимыми сочетаниями факторов риска: повышенный уровень холестерина липопротеидов низкой плотности с интеллектуальным характером трудовой деятельности; повышенное содержание креатинина с уровнем триглициридов; наследственная отягощенность по заболеваниям почек и интеллектуальным характером трудовой деятельности; наследственная отягощенность по сахарному диабету и гипертрофия левого желудочка сердца. У лиц с предгипертонией документированы перестройки структуры взаимосвязи (количество, направленность и сила корреляций) между показателями факторов риска в сравнении с лицами, имеющими «оптимальное» артериальное давление. Заключение. Выявленные особенности взаимосвязей факторов риска сердечно-сосудистых заболеваний при предгипертонии рассматриваются как проявление начальной стадии дизрегуляционной патологии и нарушения регуляции физиологических систем поддержания оптимального уровня артериального давления. The aim of the study was to investigate the relationship between risk factors for cardiovascular disease and development of prehypertension. Methods. Comparative and correlation analyses of modifiable and non-modifiable risk factors for cardiovascular disease were performed in subjects aged 30-60 with «optimal» blood pressure (n = 63, BP <120/80 mm Hg) and prehypertension (n = 52, BP = 120-139 / 80-89 mm Hg). Results. The group with prehypertension compared with the «optimal» blood pressure group had significantly increased serum levels of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol, sedentary/intellectual type of occupation, and significant combinations of risk factors. The risk factor combinations included an increased level of LDL cholesterol and a sedentary/intellectual occupation; increased serum levels of creatinine and triglycerides; hereditary burden of kidney disease and a sedentary/intellectual occupation; hereditary burden of diabetes mellitus and cardiac left ventricular hypotrophy. In subjects with prehypertension compared to subjects with «optimal» blood pressure, changes in correlations (correlation number, direction, and strength) between parameters of risk factors were documented. Conclusion. The features of interrelationships between risk factors for cardiovascular disease observed in prehypertension are considered a manifestation of early dysregulation pathology and disordered regulation of physiological systems, which maintain optimal blood pressure.

Cardiovascular Risk Assessement in Osteoporotic Patients Using Osteoprotegerin as a Reliable Predictive Biochemical Marker

2018 ◽  
pp. 253
Author(s):  
Noora Wael Rasheed ◽  
Ooroba Jameel Taresh
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Serum Level ◽  
Biochemical Markers ◽  
Hdl Cholesterol ◽  
Predictive Marker ◽  
Serum Levels ◽  
Arterial Calcification ◽  
The Metabolic Syndrome

       Some studies indicated a relationship between increased serum levels of osteoprotegerin with arterial calcification and as a result, it leads to the risk of cardiovascular disease. In our study group we selected patients with osteoporosis, with similar age and body mass index for the assessment of the relationship between cardiovascular disease and osteoprotegerin serum level. We took into account the analysis of correlation and association between the presence of distinct patterns of atherosclerosis and associated diseases like high blood pressure,  diabetes mellitus, low HDL cholesterol, increased LDL cholesterol, increased triglycerides and was the case of presence of any type of dyslipidemia, in case of pre-existent treatment. Objective of study was the assessment of osteoprotegerin value as predictive marker for cardiovascular and metabolic risk in osteoporotic patients. Our results showed significant correlations of parathyroid hormone, osteocalcin and biochemical markers of bone with glucose metabolism and lipid were found in our research, maintaining crosstalk between calcium and biochemical markers of bone and cardiovascular risk. The serum level of Osteoprotegerin has been shown to have a large predictive value for the metabolic syndrome as a cardiovascular risk standard in patients with osteoporosis. The osteoprotegerin serum levels were increased in the patients with metabolic syndrome as a protective response facing the atherosclerotic lesions.

Sexual minorities are at elevated risk of cardiovascular disease from a younger age than heterosexuals

2022 ◽  
Author(s):  
Jessica Sherman ◽  
Christina Dyar ◽  
Jodi McDaniel ◽  
Nicholas T. Funderburg ◽  
Karen M. Rose ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Sexual Minorities ◽  
Elevated Risk ◽  
Younger Age

scholarly journals Relation of serum 25(OH) D with variables of thyroid and lipid profile in perimenopausal women

2017 ◽  
Vol 6 (3) ◽  
pp. 1087
Author(s):  
Poonam Rani ◽  
Seema Gupta ◽  
Gaurav Gupta
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Lipid Profile ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
The Body ◽  
P Value ◽  
Thyroid Disorder ◽  
Vitamin D Levels ◽  
Perimenopausal Women

Background: Deficiency of vitamin D is quite prevalent among elderly population or postmenopausal women worldwide and may affect various function of the body. The status of its deficiency with their relation with other variables are not well explored in perimenopausal women.Methods: 100 perimenopausal women from the department of obstetrics and gynaecology were selected without having known risk of thyroid disorder and cardiovascular disease. The age group criteria for these women were 40 to 50 years. Thyroid profile including TSH, T3, and T4 were estimated by using enzyme linked immunesorbent assay. Serum levels of 25(OH) D3 was estimated by using spectrophotometric method. Lipid profile including TC, TG and HDL-C were estimated CHOD-POD method, GPO-PAP method, and CHOD-POD/Phosphotungustate method. LDL-C was calculated by friedewald formula.Results: There 58 women were presented with insufficient amount of vitamin D. They were characterised with increased BMI, elevated thyrotropin alongwith lower concentrations of T3 and T4. Increased levels of TC, TG and LDL-cholesterol alongwith lower concentration of HDL-C were also observed in women with vitamin d deficiency. Women having vitamin D deficiency were presented with overweight (OR-18.0, p-value=<0.001) and dyslipidemia (OR-12.13, p-value≤0.001). Vitamin D was negatively correlated with variable i.e. BMI, TSH, TC, TG and LDL-C. This negative association was significant (<0.001) while HDL-C and T4 were positively correlated with vitamin D levels in this study population.Conclusions: Vitamin D deficiency frequently occurs in middle aged perimenopausal women. Negative correlation of it with BMI, TSH and lipid variables may suggest the development of cardiovascular disease and hypothyroidism in coming years. Vitamin D supplements or vitamin D containing diet and regular exposure to sun is highly recommended to perimenopausal women.

The effect of exercise and diet on mental health and quality of life in middle-aged individuals with elevated risk factors for cardiovascular disease

1999 ◽  
Vol 17 (5) ◽  
pp. 369-377 ◽  
Author(s):  
MARIT SORENSEN ◽  
SIGMUND ANDERSSEN ◽  
INGVAR HJERMAN ◽  
INGAR HOLME ◽  
HOLGER URSIN
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Elevated Risk ◽  
Middle Aged

scholarly journals Ventricular Ectopy and Arrhythmia Characteristics for Persons Living with HIV and Uninfected Controls

2019 ◽  
Vol 18 ◽  
pp. 232595821985212
Author(s):  
Alexander Meyer ◽  
Sanjay Dandamudi ◽  
Chad Achenbach ◽  
Donald Lloyd-Jones ◽  
Matthew Feinstein
Keyword(s):  
Cardiovascular Disease ◽  
Chart Review ◽  
International Classification Of Diseases ◽  
Elevated Risk ◽  
Ventricular Ectopy ◽  
Persons Living With Hiv ◽  
Significant Difference ◽  
Classification Of Diseases ◽  
Living With Hiv

Background: Persons with HIV have elevated risk for cardiovascular disease, but little is known about the risk of ventricular ectopy and ventricular tachycardia (VE/VT) for HIV-infected (HIV+) persons. Methods: We evaluated the presence and anatomic origin of VE/VT for HIV+ persons and controls by screening a cohort using International Classification of Diseases codes and adjudicating positive screens by chart review. We sought to evaluate (1) presence of VE/VT and (2) likely anatomic origin of the VE/VT based on electrocardiogram. Results: There was no significant difference in the prevalence of VE/VT for HIV+ or uninfected persons. Among HIV+ persons, worse HIV control was associated with significantly greater odds of VE/VT. Exploratory analyses suggested that HIV+ persons may have a greater likelihood of VE/VT originating from the left ventricle. Conclusion: Although worse HIV control was associated with higher odds of VE/VT among persons with HIV, odds of VE/VT were not higher for persons with HIV than uninfected persons.

scholarly journals Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review

2019 ◽  
Vol 20 (3) ◽  
pp. 628 ◽  
Author(s):  
Stefanos Roumeliotis ◽  
Evangelia Dounousi ◽  
Theodoros Eleftheriadis ◽  
Vassilios Liakopoulos
Keyword(s):  
Cardiovascular Disease ◽  
Renal Function ◽  
Vitamin K ◽  
Serum Levels ◽  
Matrix Gla Protein ◽  
Biologically Active ◽  
Vitamin K Deficiency ◽  
K Deficiency ◽  
Dependent Protein ◽  
Existing Data

Matrix Gla Protein (MGP), a small Gla vitamin K-dependent protein, is the most powerful natural occurring inhibitor of calcification in the human body. To become biologically active, MGP must undergo vitamin K-dependent carboxylation and phosphorylation. Vitamin K deficiency leads to the inactive uncarboxylated, dephosphorylated form of MGP (dpucMGP). We aimed to review the existing data on the association between circulating dpucMGP and vascular calcification, renal function, mortality, and cardiovascular disease in distinct populations. Moreover, the association between vitamin K supplementation and serum levels of dpucMGP was also reviewed.

scholarly journals Freeze-dried Whole Grapes Lower Serum Triglycerides in Postmenopausal Women (OR22-04-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sheau Chai ◽  
Breanna Nicholson ◽  
Regina Wright ◽  
Cara Cicalo ◽  
Nicole Kushner ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Postmenopausal Women ◽  
Interaction Effect ◽  
Group Interaction ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Significant Time ◽  
Freeze Dried

Abstract Objectives After the onset of menopause, the risk of cardiovascular disease increases drastically due to ovarian hormone deficiency. Grapes are high in polyphenolic compounds that have antioxidant and anti-inflammatory properties. The present study examined the effects of freeze-dried whole grape powder (GP) in reducing cardiovascular disease risk factors. Methods In this double-blind, placebo-controlled trial, 40 postmenopausal women (1 to 5 years past menopause), not on hormone therapy, were randomly assigned to consume either 46 g of GP or grape placebo powder for 12 weeks. Fasting blood samples, anthropometrics, blood pressure, physical activity, and dietary data were collected at baseline and after 12 weeks of the intervention. A mixed-effects model (PROC MIXED) was used to examine the effects of time, group, and the interaction between time and group. Paired t-tests were performed to compare changes from baseline within the group. P < 0.05 was considered statistically significant. Results Thirty-two women successfully completed the study. There was a significant time x group interaction effect observed for serum triglyceride (TG) (P < 0.05) and a borderline significant time x group interaction effect observed for serum total cholesterol (TC) (P = 0.06). In addition, a significant main effect of group was found in fasting glucose (P < 0.05), but without significant impacts of time and time x group interaction. Within-group analysis showed that the serum levels of TG significantly decreased by 26% (P < 0.05), while the serum levels of TC and low-density lipoprotein cholesterol numerically decreased by 8% and 11%, respectively after 12 weeks of GP consumption compared with corresponding baseline values. Neither GP nor placebo powder significantly altered body weight, high-density lipoprotein cholesterol, blood pressure, insulin or homeostatic model assessment-insulin resistance. Conclusions Our findings show that daily consumption of grapes lowers serum levels of TG in postmenopausal women. Larger follow-up studies are needed to ensure the validity of these findings. Funding Sources This research was funded by the California Table Grape Commission. Funders had no role in the study design, data collection, data analysis or interpretation, or writing of the abstract.

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