scholarly journals Relation between expression of hMLH1 and p53 mRNA genes, in the feces of patients with colorectal carcinoma. Cross-sectional study

2022 ◽  
pp. 103237
Author(s):  
Ryanto Karobuana Sitepu ◽  
Rosdiana Natzir ◽  
Warsinggih ◽  
Mochammad Hatta ◽  
Reno Rudiman ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
P53 Mrna

scholarly journals The THE FREQUENCY OF MISMATCH REPAIR DEFICIENCY IN COLORECTAL CARCINOMA DETERMINED BY IMMUNOHISTOCHEMISTRY

2021 ◽  
Vol 71 (4) ◽  
pp. 1395-99
Author(s):  
Maria Naseem ◽  
Muhammad Asif ◽  
Hafeez Ud Din ◽  
Muhammad Tahir Khadim ◽  
Ahmed Ahson Khan ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Mismatch Repair ◽  
Armed Forces ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Mismatch Repair Deficiency ◽  
Cross Sectional ◽  
Repair Deficiency ◽  
The Mean ◽  
Mmr Proteins

Objective: To determine the frequency of mismatch repair deficiency in colorectal carcinoma determined by immunohistochemistry. Study Design: Cross-sectional study. Place and Duration of Study: Department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi, from Aug 2018 to Jan 2019. Methodology: A total of 101 patients of adenocarcinoma of colorectum who underwent surgical resections and their characteristic and clinical data were recorded. Immunohistochemical stains were performed using antibodies MLH1, MSH2, PMS2 and MSH6. Results were interpreted and mismatch repair deficiency status of all patients was determined. Patients with loss of expression for MLH1, MSH2, PMS2 and MSH6 antibodies were observed and noted. Results: In this study, out of 101 patients with CRC, 71 (70.3%) were male and 30 (29.7%) female. The mean age was (54 years ± 15.9). Amongst the 101 cases loss of immunohistochemical staining for MMR proteins was noted in 19 patients (18.8%). The combined loss of all four antibodies was seen in one case, loss of MLH1 and PMS2 in 7, MSH2 and MSH6 in 5 and MLH1 only in 6 patients. However, no mismatch repair deficiency was detected in remaining 82 cases. According to statistical analysis no significant association between mismatch repair deficiency and variables was found. Conclusion: The frequency of mismatch repair deficiency in colorectal carcinoma patients was found to be 18.8% in our population.

scholarly journals Incidence of Colorectal carcinoma in Young Population of Islamabad

2019 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Colorectal Carcinoma ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Undifferentiated Carcinoma ◽  
Young Population ◽  
Sectional Study ◽  
Cross Sectional ◽  
Surgical Ward ◽  
Male Patients ◽  
Gender Presentation

The Purpose of this study is to promote awareness concerning increased incidence of colorectal carcinoma in younger population and its clinical as well as pathological features compared to older patients. This cross sectional study was conducted from January 2017 to October 2017 in patients with diagnosis of colorectal carcinoma admitted through emergency or outpatient department to surgical ward of PIMS hospital of Islamabad. Data concerning age, gender, presentation, site of tumor, surgery performed and Dukes staging was used for analysis. Total numbers of patients screened were 250. Patients with colorectal carcinoma were 27. Male patients were 17(63%) and females were 10 (37%). Patients between the ages of 10-20 were 4(15%) out of these 2 were declared unfit for surgery because of widespread tumor within the abdomen as well as distant metastasis. There were 9 (33%) patients between the ages of 21 to 30 while among these 4 were inoperable because of widespread and undifferentiated carcinoma. Patients between the ages of 31 and 40 were 5 (19%), among these 2 were inoperable. The next category of patients was between the ages of 41 to 50, they were 4 (15%). There were 3 (11%) patients between the ages of 51 and 60, and 2 (7%) cases were between the ages of 61 to 70. Total 9 (33.3%) young patients were inoperable and they were of age 50 and below 50. Colorectal Carcinoma is more aggressive among young patients [1,2]. Total Stage D inoperable patients were 11(40.7%) and 18 (82%). Patients between the ages of 10 to 50 had left sided disease.

Does a Graduate Course in Fluency Disorders Make a Difference?

2010 ◽  
Vol 20 (1) ◽  
pp. 10-14 ◽  
Author(s):  
Evelyn R. Klein ◽  
Barbara J. Amster
Keyword(s):  
Undergraduate Students ◽  
Graduate Programs ◽  
The United States ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Graduate Course ◽  
Cross Sectional ◽  
Fluency Disorders ◽  
Introductory Course ◽  
Communicative Disorders

Abstract A study by Yaruss and Quesal (2002), based on responses from 134 of 239 ASHA accredited graduate programs, indicated that approximately 25% of graduate programs in the United States allow students to earn their degree without having coursework in fluency disorders and 66% of programs allow students to graduate without clinical experience treating people who stutter (PWS). It is not surprising that many clinicians report discomfort in treating PWS. This cross-sectional study compares differences in beliefs about the cause of stuttering between freshman undergraduate students enrolled in an introductory course in communicative disorders and graduate students enrolled and in the final weeks of a graduate course in fluency disorders.

Confidence toward vaccination as reported by parents of children admitted to a tertiary care hospital in Riyadh, Saudi Arabia: A cross sectional study

Vacunas ◽  
2020 ◽  
Vol 21 (2) ◽  
pp. 95-104 ◽  
Author(s):  
Y.M. AlGoraini ◽  
N.N. AlDujayn ◽  
M.A. AlRasheed ◽  
Y.E. Bashawri ◽  
S.S. Alsubaie ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional

Conflict Avoidance in Old Age

GeroPsych ◽  
2017 ◽  
Vol 30 (2) ◽  
pp. 61-70 ◽  
Author(s):  
Lia Oberhauser ◽  
Andreas B. Neubauer ◽  
Eva-Marie Kessler
Keyword(s):  
Social Support ◽  
Perceived Social Support ◽  
Well Being ◽  
Cross Sectional Study ◽  
Conflict Avoidance ◽  
Subjective Well Being ◽  
Sectional Study ◽  
Cross Sectional ◽  
Adult Lifespan ◽  
Set Up

Abstract. Conflict avoidance increases across the adult lifespan. This cross-sectional study looks at conflict avoidance as part of a mechanism to regulate belongingness needs ( Sheldon, 2011 ). We assumed that older adults perceive more threats to their belongingness when they contemplate their future, and that they preventively react with avoidance coping. We set up a model predicting conflict avoidance that included perceptions of future nonbelonging, termed anticipated loneliness, and other predictors including sociodemographics, indicators of subjective well-being and perceived social support (N = 331, aged 40–87). Anticipated loneliness predicted conflict avoidance above all other predictors and partially mediated the age-association of conflict avoidance. Results suggest that belongingness regulation accounts may deepen our understanding of conflict avoidance in the second half of life.

Internalizing Behavior During the Transition from Childhood to Adolescence

2010 ◽  
Vol 26 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Marc Vierhaus ◽  
Arnold Lohaus ◽  
Indra Shah
Keyword(s):  
Research Design ◽  
Internalizing Symptoms ◽  
Fourth Graders ◽  
Cross Sectional Study ◽  
Second Graders ◽  
Internalizing Behavior ◽  
Longitudinal Assessment ◽  
Sectional Study ◽  
Cross Sectional ◽  
The One

This investigation focuses on the question whether assessments of the development of internalizing behavior from childhood to adolescence are affected by the kind of research design (longitudinal versus cross-sectional). Two longitudinal samples of 432 second-graders and 366 fourth graders participated in a longitudinal study with subsequent measurements taken 1, 2, and 3 years later. A third sample consisting of 849 children covering the same range of grades participated in a cross-sectional study. The results show that the development of internalizing symptoms in girls – but not in boys – varies systematically with the research design. In girls, there is a decrease of internalizing symptoms (especially between the first two timepoints) in the longitudinal assessment, which may reflect, for example, the influence of strain during the first testing situation. Both longitudinal trajectories converge to a common trajectory from grade 2 to grade 7 when controlling for this “novelty-distress effect.” Moreover, when we control this effect, the slight but significant decrease characterizing the common trajectory becomes similar to the one obtained in the cross-sectional study. Therefore, trajectories based on longitudinal assessments may suggest more changes with regard to internalizing symptoms over time than actually take place, while trajectories based on cross-sectional data may be characterized by an increased level of internalizing symptoms. Theoretical and practical implications of these results are discussed.

Sign in / Sign up

Export Citation Format

Share Document