WHILE MEDICAL HISTORIANS cannot provide us with accurate statistics concerning the incidence of rickets and scurvy in centuries past, they leave little room for doubt about the high prevalence of these disorders prior to the advent of modern scientific medicine. Thus, Castiglione has written that in the sixteenth century scurvy raged throughout northern Europe, in Scandinavia, on the shores of the Baltic, and in the interior of Germany. It is interesting to note, however, that Jacques Cartier, whose sailors had been ravaged by scurvy, learned in 1536 from the Indians that the malady could be cured by juices of the almeda tree. This was 200 years before James Lind demonstrated the curative effects of lemon juice in his treatise on scurvy published in 1753 and almost 400 years before ascorbic acid, which was isolated by Szent-Gyorgi in 1928, was recognized to be vitamin C by Waugh and King in 1932.
Rickets, likewise, was occurring in a large portion of children prior to the discovery of the existence of vitamin D by Hess, Steinbock, and Windaus in 1918, of its therapeutic value by Mellanby in 1919, of the equivalent role of sunlight by Hess in 1921, and of the chemical composition of the vitamins by Windaus in 1922. But 200 years earlier Friedrick Hoffman had the answer to the control of this disease almost in hand. He attached much importance to climatic conditions as a factor in rickets, noting that if anything is specially powerful in producing this affliction, it is a surrounding atmosphere of cold foggy air. He cited as striking evidence of this the famous emporium of England, London, which he found to be specially apt to produce and foster this disease.
Role of endophytic fungi in grass litter decomposition
