The topographical properties of silica nanoparticle film preserve the osteoblast-like cell characteristics in vitro

2016 ◽  
Vol 376 ◽  
pp. 62-68
Author(s):  
Wooyoung Shim ◽  
Seung Yun Lee ◽  
Hyo-Sop Kim ◽  
Jae-Ho Kim
Keyword(s):  
Silica Nanoparticle ◽  
Nanoparticle Film

Mesoporous Silica Nanoparticles of Hydroxyurea: Potential

2020 ◽  
Vol 10 ◽  
Author(s):  
Kumar Nishchaya ◽  
Swatantra K.S. Kushwaha ◽  
Awani Kumar Rai
Keyword(s):  
Drug Release ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Average Particle Size ◽  
Silica Nanoparticle ◽  
Average Particle ◽  
Independent Variables ◽  
Lower Temperature

Background: Present malignant cancer medicines has the advancement of magnetic nanoparticles as delivery carriers to magnetically accumulate anticancer medication in malignant growth tissue. Aim: In the present investigation, a silica nanoparticles (MSNs) stacked with hydroxyurea were combined and was optimized for dependent and independent variables. Method: In this study, microporous silica nanoparticle stacked with neoplastic medication had been prepared through emulsification followed with solvent evaporation method. Prepared MSNs were optimized for dependent and independent variables. Different formulations were prepared with varying ratio of polymer, lipid and surfactant which affects drug release and kinetics of drug release pattern. The obtained MSNs were identified by FTIR, SEM, drug entrapment, in-vitro drug release, drug release kinetics study, stability testing in order to investigate the nanoparticle characteristics. Results: The percentage drug entrapment of the drug for the formulations F1, F2, F3, was found to be 27.78%, 65.52% and 48.26%. The average particle size for F2 formulation was found to be 520 nm through SEM. The cumulative drug release for the formulations F1, F2, F3 was found to be 64.17%, 71.82% and 32.68%. The formulations were found to be stable which gives controlled drug delivery for 6 hours. Conclusion: From the stability studies data it can be culminated that formulations are most stable when stored at lower temperature or in refrigerator i.e. 5˚C ± 3˚C. It can be concluded that MSN’s loaded with hydroxyurea is a promising approach towards the management of cancer due to its sustained release and less side effects.

Ultralow friction of graphene-coated silica nanoparticle film

2022 ◽  
Vol 204 ◽  
pp. 111184
Author(s):  
Haoxuan Li ◽  
Paulo S. Branicio
Keyword(s):  
Silica Nanoparticle ◽  
Ultralow Friction ◽  
Nanoparticle Film

Proton transport over nanoparticle surface in insulating nanoparticle film-based humidity sensor

2022 ◽  
Author(s):  
Shinya Kano ◽  
Harutaka MEKARU
Keyword(s):  
Activation Energy ◽  
Proton Transfer ◽  
Proton Transport ◽  
Humidity Sensor ◽  
Silica Nanoparticle ◽  
Humidity Sensors ◽  
Nanoparticle Surface ◽  
Transfer Mechanisms ◽  
Hydrophobic Ligand ◽  
Nanoparticle Film

Abstract We study a proton transport on the surface of insulating nanoparticles for humidity sensors. We use the approach to reveal proton transfer mechanisms in humidity sensitive materials. Hydrophilic and hydrophobic ligand-terminated silica nanoparticle films are adopted for evaluating temperature dependence of the ion conductivity. According to the activation energy of the conductivity, we explain the Grotthuss (H+ transfer) and vehicular (H3O+ transfer) mechanisms are mainly dominant on hydrophilic (-OH terminated) and hydrophobic (acrylate terminated) surface of nanoparticles, respectively. This investigation gives us a clue to understand a proton transfer mechanism in solution-processed humidity-sensitive materials such as oxide nanomaterials.

scholarly journals AC-STEM and HRSEM Investigation of Silica Nanoparticle Film Structure

2019 ◽  
Vol 25 (S2) ◽  
pp. 2008-2009
Author(s):  
Joe V Carpenter ◽  
Shannon Poges ◽  
Zachary C Holman
Keyword(s):  
Silica Nanoparticle ◽  
Film Structure ◽  
Nanoparticle Film

scholarly journals Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in breast cancer cells: an improved nanomedicine strategy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Chandran Murugan ◽  
Kathirvel Rayappan ◽  
Ramar Thangam ◽  
Ramasamy Bhanumathi ◽  
Krishnamurthy Shanthi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Structural Changes ◽  
Silica Nanoparticle ◽  
Therapeutic Effects ◽  
Multiple Drugs

Abstract Combination therapy of multiple drugs through a single system is exhibiting high therapeutic effects. We investigate nanocarrier mediated inhibitory effects of topotecan (TPT) and quercetin (QT) on triple negative breast cancer (TNBC) (MDA-MB-231) and multi drug resistant (MDR) type breast cancer cells (MCF-7) with respect to cellular uptake efficiency and therapeutic mechanisms as in vitro and in vivo. The synthesized mesoporous silica nanoparticle (MSN) pores used for loading TPT; the outer of the nanoparticles was decorated with poly (acrylic acid) (PAA)-Chitosan (CS) as anionic inner-cationic outer layer respectively and conjugated with QT. Subsequently, grafting of arginine-glycine-aspartic acid (cRGD) peptide on the surface of nanocarrier (CPMSN) thwarted the uptake by normal cells, but facilitated their uptake in cancer cells through integrin receptor mediated endocytosis and the dissociation of nanocarriers due to the ability to degrade CS and PAA in acidic pH, which enhance the intracellular release of drugs. Subsequently, the released drugs induce remarkable molecular activation as well as structural changes in tumor cell endoplasmic reticulum, nucleus and mitochondria that can trigger cell death. The valuable CPMSNs may open up new avenues in developing targeted therapeutic strategies to treat cancer through serving as an effective drug delivery podium.

A fast-response pressure sensor based on a dye-adsorbed silica nanoparticle film

2012 ◽  
Vol 171-172 ◽  
pp. 343-349 ◽  
Author(s):  
Masaharu Kameda ◽  
Hitoshi Seki ◽  
Taro Makoshi ◽  
Yutaka Amao ◽  
Kazuyuki Nakakita
Keyword(s):  
Pressure Sensor ◽  
Silica Nanoparticle ◽  
Fast Response ◽  
Response Pressure ◽  
Nanoparticle Film

scholarly journals A multistage assembly/disassembly strategy for tumor-targeted CO delivery

2020 ◽  
Vol 6 (20) ◽  
pp. eaba1362 ◽  
Author(s):  
Jin Meng ◽  
Zhaokui Jin ◽  
Penghe Zhao ◽  
Bin Zhao ◽  
Mingjian Fan ◽  
...  
Keyword(s):  
Controlled Release ◽  
Targeted Delivery ◽  
Tumor Tissue ◽  
Silica Nanoparticle ◽  
Tissue Cell ◽  
Anticancer Efficacy ◽  
Electrostatic Assembly ◽  
Gas Molecule

CO gas molecule not only could selectively kill cancer cells but also exhibits limited anticancer efficacy because of the lack of active tumor-targeted accumulation capability. In this work, a multistage assembly/disassembly strategy is developed to construct a new intelligent nanomedicine by encapsulating a mitochondria-targeted and intramitochondrial microenvironment–responsive prodrug (FeCO-TPP) within mesoporous silica nanoparticle that is further coated with hyaluronic acid by step-by-step electrostatic assembly, realizing tumor tissue–cell–mitochondria–targeted multistage delivery and controlled release of CO in a step-by-step disassembly way. Multistage targeted delivery and controlled release of CO involve (i) the passive tumor tissue–targeted nanomedicine delivery, (ii) the active tumor cell–targeted nanomedicine delivery, (iii) the acid-responsive prodrug release, (iv) the mitochondria-targeted prodrug delivery, and (v) the ROS-responsive CO release. The developed nanomedicine has effectively augmented the efficacy and safety of CO therapy of cancer both in vitro and in vivo. The proposed multistage assembly/disassembly strategy opens a new window for targeted CO therapy.

Influence of dispersion method on silica nanoparticle size distribution/aggregation and their chronic toxicity in-vitro

2018 ◽  
Vol 295 ◽  
pp. S207
Author(s):  
S. Murugadoss ◽  
S. van den Brule ◽  
N. Sebaihi ◽  
F. Brassinne ◽  
J. Mast ◽  
...  
Keyword(s):  
Size Distribution ◽  
Chronic Toxicity ◽  
Silica Nanoparticle ◽  
Nanoparticle Size ◽  
Dispersion Method ◽  
Nanoparticle Size Distribution ◽  
Toxicity In Vitro
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