Sauropus androgynus (L.) leaf phytochemical activated biocompatible zinc oxide nanoparticles: An antineoplastic agent against human triple negative breast cancer and a potent nanocatalyst for dye degradation

2021 ◽  
pp. 149429
Author(s):  
Josline Neetha D'Souza ◽  
G.K. Nagaraja ◽  
Ashwini Prabhu ◽  
K. Meghana Navada ◽  
Sabia Kouser ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Zinc Oxide ◽  
Triple Negative Breast Cancer ◽  
Zinc Oxide Nanoparticles ◽  
Triple Negative ◽  
Dye Degradation ◽  
Antineoplastic Agent ◽  
Oxide Nanoparticles

scholarly journals Photocatalytic activity of biogenic zinc oxide nanoparticles: In vitro antimicrobial, biocompatibility, and molecular docking studies

2021 ◽  
Vol 10 (1) ◽  
pp. 1079-1091
Author(s):  
Mahboob Alam
Keyword(s):  
Zinc Oxide ◽  
Molecular Docking ◽  
Zinc Oxide Nanoparticles ◽  
Dye Degradation ◽  
Antimicrobial Properties ◽  
Morphological Properties ◽  
Diffusion Method ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Receptor Binding Site

Abstract The biogenic synthesis of zinc oxide nanoparticles (ZnO NPs) with pinecone extract (PCE) as a reducing agent and antibacterial agent was explored. The current study aims to investigate the biosynthesis of ZnO NPs and their effect on photocatalytic dye degradation and antimicrobial properties. The physical, chemical, and morphological properties of biogenic ZnO NPs synthesized using PCE were investigated using advanced spectroscopy techniques such as Fourier transform infrared spectroscopy (FTIR), UV-visible spectroscopy, transmission electron microscopy (TEM) analysis, selected area electron diffraction (SAED), and X-ray diffraction (XRD) techniques. The photocatalytic degradation of methylene blue was measured spectrophotometrically using biogenic ZnO NPs as nanocatalysts, and decolonization of solution indicates dye degradation gradually as exposure duration increases. The antimicrobial properties of ZnONPs against the tested pathogenic strains were demonstrated using the disc diffusion method. The antimicrobial efficacy of ZnONPs was further explained using molecular docking analysis. Confirmation of the lowest binding energy was used to predict receptor binding site with NPs in order to understand the mechanistic approach. ZnONPs are likely to interact with pathogens via mechanical enfolding, which could be one of the major toxicity actions of ZnONPs against strains. Furthermore, the nontoxicity and biocompatibility of ZnO NPs were studied, revealing impressive hemocompatibility with red blood cells (RBCs) and no significant toxicity to Brine shrimps at lower ZnONP concentrations.

Frizzled-7-targeted delivery of zinc oxide nanoparticles to drug-resistant breast cancer cells

Nanoscale ◽  
2019 ◽  
Vol 11 (27) ◽  
pp. 12858-12870 ◽  
Author(s):  
Pakatip Ruenraroengsak ◽  
Darya Kiryushko ◽  
Ioannis G. Theodorou ◽  
Michał M. Klosowski ◽  
Erik R. Taylor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Zinc Oxide ◽  
Targeted Delivery ◽  
Zinc Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Oxide Nanoparticles ◽  
Drug Resistant ◽  
Cancer Subtypes ◽  
Aggressive Breast Cancer

There is a need for novel strategies to treat aggressive breast cancer subtypes and overcome drug resistance.

Sign in / Sign up

Export Citation Format

Share Document