The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: The ENRGISE Pilot study

Background: Whether multiple nutritional deficiencies have a synergic effect on mobility loss remains unknown. This study aims to evaluate associations between multi-nutritional deficits and physical performance evolution among community-dwelling older adults.Methods: We included 386 participants from the Multidomain Alzheimer Preventive Trial (MAPT) (75.6 ± 4.5 years) not receiving omega-3 polyunsaturated fatty acid (PUFA) supplementation and who had available data on nutritional deficits. Baseline nutritional deficits were defined as plasma 25 hydroxyvitamin D <20 ng/ml, plasma homocysteine >14 μmol/L, or erythrocyte omega-3 PUFA index ≤ 4.87% (lower quartile). The Short Physical Performance Battery (SPPB), gait speed, and chair rise time were used to assess physical performance at baseline and after 6, 12, 24, 36, 48, and 60 months. We explored if nutrition-physical performance associations varied according to the presence of low-grade inflammation (LGI) and brain imaging indicators.Results: Within-group comparisons showed that physical function (decreased SPPB and gait speed, increased chair rise time) worsened over time, particularly in participants with ≥2 nutritional deficits; however, no between-group differences were observed when individuals without deficit and those with either 1 or ≥2 deficits were compared. Our exploratory analysis on nutritional deficit-LGI interactions showed that, among people with ≥2 deficits, chair rise time was increased over time in participants with LGI (adjusted mean difference: 3.47; 95% CI: 1.03, 5.91; p = 0.017), compared with individuals with no LGI.Conclusions: Accumulated deficits on vitamin D, homocysteine, and omega-3 PUFA were not associated with physical performance evolution in older adults, but they determined declined chair rise performance in subjects with low-grade inflammation.Clinical Trial Registration: [https://clinicaltrials.gov/ct2/show/NCT00672685], identifier [NCT00672685].

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Associação entre obesidade e resultados graves do tratamento em pacientes com COVID-19

Full Dentistry in Science ◽

10.24077/2021;1247138142 ◽

2021 ◽

Vol 12 (47) ◽

pp. 138-142

Author(s):

Giordana Gregório Fritsch ◽

Michael Wesley Schmidt ◽

Antônio Carlos Gargioni Filho ◽

Hussein Nasser Fares

Keyword(s):

Metabolic Disorders ◽

Distress Syndrome ◽

Obesity Paradox ◽

Low Grade ◽

Double Burden ◽

Death Rates ◽

Worldwide Population ◽

Low Grade Inflammation ◽

The Relationship ◽

Activation Component

The worldwide population is facing a double burden of epidemic, the COVID-19and obesity. This is even more alarming as obesity increases the COVID-19 severity. However, the relationship between obesity and COVID-19 severity is more complex than a simple association with BMI. In particular, obesity has been associated with low death rates in patients with acute respiratory distress syndrome, a fatal comorbidity to COVID-19, possibly due to the obesity paradox. Also, visceral adiposity could be a major risk factor for COVID- -19severity, due to its immune activation component, release of ACE2 and involvement in the cytokine storm, It is also known to correlate with metabolic disorders, low-grade inflammation and higher mortality rates.

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Pilot Study: Predictive Measures of Self-Reported Confidence Levels and Physical Performance Related to Fall Risk in Community Dwelling Older Adults

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2016.08.402 ◽

2016 ◽

Vol 97 (10) ◽

pp. e129

Author(s):

Beth Bright ◽

Jamison Staley ◽

Lauren Tirey ◽

Steven Vrchota ◽

Katie Watson

Keyword(s):

Older Adults ◽

Pilot Study ◽

Physical Performance ◽

Fall Risk ◽

Community Dwelling ◽

Confidence Levels ◽

Community Dwelling Older Adults

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The Relationship Between Cognitive Reserve and Cognitive Workload in Older Adults with and Without Pre-clinical Alzheimer’s Disease: A Pilot Study

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2020.09.025 ◽

2020 ◽

Vol 101 (11) ◽

pp. e9-e10

Author(s):

Pedram Ahmadnezhad ◽

Jeffrey Burns ◽

Abiodun Akinwuntan ◽

Hannes Devos

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Pilot Study ◽

Cognitive Reserve ◽

Cognitive Workload ◽

The Relationship

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Impact of 14-day bed rest on serum adipokines and low-grade inflammation in younger and older adults

AGE ◽

10.1007/s11357-015-9848-z ◽

2015 ◽

Vol 37 (6) ◽

Cited By ~ 8

Author(s):

Mihaela Jurdana ◽

Zala Jenko-Pražnikar ◽

Nina Mohorko ◽

Ana Petelin ◽

Tadeja Jakus ◽

...

Keyword(s):

Older Adults ◽

Bed Rest ◽

Low Grade ◽

Low Grade Inflammation

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Relationship between Gout and Diabetes Mellitus after Acute Pancreatitis: A Nationwide Cohort Study

The Journal of Rheumatology ◽

10.3899/jrheum.190487 ◽

2019 ◽

Vol 47 (6) ◽

pp. 917-923 ◽

Cited By ~ 4

Author(s):

Jaelim Cho ◽

Nicola Dalbeth ◽

Maxim S. Petrov

Keyword(s):

Diabetes Mellitus ◽

Acute Pancreatitis ◽

Cox Regression ◽

Social Deprivation ◽

First Episode ◽

Low Grade ◽

Discharge Data ◽

History Of ◽

Low Grade Inflammation ◽

The Relationship

Objective.After acute pancreatitis, individuals often have low-grade inflammation, and subsequently develop metabolic sequelae such as post-pancreatitis diabetes mellitus (PPDM). Although numerous studies have investigated the relationship between gout and type 2 diabetes, little is known about the relationship between gout and PPDM. The aim was to investigate the associations between gout and PPDM.Methods.Using nationwide pharmaceutical dispensing data linked to hospital discharge data in New Zealand, gout and PPDM were identified among individuals after first episode of acute pancreatitis between January 1, 2007, and December 31, 2015. Multivariable Cox regression analyses were conducted, adjusting for age, sex, ethnicity, social deprivation index, alcohol consumption, tobacco smoking, comorbidities, medications (glucocorticoids, statins, and estrogens), and characteristics of acute pancreatitis.Results.A total of 10,117 individuals were included in the analysis of risk for gout and 9471 in the analysis of risk for PPDM. PPDM was significantly associated with a higher risk of gout in the overall cohort (adjusted HR 1.88, 95% CI 1.15–3.06) and women (2.72, 95% CI 1.31–5.65), but not in men (1.42, 95% CI 0.73–2.78). Preexisting gout was significantly associated with a higher risk of PPDM in the overall cohort (adjusted HR 1.58, 95% CI 1.04–2.41) and women (2.66, 95% CI 1.29–5.49), but not in men (1.31, 95% CI 0.78–2.20).Conclusion.The relationship between gout and PPDM is bidirectional in the post-pancreatitis setting. A history of gout is a risk factor of PPDM, particularly in women.

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Non-alcoholic fatty liver disease and cardiovascular disease: assessing the evidence for causality

Diabetologia ◽

10.1007/s00125-019-05024-3 ◽

2019 ◽

Vol 63 (2) ◽

pp. 253-260 ◽

Cited By ~ 17

Author(s):

Martijn C. G. J. Brouwers ◽

Nynke Simons ◽

Coen D. A. Stehouwer ◽

Aaron Isaacs

Keyword(s):

Cardiovascular Disease ◽

Liver Disease ◽

Fatty Liver Disease ◽

Plasma Lipids ◽

Low Grade ◽

Alcoholic Fatty Liver ◽

Important Mediator ◽

Low Grade Inflammation ◽

The Relationship ◽

Alcoholic Fatty Liver Disease

Abstract Non-alcoholic fatty liver disease (NAFLD) is highly prevalent among individuals with type 2 diabetes. Although epidemiological studies have shown that NAFLD is associated with cardiovascular disease (CVD), it remains unknown whether NAFLD is an active contributor or an innocent bystander. Plasma lipids, low-grade inflammation, impaired fibrinolysis and hepatokines are potential mediators of the relationship between NAFLD and CVD. The Mendelian randomisation approach can help to make causal inferences. Studies that used common variants in PNPLA3, TM6SF2 and GCKR as instruments to investigate the relationship between NAFLD and coronary artery disease (CAD) have reported contrasting results. Variants in PNPLA3 and TM6SF2 were found to protect against CAD, whereas variants in GCKR were positively associated with CAD. Since all three genes have been associated with non-alcoholic steatohepatitis, the second stage of NAFLD, the question of whether low-grade inflammation is an important mediator of the relationship between NAFLD and CAD arises. In contrast, the differential effects of these genes on plasma lipids (i.e. lipid-lowering for PNPLA3 and TM6SF2, and lipid-raising for GCKR) strongly suggest that plasma lipids account for their differential effects on CAD risk. This concept has recently been confirmed in an extended set of 12 NAFLD susceptibility genes. From these studies it appears that plasma lipids are an important mediator between NAFLD and CVD risk. These findings have important clinical implications, particularly for the design of anti-NAFLD drugs that also affect lipid metabolism.

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