Fe3O4 nanoparticles-mediated solar-driven enzymatic PET degradation with PET hydrolase

Nanoparticulate Carriers which is biodegradable, biocompatible and bio adhesive have significant feasible applications for administration of therapeutic molecules. The present study was aimed to formulate and optimise Capecitabine loaded Chitosan-Fe3O4 Nanoparticles and to study the in-vitro evaluation by sigma dialysis method. Capecitabine loaded chitosan – Fe3O4 nanoparticles batches with different ratios of drug: polymer (1:1, 1:2, 1:3, 1:4, 1:5, 1:6) were prepared by ionic gelation method. Increase in polymer concentration increases the nanoparticle drug content. Entrapment efficiency was 60.12% with drug to polymer ratio F3 (1:3). In-vitro release was found to be 65.20% for 12 hrs. Capecitabine from chitosanFe3O4 nanoparticles SEM image reveals discrete spherical structure and particles with size range of 100-500nm. FTIR studies represent the functional groups present with no characteristics change in formulations. Samples stored at refrigerator conditions showed better stability compared with samples kept at other conditions during 8 weeks of storage.

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Features of radiothermoluminescence of polypropylene and ethylene propylenediene elastomer SKEPT-4044 compositions with nanoscale metal-containing fillers

Physics and Chemistry of Materials Treatment ◽

10.30791/0015-3214-2020-3-66-73 ◽

2020 ◽

pp. 66-73

Author(s):

A.M. Magerramov ◽

◽

N.I. Kurbanova ◽

M.N. Bayramov ◽

N.A. Alimirzoyeva ◽

...

Keyword(s):

Transition Temperature ◽

Molecular Mobility ◽

Fe3o4 Nanoparticles ◽

Low Temperatures ◽

Frost Resistance ◽

Relaxation Processes ◽

Ethylene Propylene ◽

Temperature Range ◽

Β Relaxation

Using radiothermoluminescence (RTL), the molecular mobility features in the temperature range of 77-300 K were studied for the polypropylene (PP)/ethylene propylene diene elastomer SKEPT-4044 with NiO, Cu2O and Fe3O4 nanoparticles (NPs) based on ABS-acrylonitrile butadiene or SCS-divinyl styrene matrices. It has been shown that the introduction of nanofillers in PP significantly affects the nature and temperature of γ- and β-relaxation processes, while the region of manifestation of the β-process noticeably shifts to the region of low temperatures. Composites with Cu2O NPs have a higher β-transition temperature Tβ than composites with other NPs. It was found that PP/SKEPT-4044 composites with Cu2O NPs with a dispersion of 11-15 nm and acrylonitrile butadiene thermoplastics have optimal frost resistance compared to other compositions.

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Chlorosulfonic Acid Supported Piperidine-4-carboxylic Acid (PPCA) Functionalized Fe3O4 Nanoparticles (Fe3O4-PPCA): The Efficient, Green and Reusable Nanocatalyst for the Synthesis of Pyrazolyl Coumarin Derivatives under Solvent-Free Conditions

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207322666190325120715 ◽

2019 ◽

Vol 22 (2) ◽

pp. 123-128

Author(s):

Setareh Habibzadeh ◽

Hassan Ghasemnejad-Bosra ◽

Mina Haghdadi ◽

Soheila Heydari-Parastar

Keyword(s):

Carboxylic Acid ◽

Fe3o4 Nanoparticles ◽

High Efficiency ◽

Reaction Times ◽

Chlorosulfonic Acid ◽

Aromatic Aldehydes ◽

Solvent Free ◽

Magnetic Nanocatalyst ◽

One Pot ◽

Solvent Free Conditions

Background: In this study, we developed a convenient methodology for the synthesis of coumarin linked to pyrazolines and pyrano [2,3-h] coumarins linked to 3-(1,5-diphenyl-4,5- dihydro-1H-pyrazol-3-yl)-chromen-2-one derivatives using Chlorosulfonic acid supported Piperidine-4-carboxylic acid (PPCA) functionalized Fe3O4 nanoparticles (Fe3O4-PPCA) catalyst. Materials and Methods:: Fe3O4-PPCA was investigated as an efficient and magnetically recoverable Nanocatalyst for the one-pot synthesis of substituted coumarins from the reaction of coumarin with a variety of aromatic aldehydes in high to excellent yield at room temperature under solvent-free conditions. The magnetic nanocatalyst can be easily recovered by applying an external magnet device and reused for at least 10 reaction runs without considerable loss of reactivity. Results and Conclusion: The advantages of this protocol are the use of commercially available materials, simple and an inexpensive procedure, easy separation, and an eco-friendly procedure, and it shows good reaction times, good to high yields, inexpensive and practicability procedure, and high efficiency.

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Effective Preparation, Characterization and In Situ Surface Coating of Superparamagnetic Fe3O4 Nanoparticles with Polyethyleneimine Through Cathodic Electrochemical Deposition (CED)

Current Nanoscience ◽

10.2174/1573413713666161129160640 ◽

2017 ◽

Vol 13 (2) ◽

pp. 167-174 ◽

Cited By ~ 30

Author(s):

Isa Karimzadeh ◽

Mustafa Aghazadeh ◽

Taher Doroudi ◽

Mohammad Ganjali ◽

Peir Kolivand

Keyword(s):

Electrochemical Deposition ◽

Fe3o4 Nanoparticles ◽

Surface Coating

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Adsorption Behavior of Lysozyme on Carbon-Coated Fe3O4 Nanoparticles

Current Nanoscience ◽

10.2174/1573413712666161018143229 ◽

2017 ◽

Vol 13 (2) ◽

pp. 159-166 ◽

Cited By ~ 4

Author(s):

Linshan Wang ◽

Cholhwan Kim ◽

Zefei Zhang ◽

Qili Hu ◽

Ting Sun ◽

...

Keyword(s):

Fe3o4 Nanoparticles ◽

Adsorption Behavior ◽

Carbon Coated

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Assessment of Ploy Dopamine Coated Fe3O4 Nanoparticles for Melanoma (B16-F10 and A-375) Cells Detection

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520620666200513084616 ◽

2020 ◽

Vol 20 (16) ◽

pp. 1918-1926

Author(s):

Fahimeh H. Beigi ◽

Soheil Fatahian ◽

Sogand Shahbazi-Gahrouei ◽

Daryoush Shahbazi-Gahrouei ◽

Amin Farzadniya

Keyword(s):

Mr Imaging ◽

Mtt Assay ◽

Fe3o4 Nanoparticles ◽

Normal Skin ◽

Iron Concentration ◽

Positive Effects ◽

Skin Cells ◽

Melanoma B16 ◽

Co Precipitation

Objective: Polydopamine coated iron oxide nanoparticles (Fe3O4@PDA NPs) were synthesized, characterized, and their MR imaging contrast agents and photothermal potency were evaluated on melanoma (B16-F10 and A-375) cells and normal skin cells. To this end, MTT assay, Fe concentration, and MR imaging of both coated and uncoated NPs were assessed in C57BL/6 mice. Methods: Fe3O4 nanoparticles were synthesized using co-precipitation, and coated with polydopamine. The cytotoxicity of Fe3O4 and Fe3O4@PDA NPs on melanoma cells, with different concentrations, were obtained using MTT assay. MR images and Fe concentrations of nanoprobe and nanoparticles were evaluated under in vivo conditions. Results: Findings indicated that uncoated Fe3O4 showed the highest toxicity in animal (B16-F10) cells at 450μg/ml after 72h, while the highest toxicity in human (A-375) cells were observed at 350μg/ml. These nanoparticles did not reveal any cytotoxicity to normal skin cells, despite having some toxicity features in A-375 cells. MR image signals in the tumor were low compared with other tissues. The iron concentration in the tumor was higher than that of other organs. Conclusion: It is concluded that the cytotoxicity of Fe3O4@PDA was found to be significantly lower than uncoated nanoparticles (p <0.001), which allows some positive effects on reducing toxicity. The prepared nanoprobe may be used as a contrast agent in MR imaging.

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