Beneficial effects of Plantago albicans on high-fat diet-induced obesity in rats

2016 ◽  
Vol 84 ◽  
pp. 1768-1775 ◽  
Author(s):  
Noura Samout ◽  
Amani Ettaya ◽  
Hafsia Bouzenna ◽  
Sana Ncib ◽  
Abdelfattah Elfeki ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Beneficial Effects ◽  
Diet Induced Obesity

scholarly journals Effect of Supplementation with Hydroethanolic Extract of Campomanesia xanthocarpa (Berg.) Leaves and Two Isolated Substances from the Extract on Metabolic Parameters of Mice Fed a High-Fat Diet

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2693 ◽  
Author(s):  
Carla Maiara Lopes Cardozo ◽  
Aline Carla Inada ◽  
Claudia Andrea Lima Cardoso ◽  
Wander Fernando de Oliveira Filiú ◽  
Bernardo Barcelar de Farias ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Metabolic Disorders ◽  
Brazilian Cerrado ◽  
American Institute ◽  
High Fat ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
Protein Expressions ◽  
Hydroethanolic Extract ◽  
Lipid Parameters

There are still controversies regarding the correlation between the beneficial effects for health and the administration of isolated compounds or crude extracts in therapeutic applications. Campomanesia xanthocarpa, found in the Brazilian Cerrado, demonstrated beneficial effects in metabolic disorders associated with obesity. We investigated the effects of Campomanesia xanthocarpa hydroethanolic extract and two isolated substances from the extract (S1 and S2) in a diet-induced obesity (DIO) model. Male Swiss mice were divided into five groups: (1) American Institute of Nutrition (AIN-93M) diet, (2) high-fat diet (HF), (3) HF supplemented with C. xanthocarpa hydroethanolic leaf extract at 100 mg/kg (HFE), (4) HF supplemented with S1 at 1 mg/kg (HFS1) and (5) HF supplemented with S2 at 1 mg/kg (HFS2). The HFS1, HFS2 and HFE groups did not present decreasing body weight or visceral adiposity gain. No differences in glycemic and lipid parameters, or in the expression of protein content in two cytokines, interleukin-6 (IL-6) and anti-inflammatory (IL-10), were observed. Only the HFS1 group displayed decreased food intake. Even though substantial effects such as an improvement in obesity features or the metabolic and histological parameters promoted by S1, S2 and the extract were not observed, further investigations are necessary to evaluate the principal genes and protein expressions involved in regulating food behavior promoted by S1.

scholarly journals Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Eveliina Tauriainen ◽  
Mira Luostarinen ◽  
Essi Martonen ◽  
Piet Finckenberg ◽  
Miia Kovalainen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Fatty Liver ◽  
Calorie Restriction ◽  
High Fat Diet ◽  
Adipose Tissue Inflammation ◽  
High Fat ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
Ad Libitum ◽  
Metabolic Performance

The potential of resveratrol to mimic beneficial effects of calorie restriction (CR) was investigated. We compared the effects of both CR (70% ofad libitumenergy intake) or resveratrol (2 g/kg or 4 g/kg food) on high-fat diet-induced obesity and fatty liver formation in C57Bl/6J mice, and we examined their effects on calorimetry, metabolic performance, and the expressions of inflammatory genes and SIRT proteins. We found that resveratrol with 4 g/kg dose partially prevented hepatic steatosis and hepatocyte ballooning and induced skeletal muscle SIRT1 and SIRT4 expression while other examined parameter were unaffected by resveratrol. In contrast, CR provided superior protection against diet-induced obesity and fatty liver formation as compared to resveratrol, and the effects were associated with increased physical activity and ameliorated adipose tissue inflammation. CR increased expressions of SIRT3 in metabolically important tissues, suggesting that the beneficial effects of CR are mediated, at least in part, via SIRT3-dependent pathways.

scholarly journals The Resin fromProtium heptaphyllumPrevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Karine Maria Martins Bezerra Carvalho ◽  
José Delano Barreto Marinho Filho ◽  
Tiago Sousa de Melo ◽  
Ana Jérsia Araújo ◽  
Josiane da Silva Quetz ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Scientific Evidence ◽  
Net Energy ◽  
High Fat ◽  
Beneficial Effects ◽  
Proinflammatory Mediators ◽  
Glucose And Lipid Metabolism ◽  
Diet Induced Obesity ◽  
Obesity In Mice

Herbal compounds rich in triterpenes are well known to regulate glucose and lipid metabolism and to have beneficial effects on metabolic disorders. The present study investigated the antiobesity properties of resin fromProtium heptaphyllum(RPH) and the possible mechanisms in mice fed a high-fat diet (HFD) for 15 weeks. Mice treated with RPH showed decreases in body weight, net energy intake, abdominal fat accumulation, plasma glucose, amylase, lipase, triglycerides, and total cholesterol relative to their respective controls, which were RPH unfed. Additionally, RPH treatment, while significantly elevating the plasma level of ghrelin hormone, decreased the levels of insulin, leptin, and resistin. Besides, HFD-induced increases in plasma levels of proinflammatory mediators TNF-α, IL-6, and MCP-1 were significantly lowered by RPH. Furthermore,in vitrostudies revealed that RPH could significantly inhibit the lipid accumulation in 3T3-L1 adipocytes (measured by Oil-Red O staining) at concentrations up to 50 μg/mL. These findings suggest that the antiobese potential of RPH is largely due to its modulatory effects on various hormonal and enzymatic secretions related to fat and carbohydrate metabolism and to the regulation of obesity-associated inflammation.

Beneficial Effects of Red Yeast Rice on High-Fat Diet-Induced Obesity, Hyperlipidemia, and Fatty Liver in Mice

2015 ◽  
Vol 18 (10) ◽  
pp. 1095-1102 ◽  
Author(s):  
Ho Sung Lee ◽  
Yu Jeung Lee ◽  
Yoon Hee Chung ◽  
Yunsung Nam ◽  
Sung Tae Kim ◽  
...  
Keyword(s):  
Fatty Liver ◽  
High Fat Diet ◽  
Red Yeast Rice ◽  
High Fat ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
Red Yeast

The Anti-Obesity Effect of Instant Pu-Erh Ripe Tea in Mice with Hydrogenated Oil Diet-Induced Obesity

2014 ◽  
Vol 644-650 ◽  
pp. 5239-5243
Author(s):  
Ming Lian ◽  
Yu Fang Jiang ◽  
Shi Dong Lv ◽  
Yi Long He ◽  
Jiang Sheng Zhou ◽  
...  
Keyword(s):  
Weight Loss ◽  
Developing Countries ◽  
Lipid Metabolism ◽  
High Fat Diet ◽  
Obese Patients ◽  
High Fat ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
Hydrogenated Oil ◽  
Weight Loss Drug

Obesity has become a fast growing epidemic in developing countries, as well as in some of the developing countries. Drinking Chinese tea has been demonstrated to have multiple beneficial effects to obese patients. It showed strong effect in reducing body fat and lowering blood sugar. This article tested the effect of instant Pu-erh ripe tea on weight loss in diet-induced obese (DIO) mice. The results demonstrated that instant Pu-erh ripe tea was be able to reduce the mouse weight dose-dependently. Its effect is stronger than that of L-carnitine, a weight loss drug currently on the market. Instant Pu-erh ripe tea also accelerated lipid metabolism and eased the high-fat diet-induced liver injury.

The Anti-Obesity Effect of Instant Pu-Erh Black Tea in Mice with Hydrogenated Oil Diet-Induced Obesity

2014 ◽  
Vol 644-650 ◽  
pp. 5248-5251
Author(s):  
Ming Lian ◽  
Yu Fang Jiang ◽  
Shi Dong Lv ◽  
Yi Long He ◽  
Jiang Sheng Zhou ◽  
...  
Keyword(s):  
Weight Loss ◽  
High Fat Diet ◽  
Black Tea ◽  
Obese Patients ◽  
High Fat ◽  
Epidemic Disease ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
Hydrogenated Oil ◽  
Weight Loss Drug

Obesity is becoming a worldwide epidemic disease, and the incidence is increasing year by year. Drinking tea has been demonstrated to have multiple beneficial effects to obese patients. This article tested the effect of instant Pu-erh black tea on weight loss in diet-induced obese (DIO) mice. The results demonstrated that instant Pu-erh black tea was be able to reduce the mouse weight dose-dependently. Its effect is stronger than that of L-carnitine, a weight loss drug currently on the market. Instant Pu-erh black tea also accelerated lipid metabolism and eased the high-fat diet-induced liver injury.

Omega-3 polyunsaturated fatty acids have beneficial effects on visceral fat in diet-induced obesity model

2019 ◽  
Vol 97 (6) ◽  
pp. 693-701 ◽  
Author(s):  
Aline Haas de Mello ◽  
Rosiane de Bona Schraiber ◽  
Mariana Pereira de Souza Goldim ◽  
Khiany Mathias ◽  
Carolini Mendes ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Energy Intake ◽  
Body Mass ◽  
Visceral Fat ◽  
High Fat Diet ◽  
Omega 3 ◽  
High Fat ◽  
Beneficial Effects ◽  
Diet Induced Obesity

This study evaluated the effects of omega-3 polyunsaturated fatty acids (PUFAs) on oxidative stress and energy metabolism parameters in the visceral fat of a high-fat-diet induced obesity model. Energy intake, body mass, and visceral fat mass were also evaluated. Male Swiss mice received either a control diet (control group) or a high-fat diet (obese group) for 6 weeks. After this period, the groups were divided into control + saline, control + omega-3, obese + saline, and obese + omega-3, and to these groups 400 mg·(kg body mass)−1·day−1 of fish oil (or saline) was administered orally, for 4 weeks. Energy intake and body mass were monitored throughout the experiment. In the 10th week, the animals were euthanized and the visceral fat (mesenteric) was removed. Treatment with omega-3 PUFAs did not affect energy intake or body mass, but it did reduced visceral fat mass. In visceral fat, omega-3 PUFAs reduced oxidative damage and alleviated changes to the antioxidant defense system and the Krebs cycle. The mitochondrial respiratory chain was neither altered by obesity nor by omega-3 PUFAs. In conclusion, omega-3 PUFAs have beneficial effects on the visceral fat of obese mice because they mitigate changes caused by the consumption of a high-fat diet.

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