364. The BDNF Val66Met Polymorphism Moderates the Relationship between PTSD and Fear Extinction Learning

The purpose of this study was to synthesize research evidence from studies on the relationships among the BDNF Val66Met polymorphism, regular exercise, and cognition in human subjects. PubMed, CINAHL, and Web of Science were searched systematically. Search limiters applied in these databases included humans, English language, time limits from 2009 to 2019, and peer-reviewed journal articles. Eight studies were included in the current review. While there was some evidence to tentatively suggest that greater levels of exercise were associated with certain forms of memory in Val/Val homozygotes than Met carriers, more research is needed to corroborate these findings. Regarding attention/information processing speed, executive function as well as global cognition, the evidence is either inconsistent or sparse and does not allow for tentative conclusions. Compelling evidence from high-quality clinical trials is needed to re-examine the relationship between the BDNF Val66Met polymorphism, exercise, and cognition.

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BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

European Psychiatry ◽

10.1016/j.eurpsy.2009.10.008 ◽

2010 ◽

Vol 25 (6) ◽

pp. 311-313 ◽

Cited By ~ 50

Author(s):

G. Spalletta ◽

D.W. Morris ◽

F. Angelucci ◽

I.A. Rubino ◽

I. Spoletini ◽

...

Keyword(s):

Aggressive Behavior ◽

Neurotrophic Factor ◽

Aggressive Behaviour ◽

Brain Derived Neurotrophic Factor ◽

Gene Variants ◽

Bdnf Gene ◽

Val66met Polymorphism ◽

Schizophrenic Patients ◽

Bdnf Val66met Polymorphism ◽

The Relationship

AbstractBrain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.

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The BDNF Val66Met Polymorphism Moderates the Relationship Between Posttraumatic Stress Disorder and Trauma Script-evoked Attentional Bias to Cocaine Cues Among Patients with Cocaine Dependence

Journal of Anxiety Disorders ◽

10.1016/j.janxdis.2020.102223 ◽

2020 ◽

Vol 72 ◽

pp. 102223

Author(s):

Joseph R. Bardeen ◽

Thomas A. Daniel ◽

Kim L. Gratz ◽

Eric J. Vallender ◽

Michael R. Garrett ◽

...

Keyword(s):

Posttraumatic Stress Disorder ◽

Posttraumatic Stress ◽

Attentional Bias ◽

Stress Disorder ◽

Cocaine Dependence ◽

Val66met Polymorphism ◽

Bdnf Val66met Polymorphism ◽

The Relationship

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Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder

European Psychiatry ◽

10.1016/j.eurpsy.2011.09.005 ◽

2012 ◽

Vol 27 (5) ◽

pp. 386-390 ◽

Cited By ~ 19

Author(s):

M.A. Fullana ◽

P. Alonso ◽

M. Gratacòs ◽

N. Jaurrieta ◽

S. Jiménez-Murcia ◽

...

Keyword(s):

Treatment Response ◽

Obsessive Compulsive Disorder ◽

Behavior Therapy ◽

Cognitive Behavior Therapy ◽

Cognitive Behavior ◽

Obsessive Compulsive ◽

Extinction Learning ◽

Val66met Polymorphism ◽

Compulsive Disorder ◽

Bdnf Val66met Polymorphism

AbstractBackgroundRecent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD).MethodsOne hundred and six OCD patients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the relationship between genotype and treatment response was analyzed.ResultsAmong 98 CBT completers, 36% of those carrying the BDNF Met allele were rated as CBT responders compared to 60% of nonMet allele carriers (P = 0.027). When analyzing the different obsessive-compulsive symptom dimensions, in patients with contamination/cleaning symptoms, the Met allele was associated with a significantly worse CBT response (P<0.0001) and a lower obsessions severity decrease from pre- to posttreatment (P = 0.046).ConclusionGenetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms.

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